Category: 6850-57-3

Hu, Weiyao published the artcileRapidly and mildly transferring anatase phase of graphene-activated TiO₂ to rutile with elevated Schottky barrier: Facilitating interfacial hot electron injection for Vis-NIR driven photocatalysis, Quality Control of 6850-57-3, the publication is Nano Research, database is CAplus.

Visible and even IR (IR) light-initiated hot electrons of graphene (Gr) catalysts are a promising driven power for green, safe, and sustainable H₂O₂ synthesis and organic synthesis without the limitation of bandgap-dominated narrow light absorption to visible light confronted by conventional photocatalyst. However, the life time of photogenerated hot electrons is too short to be efficiently used for various photocatalytic reactions. Here, we proposed a straightforward method to prolong the lifetime of photogenerated hot electrons from graphene by tuning the Schottky barrier at Gr/rutile interface to facilitate the hot electron injection. The rational design of Gr-coated TiO₂ heterojunctions with interface synergy-induced decrease in the formation energy of the rutile phase makes the phase transfer of TiO₂ support proceed smoothly and rapidly via ball milling. The optimized Gr/rutile dyad could provide a H₂O₂ yield of 1.05 mM·g^-1·h^-1 under visible light irradiation (λ â‰?400 nm), which is 30 times of the state-of-the-art noble-metal-free titanium oxide-based photocatalyst, and even achieves a H₂O₂ yield of 0.39 mM·g^-1·h^-1 on photoexcitation by near-IR-region light (âˆ?800 nm).

Nano Research published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Quality Control of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Xu, Hui published the artcileDesigning fluorene-based conjugated microporous polymers for blue light-driven photocatalytic selective oxidation of amines with oxygen, Computed Properties of 6850-57-3, the publication is Applied Catalysis, B: Environmental (2021), 119796, database is CAplus.

Conjugated microporous polymers (CMPs) have been showcased with a brilliant prospect in organic semiconductor photocatalysis, attributing to accessible mol. design, chem. stability and environmental friendliness. Here, two novel fluorene-based CMPs were designed and conveniently synthesized with carbazole as an electron donor. Importantly, subtle variation of substituent at the methylene bridge (9-position) of fluorene precursor results in different performances in which di-Me substituent was proven to be more efficient than difluoro substituent for blue light photocatalysis. MFC [9,9′-(9,9-dimethyl-9H-fluorene-2,7-diyl)bis(9H-carbazole)]-CMP has a much larger sp. surface area, a more favorable redox position, and resultantly a superior photocatalytic performance during blue light-driven selective oxidation of amines into imines with oxygen (O₂) in an environmentally benign solvent ethanol (C₂H₅OH). This work suggests that subtle tweaking in electron acceptors could give rise to superior photocatalytic activity for CMPs in selective chem. conversions.

Applied Catalysis, B: Environmental published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C4H6N2, Computed Properties of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhou, Jun published the artcileCooperative photocatalysis of dye-TiO₂ nanotubes with TEMPO⁺BF^–₄ for selective aerobic oxidation of amines driven by green light, SDS of cas: 6850-57-3, the publication is Applied Catalysis, B: Environmental (2021), 120368, database is CAplus.

Visible light photocatalysis could offer an eco-friendly alternative for selective transformation of organic mols. Herein, a cooperative system is created with alizarin red S (ARS), TiO₂ nanotubes (TNTs), and an extra redox mediator. The electron transfer between oxidatively quenched ARS-TNTs and the redox mediator is the key to secure cooperative photocatalysis. The selective aerobic oxidation of primary and secondary amines was constructed by cooperative photocatalysis of ARS-TNTs with 2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate (TEMPO⁺BF^–₄) driven by green light. Specifically, the activity of anatase TNTs could reach about 2.2 times that of the P25 (Aeroxide P25) TiO₂ precursor. Due to increased polarity, TEMPO⁺BF^–₄ serves more efficiently for electron transfer than (2,2,6,6-tetramethylpiperidin-1-yl)oxy (TEMPO), conferring above 1.5 times of activity that of TEMPO for the selective aerobic conversion of amines. This work features the potential of designing redox mediators in amplifying cooperative photocatalysis driven by visible light.

Applied Catalysis, B: Environmental published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C23H20BN, SDS of cas: 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Li, Xiangjun published the artcileThermo-Enhanced Photocatalytic Activity in Aerobic Oxidative Coupling of Amines to Imines over Cu-Doped MIL-125-NH₂, Product Details of C8H11NO, the publication is Asian Journal of Organic Chemistry (2021), 10(11), 2895-2901, database is CAplus.

Photocatalytic oxidation of raw organic mols. to value-added chems. provides a cost-effective and sustainable strategy in organic synthesis. In this work, a series of Cu-doped MIL-125-NH₂ with narrower band gaps were synthesized by a one-pot hydrothermal method and used as photocatalysts for thermo-enhanced aerobic oxidative coupling of amines to imines under visible light irradiation With optimal doping content, the conversion of benzylamine over MIL-125-NH₂/Cu_2% can reach 100% at 60°C under visible light irradiation for 8 h using mol. oxygen as oxidant. It is proved that doping MIL-125-NH₂ with a suitable Cu content can broaden the visible light absorption range, promote the separation of photo-induced charge carriers and improve the photocatalytic performance. Moreover, the increase of reaction temperature of the photocatalytic system promotes the performance. Free radical capture experiments and ESR tests show that holes and superoxide free radicals are the main active species. Such an excellent photocatalytic performance can be attributed to the strong light absorption and more efficient electron-hole separation efficiency via the Cu-doping strategy in MIL-125-NH₂ catalysts.

Asian Journal of Organic Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Product Details of C8H11NO.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Yan, Xiao-Biao published the artcileNi-catalyzed hydroalkylation of olefins with N-sulfonyl amines, Formula: C8H11NO, the publication is Nature Communications (2021), 12(1), 5881, database is CAplus and MEDLINE.

Herein, a reliable method for accessing α-branched amines RNHCH(R¹)(CH₂)₂R² (R = (4-methylphenyl)sulfonyl, (2,4,6-trimethylphenyl)sulfonyl; R¹ = Ph, 4-morpholinophenyl, furan-2-yl, etc.; R² = Ph, 3-fluorophenyl, 9H-fluoren-2-yl, etc.) via nickel-catalyzed hydroalkylation reactions was reported. Specifically, by using bis(cyclooctadiene)nickel (Ni(cod)₂) together with a phosphine ligand, a formal C(sp³)-H bond insertion reaction between olefins CH₂=CHR² and N-sulfonyl amines RNHCH₂R¹ without the need for an external hydride source was achieved. The amine not only provides the alkyl motif but also delivers hydride to the olefin by means of a nickel-engaged β-hydride elimination/reductive elimination process. This method provides a platform for constructing chiral α-branched amines (R/S)-RNHCH(R¹)CH₂CH₂R² by using a P-chiral ligand, demonstrating its potential utility in organic synthesis. Notably, a sulfonamidyl boronate complex formed in situ under basic conditions promotes ring-opening of the azanickellacycle reaction intermediate, leading to a significant improvement of the catalytic efficiency.

Nature Communications published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C19H15NO3, Formula: C8H11NO.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Rahman, Shafikur Md. published the artcileDiscovery of First-in-Class Peptidomimetic Neurolysin Activators Possessing Enhanced Brain Penetration and Stability, Synthetic Route of 6850-57-3, the publication is Journal of Medicinal Chemistry (2021), 64(17), 12705-12722, database is CAplus and MEDLINE.

Peptidase neurolysin (Nln) is an enzyme that functions to cleave various neuropeptides. Upregulation of Nln after stroke has identified the enzyme as a critical endogenous cerebroprotective mechanism and validated target for the treatment of ischemic stroke. Overexpression of Nln in a mouse model of stroke results in dramatic improvement of stroke outcomes, while pharmacol. inhibition aggravates them. Activation of Nln has therefore emerged as an intriguing target for drug discovery efforts for ischemic stroke. Herein, we report the discovery and hit-to-lead optimization of first-in-class Nln activators based on histidine-containing dipeptide hits identified from a virtual screen. Adopting a peptidomimetic approach provided lead compounds that retain the pharmacophoric histidine moiety and possess single-digit micromolar potency over 40-fold greater than the hit scaffolds. These compounds exhibit 5-fold increased brain penetration, significant selectivity over highly homologous peptidases, greater than 65-fold increase in mouse brain stability, and ‘drug-like’ fraction unbound in the brain.

Journal of Medicinal Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Synthetic Route of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Yamamoto, Yuki published the artcileOne-pot construction of diverse β-lactam scaffolds via the green oxidation of amines and its application to the diastereoselective synthesis of β-amino acids, Quality Control of 6850-57-3, the publication is Journal of Organic Chemistry (2021), 86(17), 11571-11582, database is CAplus and MEDLINE.

In this study, a simple one-pot construction of β-lactam scaffolds was successfully achieved via 4,6-dihydroxysalicylic acid-catalyzed organocatalytic oxidation of amines to imines using mol. oxygen. Although some imines are highly unstable and difficult to isolate by conventional methods, the organocatalytic oxidation of amines described herein, followed by their direct reaction with acyl chlorides in the presence of a base, afforded a series of new β-lactam derivatives with excellent cis selectivity, which could not be synthesized and isolated by previously reported methods. Thus, this one-pot protocol will be one of the powerful methods applicable to the synthesis of various potential drug candidates and functional mols. Furthermore, the subsequent hydrolysis of these β-lactams successfully afforded the corresponding β-amino acids as almost single diastereomers in up to 99% yields.

Journal of Organic Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C44H28ClFeN4, Quality Control of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Schade, N. published the artcileEvaluation of Novel Substituted Furopyridines as Inhibitors of Protein Kinases Related to Tau Pathology in Alzheimer’s Disease, Recommanded Product: (2-Methoxyphenyl)methanamine, the publication is Medicinal Chemistry (Sharjah, United Arab Emirates) (2021), 17(8), 844-855, database is CAplus and MEDLINE.

A novel furopyridines with various substitution patterns were synthezised and evaluated for protein kinases inhibition studies related to tau pathol. Furopyridine derivatives were synthesized and purified using column chromatog. The protein kinase inhibitory properties were determined in ATP-competition assays with determined affinity constants for the most active compounds The compounds were prepared in simple two-component reactions of substituted 1,4- dihydropyridines and resp. quinones to obtain various substitutions of the mol. furopyridine scaffold. The substituent effects on the determined kinase inhibitory properties of cdk1, cdk2, Fyn, JNK3 and gsk-3β are discussed. Various 3-substitutions were found most sensitive for the protein kinase inhibition depending on the length, nature and a substituent positioning within. These compounds were identified as inhibitors of several kinases as a tool to potentially combat the disease progress in a multitargeting approach.

Medicinal Chemistry (Sharjah, United Arab Emirates) published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Recommanded Product: (2-Methoxyphenyl)methanamine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Bano, Kulsum published the artcileFacile Synthesis of Benzimidazole and Benzothiazole Compounds Mediated by a Zinc Precatalyst Supported by an Iminopyrrole-Morpholine Ligand, Application In Synthesis of 6850-57-3, the publication is European Journal of Inorganic Chemistry (2022), 2022(10), e202200023, database is CAplus.

Three zinc complexes, with the general formula {κ2-C₄H₃NH[2-CH=NCH₂CH₂N(CH₂CH₂)₂O]ZnX₂} [X = Cl, Br, I], supported by a neutral iminopyrrole-morpholine ligand, were synthesized by the reaction between {C₄H₃NH-2-[CH=NCH₂CH₂N (CH₂CH₂)₂O]} and anhydrous zinc dihalides (ZnCl₂, ZnBr₂, ZnI₂) at ambient temperature in dry methanol. The zinc complexes were fully characterized using multinuclear NMR spectroscopic techniques and the mol. structures of complexes in their solid states were determined by single-crystal X-ray diffraction anal. The zinc diiodo complex proved to be a competent precatalyst in the formation of a wide range of benzimidazole and benzothiazole compounds, via aerobic oxidative condensation of several benzylamines with o-phenylenediamine, N-phenyl-o-phenylene-diamine, and o-mercaptoaniline. The benzimidazole and benzothiazole derivatives were successfully characterized using ¹H and ¹³C{1H} NMR spectroscopy.

European Journal of Inorganic Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Application In Synthesis of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Kadu, Vikas D. published the artcileRapid One-Pot Aerobic Oxidative N-α-C(sp³)-H Functionalization of Arylmethylamines to Access Tetrasubstituted Imidazoles, Recommanded Product: (2-Methoxyphenyl)methanamine, the publication is Asian Journal of Organic Chemistry (2022), 11(8), e202200162, database is CAplus.

A simple copper catalyzed “one-pot” process has been developed for synthesis of polysubstituted imidazoles via direct oxidative N-α-C(sp³)-H functionalization of arylmethylamines. The readily available arylmethylamines as substrates have afforded tetrasubstituted imidazoles products up to 94% yields under mild and environmentally benign conditions. The explored substrates scope with 1,2-diketones and α-hydroxyketones have shown great utility for synthesis of tetrasubstituted imidazoles.

Asian Journal of Organic Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Recommanded Product: (2-Methoxyphenyl)methanamine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem