Xia, Guoqin published the artcileLigand-Enabled β-Methylene C(sp3)-H Arylation of Masked Aliphatic Alcohols, SDS of cas: 685517-67-3, the main research area is methylene arylation aliphatic alc salicylic directing group pyridone ligand; C−H activation; aliphatic alcohols; directing groups; ligands; synthetic methods.
Despite recent advances, reactivity and site-selectivity remain significant obstacles for the practical application of C(sp3)-H bond functionalization methods. Here, we describe a system that combines a salicylic-aldehyde-derived L,X-type directing group with an electron-deficient 2-pyridone ligand to enable the β-methylene C(sp3)-H arylation of aliphatic alcs., which has not been possible previously. Notably, this protocol is compatible with heterocycles embedded in both alc. substrates and aryl coupling partners. A site- and stereo-specific annulation of dihydrocholesterol and the synthesis of a key intermediate of englitazone illustrate the practicality of this method.
Angewandte Chemie, International Edition published new progress about Arylation. 685517-67-3 belongs to class iodides-buliding-blocks, name is 2,6-Difluoro-3-iodopyridine, and the molecular formula is C5H2F2IN, SDS of cas: 685517-67-3.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com