Tag: 100-200

Li, Qiaowei; Zhang, Wenyu; Miljanic, Ognjen S.; Sue, Chi-Hau; Zhao, Yan-Li; Liu, Lihua; Knobler, Carolyn B.; Stoddart, J. Fraser; Yaghi, Omar M. published their research in Science (Washington, DC, United States) on August 14 ,2009. The article was titled 《Docking in Metal-Organic Frameworks》.SDS of cas: 74029-40-6 The article contains the following contents:

The use of metal-organic frameworks (MOFs) so far has largely relied on nonspecific binding interactions to host small mol. guests. The authors used long organic struts (2̃ nm) incorporating 34- and 36-membered macrocyclic polyethers as recognition modules in the construction of several crystalline primitive cubic frameworks that engage in specific binding in a way not observed in passive, open reticulated geometries. MOF-1001 is capable of docking paraquat dication (PQT2+) guests within the macrocycles in a stereoelectronically controlled fashion. This act of specific complexation yields quant. the corresponding MOF-1001 pseudorotaxanes, as confirmed by x-ray diffraction and by solid- and solution-state NMR spectroscopic studies performed on MOF-1001, its pseudorotaxanes, and their mol. strut precursors. A control experiment involving the attempted inclusion of PQT2+ inside a framework (MOF-177) devoid of polyether struts showed negligible uptake of PQT2+, indicating the importance of the macrocyclic polyether in PQT2+ docking. In the experimental materials used by the author, we found 1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6SDS of cas: 74029-40-6)

1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. SDS of cas: 74029-40-6 They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Ferrocenes Bearing Highly Extended π Systems with Nitrile, Nitro, and Dimethylamino End Groups》 was published in European Journal of Organic Chemistry in 2014. These research results belong to Krausse, Nico; Butenschoen, Holger. Formula: C12H10O2 The article mentions the following:

Oligophenylene-ethynylenes are a popular class of mol. wires for mol. electronics. Replacement of some, not all, of the 1,4-phenylene units by 1,1′-ferrocenylene moieties generates less rigid entities with a limited conformational flexibility. Within this concept, the syntheses of some 1,1′-disubstituted ferrocenes that bear arylethynyl or 4-(arylethynyl)phenyl substituents is presented. In contrast to related compounds with sulfur end groups that were prepared previously, the versions presented here have nitrile end groups, which, according to reported precedence, may serve as points of attachment to gold surfaces. A crystal structure anal. of an unusual diferrocenylethyne derivative is included. In addition, one representative with a push-pull disubstitution that has a nitro and a dimethylamino end group is presented. Many of the prepared compounds have been characterized by cyclic voltammetry.1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6Formula: C12H10O2) was used in this study.

1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes. Formula: C12H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Acidic Ionic Liquid [H-NP]HSO4 Promoted One-Pot Synthesis of Dihydro-1H-Indeno[1,2-b]pyridines and Polysubstituted Imidazoles》 was written by Alinezhad, Heshmatollah; Tajbakhsh, Mahmoud; Maleki, Behrooz; Pourshaban Oushibi, Fereshteh. Electric Literature of C8H8O2This research focused ontriphenyl imidazole one pot preparation green chem; tetraphenyl imidazole one pot preparation green chem; ethyl phenyl dihydroindenopyridine carboxylate one pot preparation green chem; pyrrolidonium sulfonate ionic liquid preparation recyclability. The article conveys some information:

A green and efficient protocol for the one-pot synthesis of dihydro-1H-indeno[1,2-b]pyridines and polysubstituted imidazoles using a recyclable acidic ionic liquid [H-NP]HSO4 (H-NPBS) was reported. Non-corrosiveness, safe, low waste, generality, simplicity, easy for separation, short reaction times, high yields and environmentally benign were some of the advantages of this methodol. The [H-NP]HSO4 (H-NPBS) was effectively recycled for six consecutive cycles without appreciable loss in its activity.2-Methoxybenzaldehyde(cas: 135-02-4Electric Literature of C8H8O2) was used in this study.

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.Electric Literature of C8H8O2

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Safety of N,N-Dimethylformamide Dimethyl AcetalIn 2020 ,《Synthesis, X-ray analysis and computational studies of two novel thiophene derivatives*》 was published in Journal of Sulfur Chemistry. The article was written by Muhsinah, Abdullatif Bin; Alsayari, Abdulrhman; Algarni, H.; Soliman, Saied M.; Kheder, Nabila A.; Ghabbour, Hazem A.; Asiri, Yahya I.; Venkatesan, Kumar; Mabkhot, Yahia N.. The article contains the following contents:

The reaction of Et 3-oxobutanoate with carbon disulfide and chloroacetone in the presence of K2CO3 affords the unexpected thiophene derivative . Furthermore, refluxing compound with dimethylformamide-dimethylacetal (DMF-DMA) in DMF affords the enaminone derivative . The structures of these newly synthesized compounds were confirmed by means of various spectroscopic techniques, such as IR, MS, and NMR, as well as by X-ray diffraction. In addition, B3LYP/6-311G(d, p) basis sets were employed to optimize the mol. geometry of the two thiophene derivatives Furthermore, natural at. charges and frontier MO analyses were performed. Hirshfeld anal. of the mol. packing showed that H-H, O-H, C-H, and S-H are the most common intermol. interactions in both compounds Further anal. suggests that the O-H interactions are the most significant of these in compounds and . In addition to this study using N,N-Dimethylformamide Dimethyl Acetal, there are many other studies that have used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Safety of N,N-Dimethylformamide Dimethyl Acetal) was used in this study.

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Safety of N,N-Dimethylformamide Dimethyl Acetal

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Name: 2-(Benzyloxy)acetaldehydeIn 2019 ,《Asymmetric syn-1,3-Dioxane Construction via Kinetic Resolution of Secondary Alcohols Using Chiral Phosphoric Acid Catalysts》 was published in Asian Journal of Organic Chemistry. The article was written by Matsumoto, Akira; Asano, Keisuke; Matsubara, Seijiro. The article contains the following contents:

Herein, a novel enantioselective hemiacetalization/intramol. oxy-Michael addition cascade for the synthesis of syn-1,3-diol frameworks I [R = Ph, 2-naphthyl, PhCH=CH, etc.; OSi = OTBS, OTBPDS] via kinetic resolution of chiral secondary alcs. using chiral phosphoric acid catalysts was presented. By utilizing the recovered optically active starting material, both enantiomers of the corresponding protected 1,3-diols could be obtained with high optical purities. In addition, the products with a carbonyl group were converted diastereoselectively to longer optically active 1,3-polyols, which were representative motifs in polyketides. Moreover, the organocatalytic approach presented in this study facilitates a library construction of useful chiral building blocks for the asym. synthesis of bioactive compounds In the experiment, the researchers used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Name: 2-(Benzyloxy)acetaldehyde)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Name: 2-(Benzyloxy)acetaldehyde

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Product Details of 4637-24-5In 2020 ,《Convenient synthesis of novel sulfonamide derivatives as promising anticancer agents》 was published in Journal of Heterocyclic Chemistry. The article was written by El-Mekabaty, Ahmed; Awad, Hanem M.. The article contains the following contents:

Novel sulfonamide derivatives I [R = acetyl, 2-aminothiazol-4-yl, 4-oxo-3,1-benzoxazin-2-yl, etc.] were synthesized from the readily accessible N-(4-acetylphenyl)benzenesulfonamide I [R = acetyl]. Condensation of N-(4-acetylphenyl)benzenesulfonamide I [R = acetyl] with phenylhydrazine in refluxing Et alc. gave the corresponding phenylhydrazone I [R = N-anilino-C-methyl-carbonimidoyl], which was then added to the Vilsmeier-Haack reagent (POCl3/DMF) to give the 4-formylpyrazole derivative I [R = 4-formyl-1-phenyl-pyrazol-3-yl]. Fusion of I [R = acetyl] with thiourea in the presence of iodine at 130°C afforded the 2-aminothiazole derivative I [R = 2-aminothiazol-4-yl]. Refluxing I [R = acetyl] with an excess of N, N-dimethylformamide di-Me acetal furnished the enaminone I [R = 3-(dimethylamino)prop-2-enoyl]. The chem. reactivity of enaminone I [R = 3-(dimethylamino)prop-2-enoyl] toward some nitrogen and carbon nucleophiles has been studied to obtain polyfunctionalized heteroaromatic systems bearing a sulfonamide moiety. Besides, the enaminone I [R = 3-(dimethylamino)prop-2-enoyl] undergoes the Gewald reaction and reacts with Et cyanoacetate and elemental sulfur in the presence of morpholine to yield the 2-aminothiophene derivative I [R = 5-amino-4-ethoxycarbonyl-thiophene-2-carbonyl]. Moreover, the utility of I [R = 3-(dimethylamino)prop-2-enoyl] for the synthesis of 4-(phenylsulfonamido)benzoic acid I [R = carboxy] was investigated. The synthesized sulfonamides I were evaluated for their in vitro cytotoxic activities against two human cell lines, MCF-7 (breast adenocarcinoma cells) and RPE-1 (normal retina pigmented epithelium cells). The results revealed that compounds I [R = acetyl, N-anilino-C-methyl-carbonimidoyl, 4-formyl-1-phenyl-pyrazol-3-yl, 3-pyrazolyl, 2-oxo-1H-pyrimidin-4-yl, 2-aminopyrimidin-4-yl, 4-oxo-1H-quinoline-3-carbonyl, 5-acetyl-6-methyl-2-pyridyl, 5-amino-4-ethoxycarbonyl-thiophene-2-carbonyl, carboxy, 4-oxo-3,1-benzoxazin-2-yl] were potent cytotoxic effect on MCF-7 and less on RPE-1 cells compared to the pos. control doxorubicin. In the experiment, the researchers used many compounds, for example, N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Product Details of 4637-24-5)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Product Details of 4637-24-5

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Ether – Wikipedia,
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Related Products of 150-19-6In 2020 ,《Access to Vinyl Ethers and Ketones with Hypervalent Iodine Reagents as Oxy-Allyl Cation Synthetic Equivalents》 was published in Angewandte Chemie, International Edition. The article was written by Declas, Nina; Waser, Jerome. The article contains the following contents:

We report an Umpolung strategy of enol ethers to generate oxy-allyl cation equivalent based on the use of hypervalent iodine reagents. Under mild basic conditions, the addition of nucleophiles to aryloxy-substituted vinylbenziodoxolone (VBX) reagents, easily available in two steps from silyl alkynes, resulted in the stereoselective formation of substituted aryl enol ethers. The reaction was most efficient with phenols as nucleophiles, but preliminary results were also achieved for C- and N- nucleophiles. In absence of external nucleophiles, the 2-iodobenzoate group of the reagent was transferred. The obtained aryl enol ethers could then be transformed into α-difunctionalized ketones by oxidation The described “”allyl cation””-like reactivity contrast with the well-established “”vinyl-cation”” behavior of alkenyl iodonium salts. Thus, e.g., reaction of I with p-cresol afforded allyl ether II (80%) in DME with KOtBu as base; in absence of external nucleophile, allylic ester III was obtained (65%). In the experiment, the researchers used m-Methoxyphenol(cas: 150-19-6Related Products of 150-19-6)

m-Methoxyphenol(cas: 150-19-6) may be used as an analytical standard for the determination of the analyte in wine, coffee beans, wood samples, and mainstream smoke by gas chromatography (GC) based techniques.Related Products of 150-19-6

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of C8H8O2In 2020 ,《4,4′-Trimethylenedipiperidine (TMDP): An Efficient Organocatalyst for the Mechanosynthesis of Pyrano[4,3-b]pyrans under Solid-state Conditions》 appeared in Polycyclic Aromatic Compounds. The author of the article were Khaligh, Nader Ghaffari; Mihankhah, Taraneh; Rafie Johan, Mohd. The article conveys some information:

This paper presents a green protocol for the synthesis of pyrano[4,3-b]pyrans using a catalytic amount of 4,4′-trimethylenedipiperidine (TMDP) as a novel, efficient and recyclable organocatalyst through ball milling process at room temperature The essential part of this protocol is a Knoevenagel condensation and to the best of our knowledge, this is the first report that exhibits the catalytic efficiency 4,4′-TMDP for the one-pot multicomponent reaction under melt-state conditions. The scope of the present protocol was explored and demonstrated for the synthesis of pyrano[4,3-b]pyrans in an environment-friendly protocol. The several interesting features of the present methodol. are including a cost-effectiveness procedure, good to excellent yield of the desired products, high reaction rate, a broad substrate-scope, and recyclability of organocatalyst; as well as the 4,4′-TMDP is a nontoxic, inexpensive, and com. available catalyst. Furthermore, this efficient methodol. displays a combination of the synthetic virtues of conventional multicomponent reaction with ecol. benefits and convenience of a facile mechanochem. process. The experimental part of the paper was very detailed, including the reaction process of 2-Methoxybenzaldehyde(cas: 135-02-4Synthetic Route of C8H8O2)

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.Synthetic Route of C8H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Khaligh, Nader Ghaffari; Mihankhah, Taraneh published an article in Polycyclic Aromatic Compounds. The title of the article was 《Green and Solid-Phase Synthesis of New Dihydro-[1,2,4]Triazolo[1,5-a]Pyrimidine Scaffolds by Using Poly-Melamine-Formaldehyde as a Nitrogen-Rich Porous Organocatalyst》.Category: ethers-buliding-blocks The author mentioned the following in the article:

This work presented a new catalytic application of porous poly-melamine-formaldehyde (mPMF) for the efficient synthesis of dihydro-[1,2,4]triazolo[1,5-a]pyrimidines I [Ar = 2-MeOC6H4, 4-O2NC6H4, 2,4,6-tri-MeOC6H2, etc.]. According to the principles of green chem., the reaction was performed by planetary ball milling process at ambient and neat conditions. The heterogeneous catalyst could be reused up to five runs with no reducing of catalytic efficiency. A variety of dihydro-[1,2,4]triazolo[1,5-a]pyrimidines I were obtained in good to excellent yields under eco-friendly conditions. This work revealed that bifunctional porous organic polymers (POPs) containing base sites and acceptor-donner hydrogen bonding groups, as well as high porosity could play a vital role in the promotion of the one-pot multicomponent reactions in the solid phase. The main merits of current methodol. included short reaction time, wide substrate-scope and use of a metal-free heterogeneous organocatalyst, simple work-up process. The results came from multiple reactions, including the reaction of 2-Methoxybenzaldehyde(cas: 135-02-4Category: ethers-buliding-blocks)

2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yu, Xiaoye; Daniliuc, Constantin G.; Alasmary, Fatmah Ali; Studer, Armido published an article in 2021. The article was titled 《Direct Access to α-Aminosilanes Enabled by Visible-Light-Mediated Multicomponent Radical Cross-Coupling》, and you may find the article in Angewandte Chemie, International Edition.Electric Literature of C9H10O2 The information in the text is summarized as follows:

α-Aminosilanes are an important class of organic compounds that show biol. activity. A new approach to α-aminosilanes that uses photoredox catalysis to enable three-component coupling of organo(tristrimethylsilyl)silanes with feedstock alkylamines and aldehydes is presented. A wide range of highly functionalized α-aminosilanes can be obtained in good yields under mild conditions. Both primary amines and secondary amines are compatible with this transformation. Also, optically pure α-aminosilanes are accessible by using chiral amines. Mechanistic studies indicate that reactions proceed through radical/radical cross-coupling of silyl radicals with α-amino alkyl radicals.2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Electric Literature of C9H10O2) was used in this study.

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Electric Literature of C9H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem