Category: 6972-61-8

Hypocholesterolemic and choleretic effects of three dimethoxycinnamic acids in relation to 2,4,5-trimethoxycinnamic acid in rats fed with a high-cholesterol/cholate diet was written by Serna, Manuel;Wong-Baeza, Carlos;Santiago-Hernandez, Juan-Carlos;Baeza, Isabel;Wong, Carlos. And the article was included in Pharmacological Reports in 2015.Application of 6972-61-8 This article mentions the following:

2,4,5-Trimethoxycinnamic acid (2,4,5-TMC) is the major and non-toxic metabolite of 濞?asarone, which retains hypocholesterolemic and choleretic activities. We compared the activities of 2,4,5-TMC with those of 2,4-dimethoxycinnamic acid (2,4-DMC), 3,4-DMC and 3,5-DMC, to understand the role of the methoxyls on carbons 2, 4 and 5 on the pharmacol. properties of these compounds The methoxycinnamic acids were administered to high-cholesterol/cholate-fed rats. We measured bile flow, and quantified bile acids, phospholipids and cholesterol in bile, and cholesterol and cholesterol-lipoproteins in serum. The inhibition of HMG-CoA reductase by the methoxycinnamic acids was evaluated in vitro. The four methoxycinnamic acids decreased serum cholesterol, without affecting the concentration of HDL-cholesterol. 2,4,5-TMC produced the highest decrease in LDL-cholesterol, 73.5%, which exceeds the range of statins (20-40%), and produced the highest inhibition of the activity of HMG-CoA reductase. 3,4-DMC produced the highest increase in bile flow, bile acids and phospholipids concentrations, and reduction in bile cholesterol, which led to a decrease in the biliary cholesterol saturation index.2,4,5-TMC (which has three methoxyls) had the highest hypocholesterolemic activity, while 3,4-DMC, which lacks the methoxyl in carbon 2 but conserves the two other methoxyls in an adjacent position, had the highest choleretic activity and a probable cholelitholytic activity. In methoxycinnamic acids with two methoxyls in non-adjacent positions (2,4-DMC and 3,5-DMC), the hypocholesterolemic and choleretic activities were not as evident. 2,4,5-TMC and 3,4-DMC, which did not cause liver damage during the treatment period, should be further explored as a hypocholesterolemic and choleretic compounds in humans. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Application of 6972-61-8).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Application of 6972-61-8

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Optical studies on coumarins. II. Ultraviolet absorption of monohydroxycoumarins and derivatives was written by Bohme, Horst;Severin, Theodor. And the article was included in Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft in 1957.Application In Synthesis of 3-(2,4-Dimethoxyphenyl)acrylic acid This article mentions the following:

In comparative studies of 4 monohydroxycoumarins, the longwave absorption bands were found to be moved bathochromically by introduction of a hydroxy group in the 6 or 7 position, while the corresponding maximum of 5-and 8-hydroxycoumarins lies at shorter wave lengths. As with coumarin itself 3 bands appear with 5-, 6-, and 8-hydroxycoumarin. 7-Hydroxycoumarin does not produce the medial bands with an inflection at 240 m娓? Dihydroxy-trans-cinnamic acids are optically very similar to their methylated derivatives, but big differences were noted between hydroxycoumarins and dimethoxy-cis-cinnamic acids. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Application In Synthesis of 3-(2,4-Dimethoxyphenyl)acrylic acid).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Application In Synthesis of 3-(2,4-Dimethoxyphenyl)acrylic acid

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

More insight into the chemical composition of Greek propolis; differences and similarities with Turkish propolis was written by Celemli, Omur G.;Hatjina, Fani;Charistos, Leonidas;Schiesser, Aygun;Ozkirim, Asli. And the article was included in Zeitschrift fuer Naturforschung, C: Journal of Biosciences in 2013.Recommanded Product: 6972-61-8 This article mentions the following:

We aimed to determine the differences and similarities between Greek and Turkish propolis with respect to their chem. composition given that the two countries have many similarities in oral biodiversity. We observed that: a) Greek propolis is different from the European-type propolis, having a high terpene content; therefore we can deinitely characterize it as a Mediterranean type; b) the Turkish propolis collected along the coast line of the Aegean Sea is similiar to the examined Greek propolis; c) the remaining Turkish samples, originating from the European part of Turkey, were found to be similiar to the European-type propolis, having a high flavonoid content. Finally, especially two compounds, 灏?elemene and totarol, were found in Greek samples in quite high amounts that are thought to have important biol. properties. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Recommanded Product: 6972-61-8).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O閳ユ椊 or N閳ユ椊 bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Recommanded Product: 6972-61-8

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Curcumin Recognizes a Unique Binding Site of Tubulin was written by Chakraborti, Soumyananda;Das, Lalita;Kapoor, Neha;Das, Amlan;Dwivedi, Vishnu;Poddar, Asim;Chakraborti, Gopal;Janik, Mark;Basu, Gautam;Panda, Dulal;Chakrabarti, Pinak;Surolia, Avadhesha;Bhattacharyya, Bhabatarak. And the article was included in Journal of Medicinal Chemistry in 2011.Recommanded Product: 6972-61-8 This article mentions the following:

Although curcumin is known for its anticarcinogenic properties, the exact mechanism of its action or the identity of the target receptor is not completely understood. Studies on a series of curcumin analogs, synthesized to investigate their tubulin binding affinities and tubulin self-assembly inhibition, showed that: (i) curcumin acts as a bifunctional ligand, (ii) analogs with substitution at the diketone and acetylation of the terminal phenolic groups of curcumin are less effective, (iii) a benzylidiene derivative, compound 7, is more effective than curcumin in inhibiting tubulin self-assembly. Cell-based studies also showed compound 7 to be more effective than curcumin. Using fluorescence spectroscopy we show that curcumin binds tubulin 32 鑴?away from the colchicine-binding site. Docking studies also suggests that the curcumin-binding site to be close to the vinblastine-binding site. Structure-activity studies suggest that the tridented nature of compound 7 is responsible for its higher affinity for tubulin compared to curcumin. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Recommanded Product: 6972-61-8).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O閳ユ椊 or N閳ユ椊 bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Recommanded Product: 6972-61-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Chemical analysis of filtrate and condensate from wet-carbonized peat by gas chromatography-mass spectrometry was written by Kumari, Durga. And the article was included in International Journal of Coal Geology in 1990.Electric Literature of C11H12O4 This article mentions the following:

Peat in its naturally occurring state contains 閳?0 weight% water. To use peat as a source of energy, the bulk of water must be removed by the wet-carbonization process. In this process, wet peat is heated at 500 psi and 400鎺矲 for 40 min of residence time. Wet carbonization of peat also removes a fraction of O from the peat by decarboxylation and dehydration reactions. During wet carbonization, considerable filtrate and condensate is produced, which contains phenols, aromatic acids, n-fatty acids, alkanes, ketones, aldehydes, bicyclic alkanes, etc. Many of these identified compounds were not previously reported in peat studies. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Electric Literature of C11H12O4).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O閳ユ椊 or N閳ユ椊 bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Electric Literature of C11H12O4

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Structure-Activity Relationships of Phenylpropanoids as Antifeedants for the Pine Weevil Hylobius abietis was written by Bohman, B.;Nordlander, G.;Nordenhem, H.;Sunnerheim, K.;Borg-Karlson, A.-K.;Unelius, C. R.. And the article was included in Journal of Chemical Ecology in 2008.Electric Literature of C11H12O4 This article mentions the following:

Et cinnamate has been isolated from the bark of Pinus contorta in the search for antifeedants for the pine weevil, Hylobius abietis. Based on this lead compound, a number of structurally related compounds were synthesized and tested. The usability of the Topliss scheme, a flow diagram previously used in numerous structure-activity relationship (SAR) studies, was evaluated in an attempt to find the most potent antifeedants. The scheme was initially followed stepwise; subsequently, all compounds found in the scheme were compared. In total, 51 phenylpropanoids were tested and analyzed for SARs by using arguments from the field of medicinal chem. (rational drug design). Individual Hansch parameters based on hydrophobicity, steric, and electronic properties were examined The effects of position and numbers of substituents on the aromatic ring, the effects of conjugation in the mols., and the effects of the properties of the parent alc. part of the esters were also evaluated. It proved difficult to find strong SARs derived from single physicochem. descriptors, but our study led to numerous new, potent, phenylpropanoid antifeedants for the pine weevil. Among the most potent were Me 3-phenylpropanoates monosubstituted with chloro, fluoro, or Me groups and the 3,4-dichlorinated Me 3-phenylpropanoate. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Electric Literature of C11H12O4).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Electric Literature of C11H12O4

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis and immunosuppressive effects of novel phthalazinone derivatives was written by Wang, Ya-li;Wang, Qing-he;Yang, Hong-guang;Hao, Bo-jun;Liang, Guo-dong;Jiang, Chong-guo;Cheng, Mao-sheng. And the article was included in Yaoxue Xuebao in 2013.Quality Control of 3-(2,4-Dimethoxyphenyl)acrylic acid This article mentions the following:

A series of phthalazinone compounds were synthesized and the structures were confirmed by ¹H NMR and HR-MS spectrum. All target compounds were obtained through 7 steps, including selective reduction, nitration, bromination, ring enlargement, reduction, Knoevenagel condensation and acylation. The compounds were evaluated for their immunosuppressive effects on T-cell proliferation and inhibitory activity on IMPDH type II in vitro, as well as their structure-activity relationship were assessed. Several compounds exhibited strong immunosuppressive properties, especially compounds 7f and 7h, with IC₅₀ values of 0.093娓璵ol璺疞^-1 and 0.14 娓璵ol璺疞^-1, resp., which were superior to mycophenolic acid. The information obtained from the studies may be useful for further research on the immunosuppressive agents. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Quality Control of 3-(2,4-Dimethoxyphenyl)acrylic acid).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Quality Control of 3-(2,4-Dimethoxyphenyl)acrylic acid

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Heterogeneous vanadium-catalyzed oxidative cleavage of olefins for sustainable synthesis of carboxylic acids was written by Upadhyay, Rahul;Rana, Rohit;Sood, Aakriti;Singh, Vikash;Kumar, Rahul;Srivastava, Vimal Chandra;Maurya, Sushil K.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2021.Recommanded Product: 3-(2,4-Dimethoxyphenyl)acrylic acid This article mentions the following:

A green and sustainable protocol for the oxidative cleavage of olefins to produce pharmaceutically and biol. valuable carboxylic acids was achieved. The developed protocol involved 70% aqueous TBHP as an oxidant over a heterogeneous vanadium catalyst system. Notably, the synthesis of industrially important azelaic acid from various renewable vegetable oils was accomplished. The catalyst was recycled for up to 5 cycles without significant loss in yield and the protocol was successfully demonstrated at the gram-scale. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Recommanded Product: 3-(2,4-Dimethoxyphenyl)acrylic acid).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Recommanded Product: 3-(2,4-Dimethoxyphenyl)acrylic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis of coumarins from o-hydroxyaryl alkyl ketones was written by Chakravarti, D.;Majumdar, B.. And the article was included in Science and Culture in 1938.HPLC of Formula: 6972-61-8 This article mentions the following:

In attempting to synthesize naturally occurring coumarins by the method described it was found that (1) when there are 2 alkyl substituents in the 浼? and 灏?positions of the expected cinnamic acid, cis-cinnamic acid is formed and the coumarin is obtained in quant. yield; (2) when there is no substituent in these positions, trans-cinnamic acid is formed and ring closure does not take place to form a coumarin; (3) when only the 浼?position is occupied, trans-cinnamic acid is formed and the coumarin is not formed by ring closure. Thus o-MeOC₆H₄CHO condenses with BrCH₂CO₂Et, giving Et 2-methoxy-trans-cinnamate, b₈ 150鎺? which on hydrolysis yields 2-methoxy-trans-cinnamic acid, m. 182鎺? identical with the compound prepared from o-coumaric acid. Similarly o-MeOC₆H₄CHO and MeCHBrCO₂Et yield Et 2-methoxy-浼?methylcinnamate, b₄ 155鎺? which on hydrolysis produces the acid trans-2-methoxy-浼?methylcinnamic acid, identical with the compound described by Perkin (J. Chem. Soc. 31, 415). 灏?Resorcylaldehyde di-Me ether and BrCH₂CO₂Et give Et 2,4-dimethoxy-trans-cinnamate, b₈ 184鎺? which on hydrolysis gives the 2,4-dimethoxy-trans-cinnamic acid of Perkin and Schiess (J. Chem. Soc. 85, 162). Et 2-methoxy-trans-cinnamate, Et 2-methoxy-浼?methyl-trans-cinnamate and Et 2,4-dimethoxy-trans-cinnamate do not give the expected coumarin derivatives on heating with HI. The method developed is useful in the synthesis of 3,4-dialkylated coumarin derivatives In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8HPLC of Formula: 6972-61-8).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.HPLC of Formula: 6972-61-8

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Polymer-assisted solution-phase synthesis under combined ultrasound and microwave irradiation. Preparation of α,β-unsaturated esters and carboxylic acids, key intermediates of novel sigma ligands was written by Rossi, D.;Urbano, M.;Baraglia, A. Carnevale;Serra, M.;Bergamelli, F.;Iannelli, M.;Azzolina, O.;Collina, S.. And the article was included in Synthetic Communications in 2009.Recommanded Product: 6972-61-8 This article mentions the following:

The optimal conditions to prepare α,β-unsaturated Me esters via Wittig reaction combining polymer-assisted solution-phase synthesis (PASPS) methodol. and simultaneous ultrasound and microwave irradiation were established. The effects of temperature, solvent, and irradiation time were discussed. Results clearly indicated the superiority of combined ultrasound and microwave-assisted procedure over microwave-assisted methodol. Moreover, an efficient PASPS procedure to prepare α,β-unsaturated carboxylic acids via tandem Wittig olefination and hydrolysis reaction was developed under combined ultrasound and microwave irradiation Generally, a good conversion of aldehydes to acids was observed The optimized protocols allowed us to quickly prepare a small collection of either α,β-unsaturated esters or carboxylic acids, key intermediates for the drug-discovery process of new sigma ligands. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Recommanded Product: 6972-61-8).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Recommanded Product: 6972-61-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem