Category: 6850-57-3

Wang, Xuebao published the artcileDiscovery of N-substituted sulfamoylbenzamide derivatives as novel inhibitors of STAT3 signaling pathway based on Niclosamide, Safety of (2-Methoxyphenyl)methanamine, the publication is European Journal of Medicinal Chemistry (2021), 113362, database is CAplus and MEDLINE.

Signal transducer and activator of transcription 3 (STAT3) has been confirmed as an attractive therapeutic target for cancer therapy. Herein, a series of N-substituted sulfamoylbenzamide STAT3 inhibitors I [R¹ = H, OH; R² = H, Cl; R³ = 2-MeOC₆H₄, 3,4,5-(OMe)₃C₆H₂, 3-MeOC₆H₄CH₂, etc.; R⁴ = H, C(O)Me, C(O)Ph, etc.] based on small-mol. STAT3 inhibitor Niclosamide was synthesized. Compound I [R¹ = H, R² = Cl, R³ = 4-CO₂t-BuC₆H₄, R⁴ = H] the best active compound of this series, was identified as an inhibitor of IL-6/STAT3 signaling with an IC₅₀ of 0.61-1.11μM in MDA-MB-231, HCT-116 and SW480 tumor cell lines with STAT3 overexpression, by inhibiting the phosphorylation of STAT3 of Tyr705 residue and the expression of STAT3 downstream genes, inducing apoptosis and inhibiting the migration of cancer cells. Furthermore, in vivo study revealed that compound I [R¹ = H, R² = Cl, R³ = 4-CO₂t-BuC₆H₄, R⁴ = H] suppressed the MDA-MB-231 xenograft tumor growth in nude mice at the dose of 30 mg/kg (i.g.), which has better antitumor activity than the pos. control Niclosamide. More importantly, compound I [R¹ = H, R² = Cl, R³ = 4-CO₂t-BuC₆H₄, R⁴ = H] was an orally bioavailable anticancer agent as a promising candidate for further development.

European Journal of Medicinal Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C10H10O2, Safety of (2-Methoxyphenyl)methanamine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Lillich, Felix F. published the artcileStructure-Based Design of Dual Partial Peroxisome Proliferator-Activated Receptor γ Agonists/Soluble Epoxide Hydrolase Inhibitors, Recommanded Product: (2-Methoxyphenyl)methanamine, the publication is Journal of Medicinal Chemistry (2021), 64(23), 17259-17276, database is CAplus and MEDLINE.

A dual partial PPARγ agonist/sEH inhibitor using a structure-guided approach was designed. Exhaustive structure-activity relationship studies lead to the successful optimization of the designed lead. Crystal structures of one representative compound with both targets revealed potential points for optimization. The optimized compounds exhibited favorable metabolic stability, toxicity, selectivity, and desirable activity in adipocytes and macrophages.

Journal of Medicinal Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Recommanded Product: (2-Methoxyphenyl)methanamine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Slavchev, Ivaylo published the artcileBase-promoted direct amidation of esters: beyond the current scope and practical applications, Category: ethers-buliding-blocks, the publication is RSC Advances (2022), 12(32), 20555-20562, database is CAplus and MEDLINE.

The base-promoted direct amidation of unactivated esters is among the most useful reactions for amide bond formation in contemporary organic chem. The intensive research in this area has led to the development of a number of new methods to achive this transformation. However, to date, the existing literature is more methodol. and in many instances lacks practical directions. Therefore, the full potential of this transformation is yet to be revealed by broadening the substrate scope. In a search for new practical applications of the amidation reaction, herein a comprehensive study of a number of base-promoted direct amidations that encompass a wide range of amines and esters is presented. Furthermore, authors applied their findings in the synthesis of phosphoramidates and several industrially relevant products.

RSC Advances published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C9H9ClN2, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhang, Huixia published the artcileDiscovery, SAR, and putative mode of action of N-benzyl-2-methoxybenzamides as potential bleaching herbicides, Application In Synthesis of 6850-57-3, the publication is Pest Management Science (2021), 77(6), 2804-2811, database is CAplus and MEDLINE.

Herbicides acting on biosynthesis of plant pigments have contributed greatly to weed control in recent years. In our previous studies, 2-methoxybenzamides were discovered as a novel type of lead compound for the development of bleaching herbicides. A total of 67 benzamide analogs were synthesized and evaluated for herbicidal activity. The structure-activity relationship (SAR) revealed that a methoxyl substitution at the 2-position of the benzoyl moiety is essential for the herbicidal activity of benzamide derivatives, and introduction of small substituents at the meta- or para-position of the benzylamine moiety is also beneficial. Compounds 4, 43 and 44 showed 100% inhibition against Abutilon theophrasti and Amaranthus retroflexus at an application rate of 150 g a.i. ha^-1. The relationship between the structure and herbicidal activity of 2-methoxybenzamides was discussed intensively. Compounds 4, 43 and 44 may serve as novel candidates with a bleaching effect.

Pest Management Science published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C4H12ClNO, Application In Synthesis of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Cui, Wenjing published the artcileBase-Free Oxidative Coupling of Amines and Aliphatic Alcohols to Imines over Au-Pd/ZrO₂ Catalyst under Mild Conditions, HPLC of Formula: 6850-57-3, the publication is Russian Journal of Physical Chemistry A (2021), 95(5), 958-967, database is CAplus.

The base-free synthesis of imines from amines and aliphatic alcs. over Au-Pd alloy catalysts under ambient conditions were developed. A series of Au-Pd/ZrO₂ bimetallic catalysts with varying metal loadings and Au : Pd molar ratios were prepared and their catalytic performance were investigated. The 3.0 wt % Au-Pd/ZrO₂ alloy catalyst with Au : Pd molar ratio of 1 : 1 showed the best catalytic performance. Under air atm., various imines were obtained from coupling of amines and aliphatic alcs. without any additives or promoters. The performance of alloy NPs were superior to that of monometallic catalysts due to the synergistic effect which were demonstrated by TEM, XPS, and UV-Vis characterization. Transformation differed slightly from those reactions between amine and benzyl alc. and a possible mechanism were proposed. Moreover, the Au-Pd/ZrO₂ catalyst was easily separated and reused for at least five successive runs with high catalytic activity.

Russian Journal of Physical Chemistry A published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, HPLC of Formula: 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Lu, Ye published the artcileHydrogenation of nitriles to primary amines catalyzed by an unsupported nanoporous palladium catalyst: understanding the essential reason for the high activity and selectivity of the catalyst, Recommanded Product: (2-Methoxyphenyl)methanamine, the publication is Nanoscale (2022), 14(26), 9341-9348, database is CAplus and MEDLINE.

An efficient and highly selective heterogeneous catalyst system for nitrile hydrogenation was developed using unsupported palladium nanopores (PdNPore). The PdNPore-catalyzed selective hydrogenation of nitriles proceeded smoothly, without any additives, under mild conditions (low H₂ pressure and low temperature) to yield primary amines with satisfactory to excellent yields. Systematic studies demonstrated that the high activity and excellent selectivity of the PdNPore originated from its good Lewis acidity and porous structure. No palladium leached from the PdNPore during the hydrogenation reaction. Moreover, the catalyst was easily recovered and reused without any loss of catalytic activity. A deuterium-hydrogen exchange reaction clearly indicated that the present hydrogenation involves heterolytic H₂ splitting on the surface of the PdNPore catalyst.

Nanoscale published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Recommanded Product: (2-Methoxyphenyl)methanamine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Boosa, Venu published the artcileInfluence of Bronsted acid sites on chemoselective synthesis of pyrrolidones over H-ZSM-5 supported copper catalyst, SDS of cas: 6850-57-3, the publication is Applied Catalysis, B: Environmental (2021), 120177, database is CAplus.

Cu⁽⁰⁾/H-ZSM-5 was identified as a chemoselective catalyst in the reductive amination of levulinic acid for the synthesis of pyrrolidones at ambient pressure and in aqueous media. The chemoselective nature of Cu was explained by carbonyl interaction with surface Bronsted acid sites deduced by pyridine and acetone adsorbed in situ IR spectroscopic studies in conjunction with N₂O titration A strong polarization of band at 1685 cm^-1 and an increase in its intensity with a decrease in Si/Al ratio of the H-ZSM-5 was found to be a key factor in the reductive amination activity. Structure activity relationship was established using the physicochem. characteristics of the catalysts analyzed by XRD, BET-SA, H₂-TPR, NH₃-TPD and XPS analyses.

Applied Catalysis, B: Environmental published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, SDS of cas: 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Xu, Jianyu published the artcileNickel-Catalyzed Deaminative Cyanation: Nitriles and One-Carbon Homologation from Alkyl Amines, Category: ethers-buliding-blocks, the publication is Organic Letters (2021), 23(16), 6242-6245, database is CAplus and MEDLINE.

A nickel-catalyzed deaminative cyanation of Katritzky pyridinium salts was developed. When it was coupled with formation of the pyridinium salt from primary amines, this method enabled alkyl amines to be converted to alkyl nitriles. A less toxic cyanide reagent, Zn(CN)₂, was utilized, and diverse functional groups and heterocycles were tolerated. The method also enabled a one-carbon homologation of alkyl amines via reduction of the nitrile products, in addition to many other potential transformations of the versatile nitrile group.

Organic Letters published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C15H21BO3, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Chen, Yefeng published the artcileZ-scheme g-C3N4/Fe₂O₃ for efficient photo-oxidation of benzylamine under mild conditions, Name: (2-Methoxyphenyl)methanamine, the publication is Semiconductor Science and Technology (2021), 36(7), 075004, database is CAplus.

As an important intermediate, imine is widely used in industrial chem. The photocatalytic oxidation of amines to form imines is a green and economical method. But it remains a challenge for the efficient transformation under mild conditions. Herein, a Z-scheme carbon nitride (CM)-Fe₂O₃ heterojunction photocatalyst was synthesized by in-situ preparation of Fe₂O₃ nanoparticles on two-dimensional CM nanosheets. The as-prepared catalyst exhibited efficient photocatalysis activity in selective oxidation of benzylamine to N-benzylidene benzylamine. Under ambient air and room temperature, the selectivity and conversion rate both can reach 99.9%, and the corresponding turnover frequency value reaches up to 9.99 mmol g^-1 h^-1, superior to the most of heterogeneous photocatalysts reported in previous literatures. The excellent catalytic activity of the modified CM material may be due to the enhanced absorption of visible light and the improved photogenerated carrier separation and migration rate, and the Z-scheme mechanism also retains the strong oxidation and reduction ability of the composite material. This work will provide a promising and practical method to promote the photocatalytic conversion of solar-driven organics

Semiconductor Science and Technology published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Name: (2-Methoxyphenyl)methanamine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Lu, Shu-Ning published the artcileMetal-free Synthesis of 5-Trifluoromethyl-1,2,4-triazoles via elemental sulfur promoted oxidative cyclization of trifluoroacetimidohydrazides with benzylic and aliphatic amines, Related Products of ethers-buliding-blocks, the publication is Molecular Catalysis (2022), 112336, database is CAplus.

An elemental sulfur-mediated oxidative cyclization of readily available trifluoroacetimidohydrazides and aliphatic amines has been achieved, which provided a direct avenue to structurally diverse 5-trifluoromethyl-1,2,4-triazoles. In this transformation, sulfur acts as a traceless oxidizing agent. A myriad of benzyl amines and tertiary aliphatic amines were tolerated in this protocol. The reaction can be scaled up easily and also been applied to build GlyT1 inhibitor as an example of bio-active mol.

Molecular Catalysis published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem