Tag: 0-100

Solvents for Processing Stable Tin Halide Perovskites was written by Di Girolamo, Diego;Pascual, Jorge;Aldamasy, Mahmoud H.;Iqbal, Zafar;Li, Guixiang;Radicchi, Eros;Li, Meng;Turren-Cruz, Silver-Hamill;Nasti, Giuseppe;Dallmann, Andre;De Angelis, Filippo;Abate, Antonio. And the article was included in ACS Energy Letters in 2021.Application of 109-85-3 The following contents are mentioned in the article:

Tin is one of the most promising alternatives to lead to make lead-free halide perovskites for optoelectronics. However, the stability of tin-based perovskites is hindered by the oxidation of Sn(II) to Sn(IV). Recent works established that DMSO, which is one of the best-performing solvents for processing perovskite, is the primary source of tin oxidation The quest for a stable solvent could be a game-changer in the stability of tin-based perovskites. Starting from a database of over 2000 solvents, we identified a series of 12 new solvents suitable for the processing of formamidinium tin iodide perovskite (FASnI3) by investigating (1) the solubility of the precursor chems. FAI and SnI₂, (2) the thermal stability of the precursor solution, and (3) the possibility of forming perovskite. Finally, we demonstrate a new solvent system to produce solar cells outperforming those based on DMSO. Our work provides guidelines for further identification of new solvents or solvent mixtures for preparing stable tin-based perovskites. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Application of 109-85-3).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Application of 109-85-3

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Formation of N-P(O)-S Bonds from White Phosphorus via a Four-Component Reaction was written by Zhang, Yue;Cao, Yinwei;Chi, Yangyang;Chen, Shuanghui;Zeng, Xiangzhe;Liu, Yan;Tang, Guo;Zhao, Yufen. And the article was included in Advanced Synthesis & Catalysis in 2022.Synthetic Route of C3H9NO The following contents are mentioned in the article:

Functionalization of white phosphorus with disulfides ArSSAr (Ar = Ph, 2-fluorophenyl, 4-methylphenyl, etc.), amines R¹NHR² [R¹ = Et, cyclohexyl, furan-2-ylmethyl, etc.; R² = H, Me, Et, n-butyl; R¹R² = -(CH₂)₄-, -(CH₂)₆-, -(CH₂)₂O(CH₂)₂-, etc.] and KOH to phosphoramidodithioates P(O)(ArS)₂NR¹R² containing both P-N, P-S and P=O bonds via a four-component reaction is presented. It proceeds with high yields and provides an attractive approach for the construction of valuable N-P(O)-S motif using a one-step strategy. The advantages of this newly developed process include a clean reaction profile, complete conversion of white phosphorus, transition metal-free and halogen-free environmentally benign system, and large-scale synthetic application. Besides, phosphoramidodithioates can also be utilized to construct P-C, P-O and P=S bonds with the appropriate reagents. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Synthetic Route of C3H9NO).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Synthetic Route of C3H9NO

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Design, Synthesis, In Vitro and In Vivo Characterization of Selective NKCC1 Inhibitors for the Treatment of Core Symptoms in Down Syndrome was written by Borgogno, Marco;Savardi, Annalisa;Manigrasso, Jacopo;Turci, Alessandra;Portioli, Corinne;Ottonello, Giuliana;Bertozzi, Sine Mandrup;Armirotti, Andrea;Contestabile, Andrea;Cancedda, Laura;De Vivo, Marco. And the article was included in Journal of Medicinal Chemistry in 2021.Computed Properties of C3H9NO The following contents are mentioned in the article:

Intracellular chloride concentration [Cl^–]_i is defective in several neurol. disorders. In neurons, [Cl^–]_i is mainly regulated by the action of the Na⁺-K⁺-Cl^– importer NKCC1 and the K⁺-Cl^– exporter KCC2. Recently, we have reported the discovery of ARN23746(I) as the lead candidate of a novel class of selective inhibitors of NKCC1. Importantly, ARN23746 is able to rescue core symptoms of Down syndrome (DS) and autism in mouse models. Here, we describe the discovery and extensive characterization of this chem. class of selective NKCC1 inhibitors, with focus on ARN23746 and other promising derivatives In particular, we present compound 40 (ARN24092)(II) as a backup/follow-up lead with in vivo efficacy in a mouse model of DS. These results further strengthen the potential of this new class of compounds for the treatment of core symptoms of brain disorders characterized by the defective NKCC1/KCC2 expression ratio. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Computed Properties of C3H9NO).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Computed Properties of C3H9NO

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Solvation properties of protic ionic liquids 2-methoxyethylammonium nitrate, propylammonium hydrogen sulfate, and butylammonium hydrogen sulfate was written by Sedov, Igor A.;Magsumov, Timur I.. And the article was included in Journal of Chemical Thermodynamics in 2022.Safety of 2-Methoxyethylamine The following contents are mentioned in the article:

Solvation properties of protic ionic liquids (PILs) are virtually unexplored. We measured the limiting activity coefficients of several hydrocarbons and aliphatic alcs. in 2-methoxyethylammonium nitrate (2MEAN), propylammonium hydrogen sulfate (PAHS), and butylammonium hydrogen sulfate (BAHS) at 298 K. Comparison with the previously obtained results for other substituted ammonium PILs reveals the sensitivity of solvation properties to the changes in the structure of both cation and anion which also affect the nanostructure of the bulk phase. It was shown that hydrocarbons are less soluble in 2MEAN than in alkylammonium nitrates due to destabilizing effect of the methoxy group on apolar domains in the liquid structure preferentially solvating hydrocarbon mols. The solubility of hydrocarbons is also lower in hydrogen sulfate ILs than in nitrate ILs with the same alkylammonium cation. This can be explained by the presence of the acidic hydrogen in anion which strengthens the hydrogen bonds network and the solvophobic effects in the liquid This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Safety of 2-Methoxyethylamine).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Safety of 2-Methoxyethylamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Graft modification of polybenzimidazole membranes for organic solvent ultrafiltration with scale up to spiral wound modules was written by Oxley, Adam;Gaffney, Piers R. J.;Kim, Daeok;Marchetti, Patrizia;Livingston, Andrew G.. And the article was included in Journal of Membrane Science in 2022.Reference of 109-85-3 The following contents are mentioned in the article:

In this work the selectivity of crosslinked organic solvent stable PBI membranes is tuned by varying the molar ratio of two grafting agents: a long flexible polymer modifier (Elastamine RE-1-1000, 1000 g mol-1) and a small mol. modifier (2-methoxyethylamine, 75 g mol^-1). Grafting exclusively with the long chain modifier provided a membrane with a mol. weight cut-off (MWCO) of 2000 g mol^-1 in acetonitrile. Increasing the proportion of small mol. modifier in the grafting reaction capped the grafting sites in the membrane. This caused a decrease in the grafting d. of the polymer modifier and allowed for the MWCO to be customized between 2000 g mol^-1 and 20,000 g mol^-1 in acetonitrile. High grafting densities underlie this control of performance, with up to 43% increase in the sp. weight of the membrane during modification. This technique was scaled up to the manufacture of 5 m lengths of membrane that were incorporated into 1.8” x 12” spiral wound modules, which showed performance consistent with the flat sheet membranes. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Reference of 109-85-3).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Reference of 109-85-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Picomole-Scale Synthesis and Screening of Macrocyclic Compound Libraries by Acoustic Liquid Transfer was written by Sangouard, Gontran;Zorzi, Alessandro;Wu, Yuteng;Ehret, Edouard;Schuettel, Mischa;Kale, Sangram;Diaz-Perlas, Cristina;Vesin, Jonathan;Bortoli Chapalay, Julien;Turcatti, Gerardo;Heinis, Christian. And the article was included in Angewandte Chemie, International Edition in 2021.Application of 109-85-3 The following contents are mentioned in the article:

Macrocyclic compounds are an attractive class of therapeutic ligands against challenging targets, such as protein-protein interactions. However, the development of macrocycles as drugs is hindered by the lack of large combinatorial macrocyclic libraries, which are cumbersome, expensive, and time consuming to make, screen, and deconvolute. Here, we established a strategy for synthesizing and screening combinatorial libraries on a picomolar scale by using acoustic droplet ejection to combine building blocks at nanoliter volumes, which reduced the reaction volumes, reagent consumption, and synthesis time. As a proof-of-concept, we assembled a 2700-member target-focused macrocyclic library that we could subsequently assay in the same microtiter synthesis plates, saving the need for addnl. transfers and deconvolution schemes. We screened the library against the MDM2-p53 protein-protein interaction and generated micromolar and sub-micromolar inhibitors. Our approach based on acoustic liquid transfer provides a general strategy for the development of macrocycle ligands. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Application of 109-85-3).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Application of 109-85-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Benzothiophene derivatives as selective estrogen receptor covalent antagonists: Design, synthesis and anti-ERα activities was written by Bai, Chengfeng;Wu, Shuangjie;Ren, Shengnan;Zhu, Meiqi;Luo, Guoshun;Xiang, Hua. And the article was included in Bioorganic & Medicinal Chemistry in 2021.Category: ethers-buliding-blocks The following contents are mentioned in the article:

Estrogen receptor α emerged as a well validated therapeutic target of breast cancer for decades. However, approx. 50% of patients who initially respond to the standard-of-care (SoC), such as undergo therapy of Tamoxifen, generally inevitably progress to an endocrine-resistance ER+ phenotype. Recently, selective estrogen receptor covalent antagonists (SERCAs) targeted to ERα have demonstrated potential as therapeutic alternatives. In the present study, a series of novel 6-OH-benzothiophene (BT) derivatives targeting ERα and derived from Raloxifene were designed, synthesized, and biol. evaluated as covalent antagonists. Driven by the antiproliferative efficacy in ER+ breast cancer cells, chem. optimization finally led to compound I having potent antagonistic activity in ER+ tumor cells while not showing agonistic activity in endometrial cells. Moreover, a docking simulation was carried out to elucidate the binding mode, revealing I as an antagonist and covalently binding to the cysteine residue at the 530 position of ER helix H11. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Category: ethers-buliding-blocks).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Category: ethers-buliding-blocks

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Pyrazole Agonist of the Apelin Receptor Improves Symptoms of Metabolic Syndrome in Mice was written by Narayanan, Sanju;Wang, Shaobin;Vasukuttan, Vineetha;Vyas Devambatla, Ravi Kumar;Dai, Donghua;Jin, Chunyang;Snyder, Rodney;Laudermilk, Lucas;Runyon, Scott P.;Maitra, Rangan. And the article was included in Journal of Medicinal Chemistry in 2021.Recommanded Product: 2-Methoxyethylamine The following contents are mentioned in the article:

Apelin receptor agonism improves symptoms of metabolic syndrome. However, endogenous apelin peptides have short half-lives, making their utility as potential drugs limited. Previously, we had identified a novel pyrazole-based agonist scaffold. Systematic modification of this scaffold was performed to produce compounds with improved ADME properties. Compound 13 (I) with favorable agonist potency (cAMPi EC₅₀ = 162 nM), human liver microsome stability (T_1/2 = 62 min), and pharmacokinetic profile in rodents was identified. The compound was tested in a mouse model of diet-induced obesity (DIO) and metabolic syndrome for efficacy. Treatment with 13 led to significant weight loss, hypophagia, improved glucose utilization, reduced liver steatosis, and improvement of disease-associated biomarkers. In conclusion, a small-mol. agonist of the apelin receptor has been identified that is suitable for in vivo investigation of the apelinergic system in DIO and perhaps other diseases where this receptor has been implicated to play a role. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Recommanded Product: 2-Methoxyethylamine).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Recommanded Product: 2-Methoxyethylamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Inhibiting a dynamic viral protease by targeting a non-catalytic cysteine was written by Hulce, Kaitlin R.;Jaishankar, Priyadarshini;Lee, Gregory M.;Bohn, Markus-Frederik;Connelly, Emily J.;Wucherer, Kristin;Ongpipattanakul, Chayanid;Volk, Regan F.;Chuo, Shih-Wei;Arkin, Michelle R.;Renslo, Adam R.;Craik, Charles S.. And the article was included in Cell Chemical Biology in 2022.Recommanded Product: 2-Methoxyethylamine The following contents are mentioned in the article:

Viruses are responsible for some of the most deadly human diseases, yet available vaccines and antivirals address only a fraction of the potential viral human pathogens. Here, we provide a methodol. for managing human herpesvirus (HHV) infection by covalently inactivating the HHV maturational protease via a conserved, non-catalytic cysteine (C161). Using human cytomegalovirus protease (HCMV Pr) as a model, we screened a library of disulfides to identify mols. that tether to C161 and inhibit proteolysis, then elaborated hits into irreversible HCMV Pr inhibitors that exhibit broad-spectrum inhibition of other HHV Pr homologs. We further developed an optimized tool compound targeted toward HCMV Pr and used an integrative structural biol. and biochem. approach to demonstrate inhibitor stabilization of HCMV Pr homodimerization, exploiting a conformational equilibrium to block proteolysis. Irreversible HCMV Pr inhibition disrupts HCMV infectivity in cells, providing proof of principle for targeting proteolysis via a non-catalytic cysteine to manage viral infection. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Recommanded Product: 2-Methoxyethylamine).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Recommanded Product: 2-Methoxyethylamine

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Discovery of 4-Arylindolines Containing a Thiazole Moiety as Potential Antitumor Agents Inhibiting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction was written by Qin, Mingze;Meng, Yangyang;Yang, Haoshen;Liu, Lei;Zhang, Haotian;Wang, Simeng;Liu, Chunyang;Wu, Xia;Wu, Di;Tian, Ye;Hou, Yunlei;Zhao, Yanfang;Liu, Yajing;Xu, Congjun;Wang, Lihui. And the article was included in Journal of Medicinal Chemistry in 2021.Reference of 109-85-3 The following contents are mentioned in the article:

Through specific structural modification of a 4-phenylindoline precursor, new 4-arylindolines containing a thiazole moiety were developed and found to be promising modulators of the programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) axis. Compound A30(I) exhibited outstanding biochem. activity, with an IC₅₀ of 11.2 nM in a homogeneous time-resolved fluorescence assay. In the cell-based assay, A30 significantly promoted IFN-γ secretion and rescued T-cell proliferation, which were inhibited by PD-1 activation. Furthermore, A30 showed favorable in vivo antitumor activity in a mouse 4T1 breast carcinoma model. Moreover, in mouse CT26 colon carcinoma models, A30 potently suppressed the growth of CT26/PD-L1 tumor but did not obviously affect the growth of CT26/vector tumor. The results of flow cytometry anal. indicated that A30 inhibited tumor growth by activating the immune microenvironment. We concluded that A30 is a new starting point for further development of PD-1/PD-L1 interaction inhibitors as antitumor agents. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Reference of 109-85-3).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Reference of 109-85-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem