Category: 93-04-9

Washington, Jack B.; Assante, Michele; Yan, Chunhui; McKinney, David; Juba, Vanessa; Leach, Andrew G.; Baillie, Sharon E.; Reid, Marc published an article in 2021, the title of the article was Trialkylammonium salt degradation: implications for methylation and cross-coupling.Product Details of 93-04-9 And the article contains the following content:

This study presented a mechanistic degradation anal. of N,N,N-trimethylanilinium salts and highlighted implications for synthetic applications of this important class of salts. Kinetic degradation studies, in both solid and solution phases, had delivered insights into phys. and chem. parameters affecting anilinium salt stability. 1H NMR kinetic anal. of salt degradation had evidenced thermal degradation to Me iodide and parent aniline, consistent with a closed-shell SN2-centered degradative pathway, and Me iodide being key reactive species in applied methylation procedures. Furthermore, effect of halide and non-nucleophilic counterions on salt degradation had been investigated, along with deuterium isotope and solvent effects. New mechanistic insights had enabled investigation of use of trimethylanilinium salts in O-methylation and in improved cross-coupling strategies. Finally, detailed computational studies had helped highlight limitations in current state-of-the-art of solvation modeling of reaction in which bulk medium undergoes exptl. observable changes over reaction timecourse. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Product Details of 93-04-9

The Article related to trialkylammonium salt preparation degradation reaction mechanism dft, methoxy hydrocarbon preparation, alc acid phenol trimethylanilinium salt methylation, General Organic Chemistry: Synthetic Methods and other aspects.Product Details of 93-04-9

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On March 29, 2021, Huang, Lin; Bismuto, Alessandro; Rath, Simon A.; Trapp, Nils; Morandi, Bill published an article.Formula: C11H10O The title of the article was Ruthenium-Catalyzed Dehydrogenation Through an Intermolecular Hydrogen Atom Transfer Mechanism. And the article contained the following:

The direct dehydrogenation of alkanes is among the most efficient ways to access valuable alkene products. Although several catalysts have been designed to promote this transformation, they have unfortunately found limited applications in fine chem. synthesis. Here, we report a conceptually novel strategy for the catalytic, intermol. dehydrogenation of alkanes using a ruthenium catalyst. The combination of a redox-active ligand and a sterically hindered aryl radical intermediate has unleashed this novel strategy. Importantly, mechanistic investigations have been performed to provide a conceptual framework for the further development of this new catalytic dehydrogenation system. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Formula: C11H10O

The Article related to alkane dehydrogenation ruthenium catalyst reaction mechanism, alkenes, aryl radicals, dehydrogenation, hydrogenation atom transfer, redox-active ligands, General Organic Chemistry: Synthetic Methods and other aspects.Formula: C11H10O

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Lu, Lingling; Li, Yiming; Jiang, Xuefeng published an article in 2020, the title of the article was Visible-light-promoted oxidative halogenation of (hetero)arenes.Name: 2-Methoxynaphthalene And the article contains the following content:

Herein, a compatible oxidative halogenation of (hetero)arenes such as 4-phenylmorpholine, 1,3,5-trimethoxybenzene, imidazo[1,2-a]pyrazine, etc. with air as the oxidant and halide ions as halide sources under ambient conditions (visible light, air, aqueous system, room temperature, and normal pressure) was described. Moreover, this protocol is practically feasible for gram-scale synthesis, showing potential for industrial application. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Name: 2-Methoxynaphthalene

The Article related to haloarene preparation regioselective, arene oxidative halogenation, halo heteroarene preparation regioselective, heteroarene oxidative halogenation, General Organic Chemistry: Synthetic Methods and other aspects.Name: 2-Methoxynaphthalene

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On August 19, 2022, Ritu; Das, Saikat; Tian, Ya-Ming; Karl, Tobias; Jain, Nidhi; Konig, Burkhard published an article.Electric Literature of 93-04-9 The title of the article was Photocatalyzed Dehydrogenation of Aliphatic N-Heterocycles Releasing Dihydrogen. And the article contained the following:

Author’s report the iridium-nickel dual photocatalytic acceptorless and redox neutral dehydrogenation of aliphatic heterocycles yielding cyclic alkenes without overoxidn. at room temperature Excitation of the iridium photocatalyst initiates the formation of a nickel hydride intermediate that yields alkenes and H2 via β-hydride elimination. The reaction proceeds regioselectively and the scope was demonstrated by the synthesis of 12 biol. relevant mols. and drugs. In addition, com. and easily available N-heterocyclic alkane starting materials were converted into functionalized alkenes of high synthetic and com. value using the method. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Electric Literature of 93-04-9

The Article related to cyclic enamide enecarbamate preparation regioselective photochem, aliphatic heterocycle dehydrogenation hydride elimination iridium nickel catalyst, General Organic Chemistry: Synthetic Methods and other aspects.Electric Literature of 93-04-9

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On October 7, 2022, Ito, Tasuku; Seidel, Falk William; Jin, Xiongjie; Nozaki, Kyoko published an article.Category: ethers-buliding-blocks The title of the article was TEMPO as a Hydrogen Atom Transfer Catalyst for Aerobic Dehydrogenation of Activated Alkanes to Alkenes. And the article contained the following:

2,2,6,6-Tetramethylpiperidine-N-oxyl (TEMPO) has been extensively utilized as a radical scavenger or an oxidation catalyst. In contrast, TEMPO as a hydrogen atom transfer (HAT) catalyst has rarely been studied. Here, authors report that TEMPO, as the HAT catalyst, homolytically cleaves benzylic or allylic C-H bonds to give the corresponding alkyl radicals. Benefiting from the dual roles played by TEMPO as the HAT catalyst and the radical scavenger, the highly challenging aerobic dehydrogenation of activated alkanes to alkenes is successfully developed. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Category: ethers-buliding-blocks

The Article related to alkene preparation tempo hydrogen atom transfer catalyst, activated alkane transition metal free aerobic dehydrogenation, General Organic Chemistry: Synthetic Methods and other aspects.Category: ethers-buliding-blocks

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On February 29, 2020, Aukland, Miles H.; Siauciulis, Mindaugas; West, Adam; Perry, Gregory J. P.; Procter, David J. published an article.Synthetic Route of 93-04-9 The title of the article was Metal-free photoredox-catalysed formal C-H/C-H coupling of arenes enabled by interrupted Pummerer activation. And the article contained the following:

An expedient, one-pot assembly of (hetero)biaryl motifs using photocatalysis and two non-prefunctionalized arene partners was reported. The approach was underpinned by the functionalization of a C-H bond in an arene coupling partner using the interrupted Pummerer reaction. A unique pairing of the organic photoredox catalyst and the intermediate dibenzothiophenium salts enables highly selective reduction in the presence of sensitive functionalities. The utility of the metal-free, one-pot strategy was exemplified by the synthesis of a bioactive natural product and the modification of complex mols. of societal importance. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Synthetic Route of 93-04-9

The Article related to arene heteroarene dibenzothiophene oxide photocatalyst regioselective cross coupling reaction, heterobiaryl preparation, General Organic Chemistry: Synthetic Methods and other aspects.Synthetic Route of 93-04-9

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On August 12, 2021, Kaye, Esther G.; Kailass, Karishma; Sadovski, Oleg; Beharry, Andrew A. published an article.Related Products of 93-04-9 The title of the article was A Green-Absorbing, Red-Fluorescent Phenalenone-Based Photosensitizer as a Theranostic Agent for Photodynamic Therapy. And the article contained the following:

Phenalenone is a synthetically accessible, highly efficient photosensitizer with a near-unity singlet oxygen quantum yield. Unfortunately, its UV absorption and lack of fluorescence has made it unsuitable for fluorescence-guided photodynamic therapy against cancer. In this work, we synthesized a series of phenalenone derivatives containing electron-donating groups to red-shift the absorption spectrum and bromine(s) to permit good singlet oxygen production via the heavy-atom effect. Of the derivatives synthesized, the phenalenone containing an amine at the 6-position with bromines at the 2- and 5-positions (OE19) exhibited the longest absorption wavelength (i.e., green) and produced both singlet oxygen and red fluorescence efficiently. OE19 induced photocytotoxicity with nanomolar potency in 2D cultured PANC-1 cancer cells as well as light-induced destruction of PANC-1 spheroids with minimal dark toxicity. Overall, OE19 opens up the possibility of employing phenalenone-based photosensitizers as theranostic agents for photodynamic cancer therapy. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Related Products of 93-04-9

The Article related to red fluorescent phenalenone photosensitizer preparation theranostic imaging cancer pdt, Radiation Biochemistry: Disease Diagnosis and Therapy and other aspects.Related Products of 93-04-9

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Ether – Wikipedia,
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On March 31, 2021, Wu, Zhuo; Wei, Feng; Wan, Bin; Zhang, Yanghui published an article.Application In Synthesis of 2-Methoxynaphthalene The title of the article was Pd-Catalyzed ipso,meta-Dimethylation of ortho-Substituted Iodoarenes via a Base-Controlled C-H Activation Cascade with Dimethyl Carbonate as the Methyl Source. And the article contained the following:

A Me group can have a profound impact on the pharmacol. properties of organic mols. Hence, developing methylation methods and methylating reagents is essential in medicinal chem. We report a palladium-catalyzed dimethylation reaction of ortho-substituted iodoarenes using di-Me carbonate as a Me source. In the presence of K2CO3 as a base, iodoarenes are dimethylated at the ipso- and meta-positions of the iodo group, which represents a novel strategy for meta-C-H methylation. With KOAc as the base, subsequent oxidative C(sp3)-H/C(sp3)-H coupling occurs; in this case, the overall transformation achieves triple C-H activation to form three new C-C bonds. These reactions allow expedient access to 2,6-dimethylated phenols, 2,3-dihydrobenzofurans, and indanes, which are ubiquitous structural motifs and essential synthetic intermediates of biol. and pharmacol. active compounds The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Application In Synthesis of 2-Methoxynaphthalene

The Article related to palladium catalyzed ipso meta dimethylation, dimethylation ortho substituted iodoarene, carbonhydrogen activation cascade reaction dimethyl carbonate methyl source, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: General and other aspects.Application In Synthesis of 2-Methoxynaphthalene

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Gao, Han; Hu, Lingfei; Hu, Yanlei; Lv, Xiangying; Wu, Yan-Bo; Lu, Gang published an article in 2021, the title of the article was Origins of Lewis acid acceleration in nickel-catalyzed C-H, C-C and C-O bond cleavage.Safety of 2-Methoxynaphthalene And the article contains the following content:

The current understanding of Lewis acid effects on transition metal catalysis is generally based on the enhanced charge transfer from metal to substrate due to the formation of Lewis acid-base adducts. The critical factors of how Lewis acids manipulate complex catalyst-substrate interactions to facilitate reactions are seldom clarified. Herein, using the energy decomposition approach, we quantify the contributions of multiple factors which account for the Lewis acid acceleration in Ni-catalyzed C-X (X = H, C, O) bond cleavage via oxidative addition The results reveal that the dominant factors for Lewis acid promotion highly depend on the features of transition states with Lewis acids. In the transition states having only heteroatom-Lewis acid interactions (e.g., C-H, C-CN and C(acyl)-O oxidative additions), the reactivity is improved majorly by enhancing charge transfer from the metal to the Lewis acid-activated substrates, which is consistent with the conventional viewpoint. However, for the transition states with heteroatom-Lewis acid and heteroatom-transition metal interactions (e.g., C(benzyl)-O and C(aryl)-O oxidative additions), the decisive factor for the improved reactivity is ascribed to the reduced Pauli repulsion between occupied orbitals. Further, in the transition states having heteroatom-Lewis acid and Lewis acid-transition metal interactions (e.g., C(benzyl)-O oxidative addition), the reaction is facilitated by strengthening electrostatics and polarization due to greater charge separation and electron delocalization effects. These three types of dominant factors are generally employed by a series of different Lewis acids in promoting Ni-catalyzed bond cleavage. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Safety of 2-Methoxynaphthalene

The Article related to carbon hydrogen oxygen bond cleavage catalyst oxidative addition, Physical Organic Chemistry: Addition, Elimination, and Substitution Reactions and other aspects.Safety of 2-Methoxynaphthalene

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On August 6, 2021, Dao, Pham Duy Quang; Cho, Chan Sik published an article.SDS of cas: 93-04-9 The title of the article was Synthesis of Trinuclear Benzimidazole-Fused Hybrid Scaffolds by Transition Metal-Free Tandem C(sp2)-N Bond Formation under Microwave Irradiation. And the article contained the following:

The compounds 2-(2-bromoaryl)benzimidazoles e.g., 2-(2-bromocyclohex-1-en-1-yl)-1H-1,3-benzodiazole and 2-(2-bromovinyl)benzimidazoles e.g., 2-[(1Z)-1-bromo-1-phenylprop-1-en-2-yl]-1H-1,3-benzodiazole have been coupled and cyclized with 2-methoxybenzimidazoles e.g., 2-methoxy-1H-1,3-benzodiazole and 2-aryloxybenzimidazoles e.g., 2-methoxy-1H-naphtho[2,3-d]imidazole as building blocks in the presence of a base under microwave irradiation to give a class of trinuclear N-fused hybrid scaffolds, benzo[4,5]imidazo[1,2-a]benzo[4,5]imidazo[1,2-c]quinazolines e.g., I and benzo[4,5]imidazo[1,2-a]benzo[4,5]imidazo[1,2-c]pyrimidines e.g., II, resp., in good yields. The compounds 2-(2-bromoaryl)imidazoles e.g., 2-(2-bromocyclohex-1-en-1-yl)-4,5-diphenyl-1H-imidazole and 2-(2-bromovinyl)imidazoles e.g., (Z)-2-(1-bromo-1-phenylprop-1-en-2-yl)-4,5-diphenyl-1H-imidazole also reacted with 2-methoxybenzimidazoles (e.g., 2-methoxy-1H-1,3-benzodiazole/e.g., 2-methoxy-1H-naphtho[2,3-d]imidazole) in the presence of base under microwave irradiation to give a class of trinuclear N-fused hybrid scaffolds, benzo[4,5]imidazo[1,2-a]imidazo[1,2-c]quinazolines e.g., III and benzo[4,5]imidazo[1,2-a]imidazo[1,2-c]pyrimidines e.g., IV, resp., in similar yields. This process seems to proceed via an initial C(sp2)-N coupling by an addition-elimination nucleophilic aromatic substitution (SNAr) and subsequent cyclization accompanied by extrusion of alcs. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).SDS of cas: 93-04-9

The Article related to trinuclear fused heterocyclic compound preparation microwave green chem, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.SDS of cas: 93-04-9

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem