Category: 887581-09-1

Combs, Andrew Paul et al. published their patent in 2010 |CAS: 887581-09-1

The Article related to oxatetraazatetracyclotricosanonaene derivative preparation janus kinase jak inhibitor, azatetracyclotricosanonaene oxatetra analog preparation anaplastic lymphoma kinase alk inhibitor and other aspects.HPLC of Formula: 887581-09-1

On July 29, 2010, Combs, Andrew Paul; Sparks, Richard B.; Yue, Eddy Wai Tsun; Hao, Feng; Bower, Michael Jason; Zhu, Wenyu published a patent.HPLC of Formula: 887581-09-1 The title of the patent was Preparation of oxatetraazatetracyclotricosanonaene derivatives and analogs for use as JAK and ALK inhibitors. And the patent contained the following:

Title compounds I [each A independently = CR3, N, O, S, etc.; each D independently = bond, N, O, S, etc.; each E independently = N, O, S, etc.; each L independently = bond, CH2, CH2O, etc., provided at least one is other than a bond; Q = (CR1R2)m; each X independently = N or CR3; R1 and R2 independently = H, halo, alkyl, etc.; or together with the c atom to which they are attached form an (un)substituted cycloalkyl or heterocycloalkyl; each R3 independently = H, halo, CN, alkyl, etc.; R4 = H, (un)substituted alkyl, arylalkyl, etc.; m = 1 to 4], and their pharmaceutically acceptable salts, are prepared and disclosed as janus kinase (JAK) and anaplastic lymphoma kinase (ALK) inhibitors. Thus, e.g., II路TFA was prepared by amination of 2,4,5-trichloropyrimidine with 3-methoxybenzylamine followed by amination with 3-aminobenzenemethanol, bromination, cyclization. Select I were evaluated in JAK1 kinase assays, e.g., II路TFA demonstrated an IC50 value of 51 nM. The experimental process involved the reaction of (2-Bromo-5-methoxyphenyl)methanamine(cas: 887581-09-1).HPLC of Formula: 887581-09-1

The Article related to oxatetraazatetracyclotricosanonaene derivative preparation janus kinase jak inhibitor, azatetracyclotricosanonaene oxatetra analog preparation anaplastic lymphoma kinase alk inhibitor and other aspects.HPLC of Formula: 887581-09-1

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zang, Qin et al. published their research in ACS Combinatorial Science in 2012 |CAS: 887581-09-1

The Article related to bromoarylalkylamine vinylsulfonamide hexk reaction, aminoalkylarylvinylsulfonamide preparation aza michael reaction, isoindolylmethylsulfonamide preparation cyclization, tricyclic sultam preparation and other aspects.Quality Control of (2-Bromo-5-methoxyphenyl)methanamine

On March 12, 2012, Zang, Qin; Javed, Salim; Porubsky, Patrick; Ullah, Farman; Neuenswander, Benjamin; Lushington, Gerald H.; Basha, Fatima Z.; Organ, Michael G.; Hanson, Paul R. published an article.Quality Control of (2-Bromo-5-methoxyphenyl)methanamine The title of the article was Synthesis of a unique isoindoline/tetrahydroisoquinoline-based tricyclic sultam library utilizing a Heck-aza-Michael strategy. And the article contained the following:

The synthesis of a unique isoindoline- and tetrahydroisoquinoline (THIQ)-containing tricyclic sultam library, utilizing a Heck-aza-Michael strategy is reported. Both isoindoline and THIQ rings are installed through a Heck reaction on a vinylsulfonamide, followed by one-pot deprotection and intramol. aza-Michael reaction. Subsequent cyclization with either paraformaldehyde condensation or 1,1′-carbonyldiimidazole coupling generates a variety of tricyclic sultams, e.g., I. Overall, a 160-member library of these sultams, together with their isoindolines/THIQ and secondary sulfonamides precursors, were constructed using this strategy. The experimental process involved the reaction of (2-Bromo-5-methoxyphenyl)methanamine(cas: 887581-09-1).Quality Control of (2-Bromo-5-methoxyphenyl)methanamine

The Article related to bromoarylalkylamine vinylsulfonamide hexk reaction, aminoalkylarylvinylsulfonamide preparation aza michael reaction, isoindolylmethylsulfonamide preparation cyclization, tricyclic sultam preparation and other aspects.Quality Control of (2-Bromo-5-methoxyphenyl)methanamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hernandez-Vazquez, Eduardo et al. published their research in Organic & Biomolecular Chemistry in 2016 |CAS: 887581-09-1

The Article related to benzylamine isocyanide benzoyloxy acetaldehyde chloroacetic acid ugi reaction, bromo chloroacetylamiono oxopropylamino benzoate preparation heck reaction, pyrazinoisoquinoline preparation antitumor activity structure activity relationship and other aspects.Electric Literature of 887581-09-1

Hernandez-Vazquez, Eduardo; Miranda, Luis D. published an article in 2016, the title of the article was Practical synthesis and cytotoxic evaluation of the pyrazino[1,2-b]-isoquinoline ring system.Electric Literature of 887581-09-1 And the article contains the following content:

A practical three-step protocol for the synthesis of pyrazino[1,2-b]isoquinolines I [R1 = H, 4-Me, 5-MeO, 5-F, etc.; R2 = t-Bu, cyclohexyl, 2,6-diMeC6H3, benzyl, etc.] was reported. This approach included a one-pot parallel cyclization/cyclization parallel process followed by a non-common 6-endo Heck cyclization that transformed previously constructed Ugi adducts into diversely decorated tricyclic systems. Compounds bearing a t-Bu or 2,6-dimethylphenyl substituent showed significant cytotoxic activity. The most active analog I (R1 = CH2O2; R2 = 2,6-diMeC6H3) showed significant activity against HCT-15 and K562 (IC50 = 41.8 ± 3.3 and 57.7 ± 2.1 μM, resp.) with no cytotoxicity against human gingival fibroblasts. The experimental process involved the reaction of (2-Bromo-5-methoxyphenyl)methanamine(cas: 887581-09-1).Electric Literature of 887581-09-1

The Article related to benzylamine isocyanide benzoyloxy acetaldehyde chloroacetic acid ugi reaction, bromo chloroacetylamiono oxopropylamino benzoate preparation heck reaction, pyrazinoisoquinoline preparation antitumor activity structure activity relationship and other aspects.Electric Literature of 887581-09-1

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adams, Ruth S. et al. published their patent in 2008 |CAS: 887581-09-1

The Article related to pyrazoline derivative preparation raf kinase inhibitor potential cancer drug, phenol pyrazolinyl preparation raf kinase inhibitor potential cancer drug, semicarbazone heterocyclic preparation raf kinase inhibitor potential cancer drug, alkylidenehydrazide heterocyclic preparation raf kinase inhibitor potential cancer drug and other aspects.Related Products of 887581-09-1

On July 3, 2008, Adams, Ruth S.; Duffey, Matthew; Gould, Alexandra E.; Greenspan, Paul D.; Kulkarni, Bheemashankar A.; Vos, Tricia J. published a patent.Related Products of 887581-09-1 The title of the patent was Preparation of pyrazoline derivatives with Raf kinase inhibitory activity. And the patent contained the following:

The present invention provides certain pyrazoline compounds (shown as I; variables defined below; e.g. 2-[3-(pyridin-3-yl)-1-[[5-(pyridin-2-yl)-2-thienyl]carbonyl]-4,5-dihydro-1H-pyrazol-5-yl]phenol) useful as inhibitors of Raf kinases. The invention also provides pharmaceutical compositions and methods of using the compositions in the treatment of cancer. Semiquant. IC50 values for B-Raf kinase are reported for many examples of I. For I: R1 is a (un)substituted 5- or 6-membered N-containing heteroaryl ring, which ring optionally is fused to an aryl, heteroaryl, heterocyclyl, or cycloaliphatic ring, each of which is (un)substituted. R2 is a (un)substituted 5- or 6-membered aryl or heteroaryl ring, which ring optionally is fused to an aryl, heteroaryl, heterocyclyl, or cycloaliphatic ring, each of which is (un)substituted. R3 = H, fluoro, C1-4 aliphatic, and C1-4 fluoroaliph.; R4 is H, fluoro, or a C1-4 aliphatic or C1-4 fluoroaliph. (un)substituted, or R3 and R4, taken together with the C to which they are bound, form an (un)substituted 3- to 6-membered cycloaliphatic or 4- to 7-membered heterocyclic ring. L1 = -C(O)NRa(CRbRc)m-, -C(O)C(Rb):C(Rb)(CRbRc)m-, -C(O)(CRbRc)m-, and -SO2(CRbRc)m-, wherein the C(O) or SO2 functionality, resp., is bound to the N of the pyrazoline ring; Cy1 is a bivalent radical derived from a ring system = (un)substituted 5- or 6-membered aromatic rings having 0-4 ring N atoms and optionally 1-2 addnl. ring heteroatoms = O and S, which 5- or 6-membered aromatic ring optionally is fused to an aryl, heteroaryl, heterocyclyl, or cycloaliphatic ring, each of which is (un)substituted; et al. L2 is -(CRbRc)- or -(CRbRc)nX(CRbRc)n-; X = -O-, -C(O)-, -S-, -SO-, -SO2-, -NRa-, -C(Rf):C(Rf)-, -CC-, -NRaC(O)-, – C(O)NRa-, -SO2NRa, -NRaSO2-, and -NRaC(O)NRa-; Cy2 is a radical derived from a ring system = (un)substituted 5- or 6-membered aromatic rings having 0-4 ring N atoms and optionally 1-2 addnl. ring heteroatoms = O and S, which 5- or 6-membered aromatic ring optionally is fused to an aryl, heteroaryl, heterocyclyl, or cycloaliphatic ring, each of which is (un)substituted; et al; provided that R1 is not 6-bromo-1,2-dihydro-2-oxo-4-phenyl-3-quinolinyl; addnl. details are given in the claims. Although the methods of preparation are not claimed, preparations and/or characterization data for >400 examples of I are included. For example, 2-[3-(pyridin-3-yl)-1-[[5-(pyridin-2-yl)-2-thienyl]carbonyl]-4,5-dihydro-1H-pyrazol-5-yl]phenol was prepared in 3 steps (73, 94, and 72 % yields, resp.) starting from salicylaldehyde and 1-(pyridin-3-yl)ethanone and involving the following intermediates: (2E)-3-(2-hydroxyphenyl)-1-(pyridin-3-yl)prop-2-en-1-one and 2-[5-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-3-yl]phenol. The experimental process involved the reaction of (2-Bromo-5-methoxyphenyl)methanamine(cas: 887581-09-1).Related Products of 887581-09-1

The Article related to pyrazoline derivative preparation raf kinase inhibitor potential cancer drug, phenol pyrazolinyl preparation raf kinase inhibitor potential cancer drug, semicarbazone heterocyclic preparation raf kinase inhibitor potential cancer drug, alkylidenehydrazide heterocyclic preparation raf kinase inhibitor potential cancer drug and other aspects.Related Products of 887581-09-1

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A new synthetic route of 887581-09-1

At the same time, in my other blogs, there are other synthetic methods of this type of compound, (2-Bromo-5-methoxyphenyl)methanamine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 887581-09-1, name is (2-Bromo-5-methoxyphenyl)methanamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 887581-09-1, Application In Synthesis of (2-Bromo-5-methoxyphenyl)methanamine

General procedure: A 25 mL Schlenk tube wascharged with a magnetic stirrer and DMSO (2.0 mL). Substituted(2-bromophenyl)methylamine (1) (0.5 mmol), amidine hydrochloride (2) (1.0 mmol),CuBr (0.1 mmol, 14.2 mg), and K2CO3 (1.5 mmol, 207 mg) were added to the tube.The mixture was stirred at 80-120 oC under nitrogen atmosphere for 24 h, and thenunder air for 0.5 h. The resulting mixture was cooled to room temperature and filtered,and the solid was washed with ethyl acetate for two times (3 × 3 mL). The combinedfiltrate was concentrated by the rotary evaporator, and the residue was purified bycolumn chromatography on silica gel using petroleum ether/ ethyl acetate as eluent togive the desired target product.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, (2-Bromo-5-methoxyphenyl)methanamine, and friends who are interested can also refer to it.

Reference:
Article; Liu, Qing; Zhao, Yufen; Fu, Hua; Cheng, Changmei; Synlett; vol. 24; 16; (2013); p. 2089 – 2094;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Continuously updated synthesis method about 887581-09-1

According to the analysis of related databases, 887581-09-1, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 887581-09-1 as follows. category: ethers-buliding-blocks

Step 3: tert-butyl (2-bromo-5-methoxybenzyl)carbamate To a solution of 1-(2-bromo-5-methoxyphenyl)methanamine (3.2 mmol) in DCM (15 mL) was added BOC2O (3.2 mmol). The reaction mixture was allowed to stir at rt overnight and then concentrated. The residue was purified by column chromatography to give tert-butyl (2-bromo-5-methoxybenzyl)carbamate (3.1 mmol, 95%).

According to the analysis of related databases, 887581-09-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Millennium Pharmaceuticals, Inc.; US2008/171754; (2008); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Continuously updated synthesis method about 887581-09-1

According to the analysis of related databases, 887581-09-1, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 887581-09-1 as follows. category: ethers-buliding-blocks

Step 3: tert-butyl (2-bromo-5-methoxybenzyl)carbamate To a solution of 1-(2-bromo-5-methoxyphenyl)methanamine (3.2 mmol) in DCM (15 mL) was added BOC2O (3.2 mmol). The reaction mixture was allowed to stir at rt overnight and then concentrated. The residue was purified by column chromatography to give tert-butyl (2-bromo-5-methoxybenzyl)carbamate (3.1 mmol, 95%).

According to the analysis of related databases, 887581-09-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Millennium Pharmaceuticals, Inc.; US2008/171754; (2008); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Simple exploration of (2-Bromo-5-methoxyphenyl)methanamine

The synthetic route of 887581-09-1 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 887581-09-1, name is (2-Bromo-5-methoxyphenyl)methanamine, A new synthetic method of this compound is introduced below., Product Details of 887581-09-1

General procedure: A 25 mL Schlenk tube wascharged with a magnetic stirrer and DMSO (2.0 mL). Substituted(2-bromophenyl)methylamine (1) (0.5 mmol), amidine hydrochloride (2) (1.0 mmol),CuBr (0.1 mmol, 14.2 mg), and K2CO3 (1.5 mmol, 207 mg) were added to the tube.The mixture was stirred at 80-120 oC under nitrogen atmosphere for 24 h, and thenunder air for 0.5 h. The resulting mixture was cooled to room temperature and filtered,and the solid was washed with ethyl acetate for two times (3 × 3 mL). The combinedfiltrate was concentrated by the rotary evaporator, and the residue was purified bycolumn chromatography on silica gel using petroleum ether/ ethyl acetate as eluent togive the desired target product.

The synthetic route of 887581-09-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Liu, Qing; Zhao, Yufen; Fu, Hua; Cheng, Changmei; Synlett; vol. 24; 16; (2013); p. 2089 – 2094;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Discovery of C8H10BrNO

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (2-Bromo-5-methoxyphenyl)methanamine, its application will become more common.

Synthetic Route of 887581-09-1,Some common heterocyclic compound, 887581-09-1, name is (2-Bromo-5-methoxyphenyl)methanamine, molecular formula is C8H10BrNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A 25 mL Schlenk tube wascharged with a magnetic stirrer and DMSO (2.0 mL). Substituted(2-bromophenyl)methylamine (1) (0.5 mmol), amidine hydrochloride (2) (1.0 mmol),CuBr (0.1 mmol, 14.2 mg), and K2CO3 (1.5 mmol, 207 mg) were added to the tube.The mixture was stirred at 80-120 oC under nitrogen atmosphere for 24 h, and thenunder air for 0.5 h. The resulting mixture was cooled to room temperature and filtered,and the solid was washed with ethyl acetate for two times (3 × 3 mL). The combinedfiltrate was concentrated by the rotary evaporator, and the residue was purified bycolumn chromatography on silica gel using petroleum ether/ ethyl acetate as eluent togive the desired target product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (2-Bromo-5-methoxyphenyl)methanamine, its application will become more common.

Reference:
Article; Liu, Qing; Zhao, Yufen; Fu, Hua; Cheng, Changmei; Synlett; vol. 24; 16; (2013); p. 2089 – 2094;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Simple exploration of 887581-09-1

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (2-Bromo-5-methoxyphenyl)methanamine, other downstream synthetic routes, hurry up and to see.

Electric Literature of 887581-09-1, The chemical industry reduces the impact on the environment during synthesis 887581-09-1, name is (2-Bromo-5-methoxyphenyl)methanamine, I believe this compound will play a more active role in future production and life.

General procedure: To a magnetically stirred solution of the formyl ester 8a (400 mg, 1.6 mmol) in CH2ClCH2Cl (5 mL) at room temperature, were added sequentially 2-bromobenzyl amine 3a (420 mg, 2.2 mmol) and AcOH (0.14 mL, 2.4 mmol) followed by refluxing of the mixture for 12 h. After cooling, the reaction mixture was treated with aqueous NaHCO3 solution and extracted with ethyl acetate (3 ¡Á 12 mL). The combined organic layers were washed with brine, dried (Na2SO4), and filtered. Concentration of the filtrate followed by flash chromatography (ethyl acetate/hexane, 1:6 to 2:3) furnished the cyclic enamide 9aa (480 mg, 80%) as brown viscous oil.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (2-Bromo-5-methoxyphenyl)methanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Satyanarayana, Gedu; Maier, Martin E.; Tetrahedron; vol. 68; 6; (2012); p. 1745 – 1749;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem