Category: 947533-23-5

Gurram, Venkateshwarlu published the artcileC-C Cross-Coupling Reactions of O⁶-Alkyl-2-Haloinosine Derivatives and a One-Pot Cross-Coupling/O⁶-Deprotection Procedure, Synthetic Route of 947533-23-5, the publication is Chemistry – An Asian Journal (2012), 7(8), 1853-1861, S1853/1-S1853/41, database is CAplus and MEDLINE.

Reaction conditions for the C-C cross-coupling of O⁶-alkyl-2-bromo- and 2-chloroinosine derivatives with aryl-, heteroaryl-, and alkylboronic acids were studied. Optimization experiments with silyl-protected 2-bromo-O⁶-methylinosine led to the identification of [PdCl₂(dcpf)]/K₃PO₄ in 1,4-dioxane as the best conditions for these reactions (dcpf=1,1′-bis(dicyclohexylphosphino)ferrocene). Attempted O⁶-demethylation, as well as the replacement of the C-6 methoxy group by amines, was unsuccessful, which led to the consideration of Pd-cleavable groups such that C-C cross-coupling and O⁶-deprotection could be accomplished in a single step. Thus, inosine 2-chloro-O⁶-allylinosine was chosen as the substrate and, after re-evaluation of the cross-coupling conditions with 2-chloro-O⁶-methylinosine as a model substrate, one-step C-C cross-coupling/deprotection reactions were performed with the O⁶-allyl analog. These reactions are the first such examples of a one-pot procedure for the modification and deprotection of purine nucleosides under C-C cross-coupling conditions.

Chemistry – An Asian Journal published new progress about 947533-23-5. 947533-23-5 belongs to ethers-buliding-blocks, auxiliary class Nitrile,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (4-(Cyanomethoxy)phenyl)boronic acid, and the molecular formula is C8H8BNO3, Synthetic Route of 947533-23-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Favalli, Nicholas published the artcileLarge screening of DNA-compatible reaction conditions for Suzuki and Sonogashira cross-coupling reactions and for reverse amide bond formation, HPLC of Formula: 947533-23-5, the publication is Bioorganic & Medicinal Chemistry (2021), 116206, database is CAplus and MEDLINE.

Progress in DNA-encoded chem. library synthesis and screening crucially relies on the availability of DNA-compatible reactions, which proceed with high yields and excellent purity for a large number of possible building blocks. In the past, exptl. conditions have been presented for the execution of Suzuki and Sonogashira cross-coupling reactions on-DNA. In this article, our aim was to optimize Suzuki and Sonogashira reactions, comparing our results to previously published procedures. We have tested the performance of improved conditions using 606 building blocks (including boronic acids, pinacol boranes and terminal alkynes), achieving >70% conversion for 84% of the tested mols. Moreover, we describe efficient exptl. conditions for the on-DNA synthesis of amide bonds, starting from DNA derivatives carrying a carboxylic acid moiety and 300 primary, secondary and aromatic amines, as amide bonds are frequently found in DNA-encoded chem. libraries thanks to their excellent DNA compatibility.

Bioorganic & Medicinal Chemistry published new progress about 947533-23-5. 947533-23-5 belongs to ethers-buliding-blocks, auxiliary class Nitrile,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (4-(Cyanomethoxy)phenyl)boronic acid, and the molecular formula is C8H8BNO3, HPLC of Formula: 947533-23-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem