Application of 86770-76-5,Some common heterocyclic compound, 86770-76-5, name is 1-Phenyl-2,5,8,11-tetraoxatridecan-13-amine, molecular formula is C15H25NO4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Tert-butyl alcohol (1.5 equiv.) was added drop-wise to a stirredsolution of chlorosulfonyl isocyanate (1 equiv.) in dry DCM (15 mL)at 0 C under nitrogen. The solution was stirred for a further30 min at 0 C before a solution of the amine (1 equiv.) and drytriethylamine (1.5 equiv.) in dry DCM (15 mL)was added drop-wise.The reaction mixture was allowed to warm to room temperature,and then stirred for 16 h. The reaction mixture was then dilutedwith DCM (20 mL), washed with saturated aqueous NaHCO3(3 20 mL) and brine (3 20 mL). The combined organic extractswere dried over anhydrous MgSO4, filtered, and concentrated invacuo to give a residue that was then purified by flashchromatography.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Phenyl-2,5,8,11-tetraoxatridecan-13-amine, its application will become more common.
Reference:
Article; Suthagar, Kajitha; Watson, Andrew J.A.; Wilkinson, Brendan L.; Fairbanks, Antony J.; European Journal of Medicinal Chemistry; vol. 102; (2015); p. 153 – 166;,
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