Category: 6850-57-3

Diem Ferreira Xavier, Mauricio Carpe published the artcileDitelluride-Catalyzed synthesis of phosphoramidates: A design of experiment approach, Recommanded Product: (2-Methoxyphenyl)methanamine, the publication is Tetrahedron (2022), 132879, database is CAplus.

Di-Ph ditelluride Ph₂Te₂ in aerial oxidative conditions catalyzes amidation of hydrophosphonates HP(O)(OR²)₂ (R² = Et, Me, Bu) with primary and secondary amines RR¹NH (R¹ = H, R = alkyl, aralkyl; R = R¹ = Et, RR¹NH = pyrrolidine, morpholine), giving phosphoramidates RR¹NP(O)(OR²)₂ with high yields in mild conditions (50°, 13 mol% of Ph₂Te₂). In this contribution, we describe a selective synthesis of phosphoramidates employing di-Ph ditelluride as a simple and readily available organic catalyst. To optimize the reaction conditions, a full factorial design was carried out, demonstrating that the temperature is the critical factor for the P(O)-N bonding formation. The products were obtained in moderate to excellent yields, in mild conditions. Addnl., ³¹P and ¹²⁵Te NMR spectroscopies were used to characterize the intermediate, confirming the reaction mechanism.

Tetrahedron published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Recommanded Product: (2-Methoxyphenyl)methanamine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Mardjan, Muhammad Idham Darussalam published the artcileUltrasonic-assisted-synthesis of isoindolin-1-one derivatives, Recommanded Product: (2-Methoxyphenyl)methanamine, the publication is RSC Advances (2022), 12(29), 19016-19021, database is CAplus and MEDLINE.

A small library of 3-hydroxyisoindolin-1-ones were prepared from 3-alkylidenephthalides under ultrasonic irradiation This practical synthesis was featured by group tolerance, high efficiency and yields. The reaction was also performed in multigram scale and can be further extended to access other motifs of isoindolin-1-ones in a one-pot fashion.

RSC Advances published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Recommanded Product: (2-Methoxyphenyl)methanamine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Dong, Xiaoyun published the artcileCadmium sulfide/titanate hybrid green light photocatalysis for selective aerobic oxidative homocoupling of amines, Related Products of ethers-buliding-blocks, the publication is Journal of Colloid and Interface Science (2021), 387-395, database is CAplus and MEDLINE.

Semiconductor photocatalysis can carry out selective chem. transformations under ambient conditions, mitigating the associated environmental consequences. However, a single semiconductor photocatalyst usually cannot perform the transformations satisfactorily from the aspects of light-absorption, efficiency, and selectivity, etc. To address these challenges, cadmium sulfide (CdS)/titanate hybrid was fabricated by simultaneously growing titanate and CdS and had been comprehensively characterized. The optimized CdS/titanate hybrid can power the highly selective oxidative homocoupling of amines under the irradiation of green light-emitting diodes (LEDs). Specifically, CdS with a narrow bandgap captures green light; the conduction band of titanate activates mol. oxygen (O₂). The valence band of CdS could ensure the selective oxidative homocoupling of amines in methanol (CH₃OH). The hybridization between CdS and titanate accounts for the expeditious oxidative homocoupling of amines into imines and the improved stability. Reactive oxygen species (ROS) quenching experiments and in situ ESR (EPR) tests suggest that superoxide anion (O·^-2) and benzylamine radical are intermediates en route to imines. This work highlights the viability of hybridization of dual semiconductor nanostructures in implementing visible light-powered selective conversions.

Journal of Colloid and Interface Science published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Haas, Brittany C. published the artcilePredicting relative efficiency of amide bond formation using multivariate linear regression, Safety of (2-Methoxyphenyl)methanamine, the publication is Proceedings of the National Academy of Sciences of the United States of America (2022), 119(16), e2118451119, database is CAplus and MEDLINE.

Herein, the development of statistical models correlating measured rates to phys. organic descriptors to enable the prediction of reaction rates for untested carboxylic acid/amine pairs was reported. The key to the success of this endeavor was the development of an end-to-end data science-based work flow to select a set of coupling partners that were appropriately distributed in chem. space to facilitate statistical model development. By using a parameterization, dimensionality reduction, and clustering protocol, a training set was identified. Reaction rates for a range of carboxylic acid and primary alkyl amine couplings utilizing carbonyldiimidazole (CDI) as the coupling reagent were measured. The collected rates span five orders of magnitude, confirming that the designed training set encompasses a wide range of chem. space necessary for effective model development. Regressing these rates with high-level d. functional theory (DFT) descriptors allowed for identification of a statistical model wherein the mol. features of the carboxylic acid are primarily responsible for the observed rates. Finally, out-of-sample amide couplings are used to determine the limitations and effectiveness of the model.

Proceedings of the National Academy of Sciences of the United States of America published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Safety of (2-Methoxyphenyl)methanamine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhu, Guanxin published the artcileSelective C-C bonds formation, N-alkylation and benzo[d]imidazoles synthesis by a recyclable zinc composite, Name: (2-Methoxyphenyl)methanamine, the publication is Chinese Chemical Letters (2022), 33(1), 266-270, database is CAplus.

Earth abundant metals are much less expensive, promising, valuable metals and could be served as catalysts for the borrowing hydrogen reaction, dehydrogenation and heterocycles synthesis, instead of noble metals. The uniformly dispersed zinc composites were designed, synthesized and carefully characterized by means of XPS, EDS, TEM and XRD. The resulting zinc composite showed good catalytic activity for the N-alkylation of amines 2-R-3-R¹-4-R²-5-R³-C₆HNH₂ (R = H, Cl, Me; R¹ = H, Cl; R² = H, Cl, OMe; R³ = H, Me) with amines R⁴CH₂NH₂ (R⁴ = Ph, 2-methylphenyl, thiophen-2-yl, etc.), ketones R⁵C(O)CH₃ (R⁵ = Ph, 3-bromophenyl, naphthalen-2-yl, etc.;) with alcs. R⁶CH₂OH (R⁶ = Ph, 3,4-difluorophenyl, thiophen-2-yl, etc.) in water under base-free conditions, while unsaturated carbonyl compounds R⁵C(O)CH=CHR⁶ and R⁵C(O)(CH₂)₂R⁶ could also be synthesized by tuning the reaction conditions. Importantly, it was the first time to realize the synthesis of 2-aryl-1H-benzo[d]imidazole derivatives I (R⁷ = H, Cl, Me) by using this zinc composite under green conditions. Meanwhile, this zinc catalyst could be easily recovered and reused for at least five times.

Chinese Chemical Letters published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C11H17BN2O2, Name: (2-Methoxyphenyl)methanamine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Li, Peiyu published the artcileAn azine-linked 2D porphyrinic covalent organic framework for red light photocatalytic oxidative coupling of amines, HPLC of Formula: 6850-57-3, the publication is Materials Today Chemistry (2022), 100953, database is CAplus.

The construction of two-dimensional covalent organic frameworks (2D COFs) with robust stability for photocatalysis has gained intensive attention recently. Herein, we report the design and synthesis of a highly crystalline azine-linked porphyrinic 2D COF (Por-HZ-COF). Our results clearly show that Por-HZ-COF adopts an eclipsed AA stacking structure with a high Brunauer-Emmett-Teller (BET) sp. surface area of 1586 m2/g. In addition, Por-HZ-COF is chem. stable under various conditions, even in 12 M sodium hydroxide aqueous solution or 9 M hydrochloric acid. Moreover, Por-HZ-COF can be used for the photocatalytic aerobic oxidative coupling of benzylamines under red light irradiation with high activity and good reusability. This study demonstrates a novel robust 2D COF with azine linkage that has promising applications in photocatalysis.

Materials Today Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, HPLC of Formula: 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Kato, Kahoko published the artcilePrimary amine synthesis by hydrogen-involving reactions over heterogeneous cobalt catalysts, Computed Properties of 6850-57-3, the publication is Catalysis Science & Technology, database is CAplus.

A composite of metallic cobalt and silica particles that exhibits high catalytic performance for the selective synthesis of primary amines RNH₂ [R = heptyl, cyclohexyl, Bn, [5-(hydroxymethyl)oxolan-2-yl]methyl, etc.] via hydrogenation of nitriles RCN and reductive amination, even under mild conditions was reported. A mechanistic study revealed that the substrate nitrile and the product amine retarded the hydrogenation of secondary imine intermediates, which resulted in a selective reaction. On the basis of this knowledge, the selectivity for the primary amine was further improved by the addition of coordinating organic mols., which provided new insights into the control of selectivity toward primary amines unlike that with classical methods using ammonia.

Catalysis Science & Technology published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Computed Properties of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ma, Xuerui published the artcileTartramide Ligands for Copper-Catalyzed N-Arylation at Room Temperature, HPLC of Formula: 6850-57-3, the publication is Advanced Synthesis & Catalysis (2022), 364(12), 2023-2031, database is CAplus.

Readily accessible tartramide ligands R¹NHC(O)CH(OH)CH(OH) C(O)NHR (R = Ph, Bn, cyclohexyl, etc.)have been demonstrated to promote copper-catalyzed N-arylation under mild conditions. In addition, the coupling protocol employs cheap and readily available pre-catalyst, ligand, and base (NaOH), and overcomes many current limitations often associated with Ullmann coupling: it can be run with low catalyst loadings, does not require the use of excess amine, operates at room temperature, is fully homogeneous, and displays improved tolerance to air and moisture. Detailed kinetic studies using reaction progress kinetic anal. (RPKA) methods have provided insight into the factors influencing the reaction rate in terms of impact of ligand structure, reactant/catalyst dependence and catalyst (in)stability. These kinetic insights have been used in a quality-by-design approach for further optimization of the reaction protocol. The reaction scope was extended to 22 examples, showing broad applicability for a wide range of substituted aryl iodides ArI (Ar = 3,5-dimethylphenyl, 4-chlorophenyl, 3-cyanophenyl, etc.) with both primary and secondary amines R¹NHR² (R¹ = H); R² = -(CH₂)₂O(CH₂)₂-, -(CH₂)₂N(CH₃)(CH₂)₂-, -(CH₂)₅-, etc.

Advanced Synthesis & Catalysis published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, HPLC of Formula: 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Gopalaiah, Kovuru published the artcileSynthesis of Krohnke pyridines through iron-catalyzed oxidative condensation/double alkynylation/amination cascade strategy, HPLC of Formula: 6850-57-3, the publication is Tetrahedron (2021), 132429, database is CAplus.

An efficient protocol for the synthesis of sym. and unsym. 2,4,6-trisubstituted pyridines via oxidative cascade annulation of arylacetylenes with benzylamines was developed. The reaction proceeded smoothly by utilizing iron(II) triflate as a catalyst and mol. oxygen as an oxidant with broad substrate scope. Mechanistic studies revealed that the reaction may experience an oxidative condensation followed by double alkynylation and amination process.

Tetrahedron published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, HPLC of Formula: 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wojcik-Pszczola, Katarzyna published the artcilePan-Phosphodiesterase Inhibitors Attenuate TGF-β-Induced Pro-Fibrotic Phenotype in Alveolar Epithelial Type II Cells by Downregulating Smad-2 Phosphorylation, Application In Synthesis of 6850-57-3, the publication is Pharmaceuticals (2022), 15(4), 423, database is CAplus and MEDLINE.

Airway remodeling is a pathol. process that accompanies many chronic lung diseases. One of the important players in this process are epithelial cells, which under the influence of pro-inflammatory and pro-fibrotic factors present in the airway niche, actively participate in The remodeling process by increasing extracellular matrix secretion, acquiring migration properties, and overproducing pro-fibrotic transducers. Here, we investigated the effect of three new 8-arylalkylamino- and 8-alkoxy-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl-N-(5-(tertbutyl)-2-hydroxyphenyl)butanamides (1, 2, and 3), representing prominent pan-phosphodiesterase (pan-PDE) inhibitors on transforming growth factor type β (TGF-β)-induced alveolar epithelial type II cells (A549 cell line) of a pro-fibrotic phenotype. Our results demonstrate for the first time the strong activity of pan-PDE inhibitors in the prevention of TGF-β-induced mesenchymal markers′ expression and A549 cells′ migration. We also showed an increased p-CREB and decreased p-Smad-2 phosphorylation in TGF-β-induced A549 cells treated with 1, 2, and 3 derivatives, thereby confirming a pan-PDE inhibitor mesenchymal phenotype reducing effect in alveolar epithelial type II cells via suppression of the canonical Smad signaling pathway. Our observations confirmed that PDE inhibitors, and especially those active against various isoforms involved in the airway remodeling, constitute an interesting group of compounds modulating the pro-fibrotic response of epithelial cells.

Pharmaceuticals published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C15H16O3, Application In Synthesis of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem