Category: 707-07-3

Application of 707-07-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 707-07-3 as follows.

4-Methylbenzenesulfonic acid (3.1 g, 16 mmol) was converted to N1-benzyl-4-bromobenzene-1,2-diamine (45 g, 160 mmol).And 500 mL of dichloromethane and o-trimethyl benzoate30 mL is added to the mixed solution and reacted for about 40 hours at room temperature under nitrogen. After the reaction was completed, the organic layer was concentrated under reduced pressure, washed with 40% methanol / water and sodium hydrogencarbonate / water, and dried to obtain a product. (22.3 g, yield 40%)

According to the analysis of related databases, 707-07-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SFC Ltd.; Ryu Se-jin; Sim So-yeong; Lee Sang-hae; (51 pag.)KR102030388; (2019); B1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 707-07-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 707-07-3, name is (Trimethoxymethyl)benzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: 2-Nitroaniline derivative (1 mmol) was added to a mixture of indium powder (574 mg, 5.0 mmol for 2-nitroaniline, 918 mg 8.0 mmol for 1,2-dinitroarene), and acetic acid (0.572 mL, 10 mmol) in ethyl acetate (2 mL), followed by the addition of trimethyl orthoester (2.0 mmol) in ethyl acetate (3 mL for 2-nitroaniline; 8 mL for 1,2-dinitroarene). The reaction mixture was stirred at reflux under a nitrogen atmosphere. After the reaction was completed, the reaction mixture was diluted with ethyl acetate (30 mL), filtered through Celite, poured into 10% NaHCO3 (30 mL), and then extracted with ethyl acetate (30 mL×3). The combined organic extracts were dried over MgSO4, filtered, and concentrated. The residue was eluted with ethyl acetate/hexane (v/v=10/90) for 2-phenylbenzimidazole derivatives or methanol/dichloromethane (v/v=1/99) for 2-methylbenzimidazole derivatives through a silica gel column to give the corresponding benzimidazoles. The structures of the benzimidazoles were characterized by 1H NMR, 13C NMR, FTIR, and GC-MS, and were mostly known compounds. HRMS data were reported in addition for unknown compounds.

The synthetic route of (Trimethoxymethyl)benzene has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kim, Jaeho; Kim, Jihye; Lee, Hyunseung; Lee, Byung Min; Kim, Byeong Hyo; Tetrahedron; vol. 67; 41; (2011); p. 8027 – 8033;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 707-07-3, name is (Trimethoxymethyl)benzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 707-07-3, COA of Formula: C10H14O3

General procedure: To a stirred solution of the respective N-carbamate-protected aminovicinal diol 4 (0.50 mmol, 1 equiv) in CH2Cl2 (10 mL, 0.05 M) were added BF3·OEt2 (50 muL, 0.050 mmol, 0.1 equiv, 1.0 M solution in CH2Cl2) and trimethyl orthobenzoate (0.13 mL, 0.75 mmol, 1.5 equiv) at r.t. The resulting mixture was refluxed or stirred at r.t. under N2 until TLC showed complete conversion of the substrate. The reaction was quenched with sat. aq NaHCO3 and extracted with EtOAc (2 ×). The combined organic layers were washed with brine, dried (MgSO4), filtered, and concentrated in vacuo. The residue was purified by flash chromatography on silica gel (hexane/EtOAc) to give the desired product 5.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (Trimethoxymethyl)benzene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Park, Heemin; Kwon, Yongseok; Shin, Jae Eui; Kim, Woo-Jung; Hwang, Soonho; Lee, Seokwoo; Kim, Sanghee; Synthesis; vol. 49; 12; (2017); p. 2761 – 2767;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 707-07-3, name is (Trimethoxymethyl)benzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 707-07-3, Application In Synthesis of (Trimethoxymethyl)benzene

To a solution containing diol 2 (7.1 g, 49.6 mmol) and trimethyl orthobenzoate (15 ml, 87.3 mmol) in chloroform (150 ml), was added camphor sulphonic acid (500 mg), and the reaction mixture was concentrated to 1/3 of its original volume using a rotavap; TLC revealed that the reaction is not finished, so more chloroform (-100 ml) was added to the mixture, and the solution was concentrated to its 1/3 volume again. This cycle was repeated until TLC indicates the complete consumption of starting material (usually 3-4 cycle needed). Et3N (1 ml) was added to the reaction mixture and the solvent was removed completely; the resulting syrup was treated with a 20% [ACOH-H20] solution (140 ml). After 30 min, the reaction was concentrated to dryness. The syrupy mixture was purified by column chromatography on silica gel using 5% AcOEt-toluene to afford 20 (6.17 g, 50%) and 21 (5.47 g, 44. [6%).’H] NMR (CDCl3, 600 MHz) for 20: [88.] 03 (m, 2H, Bz), 7.55 (m, [1H,] Bz), 7.43 (m, 2H, Bz), 5.94 (ddd, 1H, [J6.] 4,10. 6,17. 0 Hz, H-4), 5.41 (ddd, 1H, J 1.3, 1.3, 17.2 Hz, [H-5_TRANS),] 5.31 (ddd, 1H, J 1.3, 1.3, 10.4 Hz, H-5_cis), 4.57 (dd, [J3.] 7,11. 9 Hz, [H-LA),] 4.42 (dd, 1H, [J 7.] 7,11. 7 Hz, H-lb), 4.28 (m, 1H, H-3), 3.80 (ddd, 1H, J 3.5, 5.3, 7.7 Hz, [H-2). H] NMR (CDC13,600 MHz) for 21: [88.] 05 (m, 2H, Bz), 7.57 (m, 1H, Bz), 7.44 (m, 2H, Bz), 5.97 (ddd, [1H,] J 7.0, 10.6, 17.4 Hz, H-4), 5.66 (m, 1H, H-3), 5.48 (ddd, 1H, J 1.1, 1.1, 17.2 Hz, H- 5trans), 5.31 (ddd, [1H,] [J0.] 9,0. 9,10. 6 Hz, H-5_cis), 3. 83 (ddd, 1H, [J4.] 4,7. 1,9. 2 Hz, H-2), 3. 78 (dd, [J3.] 7,11. 9 Hz, [H-LA),] 4.42 (dd, 1H, [J7.] 7,11. 7 Hz, H-lb),

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; BUNDLE, David, R.; LING, Chang, Chun; ZHANG, Ping; WO2003/101937; (2003); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 707-07-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 707-07-3, name is (Trimethoxymethyl)benzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Compound 18 (1.03 g, 1.77 mmol) was dissolved in dry N,N-dimethylformamide (2 ml) and trimethylorthobenzoate (1.2 ml, 7.08 mmol). The solution was stirred under vacuum (ca 10 mbar) for 10 min then d(+)-camphorsulfonic acid (0.020 g, 0.088 mmol) was added. The mixture was stirred under vacuum for 3 h then triethylamine (0.5 ml) was added and the reaction mixture was concentrated. The residue was dissolved in CH2Cl2, washed with water then the aqueous layer was extracted with CH2Cl2. The combined organic layers were dried (MgSO4), filtered and concentrated.The crude residue was dissolved in dry THF (5 ml) containing n-tetrabutylammonium fluoride (1.67 g, 3.09 mmol). The mixture was stirred at room temperature for 3 h then concentrated. The residue was taken up in CH2Cl2, washed with brine then the aqueous layer was extracted with CH2Cl2. The combined organic layers were dried (MgSO4), filtered and concentrated.To a solution of the previous residue in dry N,N-dimethylformamide (10 ml) was added benzyl bromide (0.65 ml, 3.09 mmol) under argon. The solution was cooled to 0 C then sodium hydride (0.250 g, 3.60 mmol) was added portionwise. The mixture was stirred at room temperature overnight then methanol was added and concentrated. The residue was dissolved in CH2Cl2, washed with brine then the aqueous layer was extracted with CH2Cl2. The combined organic layers were dried (MgSO4), filtered and concentrated.The residue was dissolved in a mixture of THF (5 ml), acetic acid (4 ml) and water (1 ml) and stirred at room temperature for 2 h. The solution was diluted with CH2Cl2 then washed with satd aq NaHCO3. The aqueous layer was extracted with CH2Cl2 then the combined organic layers were dried (MgSO4), filtered and concentrated.

The synthetic route of (Trimethoxymethyl)benzene has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 707-07-3, name is (Trimethoxymethyl)benzene, A new synthetic method of this compound is introduced below., Formula: C10H14O3

General procedure: To a stirred solution of the respective N-carbamate protected aminoalcohol 1 (0.50 mmol, 1 equiv) in CH2Cl2 (10 mL, 0.05 M) were added BF3·OEt2 (50 muL, 0.050 mmol, 0.1 equiv or 150 muL, 0.15 mmol, 3 equiv, 1.0 M solution in CH2Cl2) and trimethyl orthobenzoate (0.13 mL, 0.75 mmol, 1.5 equiv) at r.t. The resulting mixture was stirred at r.t. under N2 until TLC showed complete conversion of the substrate. The reaction was quenched with sat. aq NaHCO3 and extracted with EtOAc(2 ×). The combined organic layers were washed with brine, dried(MgSO4), filtered, and concentrated in vacuo. The residue was purified by flash chromatography on silica gel (hexane/EtOAc) to give the desired product 2.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Related Products of 707-07-3, A common heterocyclic compound, 707-07-3, name is (Trimethoxymethyl)benzene, molecular formula is C10H14O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

l-(2-Chloro-acetyl)-2-oxo-2,3-dihydro-lH-indole-6-carboxylic acid methyl ester (220.0 g / 0.8219 mol) was suspended in toluene (1096.8 ml) at ambient temperature. Acetic anhydride (269.4 ml / 3.49 eq) was added and the mixture stirred at reflux. To the reaction, trimethyl orthobenzoate (339.10 ml / 2.40 eq) was added within one hour and the reaction continued to stir at 104 C for 3.5 hours and than at ambient temperature for 5 days. The reaction was cooled to 0C, stirred for an additional hour and filtered. The solid was washed with toluene, toluene/EtOAc (1 :1) and Et20 and dried under vacuum to isolate 246.6 g (77.8 %) of l-(2-chloro-acetyl)-3-[l-methoxy-l-phenyl-meth-(E)-ylidene]-2-oxo-2,3-dihydro-lH- indole-6-carboxylic acid methyl ester.

The synthetic route of 707-07-3 has been constantly updated, and we look forward to future research findings.

Electric Literature of 707-07-3,Some common heterocyclic compound, 707-07-3, name is (Trimethoxymethyl)benzene, molecular formula is C10H14O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: 2-Nitroaniline derivative (1 mmol) was added to a mixture of indium powder (574 mg, 5.0 mmol for 2-nitroaniline, 918 mg 8.0 mmol for 1,2-dinitroarene), and acetic acid (0.572 mL, 10 mmol) in ethyl acetate (2 mL), followed by the addition of trimethyl orthoester (2.0 mmol) in ethyl acetate (3 mL for 2-nitroaniline; 8 mL for 1,2-dinitroarene). The reaction mixture was stirred at reflux under a nitrogen atmosphere. After the reaction was completed, the reaction mixture was diluted with ethyl acetate (30 mL), filtered through Celite, poured into 10% NaHCO3 (30 mL), and then extracted with ethyl acetate (30 mL¡Á3). The combined organic extracts were dried over MgSO4, filtered, and concentrated. The residue was eluted with ethyl acetate/hexane (v/v=10/90) for 2-phenylbenzimidazole derivatives or methanol/dichloromethane (v/v=1/99) for 2-methylbenzimidazole derivatives through a silica gel column to give the corresponding benzimidazoles. The structures of the benzimidazoles were characterized by 1H NMR, 13C NMR, FTIR, and GC-MS, and were mostly known compounds. HRMS data were reported in addition for unknown compounds.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (Trimethoxymethyl)benzene, its application will become more common.

Reference:
Article; Kim, Jaeho; Kim, Jihye; Lee, Hyunseung; Lee, Byung Min; Kim, Byeong Hyo; Tetrahedron; vol. 67; 41; (2011); p. 8027 – 8033;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 707-07-3, Name is (Trimethoxymethyl)benzene, molecular formula is , belongs to ethers-buliding-blocks compound. In a document, author is Wannomai, Tatiya, Quality Control of (Trimethoxymethyl)benzene.

Inhalation bioaccessibility and health risk assessment of flame retardants in indoor dust from Vietnamese e-waste-dismantling workshops

Although bioaccessibility testing is appliedworldwide for appropriate chemical risk assessment, fewstudies have focused on the bioaccessibility of flame retardants (FRs), especially inhalation exposure. This study assessed inhalation exposure to FRs in indoor dust by workers at e-waste-dismantling workshops in northern Vietnam, by using modified simulated epithelial lung fluid (SELF) and artificial lysosomal fluid (ALF). The average mass concentrations of FRs were 130,000 ng/g for workplace dust (n = 3), 140,000 ng/g for floor dust (n = 3), and 74,000 ng/g for settled dust (n = 2), whereas the average bioaccessible concentrations of FRs were 1900, 1400, and 270 ng/g in the SELF condition and 2600, 770, and 490 ng/g in the ALF condition, respectively. Results clearly indicate that the bioaccessible concentrations of FRs are markedly lower than their mass concentrations. Tris(2- chloroethyl) phosphate (TCEP, similar to 19%), tris(2-chloroisopropyl) phosphate (TCIPP, similar to 35%), and tris(1,3-dichloroisopropyl) phosphate (TDCIPP, similar to 22%) showed comparably high bioaccessibility in both SELF and ALF conditions. In contrast, the bioaccessibility of tetrabromobisphenol A (TBBPA, similar to 20%) was high in the SELF condition, but not in the ALF condition. With regard to the test compounds’ physicochemical properties, the inhalation bioaccessibility of FRs in both conditions increased asmolecular weight or octanol-water partition coefficient decreased, and it decreased as water solubility decreased. Health risk assessment clearly indicated that the hazard quotient of FRs via inhalation exposure for workers in the e-waste-dismantling workshops was less than 1, suggesting that the inhalation exposure to FRs during indoor dismantling of e-waste at this site was negligible based on the current methodology of non-cancer health risk assessment used in this study. (C) 2020 Elsevier B.V. All rights reserved.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 707-07-3, in my other articles. Quality Control of (Trimethoxymethyl)benzene.

Reference of 707-07-3, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 707-07-3, Name is (Trimethoxymethyl)benzene, SMILES is COC(OC)(C1=CC=CC=C1)OC, belongs to ethers-buliding-blocks compound. In a article, author is Wu, Junji, introduce new discover of the category.

Photochemical degradation of fragrance ingredient benzyl formate in water: Mechanism and toxicity assessment

Recently, fragrance ingredients have attracted increasing attention due to their imperceptible risks accompanying the comfortable feeling. To understand transformation mechanisms and toxicity evolution of benzyl formate (BF) in environment, its photochemical degradation in water was thoroughly studied herein. Results showed that 83.5% BF was degraded under ultraviolet (UV) irradiation for 30 min. Laser flash photolysis and quenching experiments demonstrated that triplet excited state ((BF)-B-3*), O-2(center dot-), and O-1(2) were three main reactive species found during BF photodegradation. Eight degradation intermediates, including benzaldehyde, benzyl alcohol, o-cresol, bibenzyl, benzyl ether, 1,2-diphenylethanol, benzoic acid, and benzylhemiformal, were mainly formed as identified by LC-Q-TOF/MS and GC-MS analyses. Furthermore, the degradation mechanism was explained as the bond cleavage of (BF)-B-3* and BF center dot+, O-2(center dot-)/O-1(2) oxidation, e(aq)(-) reduction, and (OH)-O-center dot addition reactions. Aquatic assessment suggests that except benzyl alcohol, benzoic acid, and benzylhemiformal, all the products were persistent and could result in increased aquatic toxicity compared to original BF. Consequently, these degradation products may cause more toxicity to organisms if they remain accumulated in water environment for a long time.

Reference of 707-07-3, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 707-07-3 is helpful to your research.