Category: 870563-60-3

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 870563-60-3, name is (4-Fluoro-2-methoxyphenyl)methanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of (4-Fluoro-2-methoxyphenyl)methanamine

To a solution of 2-furaldehyde (41 muL, 0.5 mmol) in methanol (1.5 mL ) 4-fluoro-2- methoxybenzylamine (86 mg, 0.55 mmol), 2,6-dimethylphenyl isocyanide (72 mg, 0.55 mmol) and 2-butynoic acid (46 mg, 0.55 mmol) were added sequentially. The reaction mixture was stirred overnight. The volatiles were removed in vacuum and the residue was dissolved in dioxane (3 mL). Ytterbium trifluoromethanesulphonate (62 mg, 0.1 mmol) was added and the solution was heated at 1000C by microwave irradiation for 15 min. The mixture was cooled down to ambient temperature, filtered, and purified using preparative HPLC. The fractions containing the target compound were combined and extracted with ethyl acetate. The organic layer was dried with magnesium sulfate, and concentrated in vacuum to yiled the titled compound as yellowish solid (74 mg, 33%). IH NMR (400 MHz, CDCl3) delta ppm 7.43 (s, 1 H), 7.18 – 7.23 (m, 1 H), 7.02 – 7.11 (m, 3 H), 6.53 – 6.61 (m, 2 H), 6.45 – 6.50 (m, 1 H), 6.23 – 6.26 (m, 1 H), 5.95 (s, 1 H), 4.85 – 4.98 (m, 2 H), 3.75 (s, 3 H), 2.17 (s, 6 H), 1.96 (s, 3 H) MS (ESI) m/z 449 [M+H], MS (ESI) m/z 447 [M-H]

The synthetic route of 870563-60-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; WO2008/8020; (2008); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 870563-60-3, name is (4-Fluoro-2-methoxyphenyl)methanamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 870563-60-3, COA of Formula: C8H10FNO

General procedure: Spirothiazamenthane 3 (1.0 eq) was dissolved in toluene (0.1 M concentration) in a microwave vial and the solution was treated with amine (10 eq) and PTSA (20 mol %). This mixture was heated at 150 C using microwaves for 4 h. After cooling, the solvents were removed by evaporation and the resulting residue was taken up in 1:1 Et2O/2M NaOH. The layers were separated and the aqueous layer was extracted 2 × with Et2O. The organic layers were combined, dried over Na2SO4, filtered and concentrated. The resulting crude products were purified as described below. Variations in reaction conditions are also noted below.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Arns, Steve; Balgi, Aruna D.; Shimizu, Yoko; Pfeifer, Tom A.; Kumar, Nag; Shidmoossavee, Fahimeh S.; Sun, Sharon; Tai, Sheldon S.-H.; Agafitei, Olga; Jaquith, James B.; Bourque, Elyse; Niikura, Masahiro; Roberge, Michel; European Journal of Medicinal Chemistry; vol. 120; (2016); p. 64 – 73;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 870563-60-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 870563-60-3, name is (4-Fluoro-2-methoxyphenyl)methanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a stirred solution of ethyl 2-(l-bromo-2-ethoxy-2-oxoethyl)benzoate (Othman, M.; Decroix, B: Synth. Comm. 1996, 26, 2803) (945 mg, 3 mmol) in acetonitrile (15 mL) containing triethyl amine (835muL, 6 mmol) a solution of 4-fluoro-2-methoxybenzylamine (698 mg, 4.5 mmol) in acetonitrile (1 mL) was added dropwise under argon at O0C. The reaction, mixture was stirred at ambient temperature for 2 h. The mixture was diluted with ethyl acetate (50 mL), washed with water and brine. The organic phase was dried over magnesium sulfate and concentrated in vacuum. The residue was purified by column chromatography on silica gel using heptane/ethyl acetate (3:2) as an eluent to yield ethyl 2- (4-fluoro-2-methoxybenzyl)-3-oxoisoindoline-l-carboxylate as yellowish oil (857 mg, o/o).IH NMR (400 MHz, CDCl3) delta ppm 7.84 – 7.88 (m, 1 H), 7.67 – 7.76 (m, 1 H), 7.59 – 7.65 (m, 1 H), 7.46 – 7.58 (m, 2 H), 7.28 – 7.33 (m, 1 H)5 6.58 – 6.66 (m, 1 H), 5.21 (d, 1 H), 4.96 (s, 1 H), 4.47 (d, 1 H), 4.17 – 4.38 (m, 2 H), 3.82 (s, 3 H), 1.32 (q, 3 H) MS (ESI) m/z 344 [M+H], MS (ESI) m/z 342 [M-H]

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (4-Fluoro-2-methoxyphenyl)methanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTRAZENECA AB; WO2008/8020; (2008); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem