Category: 79128-08-8

Application of 79128-08-8, The chemical industry reduces the impact on the environment during synthesis 79128-08-8, name is 1,3-Diisopropoxybenzene, I believe this compound will play a more active role in future production and life.

2- (2-hydroxy-4-pyrrolidinylbenzoyl) benzoic acid(1-A, 0.015 mmol, synthesized by the method described in Kamino et al., Org. Lett., 2014, 16, 258)And 1,3-diisopropoxybenzene(2-D, 0.074 mmol, synthesized by the method described in Kamino et al., Biorg. Med. Chem. Lett., 2008, 18, 4380)Was added to methanesulfonic acid (5 mL), and the mixture was stirred at 110 C. for 24 hours. The reaction solution was made basic with saturated aqueous sodium hydrogen carbonate solution and extracted with chloroform.After drying the organic layer with magnesium sulfate, the solvent was distilled off under reduced pressure. The obtained crude product was dissolved in chloroform and subjected to silica gel column chromatography to separate the compound ABPX 105-a and the compound ABPX 105-b.At this time, the compound ABPX 105 – a had flowed out first, and then the compound ABPX 105 – b flowed out. The yield was 74% in total of ABPX 105-a and ABPX 105-b. The reaction formula is shown below.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,3-Diisopropoxybenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; RIKEN; Kamino, Shinichiro; Sawada, Daisuke; Enomoto, Shuichi; Watanabe, Chikara; (37 pag.)JP2017/88879; (2017); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 79128-08-8,Some common heterocyclic compound, 79128-08-8, name is 1,3-Diisopropoxybenzene, molecular formula is C12H18O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

at 0 adding n-butyllithium (2.5M, 40mL, 100mmol) in hexane solution was added to the compoundIt was 2 (19.4g, 100mmol) in THF (10 mL), and the mixture was stirred at 15 2 hours.After the mixture was cooled to 0 again, iodine (25.4g, 100mmol) were added thereto, and 10 The mixture was stirred for 16 hours. Saturated aqueous solution of sodium sulfite (50 mL) was added to the reaction solution toThe reaction was quenched, and the organic solvent was removed under reduced pressure. Thereafter, ethyl acetate (50mL × 3) extraction residue.The organic layer was dehydrated over sodium sulfate and concentrated. By using petroleum ether as eluent, concentrate purified by silica gel columnThereof, whereby the compound 3.

The synthetic route of 79128-08-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Japan Polypropylene Corporation; Tanna, Akirahisashi; Sato, Naomasa; Konishi, Yohei; Oishi, Yasuo; (27 pag.)CN105593235; (2016); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 79128-08-8,Some common heterocyclic compound, 79128-08-8, name is 1,3-Diisopropoxybenzene, molecular formula is C12H18O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

at 0 adding n-butyllithium (2.5M, 40mL, 100mmol) in hexane solution was added to the compoundIt was 2 (19.4g, 100mmol) in THF (10 mL), and the mixture was stirred at 15 2 hours.After the mixture was cooled to 0 again, iodine (25.4g, 100mmol) were added thereto, and 10 The mixture was stirred for 16 hours. Saturated aqueous solution of sodium sulfite (50 mL) was added to the reaction solution toThe reaction was quenched, and the organic solvent was removed under reduced pressure. Thereafter, ethyl acetate (50mL × 3) extraction residue.The organic layer was dehydrated over sodium sulfate and concentrated. By using petroleum ether as eluent, concentrate purified by silica gel columnThereof, whereby the compound 3.

The synthetic route of 79128-08-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Japan Polypropylene Corporation; Tanna, Akirahisashi; Sato, Naomasa; Konishi, Yohei; Oishi, Yasuo; (27 pag.)CN105593235; (2016); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 79128-08-8, name is 1,3-Diisopropoxybenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 79128-08-8, Formula: C12H18O2

General procedure: A solution of 1,3-dialkoxybenzene (5.2 mmol) in dry THF(31 mL) was cooled to 0 C and treated with a 1.66 M solution of butyllithium in hexane (6.2 mmol). The mixture was left under magnetic stirring at room temperature for 2 h, added with dry DMF (1.0 mL, 12.9 mmol), left under stirring for additional 2 h and finally hydrolyzed with 0.5 M HCl (50 mL). The two phases were stirred for 30 min then separated. The aqueous phase was extracted with Et2O (3 20 mL) and the extracts were combined with the organic phase and dried (Na2SO4). After removal of the solvent at reduced pressure the crude benzaldehydes were obtained and purified as described below.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,3-Diisopropoxybenzene, other downstream synthetic routes, hurry up and to see.