Ethers-buliding-blocks

Biological evaluation of pyridone alkaloids on the endocannabinoid system was written by Chicca, Andrea;Berg, Regina;Jessen, Henning J.;Marck, Nicolas;Schmid, Fabian;Burch, Patrick;Gertsch, Jurg;Gademann, Karl. And the article was included in Bioorganic & Medicinal Chemistry in 2017.Formula: C14H15BO4 This article mentions the following:

Naturally occurring pyridone alkaloids as well as synthetic derivatives were previously shown to induce neurite outgrowth. However, the mol. basis for this biol. effect remains poorly understood. In this work, the authors have prepared new pyridones, and tested the effect of thirteen 4-hydroxy-2-pyridone derivatives on the components of the endocannabinoid system. Investigation of binding affinities towards CB₁ and CB₂ receptors led to the identification of a compound binding selectively to CB₁鑱?strong>I. Compound I and a closely related derivative also inhibited anandamide (AEA) hydrolysis by fatty acid amide hydrolase. Interestingly, none of the compounds tested showed any effect on 2-AG hydrolysis by monoacylglycerol lipase at 10 娓璏. Assessment of AEA uptake did, however, lead to the identification of four inhibitors with IC₅₀ values in the submicromolar range and high selectivity over the other components of the endocannabinoid system. In the experiment, the researchers used many compounds, for example, (4-((4-Methoxybenzyl)oxy)phenyl)boronic acid (cas: 156635-90-4Formula: C14H15BO4).

(4-((4-Methoxybenzyl)oxy)phenyl)boronic acid (cas: 156635-90-4) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers feature bent C閳ユ彊閳ユ弲 linkages. In dimethyl ether, the bond angle is 111鎺?and C閳ユ彊 distances are 141 pm. The barrier to rotation about the C閳ユ彊 bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Formula: C14H15BO4

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Cobalt Octacarbonyl-Catalyzed Scalable Alkyne Cyclotrimerization and Crossed [2 + 2 + 2]-Cycloaddition Reaction in a Plug Flow Reactor was written by Garcia-Lacuna, Jorge;Dominguez, Gema;Blanco-Urgoiti, Jaime;Perez-Castells, Javier. And the article was included in Organic Letters in 2018.Product Details of 16356-02-8 This article mentions the following:

Cobalt-catalyzed alkyne cyclotrimerization and crossed [2 + 2 + 2] cycloadditions are developed in a plug flow reactor. The protocol generally uses 5 mol % of Co₂(CO)₈ and is scalable at least at multigram scale. Efficient and scalable use of Co₂(CO)₈ for crossed reactions of diynes and alkynes has hardly any precedent. In the experiment, the researchers used many compounds, for example, 1,4-Dimethoxy-2-butyne (cas: 16356-02-8Product Details of 16356-02-8).

1,4-Dimethoxy-2-butyne (cas: 16356-02-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Product Details of 16356-02-8

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Rapid Catalysis for Aerobic Oxidation of Alcohols Based on Nitroxyl-Radical-Free Copper(II) under Ambient Conditions was written by Hu, Jiaming;Zhu, Yongkang;Gao, Hu;Zhang, Feng;Zhang, Zhibing. And the article was included in Industrial & Engineering Chemistry Research in 2022.SDS of cas: 105-13-5 This article mentions the following:

Aerobic oxidation of alcs. is one of the most important methods for the production of aldehydes. In this work, a scalable, continuous flow synthesis method for the aerobic oxidation of alcs. using a copper catalyst with redox-active ligand and mol. oxygen (O₂, air) was developed. The yield of benzaldehyde could reach 93.4% by optimizing the following conditions, such as copper content, solvent, O₂ flow rate, and temperature This synthesis method exhibited excellent functional group compatibility for various alcs. with excellent reactivity and reusability, avoiding the use of some nitroxyl radicals (TEMPO, ABNO) or base additives. In the microchannel reactor, the total reaction time could be reduced from 24 h to 40 min, and a simplified kinetic model was established. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5SDS of cas: 105-13-5).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.SDS of cas: 105-13-5

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Equivalent Loading of Directed Arenes in Pd(II)-Catalyzed Oxidative Cross-Coupling of Aryl C-H Bonds at Room Temperature was written by Mei, Chong;Zhao, Mengdi;Lu, Wenjun. And the article was included in Journal of Organic Chemistry in 2021.Safety of N-(3-Methoxyphenyl)pivalamide This article mentions the following:

Here, in a palladium/oxidant/acid catalytic system at room temperature, one arene could highly selectively couple with the other one to afford the target unsym. biaryls just by controlling the directing groups and the substituted groups on their Ph rings was reported. The utility of this one-one cross-coupling was also demonstrated by synthesis of a few bioactive mols. In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Safety of N-(3-Methoxyphenyl)pivalamide).

N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Safety of N-(3-Methoxyphenyl)pivalamide

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Metal-Independent Reduction of Hydrogen Peroxide by Semiquinones was written by Sanchez-Cruz, Pedro;Santos, Areli;Diaz, Stephany;Alegria, Antonio E.. And the article was included in Chemical Research in Toxicology in 2014.Safety of 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione This article mentions the following:

The quinones 1,4-naphthoquinone (NQ), tetramethyl-1,4-benzoquinone (DQ), 2-methyl-1,4-naphthoquinone (MNQ), 2,3-dimethoxy-5-methyl-1,4-benzoquinone (UBQ-0), 2,6-dimethylbenzoquinone (DMBQ), 2,6-dimethoxybenzoquinone (DMOBQ), and 9,10-phenanthraquinone (PHQ) enhance the rate of H₂O₂ reduction by ascorbate, under anaerobic conditions, as detected from the amount of methane produced after hydroxyl radical reaction with DMSO. The amount of methane produced increases with an increase in the quinone one-electron reduction potential. The most active quinone in this series, PHQ, is only 14% less active than the classic Fenton reagent cation, Fe²⁺, at the same concentration Since PHQ is a common toxin present in diesel combustion smoke, the possibility that PHQ-mediated catalysis of hydroxyl radical formation is similar to that of Fe²⁺ adds another important pathway to the modes in which PHQ can execute its toxicity. Because quinones are known to enhance the antitumor activity of ascorbate and because ascorbate enhances the formation of H₂O₂ in tissues, the quinone-mediated reduction of H₂O₂ should be relevant to this type of antitumor activity, especially under hypoxic conditions. In the experiment, the researchers used many compounds, for example, 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7Safety of 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione).

2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O閳ユ椊 or N閳ユ椊 bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Safety of 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Study on chemical constituents of Ranunculus ternatus Thumb was written by Li, Haibin;Du, Shushan;Hou, Fengfei;Wang, Dacheng;Liu, Guifang;Yang, Hongwu. And the article was included in Shenyang Yaoke Daxue Xuebao in 1999.Reference of 57179-35-8 This article mentions the following:

Ten compounds were isolated from Ranunculus ternatus Thumb by chromatog. methods, and six of them were identified. The six compounds were identified as stigmasterol (I), hexadecanoic acid (II), eicosanoic acid (III), nonacosanol (IV), ternatolide A (V), and 5-hydroxy-3-methoxy-benzaldehyde (VI). In the experiment, the researchers used many compounds, for example, 3-Hydroxy-5-methoxybenzaldehyde (cas: 57179-35-8Reference of 57179-35-8).

3-Hydroxy-5-methoxybenzaldehyde (cas: 57179-35-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Reference of 57179-35-8

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reductions of disubstituted nitrobenzenes with metal hydrides. Part II. Use of sodium borohydride in the preparation of tetrasubstituted azoxybenzenes was written by Islam, Nurul;Khan, Abdus Samad. And the article was included in Bangladesh Journal of Scientific and Industrial Research in 1992.COA of Formula: C8H9NO3 This article mentions the following:

Five azoxybenzenes X(Me)C₆H₄N(O):NC₆H₄(Me)X (X = halide) were prepared in 80-90% yield by reduction of halo(methyl)nitrobenzenes with NaBH₄ in EtOH or MeOH. Nitrobenzenes containing an o– or p-fluoride relative to the nitro group were not reduced; rather, the F was replaced by alkoxide from the solvent. Oxidation of dihalodimethylazobenzenes X(Me)C₆H₄N:NC₆H₄(Me)X with AcOOH (30% H₂O₂ in AcOH) afforded 8 tetrasubstituted azoxybenzenes in 83-88% yield. Reduction of the azoxybenzenes with Zn dust and AcOH gave the corresponding azobenzenes. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitroanisole (cas: 5367-32-8COA of Formula: C8H9NO3).

3-Methyl-4-nitroanisole (cas: 5367-32-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.COA of Formula: C8H9NO3

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Regio-Selective C3- and N-Alkylation of Indolines in Water under Air Using Alcohols was written by Maji, Milan;Borthakur, Ishani;Srivastava, Sameer;Kundu, Sabuj. And the article was included in Journal of Organic Chemistry in 2022.COA of Formula: C8H10O2 This article mentions the following:

Authors disclosed a regio-selective C-H and N-H bond functionalization of indolines using alcs. in water via tandem dehydrogenation of N-heterocycles and alcs. A diverse range of N- and C3-alkylated indolines/indoles were accessed utilizing a new cooperative iridium catalyst. The practical applicability of this methodol. was demonstrated by the preparative-scale synthesis and synthesis of a psychoactive drug, N,N-dimethyltryptamine. A catalytic cycle is proposed based on several kinetic experiments and a series of control experiments and d. functional theory calculations In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5COA of Formula: C8H10O2).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers feature bent C閳ユ彊閳ユ弲 linkages. In dimethyl ether, the bond angle is 111鎺?and C閳ユ彊 distances are 141 pm. The barrier to rotation about the C閳ユ彊 bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.COA of Formula: C8H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Pharmacokinetic profiling of anticancer phytocompounds using computational approach was written by Sharma, Ashish;Sharma, Shilpa;Gupta, Mansi;Fatima, Shehnaz;Saini, Ravi;Agarwal, Subhash Mohan. And the article was included in Phytochemical Analysis in 2018.Computed Properties of C11H16O3 This article mentions the following:

Introduction : Natural products exhibit diverse scaffolds and are considered as suitable candidates for development of leads. However, poor pharmacokinetics often acts as a hindrance during the drug discovery process. Objective : With a view of exploring the absorption, distribution, metabolism, excretion and toxicity (ADMET) profile of plant-based anticancer compounds, open-access databases (NPACT, CancerHSP and TaxKB) were analyzed to identify mols. having properties favorable for drug ability. Methodol. : Our workflow involved identification of mols. capable of passing each of the ADMET barriers based on physicochem. properties of mols., and physiol. barriers and factors. Results : The results revealed that out of 5086 phytomols., 63% were orally absorbable and 52% distributable. Also, an appreciable proportion of these compounds (45%) could be metabolised and excreted. Furthermore, 28% were found to be non-toxic for cardio toxicity and central nervous system (CNS) activity. Addnl., comparison against known anticancer drugs (reference dataset) revealed that the three libraries exhibit similar trends, thus providing addnl. confidence to the predictions. Overall, 28% of the mol. dataset was found to have suitable pharmacokinetic properties. We have also discussed a few natural products which exhibit favorable ADMET as well as low nano-micromolar in vitro anticancer activity. Conclusion : We have created an interactive database (ADMETCan), which provides access to predicted ADMET of these anticancer phytomols. The ease of availability of this dataset is expected to minimise failure rate of these compounds and thus is expected to be beneficial to the scientific community involved in anticancer identification and development. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Computed Properties of C11H16O3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Computed Properties of C11H16O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Copper-Catalyzed Intermolecular Enantioselective Radical Oxidative C(sp³)-H/C(sp)-H Cross-Coupling with Rationally Designed Oxazoline-Derived N,N,P(O)-Ligands was written by Liu, Lin;Guo, Kai-Xin;Tian, Yu;Yang, Chang-Jiang;Gu, Qiang-Shuai;Li, Zhong-Liang;Ye, Liu;Liu, Xin-Yuan. And the article was included in Angewandte Chemie, International Edition in 2021.Related Products of 3929-47-3 This article mentions the following:

Here, a copper-catalyzed asym. C(sp³)-C(sp) cross-coupling of (hetero)benzylic and (cyclic)allylic C-H bonds with terminal alkynes that occurs with high to excellent enantioselectivity was reported. Critical to the success is the rational design of chiral oxazoline-derived N,N,P(O)-ligands that not only tolerate the strong oxidative conditions which were requisite for intermol. hydrogen atom abstraction (HAA) processes but also induce the challenging enantiocontrol. Direct access to a range of synthetically useful chiral benzylic alkynes and 1,4-enynes, high site-selectivity among similar C(sp³)-H bonds, and facile synthesis of enantioenriched medicinally relevant compounds make this approach very attractive. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Related Products of 3929-47-3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Related Products of 3929-47-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem