Category: 88149-49-9

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 88149-49-9 as follows. Formula: C7H4Br2F3NO

a) N-(2,6-dibromo-4-(trifluoromethoxy)phenyl)acetamide To a solution of 2,6-dibromo-4-(trifluoromethoxy)aniline (5.0 g, 14.9 mmol) in acetic acid (10 mL) was added acetic anhydride (2.1 mL, 22.5 mmol) and the mixture stirred for 48 hrs at 90° C. The resulting residue was cooled to room temperature, poured into ice water and the resulting precipitate collected by filtration, washed with water and dried under vacuum to yield N-(2,6-dibromo-4-(trifluoromethoxy)phenyl)acetamide.

According to the analysis of related databases, 88149-49-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Janssen Pharmaceutica NV; Sui, Zhihua; Subasinghe, Nalin; US2014/275172; (2014); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 88149-49-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 88149-49-9, name is 2,6-Dibromo-4-(trifluoromethoxy)aniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

The acid chloride reaction is completed, and 90.5 g (0.27 mol) of 2,6-dibromo-4-trifluoromethoxyaniline is added to the reaction vessel. Add catalyst 2 g of zinc chloride (0.015 mol) and benzoyl peroxide 2.5g (0.01mol), Rinse at 90 ° C for 4 h, The amidation incubation reaction is carried out. (3) Post-treatment: After the amidation reaction was completed, 80 mL of toluene was removed under reduced pressure, 100 mL of water was added, and 20 mL of toluene was removed under reduced pressure, and the temperature was lowered to 40 ° C. Filtration to obtain 124.9 g of solid thiazolamide. The purity was 96.7percent, and the yield was 91.5percent.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,6-Dibromo-4-(trifluoromethoxy)aniline, other downstream synthetic routes, hurry up and to see.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 88149-49-9, name is 2,6-Dibromo-4-(trifluoromethoxy)aniline, A new synthetic method of this compound is introduced below., Recommanded Product: 88149-49-9

Step one: 0.237 mol,52.63 g of 2-methyl-4-trifluoromethyl-5-thiazolecarboxylic acid(content 95percent)With 0.261 mol,89.2 g of 2,6-dibromo-4-trifluoromethoxyaniline (content 98percent)As for a certain amount of acetonitrile,Warm up to 55°C,Stir for about 0.5 h;Step two:A 0.261 mol catalyst was slowly added dropwise to the above reactants.40 g phosphorus oxychloride,After the addition,Warming to reflux,Insulation reflux reaction,The control was almost complete,The reaction time is about 8 h;Step 3:The above product is lowered to room temperature,Slowly drip it into a certain amount of crushed ice.Then stir for 0.5 h,The target product thiadiamide is obtained.Filter and dry, weigh:112.2 g detected purity: 94.3percent, yield: 84.6percent.

The synthetic route of 88149-49-9 has been constantly updated, and we look forward to future research findings.