Category: 91-16-7

Guo, Ge published the artcileCatalytic depolymerization of Kraft lignin towards liquid fuels over bifunctional molybdenum oxide based supported catalyst, Application of 1,2-Dimethoxybenzene, the publication is Fuel (2021), 121599, database is CAplus.

Catalytic depolymerization of Kraft lignin towards valuable liquid fuels and monomeric phenols has been a significant and extremely attractive target, but it remains a great challenge. Herein, we report a catalytic system consisted of bifunctional molybdenum oxide based supported catalyst for catalytic lignin hydroconversion into alkylated benzenes and phenols. In the meantime, the achieved yield of liquid product was 95% and petroleum ether extracted product was 65% at 300°C for 12 h over 20%MoO_x/ZIF-8@ZIF-67 catalyst. The calorific value was increased from 25.66 MJ/ Kg to 34.31 MJ/Kg. The characterization studies show the incorporation of MoOx species leads to the synergy between redox sites and acid sites. The product anal. and catalytic studies demonstrate its synergism to promote catalytic cleavage of C-O linkages via the coupled hydrodeoxygenation and alkylation reaction. The reasonable catalytic mechanism and redox cycle route of catalyst indicate that the cooperative catalytic system paves the way for high-efficiency waste lignin utilization.

Fuel published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Application of 1,2-Dimethoxybenzene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Monopoli, Antonio published the artcileA new expeditious synthesis of the core scaffold of salvianolic acid F trough a one-pot sequential Heck coupling catalyzed by palladium nanoparticles in ionic liquids, SDS of cas: 91-16-7, the publication is Journal of Organometallic Chemistry (2022), 122193, database is CAplus.

A new expeditious synthesis of tetra-Me salvianolic acid F (I) is presented. Starting from the naturally occurring veratrole, the target mol. is easily obtained in a one-pot mode via a sequential double Heck coupling catalyzed by palladium nanoparticles dispersed in ionic liquids The present method involves the chemoselective displacement of two different halogen atoms present on the veratrole ring and limits the need for tedious exptl. procedures. A 66% of overall yield can be achieved, that represents, as far as we know, one of the best results present in the literature, until now. This protocol can also open the way for the synthesis of unnatural salvianolic-like compounds with potential bioactivity.

Journal of Organometallic Chemistry published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, SDS of cas: 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Felipe, Josyelen L. published the artcileAnti-inflammatory, ulcerogenic and platelet activation evaluation of novel 1,4-diaryl-1,2,3-triazole neolignan-celecoxib hybrids, Category: ethers-buliding-blocks, the publication is Bioorganic Chemistry (2022), 105485, database is CAplus and MEDLINE.

This study reports the synthesis of novel neolignans-celecoxib hybrids and the evaluation of their biol. activity. Analogs 8-13 (L13-L18) exhibited anti-inflammatory activity, inhibited glycoprotein expression (P-selectin) related to platelet activation, and were considered non- ulcerogenic in the animal model, even with the administration of 10 times higher than the dose used in reference therapy. In silico drug-likeness showed that the analogs are compliant with Lipinskis rule of five. A mol. docking study showed that the hybrids 8-13 (L13-L18) fitted similarly with celecoxib in the COX-2 active site. According to this data, it is possible to infer that extra hydrophobic interactions and the hydrogen interactions with the triazole core may improve the selectivity towards the COX-2 active site. Furthermore, the mol. docking study with P-selectin showed the binding affinity of the analogs in the active site, performing important interactions with amino acid residues such as Tyr 48. Whereas the P-selectin is a promising target to the design of new anti-inflammatory drugs with antithrombotic properties, a distinct butterfly-like structure of 1,4-diaryl-1,2,3-triazole neolignan-celecoxib hybrids synthesized in this work may be a safer alternative to the traditional COX-2 inhibitors.

Bioorganic Chemistry published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Lui, Yuen Wai published the artcileMethylation with Dimethyl Carbonate/Dimethyl Sulfide Mixtures: An Integrated Process without Addition of Acid/Base and Formation of Residual Salts, COA of Formula: C8H10O2, the publication is ChemSusChem (2022), 15(3), e202102538, database is CAplus and MEDLINE.

Di-Me sulfide, a major byproduct of the Kraft pulping process, was used as an inexpensive and sustainable catalyst/co-reagent (Me donor) for various methylations with di-Me carbonate (as both reagent and solvent), which afforded excellent yields of O-methylated phenols and benzoic acids, and mono-C-methylated arylacetonitriles. Furthermore, these products could be isolated using a remarkably straightforward workup and purification procedure, realized by di-Me sulfide’s neutral and distillable nature and the absence of residual salts. The likely mechanisms of these methylations were elucidated using exptl. and theor. methods, which revealed that the key step involves the generation of a highly reactive trimethylsulfonium methylcarbonate intermediate. The phenol methylation process represents a rare example of a Williamson-type reaction that occurs without the addition of a Bronsted base.

ChemSusChem published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, COA of Formula: C8H10O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Chen, Zekun published the artcileUV-Visible Absorption Spectra of Solvated Molecules by Quantum Chemical Machine Learning, HPLC of Formula: 91-16-7, the publication is Journal of Chemical Theory and Computation (2022), 18(8), 4891-4902, database is CAplus and MEDLINE.

Predicting UV-visible absorption spectra is essential to understand photochem. processes and design energy materials. Quantum chem. methods can deliver accurate calculations of UV-visible absorption spectra, but they are computationally expensive, especially for large systems or when one computes line shapes from thermal averages Here, we present an approach to predict UV-visible absorption spectra of solvated aromatic mols. by quantum chem. (QC) and machine learning (ML). We show that a ML model, trained on the high-level QC calculation of the excitation energy of a set of aromatic mols., can accurately predict the line shape of the lowest-energy UV-visible absorption band of several related mols. with less than 0.1 eV deviation with respect to reference exptl. spectra. Applying linear decomposition anal. on the excitation energies, we unveil that our ML models probe vertical excitations of these aromatic mols. primarily by learning the at. environment of their Ph rings, which align with the phys. origin of the π →π* electronic transition. Our study provides an effective workflow that combines ML with quantum chem. methods to accelerate the calculations of UV-visible absorption spectra for various mol. systems.

Journal of Chemical Theory and Computation published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, HPLC of Formula: 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Kori, Santosh published the artcileRoom temperature HFIP/Ag-promoted palladium-catalyzed C-H functionalization of benzothiazole with iodoarenes, Product Details of C8H10O2, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(6), 847-850, database is CAplus and MEDLINE.

A versatile synthetic protocol involving the room temperature direct arylation of benzothiazoles I (R = H, Me, Cl, F) with a wide variety of iodoarenes R¹I (R¹ = C₆H₅, 4-ClC₆H₄, 2-naphthyl, etc.) under Ag-promoted Pd-catalyzed conditions in HFIP as the reaction solvent has been presented. A sequential HFIP-promoted selective iodination of arenes followed by Pd-catalyzed direct arylation of benzothiazoles I has also been disclosed. The utility of the developed protocol has been demonstrated by the synthesis of anti-tumor agents II, PMX-610 and CJM-126 (precursor).

Chemical Communications (Cambridge, United Kingdom) published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Product Details of C8H10O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Bolt, Yaroslav V. published the artcileNovel Benzothiophene-Based Fluorescent Dye Exhibiting a Large Stokes Shift, Name: 1,2-Dimethoxybenzene, the publication is Synlett (2021), 32(20), 2059-2062, database is CAplus.

We report a simple two-step method for the synthesis of a novel highly fluorescent benzothiophene-based dye comprising five fused rings and exhibiting a large Stokes shift (Δλ = 152 nm or Δν = 5482 cm^-1 in ethanol). Structural features of the obtained compound allow easy functionalization of the carbon core and open new possibility for the development of a series of new classes of fluorescent dyes.

Synlett published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Name: 1,2-Dimethoxybenzene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Singh, Bara published the artcilePd-Catalyzed Nazarov-Type Cyclization: Application in the Total Synthesis of β-Diasarone and Other Complex Cyclopentanoids, Synthetic Route of 91-16-7, the publication is Organic Letters (2022), 24(4), 1043-1048, database is CAplus and MEDLINE.

Author describe the palladium-catalyzed Nazarov-type cyclization of easily accessible (hetero)arylallyl acetates to pentannulated (hetero)arenes. This method provides ready access to various types of bi-, tri-, tetra-, and pentacyclic cyclopentanoids under neutral conditions. The synthetic utility is further demonstrated in the first total synthesis of β-diasarone (I) and several other complex cyclopentanoids relevant to medicinal chem. and materials science.

Organic Letters published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C5H10N2OS, Synthetic Route of 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Yerien, Damian E. published the artcileRose Bengal-photocatalyzed perfluorohexylation reactions of organic substrates in water. Applications to late-stage syntheses, Application In Synthesis of 91-16-7, the publication is Photochemical & Photobiological Sciences (2022), 21(5), 803-812, database is CAplus and MEDLINE.

Rose Bengal-photocatalyzed perfluorohexylation of olefins, alkynes and electron-rich aromatic compounds in water was achieved employing perfluorohexyl iodide as fluoroalkyl source and TMEDA as sacrificial donor under green LED irradn to afford perfluoro compounds R¹CHICH₂C₆F₁₃ [R¹ = CH₂OPh, CHOH(CH₂)₅], R²HC=CHC₆F₁₃ [R² = Ph, n-pentyl, (D)-(-)Norgestreyl] and I [R³ = 4-Me, 4-NO₂, 2,6-(Me)₂, etc.; R⁴ = OMe, NH₂]. Alkenes and alkynes rendered products derived from the atom transfer radical addition (ATRA) pathway, and in the case of alkynes, exclusively as E-stereoisomers. These were the first examples of photocatalyzed ATRA reactions carried out excursively in water alone. The reactions of aromatic compounds under the current protocol in water present the advantage of employing a perfluoroalkyl iodide (C₆F₁₃-I) as source of perfluorohexyl radicals. Examples of photocatalytic late-stage incorporations of fluoroalkyl moieties into two com. drugs of widespread used were reported.

Photochemical & Photobiological Sciences published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C2H10Cl2N2, Application In Synthesis of 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem