Category: 93489-14-6

Research on new synthetic routes about C10H15NO2

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 93489-14-6, its application will become more common.

Some common heterocyclic compound, 93489-14-6, name is (4-Ethoxy-3-methoxyphenyl)methanamine, molecular formula is C10H15NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: (4-Ethoxy-3-methoxyphenyl)methanamine

Ethyl 2- (4 , 5-dibromo-6-oxopyridazin-l (6H) -yl) acetate (500 mg, 1.47 mmol) and 3-ethoxy-4-methoxybenzylamine(960 mg, 4.41 mmol) in 1, 4-dioxane-water (1:1, 5 mL) were stirred with triethylamine (0.615 mL) at 100C for 2.5 hours. After cooling, ethyl acetate was added, and the organic layer was washed with saturated aqueous ammonium chloride and saturated aqueous sodium chloride and dried over anhydrous magnesium sulfate, and the solvent was removed by distillation. The resulting residue was purified by silica gel chromatography (chloroform/2- propanol = 20/1) to give the desired product (640 mg, 98% yield) .Morphology: pale yellow solid LC/MS: Condition 3, retention time 3.70 min LC/MS (ESI+) :440, 442 [MH-I] + LC/MS(ESI-) :438, 440 [M-I]-

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 93489-14-6, its application will become more common.

Reference:
Patent; NISSAN CHEMICAL INDUSTRIES, LTD.; WO2009/57827; (2009); A1;,
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