Category: ethers-buliding-blocks

Green, versatile, and scale-up synthesis of amides by aerobic oxidative amination over Ag₂O/P-C₃N₄ photocatalyst was written by Deng, Lanqing;Chen, Lang;Zhu, Liangdi;Li, Yang;Ou-Yang, Jie;Wu, Shaofeng;Chen, Peng;Shen, Sheng;Guo, Junkang;Zhou, Yongbo;Au, Chak-Tong;Yin, Shuang-Feng. And the article was included in Chemical Engineering Science in 2022.Quality Control of (4-Methoxyphenyl)methanol This article mentions the following:

Being extensively applied in various fields of chem. and chem. industry, the development of a green and versatile method for the synthesis of amides is in line with the demand of sustainable chem. Herein, a direct, highly selective, and scale-up (5-20 mmol) method for photocatalytic synthesis of amides through aerobic oxidative amination of alcs. with amines was developed under visible light, room temperature, using air as the oxidant. Benefiting from the adsorption of sodium hemiaminal on catalyst lengthens the C-H bond (1.148 鑴?, this novel process is feasible for a broad range of functionlized amides (69 examples), especially those for drug manufacture (e.g., moclobemide and pipobroman). Imines was almost prevented with excellent amide selectivity up to 99% could be ascribed to the low energy barrier for hemiaminal dehydrogenation while that for dehydration is high (2.13 eV). This green and efficient protocol represents an ideal alternative to the currently known methods. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Quality Control of (4-Methoxyphenyl)methanol).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O閳ユ椊 or N閳ユ椊 bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Quality Control of (4-Methoxyphenyl)methanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Impregnated Platinum on Magnetite as an Efficient, Fast, and Recyclable Catalyst for the Hydrosilylation of Alkynes was written by Cano, Rafael;Yus, Miguel;Ramon, Diego J.. And the article was included in ACS Catalysis in 2012.Recommanded Product: 16356-02-8 This article mentions the following:

New impregnated platinum on magnetite catalyst has been prepared, characterized and used for the hydrosilylation of different alkynes. The catalyst showed a wide reaction scope, allowing its use for different functionalized alkynes, localized triple bonds, and silane reagents. The reaction is selective for the case of diynes, obtaining the desired mono- or dihydrosilylation processes. The reaction with disilane reagents lead to the incorporation of two alkyne units to the final product. The catalyst is easily prepared and handled, avoiding the use of expensive and difficult to handle organic ligands, and it could be removed from the reaction medium just by sequestering by a magnet. The catalyst could be reused up to ten times with exactly the same activity. In the experiment, the researchers used many compounds, for example, 1,4-Dimethoxy-2-butyne (cas: 16356-02-8Recommanded Product: 16356-02-8).

1,4-Dimethoxy-2-butyne (cas: 16356-02-8) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Recommanded Product: 16356-02-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Total Synthesis and Cytotoxic Activity of 7-O-Methylnigrosporolide and Pestalotioprolide D was written by Thiraporn, Aticha;Iawsipo, Panata;Tadpetch, Kwanruthai. And the article was included in Synlett in 2022.Recommanded Product: 105-13-5 This article mentions the following:

A convergent total synthesis of 7- O-methylnigrosporolide and pestalotioprolide D has been accomplished in 17 linear steps and overall yields of 1.7% and 2.6%, resp., starting from ( S)-propylene oxide and ( S)-benzyl glycidyl ether. Our synthesis exploited an acetylide addition and a Shiina macrolactonization to assemble the macrocycle, a Lindlar reduction, and Wittig and Still-Gennari olefinations to construct the three alkene groups, as well as a Jacobsen hydrolytic kinetic resolution to install the stereogenic center. The selection of the silyl protecting group of the C-4 alc. was crucial for the final deprotection step. Our synthesis also led to a hypothesis that pestalotioprolide D might be an artifact of 7- O-methylnigrosporolide. The cytotoxic activities of the two synthetic compounds against six human cancer cell lines were evaluated. Synthetic pestalotioprolide D showed more potent cytotoxic activity than 7-O-methylnigrosporolide against all the cancer cell lines tested, and the SiHa cervical cancer cell line was the most sensitive to both synthetic compounds In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Recommanded Product: 105-13-5).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Recommanded Product: 105-13-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis and biological activities of novel 2,5-disubstituted-1,3,4-thiadiazole derivatives was written by Li, Yingjun;Yu, Yang;Jin, Kun;Gao, Lixin;Luo, Tongchuan;Sheng, Li;Shao, Xin;Li, Jia. And the article was included in Youji Huaxue in 2015.Computed Properties of C9H10O4 This article mentions the following:

Sixteen novel 2,5-disubstituted-1,3,4-thiadiazole derivatives containing benzisoselenazolone moiety were synthesized by the reaction of 2-amino-5-substituted-1,3,4-thiadiazoles with ortho-(chloroseleno)benzoyl chloride. The structures were characterized by IR, ¹H NMR spectra and elemental anal. Their biol. activities were evaluated. The exptl. results indicate that some compounds exhibit inhibitory activity against cell division cycle 25B phosphatase (Cdc25B)(IC₅₀=1.67-6.66 娓璵ol璺疞^-1). All the target compounds showed good inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) (IC₅₀=0.73-4.50 娓璵ol璺疞^-1), and some compounds exhibited higher inhibitory activity than pos. control oleanolic acid (IC₅₀=1.90 娓璵ol璺疞^-1). Compound I displayed antitumor activity in vitro for human colon cancer (HCT-8) cell (IC₅₀=12.54 娓璵ol璺疞^-1). Some compounds showed the medium scavenging ability for hydroxyl radical (HO璺? and superoxide anion (O₂^璺?). Some compounds showed the medium scavenging ability for hydroxyl radical (HO璺? and superoxide anion (O₂^璺?), but no scavenging ability for DPPH 璺? In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Computed Properties of C9H10O4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Computed Properties of C9H10O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis, in vivo occupancy, and radiolabeling of potent phosphodiesterase subtype-10 inhibitors as candidates for positron emission tomography imaging was written by Andres, Jose-Ignacio;De Angelis, Meri;Alcazar, Jesus;Iturrino, Laura;Langlois, Xavier;Dedeurwaerdere, Stefanie;Lenaerts, Ilse;Vanhoof, Greet;Celen, Sofie;Bormans, Guy. And the article was included in Journal of Medicinal Chemistry in 2011.Related Products of 63071-12-5 This article mentions the following:

We have recently reported the phosphodiesterase 10A (PDE10A) inhibitor 2-[4-[1-(2-[¹⁸F]fluoroethyl)-4-pyridin-4-yl-1H-pyrazol-3-yl]-phenoxymethyl]-quinoline (I) as a promising candidate for in vivo imaging using positron emission tomog. (PET). We now describe the synthesis and biol. evaluation of a series of related pyridinyl analogs II (R¹ = FCH₂CH₂, FCH₂CH₂CH₂, F₃CCH₂; R² = 3,5-di-Me, 5-methoxy, 6-bromo, etc.) that exhibit high potency and selectivity as PDE10A inhibitors. The most interesting compounds were injected in rats to measure their levels of PDE10A occupancy through an in vivo occupancy assay. The 3,5-dimethylpyridine derivative II (R¹ = FCH₂CH₂, R² = 3,5-di-Me) and the 5-methoxypyridine derivative II (R¹ = FCH₂CH₂, R² = 5-methoxy) showed a comparable level of occupancy to that of I. Because these derivatives showed lower in vitro activity and are slightly less lipophilic than I, we hypothesized that they could behave as better PET imaging ligands. Compounds II (R¹ = ¹⁸FCH₂CH₂, R² = 3,5-dimethyl; R¹ = ¹⁸FCH₂CH₂, R² = 5-methoxy; R¹ = FCH₂CH₂, R² = 5-¹¹CH₃O) were radio synthesized and subjected to biodistribution studies in rats for a preliminary evaluation as candidate PET radioligands for in vivo imaging of PDE10A in the brain. In the experiment, the researchers used many compounds, for example, (6-Methoxypyridin-2-yl)methanol (cas: 63071-12-5Related Products of 63071-12-5).

(6-Methoxypyridin-2-yl)methanol (cas: 63071-12-5) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Ethers feature bent C閳ユ彊閳ユ弲 linkages. In dimethyl ether, the bond angle is 111鎺?and C閳ユ彊 distances are 141 pm. The barrier to rotation about the C閳ユ彊 bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Related Products of 63071-12-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Photolytic and photocatalytic decomposition of fenitrothion by PW₁₂O₄₀^3- and TiO₂: a comparative study was written by Kormali, P.;Dimoticali, D.;Tsipi, D.;Hiskia, A.;Papaconstantinou, E.. And the article was included in Applied Catalysis, B: Environmental in 2004.Category: ethers-buliding-blocks This article mentions the following:

The photocatalytic degradation of fenitrothion under UV and near visible light in the presence of the polyoxometallate (POM) photocatalyst PW₁₂O₄₀^3- in aqueous solutions has been studied and compared with the photodegradation by TiO₂ suspensions. Fenitrothion is effectively degraded in the presence of both photocatalysts following pseudo-first-order kinetics. Complete mineralization of fenitrothion is achieved using both photocatalysts, leading to the formation of CO₂ and inorganic ions (PO₄^3-, SO₄^2-, NO₂^–, and NO₃^–) as final products. Various intermediates, identical in the presence of both photocatalysts, have been detected and identified using HPLC and gas chromatog.-mass spectrometry (GC-MS) techniques. The similarity of the intermediates by these two methods, i.e., PW₁₂O₄₀^3- and TiO₂, tends to suggest that the photodegradation mechanism of fenitrothion in as other cases as well takes place mainly via a common reagent, i.e., OH radicals. A photodegradation mechanism is proposed. Photolysis of fenitrothion, i.e., in the absence of catalysts, is very slow and far from producing complete mineralization. A relatively large number of intermediates is observed, most of which are not detected in the photocatalytic processes. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitroanisole (cas: 5367-32-8Category: ethers-buliding-blocks).

3-Methyl-4-nitroanisole (cas: 5367-32-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers feature bent C閳ユ彊閳ユ弲 linkages. In dimethyl ether, the bond angle is 111鎺?and C閳ユ彊 distances are 141 pm. The barrier to rotation about the C閳ユ彊 bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Heat capacity of six glymes in N,N-dimethylformamide + water mixtures. Solvation of glymes was written by Jozwiak, Malgorzata;Komudzinska, Marlena;Tyczynska, Magdalena;Marczak, Wojciech;Jozwiak, Andrzej. And the article was included in Journal of Molecular Liquids in 2022.Formula: C8H18O4 This article mentions the following:

The paper presents the heat capacities of glyme solutions: monoglyme, diglyme, triglyme, tetraglyme, pentaglyme and hexaglyme, in binary solvents N,N-dimethylformamide + water at four temperatures (293.15 K, 298.15 K, 303.15 K, 308.15 K) obtained using differential calorimeter Micro DSC III, Setaram – France. The concentration of glymes was approx. 0.25 mol/kg. On the basis of the obtained exptl. results, the apparent isobaric heat capacities of the glymes were calculated It was noted that the larger the glyme mol. was, the more pronounced the increase in the value of the apparent molar heat capacity function with the increase in water content in the two-component solvent. The observed changes in apparent isobaric heat capacity as a function of the water content in the mixed solvent are discussed in terms of the hydrophobic nature of the glymes. Moreover, it was shown that the apparent molar isobaric heat capacity of the glymes in pure solvents, i.e. in water and in N,N-dimethylformamide, increases linearly with the increase in the number of oxygen atoms in the glyme mols. i.e. with the size of glyme mols. Furthermore, a linear correlation was observed between the apparent isobaric molar heat capacity and the enthalpic effect of the hydrophobic hydration of the studied glymes at 298.15 K. The results obtained in this paper are compare with the same obtained for selected cyclic ethers. In the experiment, the researchers used many compounds, for example, 2,5,8,11-Tetraoxadodecane (cas: 112-49-2Formula: C8H18O4).

2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Formula: C8H18O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Selective Production of Diethyl Maleate via Oxidative Cleavage of Lignin Aromatic Unit was written by Cai, Zhenping;Long, Jinxing;Li, Yingwen;Ye, Lin;Yin, Biaolin;France, Liam John;Dong, Juncai;Zheng, Lirong;He, Hongyan;Liu, Sijie;Tsang, Shik Chi Edman;Li, Xuehui. And the article was included in Chem in 2019.Name: 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione This article mentions the following:

Green production of bulk chems. traditionally obtained from fossil resources is of great importance. One potential route toward realizing this goal is through the utilization of renewable lignin; however, current techniques generally lead to low product specificity because of the structural diversity of this recalcitrant biopolymer. Herein, we devised a new catalytic system to promote selectively oxidative lignin in air, and di-Et maleate was formed at impressively high yield of 404.8 mg g^-1 and selectivity of 72.7% over the polyoxometalate ionic liquid of [BSmim]CuPW₁₂O₄₀. This high catalytic activity is ascribed to a five-coordinated Cu⁺ species, which, through the formation of end-on dioxygen species in vacant orbitals, facilitates the selective oxidation of basic lignin aromatic units (phenylpropane C₉ units). Therefore, these results represent significant progress toward the realization of an industrially applicable and highly selective lignin oxidation process for the generation of value-added and bulk chems. In the experiment, the researchers used many compounds, for example, 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7Name: 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione).

2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione (cas: 605-94-7) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Name: 2,3-Dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Curcumin Recognizes a Unique Binding Site of Tubulin was written by Chakraborti, Soumyananda;Das, Lalita;Kapoor, Neha;Das, Amlan;Dwivedi, Vishnu;Poddar, Asim;Chakraborti, Gopal;Janik, Mark;Basu, Gautam;Panda, Dulal;Chakrabarti, Pinak;Surolia, Avadhesha;Bhattacharyya, Bhabatarak. And the article was included in Journal of Medicinal Chemistry in 2011.Recommanded Product: 6972-61-8 This article mentions the following:

Although curcumin is known for its anticarcinogenic properties, the exact mechanism of its action or the identity of the target receptor is not completely understood. Studies on a series of curcumin analogs, synthesized to investigate their tubulin binding affinities and tubulin self-assembly inhibition, showed that: (i) curcumin acts as a bifunctional ligand, (ii) analogs with substitution at the diketone and acetylation of the terminal phenolic groups of curcumin are less effective, (iii) a benzylidiene derivative, compound 7, is more effective than curcumin in inhibiting tubulin self-assembly. Cell-based studies also showed compound 7 to be more effective than curcumin. Using fluorescence spectroscopy we show that curcumin binds tubulin 32 鑴?away from the colchicine-binding site. Docking studies also suggests that the curcumin-binding site to be close to the vinblastine-binding site. Structure-activity studies suggest that the tridented nature of compound 7 is responsible for its higher affinity for tubulin compared to curcumin. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Recommanded Product: 6972-61-8).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O閳ユ椊 or N閳ユ椊 bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Recommanded Product: 6972-61-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis and Biological Activity of Ethyl 4-Alkyl-2-(2-(substituted phenoxy)acetamido)thiazole-5-carboxylate was written by Mo, Wenyan;Shi, Yanxia;He, Junbo;Li, Baoju;Peng, Hao;He, Hongwu. And the article was included in Journal of Heterocyclic Chemistry in 2016.Related Products of 1877-75-4 This article mentions the following:

A series of novel Et 4-(methyl)-2-(2-(substituted phenoxy)acetamido)thiazole-5-carboxylates I [R¹ = 4-CH₃, 4-OCH₃, 4-Cl, etc.] and Et 4-(trifluoromethyl)-2-(2-(substituted phenoxy)acetamido)thiazole-5-carboxylates II [R¹ = H, 4-CH₃, 4-OCH₃, 4-Cl] were synthesized, and their structures were confirmed by IR, ¹H-NMR, MS spectra and elemental anal. The results of preliminary bioassays show that some of the title compounds exhibited moderate to good herbicidal activities. Compared with the fluorine free compounds I [R¹ = 4-F, 2,4-Cl₂, 2-Cl,4-F], the compounds bearing fluorine II [R¹ = 4-F, 2,4-Cl₂, 2-Cl,4-F] showed higher herbicidal activities with 70-100% inhibition against Capsella bursa-pastoris, Amaranthus restroflexus, and Eclipta prostrata at the dosage of 150 g/ha, which indicated that the trifluoromethyl on the thiazole ring was beneficial for the herbicidal activity. Furthermore, compounds II were tested for fungicidal activity against Pseudoperonospora cubensis at 500 娓璯/mL. Compounds II [R¹ = H, 4-F] showed the best fungicidal activity with more than 80% inhibition. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Related Products of 1877-75-4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers feature bent C閳ユ彊閳ユ弲 linkages. In dimethyl ether, the bond angle is 111鎺?and C閳ユ彊 distances are 141 pm. The barrier to rotation about the C閳ユ彊 bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Related Products of 1877-75-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem