Category: 944561-44-8

944561-44-8, name is 2-[2-(2-Propynyloxy)ethoxy]ethylamine, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 944561-44-8

Example 3: Synthesis of XZ-14424 Compound 7 (107 mg), amine 17 (84 mg), and DIPEA (193 muL) in 5 mL DMF were stirred at 85 C for 16 hours. Water was added to the reaction mixture and extracted with EtOAc. The organic phase was washed with water x1, brine x1, dried over Na2SO4, filtered and evaporated to dryness. The resulting mixture was purified by column chromatography using EtOAc and hexanes as eluents to afford 50 mg compound 18 as a green solid. Yield 32%. 1H NMR (400 MHz, CDCl3) delta 7.98 (s, 1H), 7.62-7.35 (m, 1H), 7.11 (d, J = 7.1 Hz, 1H), 6.93 (d, J = 8.5 Hz, 1H), 4.92 (dd, J = 11.9, 5.3 Hz, 1H), 4.21 (d, J = 2.3 Hz, 2H), 3.78-3.66 (m, 6H), 3.49 (t, J = 5.4 Hz, 2H), 2.93- 2.68 (m, 3H), 2.48-2.41 (m, 1H), 2.18-2.09 (m, 1H) ppm.

The synthetic route of 944561-44-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BIOVENTURES, LLC; ZHENG, Guangrong; ZHOU, Daohong; ZHANG, Xuan; WANG, Yingying; CHANG, Jianhui; (269 pag.)WO2017/184995; (2017); A1;,
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Ether | (C2H5)2O – PubChem

Synthetic Route of 944561-44-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 944561-44-8, name is 2-[2-(2-Propynyloxy)ethoxy]ethylamine, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a solution of compound 7 (200 mg, 0.34 mmol) and terminalalkynyl substituted amine (0.43 mmol) in DMF (10 mL), Na2CO3(72 mg, 0.68 mmol) was added. The resulting solution was vigorouslystirred for 24 h at 60 C. The solvent was removed bysteaming. The residue was purified by column chromatography.

The chemical industry reduces the impact on the environment during synthesis 2-[2-(2-Propynyloxy)ethoxy]ethylamine. I believe this compound will play a more active role in future production and life.

Reference:
Article; Liang, Shuobin; Li, Man; Yu, Xiaojuan; Jin, Hongwei; Zhang, Yongmin; Zhang, Lihe; Zhou, Demin; Xiao, Sulong; European Journal of Medicinal Chemistry; vol. 166; (2019); p. 328 – 338;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem