Category: 6943-97-1

Adding a certain compound to certain chemical reactions, such as: 6943-97-1, name is 1-(3-Bromopropyl)-3-methoxybenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6943-97-1, HPLC of Formula: C10H13BrO

4 4′-Oxo-3′,4′,7,8-tetrahvdro-2’H,6H-spironmidazori ,5-alpyridine-5,1′-naphthalenel-6′- carbonitrile starting from 1-(3-bromopropyl)-3-methoxybenzene [6943-97-1].

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; SPEEDEL EXPERIMENTA AG; WO2006/128851; (2006); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 6943-97-1, These common heterocyclic compound, 6943-97-1, name is 1-(3-Bromopropyl)-3-methoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 10.10: Intermediate 10.1.9: (S)-3 -tert-Butoxycarbonylamino- 1 , 1 -bis- [3 -(3 -methoxy-phenyl)-propyl] – piperidinium hydroxide Chiral (S)-Piperidin-3-yl-carbamic acid tert-butyl ester (2.72 g, 13.6 mmol) and l-(3-Bromo-propyl)-3-methoxy- benzene (6.6 g, 28.8 mmol), potassium carbonate (2.5 g, 18 mmol) and sodium iodide (4 g, 26.7 mmol) are dissolved in acetonitril (40 ml) and stirred at reflux for 1 day and the solvent is removed under vacuo. The residue is taken up in dichloromethane, filtered through a pad of silica, washed with a mixture of di- chloromethane:methanol: cone. ammonia = 4: 1 :0.1 and the filtrate is evaporated. LC (method L): tR = 1.30 min; Mass spectrum (ESI+): m/z = 497 [M]+.

Statistics shows that 1-(3-Bromopropyl)-3-methoxybenzene is playing an increasingly important role. we look forward to future research findings about 6943-97-1.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WIEDENMAYER, Dieter; HAMPRECHT, Dieter; HECKEL, Armin; WO2015/18754; (2015); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 6943-97-1,Some common heterocyclic compound, 6943-97-1, name is 1-(3-Bromopropyl)-3-methoxybenzene, molecular formula is C10H13BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A flask containing solution of Mg turnings (271 mg, 11.31 mmol) in THF (10 mL) and a few crystals of iodine under nitrogen was added a solution of compound 15 (2.42 g, 11.31 mmol) in THF (15 mL) drop wise and reflux for 3 hrs. After 3 hrs the majority of the Mg had dissolved and a clear grayish colored solution had formed. The solution was cooled to 0 C and a solution of compound 16 (1.5 g, 7.07 mmol) in THF was added drop wise. The mixture was allowed to warm slowly to rt and reaction was monitored by tlc. Once the starting material is consumed the reaction mixture was quenched by saturated aqueous NH4Cl solution (30 mL). The reaction mixture was extracted with EtOAc (20 mL x 3) and layer was separated and washed with brine and dried over MgSO4. Removal of solvent and drying under vacuum provided the crude product that was separated by flash chromatography.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-(3-Bromopropyl)-3-methoxybenzene, its application will become more common.

Reference:
Article; Asim, Muhammad; Klonowska, Daria; Choueiri, Christine; Korobkov, Ilia; Carlson, Kathryn E.; Katzenellenbogen, John A.; Durst, Tony; Bioorganic and Medicinal Chemistry Letters; vol. 22; 11; (2012); p. 3713 – 3717;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6943-97-1, name is 1-(3-Bromopropyl)-3-methoxybenzene, A new synthetic method of this compound is introduced below., HPLC of Formula: C10H13BrO

Step C Preparation of 2-[3-(3-Methoxy-phenyl)-propyl]-malonic acid diethyl ester Diethylmalonate (7.65 mL, 0.050 mol) was added slowly to a vigorously stirred suspension of pre-washed NaH (60%) (2.4 g, 0.050 mol) in dry DMF (50 mL) at 0 C. under Ar. After 15 min, 3-(3-methoxyphenyl)propylbromide (11.5 g, 0.050 mol) was added slowly, the ice bath was removed, and the reaction mixture was stirred at 65 C. for 16 hr. The mixture was cooled, partitioned between EtOAc (250 mL) and H2O (200 mL), the organic layer washed with H2O (2*500 mL), dried (Na2SO4), filtered, and concentrated to dryness to give the title compound. FAB MS(M+1) 309.1

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; deSolms, S. Jane; Stokker, Gerald E.; Shaw, Anthony W.; US2002/99007; (2002); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 6943-97-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6943-97-1, name is 1-(3-Bromopropyl)-3-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows.

(16-3) Synthesis of [5-(2-{4-[3-(3-methoxyphenyl)propoxy]-3-trifluoromethylphenyl}ethyl)-2,2-dimethyl-1,3-dioxan-5-yl]carbamic acid t-butyl ester (compound 16-3) Reference Example compound 2-6 (500 mg) was dissolved in N,N-dimethylformamide (10 ml), potassium carbonate (493 mg) and compound 16-2 (328 mg) were added, and the mixture was stirred at 80C for 2 hr. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate, washed with water and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give the object product (800 mg) as a white solid. 1H-NMR(CDCl3) delta (ppm): 1.42(3H, s), 1.44(3H, s), 1.47(9H, s), 1.93-1.98(2H, m), 2.08-2.12(2H, m), 2.51-2.56(2H, m), 2.81(2H, t, J=7.5Hz), 3.69(2H, d, J=11.7Hz), 3.76(3H, s), 3.89(2H, d, J=11.7Hz), 3.99(2H, t, J=6.0Hz), 4.98(1H, brs), 6.72-6.84(4H, m), 7.19(1H, t, J=7.5Hz), 7.24(1H, d, J=1.8Hz), 7.36(1H, d, J=1.8Hz).

The chemical industry reduces the impact on the environment during synthesis 1-(3-Bromopropyl)-3-methoxybenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; EP2168944; (2010); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 6943-97-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6943-97-1, name is 1-(3-Bromopropyl)-3-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows.

(16-3) Synthesis of [5-(2-{4-[3-(3-methoxyphenyl)propoxy]-3-trifluoromethylphenyl}ethyl)-2,2-dimethyl-1,3-dioxan-5-yl]carbamic acid t-butyl ester (compound 16-3) Reference Example compound 2-6 (500 mg) was dissolved in N,N-dimethylformamide (10 ml), potassium carbonate (493 mg) and compound 16-2 (328 mg) were added, and the mixture was stirred at 80C for 2 hr. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate, washed with water and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give the object product (800 mg) as a white solid. 1H-NMR(CDCl3) delta (ppm): 1.42(3H, s), 1.44(3H, s), 1.47(9H, s), 1.93-1.98(2H, m), 2.08-2.12(2H, m), 2.51-2.56(2H, m), 2.81(2H, t, J=7.5Hz), 3.69(2H, d, J=11.7Hz), 3.76(3H, s), 3.89(2H, d, J=11.7Hz), 3.99(2H, t, J=6.0Hz), 4.98(1H, brs), 6.72-6.84(4H, m), 7.19(1H, t, J=7.5Hz), 7.24(1H, d, J=1.8Hz), 7.36(1H, d, J=1.8Hz).

The chemical industry reduces the impact on the environment during synthesis 1-(3-Bromopropyl)-3-methoxybenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; EP2168944; (2010); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem