Category: 7252-83-7

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 7252-83-7, name is 2-Bromo-1,1-dimethoxyethane, A new synthetic method of this compound is introduced below., Application In Synthesis of 2-Bromo-1,1-dimethoxyethane

Example 74; (IS, 2R) and (IR, 2S)-2-(4-chlorophenyl)-l’-(2-(4-isopropylpiperazin-l-yl)ethyl)spiro [cyclopropane-l,3′-indolin]-2′-oneSynthesis of (IR, 2S) and (IS, 2R)-2-(4-chlorophenyl)-l’-(2,2- dimethoxyethyl)spiro[cyclopropane-l,3′-indolin]-2′-one; To a solution of (IR, 2S) and (I S, 2R)-2-(4-chlorophenyl)spiro[cyclopropane-l,3′-indolin]- 2′-one (135 mg, 1 mmol) in DMF (1 mL) was added KHMDS (0.5 M in THF, 1.1 mL) was dropwise at room temperature. The mixture was stirred for half an hour before adding bromoacetaldehyde dimethyl acetal (95 mg, 0.55 mmol). The mixture was warmed to 50 C and stirred at that temperature for 2 hours. The mixture was poured into water, extracted with ethyl acetate (3 x 15 mL), dried and concentrated under reduced pressure. Purification by flash column chromatography on silica gel, eluting with hexanes-EtOAc (6: 1 and then 4: 1) gave the desire product as colorless oil (268 mg, 75%). LC/MS m/e calcd. for C2oH2oClN03: 3570, observed (M+H)+: 358.7.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; CHEN, Li; HUANG, Mengwei; FENG, Lichun; HE, Yun; YUN, Hongying; WO2011/69298; (2011); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 7252-83-7,Some common heterocyclic compound, 7252-83-7, name is 2-Bromo-1,1-dimethoxyethane, molecular formula is C4H9BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

13. Alkylation step C [00257] In a 20 ml microwave vial containing III-2 (1 equivalent), alkyl halide (4 equivalents), KI (2 equivalents), and Cs2CO3 (2 equivalents) was added anhydrous DMF, 10 –>ml. This was heated under microwave conditions at 1200C for 60 minutes. The reaction was added to a seperatory funnel containing water and washed 3x with EtOAc. The combined organic layers were washed with saturated aqueous brine solution. The organic layer was dried with MgSU4 concentrated in vacuo. This was filtered through a silica plug, washed 3x with EtOAc, and concentrated in vacuo to yield III-3 (100 %). This material was used without further purification. 4-BROMO-N-(3-BROMO-4-(2,2-DIMETHOXYETHOXY)PHENETHYL)THIOPHENE-2- CARBOXAMIDE [00258] 1H NMR (400 MHz, DMSO-d6) delta 8.64 (t, J= 5.2 Hz, IH), 7.88 (s, IH), 7.75 (s, IH), 7.45 (d, J= 2.0 Hz, IH), 7.16 (dd, J= 8.4, 1.6 Hz, IH), 7.06 (d, J= 8.4, IH), 4.68 (t, J= 5.2 Hz, IH), 4.00 (d, J= 7.2 Hz, 2H), 3.42 (q, J= 6.0 Hz, 2H), 3.37 (s, 6H), 2.76 (t, J= 6.8 Hz, 2H).

The synthetic route of 7252-83-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; VANDERBILT UNIVERSITY; WO2009/152071; (2009); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 7252-83-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7252-83-7, name is 2-Bromo-1,1-dimethoxyethane, This compound has unique chemical properties. The synthetic route is as follows.

Example 15-9: Preparation of 2-(4-methyl-2-nitro-phenyl)-thiazole (65).; The procedure described in Example 15-1 was followed except that 4-methyl-2-nitro- thiobenzamide (56) was used instead of 4-trifluoromethyl-2-nitro-thiobenzamide, bromoacetaldehyde-dimethylacetal was used instead of 1 -bromo-3-methyl-butan-2-one, and the reaction was acid catalyst with 5% acetic acid. This gave the title compound (66 mg, 75%). LC/MS: (Method I): tR= 0.98 min, >90%, m/z (ESI+)= 221 (MH+).

The chemical industry reduces the impact on the environment during synthesis 2-Bromo-1,1-dimethoxyethane. I believe this compound will play a more active role in future production and life.

Reference:
Patent; TIBOTEC PHARMACEUTICALS LTD.; MEDIVIR AB; WO2007/14922; (2007); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

7252-83-7, A common compound: 7252-83-7, name is 2-Bromo-1,1-dimethoxyethane, belongs to ethers-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

To a mixture of 4-hydroxybenzothioamide (30.64 g, 0.20 mol) and 2-bromo-1,1-dimethoxyethane (31.00 g, 0.20 mol) in EtOH (600 mL) was added 4-methylbenzenesulfonic acid (34.44 g, 0.20 mol) with stirring at rt. The reaction mixture was heated at 90 C. for 24 h, then cooled to rt and concentrated in vacuo. The mixture was diluted with H2O (200 mL), adjusted to pH 10 with saturated NaHCO3 aqueous solution and extracted with DCM (200 mL*3). The combined organic phases were concentrated in vacuo to give the title compound as s yellow solid (21.3 g, 60%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-1,1-dimethoxyethane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; Zhang, Yingjun; Zhang, Jiancun; Wang, Xiaojun; Lin, Runfeng; Cao, Shengtian; Wang, Zhaohe; Li, Jing; US2015/87639; (2015); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem