Category: 701-56-4

Reference of 701-56-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 701-56-4, name is 4-Methoxy-N,N-dimethylaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

4-(N,N-dimethylamino)-3-nitrosoanisole (123). To a stirred solution of N,N-dimethylanisidine 122 (3.09 g, 20.4 mmol) in 5% HCI (30 ml. ), NaNO2 (1.94 g, 28.2 mmol) in 10 mL water was added dropwise upon ice/water bath cooling, and reaction was stirred for 15 min. The mixture was poured in 200 mL of 3N NaOAc (200 mL) and extracted with EtOAc (3 x 150 mL). The combined extract was washed with sat. NaHCO3 (200 mL), brine (200 mL), dried over Na2SO4 and evaporated to give nitroso derivative 123 (3.68 g, 100%) as brown solid.

The synthetic route of 4-Methoxy-N,N-dimethylaniline has been constantly updated, and we look forward to future research findings.

Reference:
Patent; INVITROGEN CORPORATION; WO2008/76524; (2008); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 701-56-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 701-56-4 name is 4-Methoxy-N,N-dimethylaniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Charged a round bottom flask with N-methylaniline 1 (1.5 mmol), maleimide 2 (1.0 mmol) and K2S2O8 (1.5equiv) in CH3CN (3 mL). The contents were stirred at rt for 6-8 h. After the completion of reaction (as indicated by TLC), it was quenched with water (10 mL) and extracted with ethyl acetate (3 ¡Á 10 mL). The organic phase was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to yield the crude product, which was purified by silica gel column chromatography using a mixture of EtOAc-hexane (2:8) to give the pure product 3 in excellent yields. The structure of the products was confirmed by comparison of mp and 1H, 13C NMR and MS spectral data with those reported in the literature.1

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Methoxy-N,N-dimethylaniline, and friends who are interested can also refer to it.

Reference:
Article; Yadav, Arvind K.; Yadav, Lal Dhar S.; Tetrahedron Letters; vol. 57; 13; (2016); p. 1489 – 1491;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 701-56-4, name is 4-Methoxy-N,N-dimethylaniline, A new synthetic method of this compound is introduced below., Formula: C9H13NO

General procedure: Under an atmosphere of N2, KOt-Bu (2.2 mmol), dioxane (0.9 mL), DMSO (1.65 mmol), tertiary amine 1 (0.55 mmol), and aryl halide 2 (1.65 mmol) were successively added to a Schlenk reaction tube. The mixture was stirred vigorously at 80-120 C for 12 h. Then the mixture was diluted with EtOAc, washed with sat. brine, and dried (anhyd Na2SO4). Then the solvent was removed under reduced pressure andthe residue was purified by flash column chromatography (petroleum ether and petroleum ether-EtOAc, 100:1 for the methoxy group derived products) to give pure products 3.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Huang, Pei; He, Bang-Yue; Wang, Hui-Min; Lu, Jian-Mei; Synthesis; vol. 47; 2; (2015); p. 221 – 227;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem