Category: 888327-32-0

Related Products of 888327-32-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 888327-32-0, name is 4-Bromo-1-(difluoromethoxy)-2-methylbenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 77 Preparation of: 2-amino-5-[4-(difluoromethoxy)-3-methylphenyl]-3-methyl-5-(3-methylphenyl)- 3,5-dihydro-4H-imidazol-4-oneStep 1 : 1-(difluoromethoxy)-2-(2-fluoroethyl)-4-(phenylethvnyl)benzene; In a 50 mL round-bottomed flask was placed 4-bromo-1-(difluoromethoxy)-2- methylbenzene (0.8 g, 3.37 mmol) and DMF (6.75 mL) was added to give a colorless solution.1-Ethynyl-3-methylbenzene (0.436 mL, 3.37 mmol) and triethylamine (2.352 mL, 16.87 mmol) were added. The reaction was degassed by bubbling with N2.Bis(triphenylphosphine)palladium(ll) chloride (0.118 g, 0.169 mmol) was added and N2 bubbling was continued. Copper iodide (0.032 g, 0.169 mmol) was added. The reaction was heated to 60 C for 12h. The reaction was cooled and partitioned between ether (70 mL) and 1MHCI (50 mL). The organic was washed with 1 M HCI (50 mL) and brine (2 x 50 mL). The organic layer was dried over Na2SO4. The crude was purified by flash chromatography (100% hexanes) to provide 1-(difluoromethoxy)-2-methyl-4-(m-tolylethynyl)benzene (0.88 g, 3.23 mmol, 96% yield) as a yellow oil with minor impurities.1H NMR (400 MHz, DMSO-d6) § 7.05-7.70 (m, 7H), 7.18 (t, JH.F = 74 Hz, 1H), 2.30 (s, 3H), 2.20(s, 3H)

The synthetic route of 4-Bromo-1-(difluoromethoxy)-2-methylbenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; WYETH; WO2008/115552; (2008); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 888327-32-0, name is 4-Bromo-1-(difluoromethoxy)-2-methylbenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 888327-32-0, COA of Formula: C8H7BrF2O

EXAMPLE 71 Preparation of 2-Amino-5,5-bis-[4-(difluoromethoxy)-3-methylphenyl]-3-methyl-3,5-dihydro-4H- imidazol-4-one; Step 1 : bis(4-difluoromethoxy-3-methyl-phenyl)acetyleneIn a CEM snap top microwave vial were combined trimethylsilylacetylene (0.207 g, 2.11 mmol), 4-Bromo-1-difluoromethoxy-2-methyl-benzene (1.00 g, 4.22 mmol), tetrakis(triphenylphosphine)palladium (56 mg, 0.0485 mmol) and pyrrolidine (1 ml_, 12 mmol).The reaction vial was placed in a CEM Explorer microwave and irradiated for 30 minutes at 8O0C. The crude reaction mixture was poured directly onto silica gel and purified by column chromatography (hexanes) to yield 0.519 g of 1 ,1′-(1.2-ethynediyl)bis[4-difluoromethoxy-3- methylbenzene] as a clear oil (73%). 1H NMR (400 MHz, DMSO-cfe) delta ppm 2.24 (s, 6 H) 7.19 (d, 2 H) 7.26 (t, J=73.7 Hz, 2H) 7.44 (q,J=8.6, 2.1 Hz, 2 H) 7.51 (d, J=1.4 Hz, 2 H); MS (El) m/z 338 [M+.]

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1-(difluoromethoxy)-2-methylbenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; WYETH; WO2008/115552; (2008); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 888327-32-0, name is 4-Bromo-1-(difluoromethoxy)-2-methylbenzene, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 4-Bromo-1-(difluoromethoxy)-2-methylbenzene

l-(4-Difluoromethoxy-3-methyl-phenyl)-cis-3,5-dimethyl-piperazine:; To 4-bromo-l- (difluoromethoxy)-2-methylbenzene (2.36 g, 10.00 mmol) in toluene (50 mL) was added cis-2,6- dimethylpiperazine (5 g, 58.14 mmol), Pd(OAc)2 (120 mg, 0.53 mmol), BINAP (380 mg, 0.61 mmol), and t-BuOK (2.2 g, 19.64 mmol). The resulting solution was stirred for 4 hours at 80C. The solution was cooled to room temperature and washed with H2O (2 X 50 mL), dried over Na2SCt, concentrated, and purified by silica gel column chromatography (10:1 CH2CWMeOH) to give 1.1 g (41%) of l-(4- (difluoromethoxy)-3-methylphenyl)-3,5-dimethylpiperazine.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 888327-32-0.

Related Products of 888327-32-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 888327-32-0, name is 4-Bromo-1-(difluoromethoxy)-2-methylbenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Step 2: ((4-(Difluoromethoxy)-3-methylphenyl)ethvnyl)trimethylsilane; In a 250 mL round-bottomed flask was placed 4-bromo-1-(difluoromethoxy)-2- methylbenzene (14 g, 59.1 mmol) from the previous step. Pyrrolidine (23.6 mL) and acetonitrile (35.4 mL) were added to give a colorless solution. The reaction was degassed by bubbling with N2. Ethynyltrimethylsilane (7.0 g, 10 mL, 70.9 mmol) was added followed by bis(triphenylphosphine)dichloropalladium (2.07 g, 2.95 mmol) and copper(l) iodide (0.56 g, 2.95 mmol) was added. The reaction was warmed to 65 0C for 4h. The reaction was cooled. The solution was partitioned between EtOAc (200 mL) and 1 M HCI (200 ml_). The organic was washed with 1M HCI (200 mL) and brine (200 mL). The organic layer was dried over Na2SO4 and filtered. The solvent was removed and the resulting crude material was purified by flash chromatography (SiO2, 100% hexanes) to provide 12.4 g, 83%, of the title compound as a light yellow oil.

The synthetic route of 4-Bromo-1-(difluoromethoxy)-2-methylbenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; WYETH; WO2008/115552; (2008); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem