Category: 74654-07-2

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 74654-07-2 as follows. name: 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine

3′-Amino-6 ‘- (tert-butoxycarbonylamino)Spiro [isobenzofuran-1 (3H), 9 ‘- [9H] xanthene]-3-one(100 mg, 0.23 mmol) was dissolved in dichloromethane (2.0 mL), 2,6-lutidine (0.11 mL, 0.93 mmol) was added and cooled to 0 C. Triphosgene (31 mg, 0.12 mmol) was added and stirred at 0 C. for 30 min,After further reacting at room temperature for 1 hour,[2- [2- (2-methoxyethoxy) ethoxy] ethyl] amine (105 mg, 0.46 mmol) was added and reacted as such for 1 hour.After diluting the reaction solution with ethyl acetate (100 mL)The organic layer was washed with 1 M hydrochloric acid (50 mL), saturated aqueous sodium hydrogen carbonate solution (50 mL)And saturated brine (50 mL) in this order, and dried over anhydrous sodium sulfate.The solvent was distilled off under reduced pressure,The obtained residue was purified by silica gel chromatography (chloroform,Then 50% ethyl acetate / chloroform) to giveSpiro [isobenzofuran-1 (3H), 9 ‘- [9H (3H), 3’ – [[2- [2- (2-methoxyethoxy) ethoxy] ethyl] aminocarbonylamino] ] Xanthen] -3-one (130 mg, yield 90%) as a yellow solid.

According to the analysis of related databases, 74654-07-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CD: Tosoh Corporation; Satoru: Sgami Chemical Research Institute; Inoe, So Sen; Araki, Hiroshi; Miki, Daisuke; Futami, Itaru; Saijou, Satoshi Bun; (65 pag.)JP2017/222609; (2017); A;,
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Application of 74654-07-2,Some common heterocyclic compound, 74654-07-2, name is 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine, molecular formula is C7H17NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A solution of 2 (1000 mg, 1.33 mmol), 1,3-dicyclohexylcarbodiimide (140 mg, 2.03 mmol), and allylamine (150 mg, 2.33 mmol) in 50 cm3 of dichloromethane and 1-hydroxybenzotriazole hydrate (225 mg, 1.46 mmol) dissolved in 15 cm3 of tetrahydrofuran were mixed together and stirred at 0 C for 1 h. After this time, the reaction mixture was stirred at room temperature for a further 24 h. Then the solvents were distilled under reduced pressure to dryness. The residue was suspended in hexane and filtered off to remove the 1,3-dicyclohexylurea by-product. The filtrate was evaporated under reduced pressure and purified by Dry Column Vacuum Chromatography on silica gel (Fluka type 60) to give 3a as a colourless solid (893 mg, 85% yield). Pure compound 3a was dissolved in acetonitrile. The solution was allowed to evaporate at room temperature. After several days the crystals were formed in 57% yield.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine, its application will become more common.

Reference:
Article; Huczynski, Adam; Janczak, Jan; Stefanska, Joanna; Antoszczak, Michal; Brzezinski, Bogumil; Bioorganic and Medicinal Chemistry Letters; vol. 22; 14; (2012); p. 4697 – 4702;,
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Adding a certain compound to certain chemical reactions, such as: 74654-07-2, name is 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 74654-07-2, Computed Properties of C7H17NO3

(iv) tert-Butyl (4-((2-((3-ethvnyl-5-((2-(2-(2-methoxyethoxy)ethoxy)ethyl)carbamoyl)- phenyl)amino)pyridin-4-yl)oxy)naphthalen-1-yl)carbamateHATU (500 mg, 1.315 mmol) was added to a stirred solution of the product from step (iii) above (500 mg, 1.009 mmol), 2-(2-(2-methoxyethoxy)ethoxy)ethanamine (277 mg, 1.695 mmol) and triethylamine (250 pL, 1.796 mmol) in N,N-dimethylformamide (10 mL). The mixture was stirred at rt for 18 h. The mixture was diluted with EtOAc (50 mL) and washed with water (50 mL), 20% brine (3 x 50 mL) and saturated brine (50 mL). The organic phase was dried (MgSC ), filtered and concentrated under reduced pressure. The crude product was purified by chromatography on the Companion (40 g column, EtOAc) to afford the sub-title compound (580 mg) as a tan foam.LCMS m/z 641 (M+H)+(ES+); 639 (M-H)”(ES”)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine, and friends who are interested can also refer to it.

Reference:
Patent; RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED; FYFE, Matthew Colin Thor; THOM, Stephen Malcolm; BAKER, Thomas Matthew; HARBOTTLE, Gareth William; HASIMBEGOVIC, Vedran; RIGBY, Aaron; WO2015/92423; (2015); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 74654-07-2, A common heterocyclic compound, 74654-07-2, name is 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine, molecular formula is C7H17NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A solution of compound (ZDR019) (3.0 g, 7.88 mmol), dimethylamine hydrochloride (1.92 g, 23.6 mmol), sodium triacetoxyborohydride (3.32 g, 15.7 mmol) and N,N- diisopropylethylamine (4.8 ml_, 27.5 mmol) in 1,2-dichloroethane (150 mL) was stirred at room temperature for 18 h. The reaction was quenched through the addition of water (100 mL) and the pH adjusted to pH 6-7 using aqueous phosphate buffer solution (0.5 M, pH 7) . The mixture was then diluted with dichloromethane (100 mL) and the separated aqueous layer further extracted with dichloromethane (2 x 50 mL). The combined organic layers were washed with aqueous phosphate buffer solution (0.5 M, pH 7) (100 mL), dried over anhydrous magnesium sulfate, filtered and the filtrate concentrated in vacuo. Purification by flash chromatography (dichloromethane/methanol, 20: 1 10: 1 7: 1) afforded compound (ZDR022) as a white solid (2.40 g, 5.86 mmol, 74%).

The synthetic route of 74654-07-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; OTAGO INNOVATION LIMITED; BRIMBLE, Margaret Anne; COOK, Greg Murray; FERGUSON, Scott Andrew; HEIKAL, Adam; RENNISON, David; (130 pag.)WO2019/125185; (2019); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 74654-07-2, name is 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 74654-07-2

Example 58A tert-Butyl [(trans-4-{[(2S)-3-[4′-({2-[2-(2-methoxyethoxy)ethoxy]ethyl}carbamoyl)-2′-methylbiphenyl-3-yl]-1-oxo-1-{[4-(1H-tetrazol-5-yl)phenyl]amino}propan-2-yl]carbamoyl}cyclohexyl)methyl]carbamate 3′-[(2S)-2-{[(trans-4-{[(tert-Butoxycarbonyl)amino]methyl}cyclohexyl)carbonyl]amino}-3-oxo-3-{[4-(1H-tetrazol-5-yl)phenyl]amino}propyl]-2-methylbiphenyl-4-carboxylic acid and 2-[2-(2-methoxyethoxy)ethoxy]ethanamine (29 mg, 0.17 mmol) were dissolved in tetrahydrofuran (4 ml), N-[(dimethylamino)(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy)methylidene]-N-methylmethanaminium hexafluorophosphate (67 mg, 0.17 mmol) and N,N-diisopropylethylamine (23 mg, 0.17 mmol) were added and the mixture was stirred at RT overnight. Subsequently, the mixture was concentrated and the residue was purified chromatographically by HPLC (Method 10). This gave 53 mg (44% of theory) of the title compound. LC-MS (Method 4): Rt=1.17 min; MS (ESIpos): m/z=827.6 [M+H]+.

The synthetic route of 74654-07-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bayer Pharma Aktiengesellschaft; ROeHN, Ulrike; ELLERMANN, Manuel; STRASSBURGER, Julia; WENDT, Astrid; ROeHRIG, Susanne; WEBSTER, Robert Alan; SCHMIDT, Martina Victoria; TERSTEEGEN, Adrian; BEYER, Kristin; SCHAeFER, Martina; BUCHMUeLLER, Anja; GERDES, Christoph; SPERZEL, Michael; SANDMANN, Steffen; HEITMEIER, Stefan; HILLISCH, Alexander; ACKERSTAFF, Jens; TERJUNG, Carsten; (163 pag.)US2016/244437; (2016); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 74654-07-2, A common heterocyclic compound, 74654-07-2, name is 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine, molecular formula is C7H17NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

5-Amino-3,5-dichloro-l,2,4-triazine (1.460 g, 8.85 mmol) was dissolved in dioxane (30 mL) at room temperature. Triethylamine (2.7 mL, 19.37 mmol) was added, followed by addition of mPEG3-NH2 (1.9812 g, 12.14 mmol). The resulting mixture was stirred at 95 C for 7 h. The mixture was cooled to room temperature, filtered to remove the white solid and the solid was washed with ethyl acetate. The combined organic solution was concentrated and purified with flash column chromatography on silica gel (1-10% methanol/dichloromethane) to afford 2.1236 g of product as solid. The yield was 82%. [0485] 1H-NMR (500 MHz, CDC13): 3.691-3.654 (m, 6H, 3CH2), 3.625-3.594 (m, 6H, 3CH2), 3.436 (s, 3H, CH3). LC-MS: 292.1 (MH+/z).

The synthetic route of 74654-07-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NEKTAR THERAPEUTICS (INDIA) PVT. LTD.; NEKTAR THERAPEUTICS; SHARMA, PANKAJ; KHATRI, VIJAY KUMAR; GU, XUYUAN; SONG, YUAN; SHEN, MICHAEL LIXIN; SAUTHIER, JENNIFER RIGGS; ANAND, NEEL K.; KOZLOWSKI, ANTONI; ODINECS, ALEKSANDRS; RILEY, TIMOTHY A.; REN, ZHONGXU; MU. YONGQI; SHEN, XIAOMING; YUAN. XUEJUN; AURRECOECHEA, NATALIA; O’MAHONY, DONOGH JOHN ROGER; WO2015/92819; (2015); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 74654-07-2, name is 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 74654-07-2, Recommanded Product: 74654-07-2

To a solution of N-((S)-2-((S)-3-aminopyrrolidin-l -yl)-l -phenylethyl)-2-(3,4- dichlorophenyl)-N-methylacetamide (150 mg, 0.37 mmol) in acetonitrile (3 mL) was added mPEG3-NH2 (66 mg, 0.407 mmol) and potassium carbonate (153 mg, 1.1 1 mmol). The mixture was heated to 50 C for 18 hours. After 18 hours, the mixture was concentrated under vacuum and the resulting crude was dissolved in ethyl acetate (10 mL). The organic layer, after washes with aq. ammonium chloride (10 mL), water (10 mL) and brine (10 mL), was dried over anhydrous sodium sulfate and concentrated under vacuum to give the crude compound. The crude compound post purification by column chromatography afforded 2- (3,4-dichlorophenyl)-N-((5)-2-((,S)-3-((2-(2-(2- methoxyethoxy)ethoxy)ethyl)amino)pyrrolidin-l -yl)-l -phenylethyl)-N-methylacetamide as the free base (0.081 g, 40% yield). NMR (500 MHz, CDC13): delta 7.61 (m, 1 H), 7.40-7.27 (m, 7H), 5.22 (m, 1 H), 4.20 (t, 2H), 3.70-3.45 (m, 10H), 3.32 (s, 3H), 3.24 (m, 2H), 3.04 (m, 1 H), 2.79-2.72 (m, 2H), 2.62 (s, 3H), 2.46-2.30 (m, 4H), 1.54- 1 .79 (m, 2H); MS (EI) for C28H39C12N304: 553 (MH+).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NEKTAR THERAPEUTICS; ANAND, Neel, K.; DUARTE, Franco, J.; ZHANG, Wen; REN, Zhongxu; WO2014/210436; (2014); A2;,
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Application of 74654-07-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 74654-07-2 name is 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Cyanomethanesulfonyl chloride was found to be relatively unstable in air and was reacted immediately (3.44 mmol) with previously synthesized 2-(2-(2-methoxyethoxy)ethoxy)ethanamine (A2, 5.41 mmol) in DCM (10 mL). HOBt (5.43 mmol) was added dropwise to the reaction mixture once cooled to 0 C., followed by EDC (5.43 mmol). The reaction was then let stir for 6 hours at 0 C., concentrated under reduced pressure, and purified by silica gel chromatography to obtain the 1-cyano-N-(2-(2-(2-methoxyethoxy)ethoxy)ethyl)methanesulfonamide B5 in 86% yield as a clear oil.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine, and friends who are interested can also refer to it.

Reference:
Patent; The Regents of the University of California; Amydis, Inc.; Yang, Jerry; Theodorakis, Emmanuel A.; Sarraf, Stella; US2018/327373; (2018); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 74654-07-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 74654-07-2 name is 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step a):Under inert atmosphere,5.00 g of 4-bromo-1,8-naphthalic anhydride was added to 100 mL of anhydrous methanol,1.96 g of 3,6,9-trioxa-1-aminodecane was further injected, and the mixture was refluxed for 10 hours.After the reaction was completed, overnight needle-like crystals were precipitated, filtered, washed with cold ethanol three times,The intermediate N-3,6,9-trioxadecyl-4-bromo-1,8-naphthalimide was obtained4.90 g (96% yield).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine, and friends who are interested can also refer to it.

Reference:
Patent; Zhejiang Sci-Tech University; Han Yifeng; Chen Bo; Wei Ting; (13 pag.)CN105542756; (2017); B;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 74654-07-2, These common heterocyclic compound, 74654-07-2, name is 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of cyanoacetic acid (621 mg, 7.3 mmol) in anhydrous DCM (15 mL) was cooled to 0 C. Separately, a solution of hydroxybenzothiazole (HOBt) (1.48 g, 10.97 mmol) and 2-(2-(2-methoxyethoxy)ethoxy)ethanamine (A2, 1.79 g, 10.97 mmol) was prepared in DCM (10 mL); this solution was then added dropwise to the cooled solution of cyanoacetic acid. The resulting solution was allowed to stir for 10 minutes at 0 C., upon which 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) (2.1 g, 10.97 mmol) was added in one portion and the reaction stirred under argon at 0 C. for 12 hours. The reaction was then concentrated and purified by silica gel chromatography (0-2% MeOH/DCM) to obtain 2-cyano-N-(2-(2-(2-methoxyethoxy)ethoxy)ethyl)acetamide A3 as a yellow oil in 83% yield.

Statistics shows that 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine is playing an increasingly important role. we look forward to future research findings about 74654-07-2.

Reference:
Patent; The Regents of the University of California; Amydis, Inc.; Yang, Jerry; Theodorakis, Emmanuel A.; Sarraf, Stella; US2018/327373; (2018); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem