Category: 93-04-9

On December 31, 2020, Lopez-Arencibia, Atteneri; Bethencourt-Estrella, Carlos J.; Freijo, Monica B.; Reyes-Batlle, Maria; Sifaoui, Ines; Nicolas-Hernandez, Desiree San; McNaughton-Smith, Grant; Lorenzo-Morales, Jacob; Abad-Grillo, Teresa; Pinero, Jose E. published an article.Product Details of 93-04-9 The title of the article was New phenalenone analogues with improved activity against Leishmania species. And the article contained the following:

The in vitro activity against Leishmania spp. of five novel designed compounds, phenalenone derivatives, is described in this study. Previous works have shown that some phenalenones present leishmanicidal activity, some of which could induce programmed cell death events in L. amazonensis parasites. In this research, we focused on the determination of the programmed cell death evidence by detecting the characteristic features of the apoptosis-like process, such as phosphatidylserine exposure and mitochondrial membrane potential, among others. The results showed that the new derivatives have comparable or better activity and selectivity than the commonly prescribed anti-leishmanial drug. This result was obtained by inducing stronger mitochondrial depolarization or more intense phosphatidylserine exposure than miltefosine, highlighting compound 8 with moreover 9-times better selectivity index. In addition, the new five mols. activated the apoptosis-like process in the parasite. All the signals observed were indicative of the death process that the parasites were undergoing. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Product Details of 93-04-9

The Article related to leishmania species phenalenone analog phosphatidylserine mitochondrial membrane, leishmania amazonensis, phenalenones, apoptosis-like, chemotherapy, Pharmacology: Methods and other aspects.Product Details of 93-04-9

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On October 21, 2021, Pancrazzi, Francesco; Maestri, Giovanni; Maggi, Raimondo; Viscardi, Rosanna published an article.Formula: C11H10O The title of the article was Oxidative Dearomatization of Phenols and Polycyclic Aromatics with Hydrogen Peroxide Triggered by Heterogeneous Sulfonic Acids. And the article contained the following:

Authors report herein a method for the oxidative dearomatization of phenols and bare polycyclic arenes into the corresponding quinoid derivatives using hydrogen peroxide. The reaction is catalyzed by sulfonic acids and best results were achieved using heterogenized species. The best results using phenols were achieved using a hybrid material, namely a perfluorinated polymer functionalized with sulfonic acid groups supported on silica. The dearomatization of polycyclic aromatic hydrocarbons performed better using the polymeric acid catalyst. These methods operate under mild conditions, using mild and benign oxidants and thus minimizing the formation of waste. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Formula: C11H10O

The Article related to quinoid preparation heterogeneous sulfonic acid, phenol polycyclic aromatic hydrogen peroxide oxidative dearomatization, Alicyclic Compounds: Cyclohexanes and other aspects.Formula: C11H10O

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On July 31, 2021, Koparan, Arzu; Gokalp, Mine published an article.Formula: C11H10O The title of the article was A Validated Method for Separation and Determination of Codeine Phosphate Hemihydrate Impurities in Bilayer Tablet Dosage Form of Naproxen Sodium and Codeine Phosphate by Using UHPLC. And the article contained the following:

Apranax Plus is a new bilayer tablet dosage form, which combines two active pharmaceutical ingredients: naproxen sodium and codeine phosphate. The purpose of this work was to develop an Ultra-High-Performance Liquid Chromatog. (UHPLC) method for the separation and determination of codeine phosphate hemihydrate impurities in a bilayer tablet dosage form. The separation and determination of codeine phosphate hemihydrate and its impurities, methylcodeine, morphine, codeine dimer, 10-hydroxycodeine, 14-hydroxycodeine, thebaine and codeinone were achieved by using reversed-phase liquid chromatog. with TUV (Tunable UV Detector) and PDA (Photodiode Array Detector) detection by UHPLC. The new proposed method utilized by the Waters Acquity UHPLC TUV and PDA systems using a UHPLC column Waters Acquity, BEH, C18, 2.1×100 mm, 1.7μm particle size with a mixture of component A and acetonitrile in a gradient mode at a flow rate of 0.3mL/min, at 25°C with a load of 5μL. The detection for all eluted compounds was carried out at 245nm. The codeine phosphate hemihydrate and peaks of its impurities were adequately obtained, thus proving the stability-indicating power of the method. The developed method was validated as per the ICH guidelines with respect to parameters such as precision, accuracy, linearity, Limit of Detection (LOD), Limit of Quantification (LOQ) and robustness. It was verified as being adequate for all the mentioned impurities of codeine phosphate hemihydrate. The described method was found to be useful for routine purity testing and was also found suitable for the anal. of the stability samples of the drug product. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Formula: C11H10O

The Article related to codeine phosphate hemihydrate naproxen sodium uhplc, Pharmaceutical Analysis: General and other aspects.Formula: C11H10O

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Inoue, Satoru; Higashino, Toshiki; Arai, Shunto; Kumai, Reiji; Matsui, Hiroyuki; Tsuzuki, Seiji; Horiuchi, Sachio; Hasegawa, Tatsuo published an article in 2020, the title of the article was Regioisomeric control of layered crystallinity in solution-processable organic semiconductors.Related Products of 93-04-9 And the article contains the following content:

The construction and control of 2D layered mol. packing motifs with functionally substituted π-electron cores are crucial for developing organic electronic materials and devices. We investigated a regioisomeric structure-property relationship in high-performance and solution-processable layered organic semiconductors based on mono-octyl-substituted benzothieno[3,2-b]naphtho[2,3-b]thiophene (mono-C8-BTNT). We demonstrated that an isomorphous bilayer-type layered herringbone packing motif is obtainable in a series of four positional isomers of mono-C8-BTNTs whose π-electron core is substituted by an octyl chain at one of the four most peripheral positions with roughly keeping the rod-like mol. shape. These regioisomeric compounds exhibited systematic variations in the solvent solubility and liquid-crystalline phase transitions at elevated temperatures The anal. of intermol. interaction energies in the crystals based on dispersion-corrected DFT calculations revealed that the crystals of 2- and 8-mono-C8-BTNTs are more stable than those of 3- and 9-mono-C8-BTNTs owing to the higher ordering of alkyl chain layers in the crystals. Such differences of the stability in their crystal formation are closely correlated with TFT performances, where the single-crystal devices of the 2- and 8-mono-C8-BTNTs substituted at the most peripheral positions exhibit high-performance TFT characteristics with a mobility of approx. 10 cm2 V-1 s-1. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Related Products of 93-04-9

The Article related to trimethylsilylacetylene organic semiconductor crystallinity, Placeholder for records without volume info and other aspects.Related Products of 93-04-9

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Rao, L. Vaikunta; Rao, K. Tirumala; Kandepi, V. V. Krishna Mohan published an article in 2020, the title of the article was A validated RP-HPLC method for estimation of related compounds in hydroxy naproxen.Related Products of 93-04-9 And the article contains the following content:

A simple, linear gradient liquid chromatog. method (RP-HPLC) is proposed for the simultaneous estimation of related compounds in hydroxy naproxen samples. Chromatog. separation was achieved on Zorbax SB C8 (150 x 4.6) mm, 3.5 μm particle size RRLC short column and eluent A used as 0.1% volume/volume trifluoroacetic acid in water and eluent B used as acetonitrile using Agilent RRLC (UHPLC) system. The mobile phase flow rate was 1.0 mL/min and the eluted compounds were monitored at 235 nm for related substance method and assay method. The excellent resolution was obtained between hydroxy naproxen and its related compounds, which were eluted within 25 min. The performance of the method was validated with respect to ICH guidelines for specificity, limit of detection, limit of quantification, linearity, accuracy, precision and robustness. The correlation coefficient(r) was > 0.995 for both the methods from linearity data and percentage of recovery is 98.0 to 102.0 for assay method and 80.0 to 120.0% for related substance method. Sensitivity of the method was found be less than 0.5 μg/mL. Peak homogeneity data for naproxen in the chromatograms from the selectivity solution obtained by use of the photodiode array detector demonstrated the specificity of the method for anal. of hydroxy naproxen in presence of the related compounds The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Related Products of 93-04-9

The Article related to hydroxy naproxen reverse phase hplc, Placeholder for records without volume info and other aspects.Related Products of 93-04-9

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On December 31, 2021, Zeng, Renping; Jiang, Huang; Lai, Ningshan; Yang, Huanping; Xu, Yanlian; Bai, Weibin published an article.Recommanded Product: 2-Methoxynaphthalene The title of the article was Preparation and application of microporous carbons as excellent adsorbents for reversible iodine capture and efficient removal of dye. And the article contained the following:

Because of the application of treating hazardous wastes such as organic dyes and radioactive iodine, the porous carbon with high adsorption capacity has been a research hotspot. In this work, by the pyrolysis method with KOH activation, the hypercrosslinked polynaphthalenes were used as carbonaceous precursors to prepare porous carbons, which showed high sp. surface areas between 943.8 and 2754.5 m2 g-1 with high micropore ratios. Notably, the microporous carbonaceous materials showed an excellent iodine capture capacity of 739 wt% and a high adsorption capacity of malachite green with 1194.8 mg g-1. These porous carbons provided potential applications in environmental remediation as promising adsorbent materials for adsorption of radioactive iodine, and removal of organic pollutants from aqueous solutions The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Recommanded Product: 2-Methoxynaphthalene

The Article related to microporous carbon adsorbent reversible iodine capture dye removal, Placeholder for records without volume info and other aspects.Recommanded Product: 2-Methoxynaphthalene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On December 6, 2021, Wen, Zhenghui; Wan, Ting; Vijeta, Arjun; Casadevall, Carla; Buglioni, Laura; Reisner, Erwin; Noel, Timothy published an article.Recommanded Product: 93-04-9 The title of the article was Photocatalytic C-H Azolation of Arenes Using Heterogeneous Carbon Nitride in Batch and Flow. And the article contained the following:

The functionalization of aryl C(sp2)-H bonds is a useful strategy for the late-stage modification of biol. active mols., especially for the regioselective introduction of azole heterocycles to prepare medicinally-relevant compounds Herein, we describe a practical photocatalytic transformation using a mesoporous carbon nitride (mpg-CNx) photocatalyst, which enables the efficient azolation of various arenes through direct oxidation The method exhibits a broad substrate scope and is amenable to the late-stage functionalization of several pharmaceuticals. Due to the heterogeneous nature and high photocatalytic stability of mpg-CNx, the catalyst can be easily recovered and reused leading to greener and more sustainable routes, using either batch or flow processing, to prepare these important compounds of interest in pharmaceutical and agrochem. research. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Recommanded Product: 93-04-9

The Article related to aryl azole preparation visible light carbon nitride photocatalyst, azolation, carbon nitride, flow chemistry, heterogeneous catalysis, photocatalysis, Placeholder for records without volume info and other aspects.Recommanded Product: 93-04-9

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On November 8, 2021, Borys, Andryj M.; Hevia, Eva published an article.HPLC of Formula: 93-04-9 The title of the article was The Anionic Pathway in the Nickel-Catalysed Cross-Coupling of Aryl Ethers. And the article contained the following:

The Ni-catalyzed cross-coupling of aryl ethers is a powerful method to forge new C-C and C-heteroatom bonds. However, the inert C(sp2)-O bond means that a canonical mechanism that relies on the oxidative addition of the aryl ether to a Ni0 center is thermodynamically and kinetically unfavorable, which suggests that alternative mechanisms may be involved. Here, we provide spectroscopic and structural insights into the anionic pathway, which relies on the formation of electron-rich hetero-bimetallic nickelates by adding organometallic nucleophiles to a Ni0 center. Assessing the rich co-complexation chem. between Ni(COD)2 and PhLi has led to the structures and solution-state chem. of a diverse family of catalytically competent lithium nickelates being unveiled. In addition, we demonstrate dramatic solvent and donor effects, which suggest that the cooperative activation of the aryl ether substrate by Ni0-ate complexes plays a key role in the catalytic cycle. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).HPLC of Formula: 93-04-9

The Article related to nickel cross coupling lithiation catalyst crystal structure, catalysis, cross-coupling, hetero-bimetallic compounds, nickel, organolithium, Placeholder for records without volume info and other aspects.HPLC of Formula: 93-04-9

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Peng, Bing; Wu, Lanyan; Li, Qingzhu; Wang, Qingwei; Li, Kaizhong; Zhou, Zeyan published an article in 2022, the title of the article was Photodegradation of naproxen using CuZnAl-layered double hydroxides as photocatalysts.Application of 93-04-9 And the article contains the following content:

Naproxen (NPX), as a typical pharmaceutical and personal care product (PPCP), is frequently detected in water and is difficult to remove effectively by conventional methods. Layered double hydroxides, as highly efficient photocatalysts, have not been used in photocatalysis of PPCP. In this study, CuZnAl-layered double hydroxide (CuZnAl-LDH) was prepared and its performance in the photocatalytic degradation of NPX under UV light illumination was investigated. The results indicated that the NPX photodegradation is considerably enhanced by CuZnAl-LDH with an efficiency of 98.25% in the optimal conditions, which was obviously more than that under pure light condition (efficiency less than 30%). In addition, the CuZnAl-LDH photocatalyst exhibited superior photocatalytic stability confirmed by the analyses of the catalyst structure, morphol., and cycle experiments Moreover, by the comparison of optical properties of ZnAl-LDH and CuZnAl-LDH, it was found that Cu2+ can broaden light absorption and facilitate the separation of photogenerated charges electrons (e-) and holes (h+), and in the CuZnAl-LDH system, the formation mechanism of active species complies with the mechanisms of the ligand-to-metal charge transfer (LMCT) from the 2p orbital of oxygen to the 3d orbital of M2+ and of the d-d transition of Cu2+ ions of the CuO6 unit. Besides, ESR and scavenging tests revealed that the photocatalytic process was enhanced by the synergistic effect of h+, O2-, and OH, which displayed the sequence of h+ > .O2- > .OH. Finally, the intermediate products were identified by LCMS-IT-TOF, and no intermediates with greater toxicity than NPX were produced. The possible degradation pathway of NPX was proposed involving the decarboxylation, demethylation, and hydroxylation reactions and ring-opening based on intermediates. These results are expected to provide new data on the photodegradation of naproxen. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Application of 93-04-9

The Article related to copper zinc aluminum ldh naproxen photodegradation photocatalytic wastewater treatment, Placeholder for records without volume info and other aspects.Application of 93-04-9

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem