Category: 887581-09-1

On June 2, 2016, Davie, Rebecca Louise; Edwards, Hannah Joy; Evans, David Michael; Hodgson, Simon Teanby published a patent.Application In Synthesis of (2-Bromo-5-methoxyphenyl)methanamine The title of the patent was Preparation of N-((het)arylmethyl)heteroaryl-carboxamides compounds as plasma kallikrein inhibitors. And the patent contained the following:

The invention provides compounds of formula I, compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds Compounds of formula I wherein B is (un)substituted Ph, benzothiophenyl, benzofuranyl, benzomorpholinyl, etc.; W is C and X, Y, Z are independently C, N, O and S; R5 and R6 are independently H, alkyl, NH2, etc.; R7 is H; A is (un)substituted aryl and (un)substituted heteroaryl; are claimed. Example compound II was prepared by amidation of 3-(methoxymethyl)-1-(4-((2-oxopyridin-1(2H)-yl)methyl)benzyl)-1H-pyrazole-4-carboxylic acid with (3,5-dimethoxyphenyl)methanamine. The invention compounds were evaluated for their plasma kallikrein inhibitory activity (data given). The experimental process involved the reaction of (2-Bromo-5-methoxyphenyl)methanamine(cas: 887581-09-1).Application In Synthesis of (2-Bromo-5-methoxyphenyl)methanamine

The Article related to hetero arylmethyl heteroaryl carboxamide preparation plasma kallikrein inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Application In Synthesis of (2-Bromo-5-methoxyphenyl)methanamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Cheng, Cang; Zuo, Xiang; Tu, Dongdong; Wan, Bin; Zhang, Yanghui published an article in 2021, the title of the article was Palladium-catalyzed diastereoselective cross-coupling of two aryl halides via C-H activation: synthesis of chiral eight-membered nitrogen heterocycles.Category: ethers-buliding-blocks And the article contains the following content:

A method for the synthesis of enantiopure eight-membered nitrogen heterocycles, e.g., I was developed through diastereoselective cross-coupling of 2-iodobiphenyls with 2-bromobenzylamines. The products represented a novel type of chiral scaffold, which feature easy modification and high configurative stability and had the potential to be applied in asym. synthesis. Palladacycles that were formed via the C-H activation of 2-iodobiphenyls should act as the intermediates. The reaction provided a new strategy for the synthesis of medium-sized ring compounds The experimental process involved the reaction of (2-Bromo-5-methoxyphenyl)methanamine(cas: 887581-09-1).Category: ethers-buliding-blocks

The Article related to chiral eight membered nitrogen heterocycle diastereoselective preparation, aryl halide ch activation palladium catalyst cross coupling, Heterocyclic Compounds (One Hetero Atom): Higher-Membered Rings and other aspects.Category: ethers-buliding-blocks

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Ether – Wikipedia,
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On November 6, 2015, Miranda, Luis D.; Hernandez-Vazquez, Eduardo published an article.Related Products of 887581-09-1 The title of the article was Multicomponent/Palladium-Catalyzed Cascade Entry to Benzopyrrolizidine Derivatives: Synthesis and Antioxidant Evaluation. And the article contained the following:

A versatile and efficient protocol for the synthesis of highly substituted benzopyrrolizidines (tetrahydro-3H-pyrrolo[2,1-a]isoindol-3-ones) is reported. The strategy consisted of an Ugi four-component reaction/elimination methodol. to afford dehydroalanines containing trans-cinnamic acid derivatives and different substituted 2-bromobenzylamines, followed by a palladium-catalyzed 5-exo-trig/5-exo-trig cascade carbocyclization process. Gratifyingly, benzopyrrolizidines, e.g. I, were obtained in moderate to good yields (42-77%) with a Z geometry due to the structural requirements for syn-β-hydride elimination. The prepared heterocyclic scaffolds are decorated with several substituents and incorporate a benzopyrrolizidine-fused system, along with an embedded cinnamic acid derivative, two privileged medicinal chem. scaffolds. Addnl., since some of the compounds are derived from the well-known antioxidants ferulic and sinapinic acids, they were tested for their in vitro antioxidant capacity. The data suggested that compounds having a p-hydroxyl group showed moderate 2,2-diphenyl-1-picrylhydrazyl-radical-scavenging activity and were effective antioxidants in preventing lipoperoxidation in a thiobarbituric acid reactive substances assay. The experimental process involved the reaction of (2-Bromo-5-methoxyphenyl)methanamine(cas: 887581-09-1).Related Products of 887581-09-1

The Article related to multicomponent ugi elimination palladium catalyst cascade carbocyclization, benzopyrrolizidine preparation antioxidant, Heterocyclic Compounds (One Hetero Atom): Pyrroles and Pyrrolizines and other aspects.Related Products of 887581-09-1

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On November 1, 2012, Tsuhako, Amy Lew; Marlowe, Charles K.; Zaharia, Christiana A.; Kabigting, Lori; Bajjalieh, William; Tesfai, Zerom; Huang, Ping; Moon, Kim; Aay, Naing; Tambo-Ong, Arlyn; Nuss, John M.; Xu, Wei; Kearney, Patrick published a patent.Safety of (2-Bromo-5-methoxyphenyl)methanamine The title of the patent was Pyrimidine derivatives as inhibitors of inducible form of 6-phosphofructose-2-kinase and their preparation and use for the treatment of cancer. And the patent contained the following:

The invention relates to pyrimidines of formula I, which are inhibitors of inducible form of 6-phosphofructose-2-kinase (iPFK-2) and which are useful in the treatment of cancer. Compounds of formula I wherein W is (un)substituted (un)branched C1-12 aliphatic chain; X1, X2 and X3 are independently absent, (un)substituted aryl, (un)substituted heteroaryl, etc.; Y is absent and (un)substituted (un)branched C1-12 aliphatic chain; Z is H, (un)substituted C1-8 aliphatic, (un)substituted aryl, etc.; L is absent, NH and derivatives and (un)substituted (un)branched C1-4 aliphatic chain; A is (un)substituted aryl, (un)substituted heteroaryl, etc.; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a general procedure (procedure given). All the invention compounds were evaluated for their iPFK-2 inhibitory activity. From the assay, it was determined that compound II exhibited an IC50 value of <500 nM. The experimental process involved the reaction of (2-Bromo-5-methoxyphenyl)methanamine(cas: 887581-09-1).Safety of (2-Bromo-5-methoxyphenyl)methanamine

The Article related to pyrimidine preparation phosphofructose kinase inhibitor treatment cancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Safety of (2-Bromo-5-methoxyphenyl)methanamine

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On November 19, 2010, Wang, Chen; Li, Shangfu; Liu, Hongxia; Jiang, Yuyang; Fu, Hua published an article.Category: ethers-buliding-blocks The title of the article was Copper-Catalyzed Synthesis of Quinazoline Derivatives via Ullmann-Type Coupling and Aerobic Oxidation. And the article contained the following:

A simple and efficient copper-catalyzed approach to quinazoline derivatives has been developed, and the protocol uses readily available substituted (2-bromophenyl)methylamines and amides as the starting materials, and the cascade reactions were performed under air via sequential Ullmann-type coupling and aerobic oxidation without addition of any ligand or additive. The present method provides a convenient and practical strategy for synthesis of quinazoline derivatives The experimental process involved the reaction of (2-Bromo-5-methoxyphenyl)methanamine(cas: 887581-09-1).Category: ethers-buliding-blocks

The Article related to quinazoline preparation, ullmann type coupling aerobic oxidation bromophenylmethylamine amide, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Category: ethers-buliding-blocks

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Ether – Wikipedia,
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On October 1, 2013, Liu, Qing; Zhao, Yufen; Fu, Hua; Cheng, Changmei published an article.Formula: C8H10BrNO The title of the article was Copper-catalyzed sequential N-arylation and aerobic oxidation: synthesis of quinazoline derivatives. And the article contained the following:

A novel and efficient copper-catalyzed cascade method for the synthesis of quinazoline derivatives was developed. The protocol uses readily available substituted (2-bromophenyl)methanamines and amidine hydrochlorides as the starting materials, inexpensive CuBr as the catalyst, and economical and environment friendly air as the oxidant, and the corresponding quinazoline derivatives were obtained in moderate to good yields. The procedure underwent sequential intermol. N-arylation, intramol. nucleophilic substitution and aerobic oxidation The experimental process involved the reaction of (2-Bromo-5-methoxyphenyl)methanamine(cas: 887581-09-1).Formula: C8H10BrNO

The Article related to bromobenzylamine amidine hydrochloride cascade arylation copper catalyst, quinazoline preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Formula: C8H10BrNO

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Coulomb, Julien; Certal, Victor; Larraufie, Marie-Helene; Ollivier, Cyril; Corbet, Jean-Pierre; Mignani, Gerard; Fensterbank, Louis; Lacote, Emmanuel; Malacria, Max published an article in 2009, the title of the article was Intramolecular Homolytic Substitution of Sulfinates and Sulfinamides.Formula: C8H10BrNO And the article contains the following content:

A general and efficient method for the synthesis of cyclic sulfinates and sulfinamides based on intramol. homolytic substitution (SHi) at the sulfur atom by aryl or alkyl radicals is described. Both alkyl and benzofused compounds can be accessed directly from easily prepared acyclic precursors. Enantiomerically enriched sulfur-based heterocycles were formed through an SHi process with inversion of configuration at the sulfur atom. Cyclization of prochiral radicals proceeded with varying stereochem. outcomes, depending on the size of the incoming radical. 2-Pyridyl and 2-quinolyl radicals led to biaryl compounds, which result from attack onto the ortho position of the arylsulfinate rather than a thiophilic substitution. The experimental process involved the reaction of (2-Bromo-5-methoxyphenyl)methanamine(cas: 887581-09-1).Formula: C8H10BrNO

The Article related to intramol homolytic substitution sulfinate sulfinamide oxathiolane isothiazolidine preparation, Heterocyclic Compounds (More Than One Hetero Atom): Dioxoles, Oxathioles, Dithioles and other aspects.Formula: C8H10BrNO

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Satyanarayana, Gedu; Maier, Martin E. published an article in 2012, the title of the article was Tricyclic isoindolines by Heck cyclization.Product Details of 887581-09-1 And the article contains the following content:

A series of 4-formyl esters, e.g., I, were prepared by Michael addition of an enamine with Et acrylate. A subsequent condensation with 2-bromobenzylamines gave rise to cyclic enamides, e.g., II. In a Heck cyclization reaction tricyclic isoindoles, e.g., III, were formed in good yields. The experimental process involved the reaction of (2-Bromo-5-methoxyphenyl)methanamine(cas: 887581-09-1).Product Details of 887581-09-1

The Article related to tricyclic isoindoline preparation, formyl ester preparation bromobenzylamine condensation, cyclic enamide preparation heck cyclization, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Product Details of 887581-09-1

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Garcia-Gonzalez, Ma. Carmen; Hernandez-Vazquez, Eduardo; Gordillo-Cruz, Raul E.; Miranda, Luis D. published an article in 2015, the title of the article was Ugi-derived dehydroalanines as a pivotal template in the diversity oriented synthesis of aza-polyheterocycles.SDS of cas: 887581-09-1 And the article contains the following content:

Various readily available, Ugi-derived dehydroalanines were used as pivotal templates to easily and efficiently assemble diverse pharmacol. important polyheterocyclic systems through a cascade palladium-catalyzed C-C bond formation processes (tandem reaction). Allyl, homoallyl and propargyl amine led to the formation of benzopyrrolizidinone derivatives, benzoindolizidinone derivatives and pyrazinoisoquinoline derivatives, resp., while benzylamines and o-bromobenzylamine were used as precursors of tetracyclic-fused systems and pyrazionoisoquinolindione derivatives Under optimized conditions the synthesis of the target compounds was achieved using dichlorobis(triphenylphosphine)palladium as a catalyst. Starting materials included 2-propen-1-amine (allyl amine), 2-iodobenzoic acid derivatives 2-bromobenzoic acid derivatives, 2-(benzoyloxy)acetaldehyde, isocyanides (isonitriles), 3-buten-1-amine (homoallyl amine). Dehydro amino acid amides (dehydroalanine derivatives) intermediates included N-[1-[[(1,1-dimethylethyl)amino]carbonyl]ethenyl]-2-iodo-N-(phenylmethyl)benzamide, thiophene derivatives, furan derivatives, pyrrole derivatives, indole derivatives The title compounds thus formed included (methylene)(oxo)pyrrolo[2,1-a]isoindolecarboxamides, (methylene)(oxo)pyrido[2,1-a]isoindolecarboxamides, isoindolo[2,1-b]isoquinolinecarboxamides, pyrazino[1,2-b]isoquinolinedione derivatives. The experimental process involved the reaction of (2-Bromo-5-methoxyphenyl)methanamine(cas: 887581-09-1).SDS of cas: 887581-09-1

The Article related to benzopyrrolizidinone benzoindolizidinone pyrazinoisoquinoline pyrazionoisoquinolindione preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.SDS of cas: 887581-09-1

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On July 19, 2019, Zhang, Shanshan; Chen, Fei; He, Yan-Mei; Fan, Qing-Hua published an article.Application In Synthesis of (2-Bromo-5-methoxyphenyl)methanamine The title of the article was Asymmetric Hydrogenation of Dibenzo[c,e]azepine Derivatives with Chiral Cationic Ruthenium Diamine Catalysts. And the article contained the following:

An efficient Ru-catalyzed asym. hydrogenation of dibenzo[c,e]azepines is reported. A series of seven-membered cyclic amines were obtained with moderate to excellent enantioselectivity. The catalyst counteranion played an important role in achieving high-level chiral induction. Moreover, a one-pot synthesis of chiral 6,7-dihydro-5H-dibenz[c,e]azepines via two-step reductive amination was also developed. The experimental process involved the reaction of (2-Bromo-5-methoxyphenyl)methanamine(cas: 887581-09-1).Application In Synthesis of (2-Bromo-5-methoxyphenyl)methanamine

The Article related to asym hydrogenation dibenzoazepine derivative ruthenium diamine catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydroxylamines, Hydrazines, Triazenes, Azides, Azines, and Azo and Diazo Compounds and other aspects.Application In Synthesis of (2-Bromo-5-methoxyphenyl)methanamine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem