Tag: 0-100

3-Vinyl oxindole-chromone synthon as a skeletal reconstruction reactant for the synthesis of 2-hydroxy benzoyl pyridones was written by Zhang, Lei;Liu, Ren-Ming;Wang, Wei-Na;Liu, Xiong-Li;Dai, Yi-Feng;Yu, Zhang-Biao;Peng, Li-Jun. And the article was included in New Journal of Chemistry in 2022.Quality Control of 2-Methoxyethylamine The following contents are mentioned in the article:

The first example of ring-opening and recyclization reaction of 3-vinyl oxindole-chromones I [R¹ = H, 4-F, 5-Br, etc.; R² = H, 5-F, 4-Cl, etc.] as versatile synthons, which can react with ammonia or primary aliphatic amines as binucleophiles was developed, serving as a fruitful strategy for the eco-friendly and atom-economic synthesis of a new family of skeletally diverse 2-hydroxy benzoyl pyridones II [R³ = H, CH₂CH₂OMe, CH₂CH₂CN, etc.] with high to excellent yields (70-92%). The advantages of this methodol., including the use of easily available raw materials and the catalyst-free, wide functional group tolerance, and gram-scale synthesis, make the developed methodol. a practical way to access important biol. active 2-hydroxy benzoyl pyridone mols. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Quality Control of 2-Methoxyethylamine).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Quality Control of 2-Methoxyethylamine

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Anodic Oxidation of Iodobenzene and Iodobenzoic Acids in Acetic Acid Environment – Electrochemical Investigation and Density Functional Theory Study was written by Bystron, Tomas;Devadas, Balamurugan;Bouzek, Karel;Svoboda, Jan;Kolarikova, Viola;Kvicala, Jaroslav. And the article was included in ChemElectroChem in 2021.Name: 2-Methoxyethylamine The following contents are mentioned in the article:

Kinetic and mechanistic aspects of an anodic oxidation of iodobenzene and its selected derivatives leading to the corresponding iodosyl compounds, were investigated in anhydrous acidic acetic acid environment using boron-doped diamond electrode. The first electron removal leading to the formation of radical cation was identified as the rate determining step of the process. Oxidation potential values of the investigated compounds were rationalised by their solution phase ionisation energies (in conformation of the radical cations as products of the first electron removal), calculated by advanced DFT methods. Unexpectedly low oxidation potential of 2-iodobenzoic acid and its functional derivatives compared to iodobenzene, 3-iodo and 4-iodobenzoic acids was explained by decreased electron d. at iodine atom leading to planar 2-iodobenzoic acid radical cation. This is connected with reordering of its frontier MOs compared to non-planar neutral mol. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Name: 2-Methoxyethylamine).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Name: 2-Methoxyethylamine

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Ether – Wikipedia,
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Sequence-Encoded Macromolecules with Increased Data Storage Capacity through a Thiol-Epoxy Reaction was written by Soete, Matthieu;Mertens, Chiel;Aksakal, Resat;Badi, Nezha;Du Prez, Filip. And the article was included in ACS Macro Letters in 2021.Name: 2-Methoxyethylamine The following contents are mentioned in the article:

Sequence-encoded oligo(thioether urethane)s with two different coding monomers per backbone unit were prepared via a solid phase, two-step iterative protocol based on thiolactone chem. The first step of the synthetic cycle consists of the thiolactone ring opening with a primary amine, whereby the in situ released thiol is immediately reacted with an epoxide. In the second step, the thiolactone group is reinstalled to initiate the next cycle. This strategy allows to introduce two different coding monomers per synthetic cycle, rendering the resulting macromols. especially attractive in the area of (macro)mol. data storage because of their increased data storage capacity. Subsequently, the efficiency of the herein reported synthesis route and the applicability of the dual-encoded sequence-defined macromols. as a potential data storage platform were demonstrated by unraveling the exact monomer order using tandem mass spectrometry techniques. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Name: 2-Methoxyethylamine).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Name: 2-Methoxyethylamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Discovery of a Novel Series of Potent and Selective Alkynylthiazole-Derived PI3Kγ Inhibitors was written by Bandarage, Upul K.;Aronov, Alex M.;Cao, Jingrong;Come, Jon H.;Cottrell, Kevin M.;Davies, Robert J.;Giroux, Simon;Jacobs, Marc;Mahajan, Sudipta;Messersmith, David;Moody, Cameron S.;Swett, Rebecca;Xu, Jinwang. And the article was included in ACS Medicinal Chemistry Letters in 2021.Synthetic Route of C3H9NO The following contents are mentioned in the article:

Phosphoinositide 3-kinases (PI3Ks) are a family of enzymes that control a wide variety of cellular functions such as cell growth, proliferation, differentiation, motility, survival, and intracellular trafficking. PI3Kγ plays a critical role in mediating leukocyte chemotaxis as well as mast cell degranulation, making it a potentially interesting target for autoimmune and inflammatory diseases. We previously disclosed a novel series of PI3Kγ inhibitors derived from a benzothiazole core. The truncation of the benzothiazole core led to the discovery of a structurally diverse alkynyl thiazole series which displayed high PI3Kγ potency and subtype selectivity. Further medicinal chem. optimization of the alkynyl thiazole series led to identification of compounds such as 14 and 32, highly potent, subtype selective, and CNS penetrant PI3Kγ inhibitors. Compound 14 showed robust inhibition of PI3Kγ mediated neutrophil migration in vivo. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Synthetic Route of C3H9NO).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Synthetic Route of C3H9NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Tert-Butyl Hydroperoxide Promoted the Reaction of Quinazoline-3-oxides with Primary Amines Affording Quinazolin-4(3H)-ones was written by Luo, Jin;Wan, Juelin;Wu, Lianlian;Yang, Lingyun;Wang, Tao. And the article was included in Journal of Organic Chemistry in 2022.Name: 2-Methoxyethylamine The following contents are mentioned in the article:

An efficient and facile approach for the synthesis of quinazolin-4(3H)-ones I [R¹ = C₆H₅, 2-MeC₆H₄, 4-MeC₆H₄, 2-furyl, n-Pr, etc., R² = R³ = H; R¹ = Ph, R² = H, 7-OMe, 6,7-(OMe)₂, 6-F, etc., R³ = H, Me] via the reaction of quinazoline-3-oxides II with primary amines R¹CH₂Ph is described. This approach was demonstrated to be applicable for a broad range of substrates and proceeds efficiently under metal-free and mild reaction conditions employing easily available tert-Bu hydroperoxide as the oxidant. Remarkably, I [R¹ = 1H-indol-3-ylmethyl], which was conveniently obtained by this process in 70% yield, was an excellent precursor for the synthesis of bioactive evodiamine and rutaecarpine. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Name: 2-Methoxyethylamine).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Name: 2-Methoxyethylamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Discovery of N-(4-(3-isopropyl-2-methyl-2H-indazol-5-yl)pyrimidin-2-yl)-4-(4-methylpiperazin-1-yl)quinazolin-7-amine as a Novel, Potent, and Oral Cyclin-Dependent Kinase Inhibitor against Haematological Malignancies was written by Huang, Jianhang;Wang, Xinren;Dong, Ruinan;Liu, Xiaoyue;Li, Hongmei;Zhang, Tianyi;Xu, Junyu;Liu, Chenhe;Zhang, Yanmin;Hou, Shaohua;Tang, Weifang;Lu, Tao;Chen, Yadong. And the article was included in Journal of Medicinal Chemistry in 2021.Synthetic Route of C3H9NO The following contents are mentioned in the article:

Hematol. malignancies (HM) start in blood forming tissue or in the cells of the immune system. Cyclin-dependent kinases (CDKs) regulate cell cycle progression, and some of them control cellular transcription. CDK inhibition can trigger apoptosis and could be particularly useful in hematol. malignancies. Herein, we describe our efforts toward the discovery of a novel series of quinazoline derivatives as CDK inhibitors. Intensive structural modifications lead to the identification of compound 37d as the most active inhibitors of CDKs 1, 2, 4, 8 and 9 with balancing potency and selectivity against CDKs. Further biol. studies revealed that compound 37d can arrest the cell cycle and induce apoptosis via activating PARP and caspase 3. More importantly, compound 37d showed good antitumor efficacy in multiple HM mice xenograft models with no obvious toxicity. These results indicated that CDK 1, 2, 4, 8, and 9 inhibitors could be potentially used to treat certain hematol. malignancies. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Synthetic Route of C3H9NO).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Synthetic Route of C3H9NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Design and synthesis of Grp94 selective inhibitors based on Phe199 induced fit mechanism and their anti-inflammatory effects was written by Xu, Shicheng;Guo, Anping;Chen, Nan-nan;Dai, Wei;Yang, Huan-aoyu;Xie, Wenqin;Wang, Mengjie;You, Qi-Dong;Xu, Xiao-Li. And the article was included in European Journal of Medicinal Chemistry in 2021.Safety of 2-Methoxyethylamine The following contents are mentioned in the article:

Glucose-regulated protein 94 (Grp94), a member of the Heat shock protein 90 (Hsp90) family, is implicated in many human diseases, including cancer, neurodegeneration, inflammatory, and infectious diseases. Here, we describe our effort to design and develop a new series of Grp94 inhibitors based on Phe199 induced fit mechanism. Using an alkynyl-containing inhibitor as a starting point, we developed compound 4 (I), which showed potent inhibitory activity toward Grp94 in a fluorescence polarization-based assay. With improved physicochem. properties and suitable pharmacokinetic properties, compound 4 was advanced into in vivo bioactivity evaluation. In a dextran sulfate sodium (DSS)-induced mouse model of ulcerative colitis (UC), compound 4 showed anti-inflammatory property and reduced the levels of pro-inflammatory cytokines (TNF-α and IL-6). Together, these findings provide evidence that this approach may be promising for further Grp94 drug development efforts. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Safety of 2-Methoxyethylamine).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Safety of 2-Methoxyethylamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Green, versatile, and scale-up synthesis of amides by aerobic oxidative amination over Ag₂O/P-C₃N₄ photocatalyst was written by Deng, Lanqing;Chen, Lang;Zhu, Liangdi;Li, Yang;Ou-Yang, Jie;Wu, Shaofeng;Chen, Peng;Shen, Sheng;Guo, Junkang;Zhou, Yongbo;Au, Chak-Tong;Yin, Shuang-Feng. And the article was included in Chemical Engineering Science in 2022.Synthetic Route of C3H9NO The following contents are mentioned in the article:

Being extensively applied in various fields of chem. and chem. industry, the development of a green and versatile method for the synthesis of amides is in line with the demand of sustainable chem. Herein, a direct, highly selective, and scale-up (5-20 mmol) method for photocatalytic synthesis of amides through aerobic oxidative amination of alcs. with amines was developed under visible light, room temperature, using air as the oxidant. Benefiting from the adsorption of sodium hemiaminal on catalyst lengthens the C-H bond (1.148 Å), this novel process is feasible for a broad range of functionlized amides (69 examples), especially those for drug manufacture (e.g., moclobemide and pipobroman). Imines was almost prevented with excellent amide selectivity up to 99% could be ascribed to the low energy barrier for hemiaminal dehydrogenation while that for dehydration is high (2.13 eV). This green and efficient protocol represents an ideal alternative to the currently known methods. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Synthetic Route of C3H9NO).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Synthetic Route of C3H9NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electrochemical TEMPO-Catalyzed Oxidative Ugi-Type Reaction was written by Pan, Na;Xinen Lee, Maegan;Bunel, Louis;Grimaud, Laurence;Vitale, Maxime R.. And the article was included in ACS Organic & Inorganic Au in 2021.Synthetic Route of C3H9NO The following contents are mentioned in the article:

Oxidative isocyanide-based multicomponent reactions (oxidative IMCRs) are very useful tools for the rapid construction of mol. diversity starting from readily available and stable substrates. Despite all their benefits, such multicomponent reactions are underdeveloped and strictly limited to 3-component processes. Indeed, in the presence of several reaction partners, the oxidation event needs to be rigorously chemoselective, which becomes incredibly more intricate as the number of reactive components increases. Nonetheless, authors could overcome this significant pitfall and reach the first oxidative Ugi-type 4-IMCR by capitalizing on a very mild and green TEMPO-catalyzed electro-oxidation process. Employing alcs. as aldehyde surrogates and in the notable absence of any supporting electrolyte, this transformation proved to be extremely chemoselective in the presence of an amine and was compatible with a wide range of alcs., amines, isocyanides, and carboxylic acids. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Synthetic Route of C3H9NO).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Synthetic Route of C3H9NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Asymmetric Synthesis of 3-Pyrrolines through an Aryne-Induced Domino Process was written by Hwu, Jih Ru;Panja, Avijit;Gupta, Nitesh K.;Huang, Wen-Chieh;Hu, Yu-Chen;Lin, Chun-Cheng;Hwang, Kuo-Chu;Chan, Wei-Jen;Tsay, Shwu-Chen. And the article was included in Asian Journal of Organic Chemistry in 2021.Computed Properties of C3H9NO The following contents are mentioned in the article:

Here, the accomplishment of a newly developed domino reaction was reported for synthesizing optically active 3-pyrrolines I [R¹ = H, OMe, OCH₂O; R² = H, p-Me, p-OMe, m-Br; R³ = OMe, CN, CO₂Me; R⁴ = CO₂Me, CO₂Et; R⁵ = H, CO₂Me, CO₂Et], a class of compounds with various biol. properties. The reaction involved the use of (trimethylsilyl)aryl triflates, Schiff bases, and alkynes in the presence of a chiral catalyst (R)-(-)-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate. The key features of this new reaction include the generation of a single product in very good yields (75-85%) with high stereo- and enantio-selectivity; the enantiomeric ratio reaches as high as 98.5 : 1.5. Moreover, it involved an aryne-induced domino reaction and an unusual 1,4-intramol. proton transfer, which overwhelms the well-established 1,5-proton transfer. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Computed Properties of C3H9NO).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Computed Properties of C3H9NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem