Tag: 100-200

Zhang, Changyuan; Qiu, Yun; Zhang, Jiantao; Chen, Lulu; Xu, Shuting; Guo, Huosheng; Luo, Jian; Tan, Yao published their research in Asian Journal of Organic Chemistry in 2021. The article was titled 《CAN-mediated Oxidative Coupling-Reaction of Xanthenes with Enaminones》.Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal The article contains the following contents:

An efficient CAN-mediated C-C bond formation in the oxidative reactions of xanthenes with enaminones under mild reaction conditions was described. A variety of 9H-xanthene-9-ylidene aldehydes I [R = H, 2-Cl, 3-Ph, etc.; R1 = Ph, 2-thienyl, cyclohexyl, etc.; X = O, NMe, S] could be synthesized in up to 90% yield via one-pot manner with good functional group compatibility, which achieved the simultaneous construction of carbon-carbon double bond and carbon-oxygen double bond. The experimental process involved the reaction of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Recommanded Product: N,N-Dimethylformamide Dimethyl Acetal

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《Green synthesis of 1H-pyrazolo[1,2-b]phthalazine-2-carbonitrile derivatives using a new bifunctional base-ionic liquid hybrid magnetic nanocatalyst》 was written by Hamidinasab, Mahdia; Bodaghifard, Mohammad Ali; Mobinikhaledi, Akbar. Synthetic Route of C8H8O2 And the article was included in Applied Organometallic Chemistry in 2020. The article conveys some information:

The ionic liquid-base N,N,2,2,6,6-hexamethyl-N-(3-(trimethoxysilyl)propyl)piperidin-4-ammonium iodide was grafted onto titana-coated NiFe2O4 nanoparticles for obtaining an efficient and reusable ionic liquid-base hybrid nanocatalyst. The structure of hybrid nanoparticles was characterized using FT-IR (Fourier-transform IR spectroscopy), field emission SEM, EDS (energy-dispersive X-ray spectroscopy), EDS map scan, Brunauer-Emmett-Teller surface area anal., CHN (elemental anal.), vibrating sample magnetometer and thermogravimetric anal. techniques. Furthermore, this novel hybrid catalyst was used in one-pot three-component synthesis of 3-amino-1-aryl-5,10-dioxo-1H-pyrazolo[1,2-b]phthalazine-2-carbonitrile derivatives I [R = H, 2-Cl, 4-NO2, etc.] under green and environmentally benign conditions. This protocol avoids the use of harmful catalysts, toxic solvents and harsh reaction conditions. The products were synthesized in excellent yields within short reaction time and identified using elemental anal., FT-IR, 1H NMR and 13C NMR spectroscopies. The results came from multiple reactions, including the reaction of 2-Methoxybenzaldehyde(cas: 135-02-4Synthetic Route of C8H8O2)

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.Synthetic Route of C8H8O2

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《Novel fused pyridine derivatives containing pyrimidine moiety as prospective tyrosyl-tRNA synthetase inhibitors: Design, synthesis, pharmacokinetics and molecular docking studies》 was written by Othman, Ismail M. M.; Gad-Elkareem, Mohamed A. M.; Anouar, El Hassane; Snoussi, Mejdi; Aouadi, Kaiss; Kadri, Adel. Category: ethers-buliding-blocks And the article was included in Journal of Molecular Structure in 2020. The article conveys some information:

Thirteen fused pyridine derivatives have been designed, synthesized. Their in vitro antimicrobial activity was investigated against some pathogenic bacteria and fungi and the majority of them showed excellent to moderate activity, especially compounds I and II displaying the potent inhibitory effect against K. pneumoniae with MIC values of 2.44 mM and 8.10 mM, resp. Their pharmacokinetic assessment also revealed promising druglikeness characteristics and ADME properties. The binding interactions of the most active analogs were performed through mol. docking against Staphylococcus aureus tyrosyl-tRNA synthetase. Results revealed that the enhanced activity of compound I can be modulated by the establishment, in 10-tyrosyltRNA synthetase complex, of hydrogen bond interactions between the lone pair of sulfur atom of the thiophen-3-amine ring and the hydrogen atom of the hydroxyl group of TYR 170 of 3.80 Å . These findings suggest that analogs I and II can be served as best candidates for designing and discovering of novel antimicrobial agents. In the experiment, the researchers used many compounds, for example, N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Category: ethers-buliding-blocks)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Category: ethers-buliding-blocks

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《Manganese-Catalyzed Hydroarylation of Unactivated Alkenes》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Liu, Ting; Yang, Yunhui; Wang, Congyang. Name: 3-Methoxyphenylboronic acid The article mentions the following:

Transition-metal-catalyzed hydroarylation of unactivated alkenes with strategic use of remote coordinating functional groups has received significant attention recently to address the issues of both low reactivity and poor selectivity. The bidentate 8-aminoquinoline amide group is the most successfully adopted in unactivated alkenes for Pd and Ni catalysis. The authors describe the first manganese-catalyzed hydroarylation of unactivated alkenes bearing diverse simple functionalities with arylboronic acids. A series of δ- and γ-arylated amides, ketones, pyridines, and amines was accessed with excellent regioselectivity and in high yields. Hydroalkenylation of unactivated alkenes also is applicable under this manganese-catalysis regime. The method features earth-abundant manganese catalysis, easily available substrates, broad functional-group tolerance, and excellent regioselective control. The results came from multiple reactions, including the reaction of 3-Methoxyphenylboronic acid(cas: 10365-98-7Name: 3-Methoxyphenylboronic acid)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Name: 3-Methoxyphenylboronic acid

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The author of 《Ni0 NPs anchored on acid-activated montmorillonite (Ni0-Mont) as a highly efficient and reusable nanocatalyst for synthesis of biscoumarins and bisdimedones》 were Rahmani, Soleiman; Zeynizadeh, Behzad. And the article was published in Research on Chemical Intermediates in 2019. Electric Literature of C8H8O2 The author mentioned the following in the article:

Ni0 nanoparticles were immobilized on acid-activated montmorillonite (Ni0-Mont) by anchoring Ni(OAc)2·4H2O on modified micro/mesoporous montmorillonite followed by reduction with ethylene glycol. The prepared clay composite system was then characterized using Fourier-transform IR (FT-IR) spectroscopy, SEM, energy-dispersive X-ray (EDX) spectroscopy, X-ray diffraction (XRD) anal., and Brunauer-Emmett-Teller (BET) anal. SEM anal. revealed perfect dispersion of metallic nickel nanoparticles with size distribution of 6-41 nm on the clay matrix. Micro/mesoporous montmorillonite was prepared by activation of Na+-montmorillonite with HCl (4 M) under controlled conditions. The catalytic activity of the prepared Ni0-Mont clay was studied in one-pot microwave-assisted synthesis of biscoumarins and bisdimedones via Knoevenagel reaction of aromatic aldehydes with 4-hydroxycoumarin or dimedone in solvent-free conditions. All reactions were carried out at room temperature within 5-15 min (for biscoumarins) and 5-20 min (for bisdimedones) to afford the products in high to excellent yield. The reusability of the Ni0-Mont catalyst was also investigated in seven consecutive cycles, without significant loss of catalytic activity. In the experimental materials used by the author, we found 2-Methoxybenzaldehyde(cas: 135-02-4Electric Literature of C8H8O2)

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.Electric Literature of C8H8O2

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The author of 《Enantioselective Palladium-Catalyzed Cross-Coupling of α-Bromo Carboxamides and Aryl Boronic Acids》 were Li, Bowen; Li, Tiejun; Aliyu, Muinat A.; Li, Zhen Hua; Tang, Wenjun. And the article was published in Angewandte Chemie, International Edition in 2019. HPLC of Formula: 10365-98-7 The author mentioned the following in the article:

We herein report an enantioselective palladium-catalyzed cross-coupling between α-bromo carboxamides and aryl boronic acids, generating a series of chiral α-aryl carboxamides in good yields and excellent enantioselectivities. The development of a chiral P,P=O ligand was critical in overcoming the second transmetalation issue and allows the first asym. palladium-catalyzed coupling of α-bromo carbonyl compounds In the experiment, the researchers used many compounds, for example, 3-Methoxyphenylboronic acid(cas: 10365-98-7HPLC of Formula: 10365-98-7)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.HPLC of Formula: 10365-98-7

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Hu, Zhiyong; Wei, Xiao-Jing; Handelmann, Jens; Seitz, Ann-Katrin; Rodstein, Ilja; Gessner, Viktoria H.; Goossen, Lukas J. published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Coupling of Reformatsky reagents with aryl chlorides enabled by ylide-functionalized phosphine ligands》.Computed Properties of C7H7BrO The article contains the following contents:

The coupling of aryl chlorides with Reformatsky reagents is a desirable strategy for the construction of α-aryl esters but has so far been substantially limited in the substrate scope due to many challenges posed by various possible side reactions. This limitation has now been overcome by the tailoring of ylide-functionalized phosphines to fit the requirements of Negishi couplings. Record-setting activities were achieved in palladium-catalyzed arylations of organozinc reagents with aryl electrophiles using a cyclohexyl-YPhos ligand bearing an ortho-tolyl-substituent in the backbone. This highly electron-rich, bulky ligand enables the use of aryl chlorides in room temperature couplings of Reformatsky reagents. The reaction scope covers diversely functionalized arylacetic and arylpropionic acid derivatives Aryl bromides and chlorides can be converted selectively over triflate electrophiles, which permits consecutive coupling strategies. In addition to this study using 1-Bromo-3-methoxybenzene, there are many other studies that have used 1-Bromo-3-methoxybenzene(cas: 2398-37-0Computed Properties of C7H7BrO) was used in this study.

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.Computed Properties of C7H7BrO

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Ether – Wikipedia,
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《Design, diversity-oriented synthesis and biological evaluation of novel heterocycle derivatives as non-nucleoside HBV capsid protein inhibitors》 was written by Jia, Haiyong; Yu, Ji; Du, Xianhong; Cherukupalli, Srinivasulu; Zhan, Peng; Liu, Xinyong. SDS of cas: 4637-24-5 And the article was included in European Journal of Medicinal Chemistry in 2020. The article conveys some information:

This study focous on scaffold hopping, bioisosterism, and pharmacophore hybrid-based strategies to design and synthesize six series of various heterocycle derivatives (pyrazole, thiazole, pyrazine, pyrimidine, and pyridine) and screened for in vitro anti-HBV non-nucleoside activity. Drug candidate NZ-4 and AT-130 were used as lead compounds Several compounds exhibited prominent anti-HBV activity compared to lead compound NZ-4 and pos. drug Lamivudine, especially compound II-8b, showed the most prominent anti-HBV DNA replication activity (IC50 = 2.2 ± 1.1μM). Also compounds IV-8e and VII-5b showed the best in vitro anti-HBsAg secretion (IC50 = 3.8 ± 0.7μM, CC50 > 100μM) and anti-HBeAg secretion (IC50 = 9.7 ± 2.8μM, CC50 > 100μM) resp. Besides, II-8b was interact HBV capsid protein with good affinity constants (KD = 60.0μM), which was equivalent to lead compound NZ-4 (KD = 50.6μM). The preliminary structure-activity relationships (SARs) of the newly synthesized compounds were summarized, which may help researchers to discover more potent anti-HBV agents. The results came from multiple reactions, including the reaction of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5SDS of cas: 4637-24-5)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.SDS of cas: 4637-24-5

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《Aza-Piancatelli Cyclization as a Platform for the Preparation of Scaffolds of Natural Compounds: Application to the Total Synthesis of Bruceolline D》 was published in European Journal of Organic Chemistry in 2020. These research results belong to Marin, Lucile; Force, Guillaume; Gandon, Vincent; Schulz, Emmanuelle; Leboeuf, David. Application of 60656-87-3 The article mentions the following:

The aza-Piancatelli cyclization provides an expedient synthesis of 4-aminocyclopentenone building blocks that may be converted into aminocyclopentitols, which are heavily represented motifs among natural products. However, its use as a key step in total synthesis was still unprecedented. Here, we disclose our in-depth investigations regarding this reaction in order to access highly complex structures representing the core of some natural mols. The applicability of the cyclization was highlighted by the 3-step total synthesis of bruceolline D. Thus, we anticipate that this work will lay the ground for further applications in total synthesis. In the experiment, the researchers used many compounds, for example, 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Application of 60656-87-3)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.Application of 60656-87-3

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In 2019,Angewandte Chemie, International Edition included an article by Wang, Huamin; Zhang, Junyou; Tu, Youshao; Zhang, Junliang. Related Products of 673-22-3. The article was titled 《Phosphine-Catalyzed Enantioselective Dearomative [3+2]-Cycloaddition of 3-Nitroindoles and 2-Nitrobenzofurans》. The information in the text is summarized as follows:

Over the past years, the metal-catalyzed dearomative cycloaddition of 3-nitroindoles and 2-nitrobenzofurans have emerged as a powerful protocol to construct chiral fused heterocyclic rings. However, organocatalytic dearomative reaction of these two classes of heteroarenes has become a long-standing challenging task. Herein, a report on the first example of phosphine-catalyzed asym. dearomative [3+2]-cycloaddition of 3-nitroindoles and 2-nitrobenzofurans, which provides a new, facile, and efficient protocol for the synthesis of chiral 2,3-fused cyclopentannulated indolines and dihydrobenzofurans by reacting with allenoates and MBH carbonates, resp. through a dearomative [3+2]-cycloaddn has been described. In the experimental materials used by the author, we found 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Related Products of 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Related Products of 673-22-3

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