Category: 6850-57-3

Kawecki, Robert published the artcileSynthesis of N-sulfenylimines from disulfides and primary methanamines, Formula: C8H11NO, the publication is Journal of Organic Chemistry (2022), 87(11), 7514-7520, database is CAplus and MEDLINE.

N-sulfenylimines (sulfenimines, thiooximes, N-alkylidenesulfenamides) were efficiently synthesized through the reaction of primary amines and disulfides with NBS or bromine. This reaction can be carried out in an open flask at room temperature without the need for any transition metal-containing additives. The use of thiols instead of disulfides gave similar results. A wide range of amines were reacted with aryl and alkyldisulfides, resulting in the formation of sulfenimines in a yield of 44-99%.

Journal of Organic Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Formula: C8H11NO.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wu, Jing published the artcileDiscovery of novel paeonol-based derivatives against skin inflammation in vitro and in vivo, COA of Formula: C8H11NO, the publication is Journal of Enzyme Inhibition and Medicinal Chemistry (2022), 37(1), 817-831, database is CAplus and MEDLINE.

In this study, a series of paeonol derivatives I [R = NHMe, PhNH, BnNH, etc.] was designed and synthesized using a fragment growing approach, and their anti-inflammatory activities against lipopolysaccharide (LPS)-induced nitric oxide production in RAW264.7 cells were tested. Among them, compound I [R = 3-CF₃C₆H₄NH] yielded the best results (IC₅₀ = 2.14μM) with low toxicity (IC₅₀ > 50μM). Preliminary mechanistic studies indicated that this compound could inhibit the TOPK-p38/JNK signalling pathway and phosphorylate downstream related proteins. A murine psoriasis-like skin inflammation model was used to determine its therapeutic effect.

Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, COA of Formula: C8H11NO.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wang, Yuexin published the artcileCooperative Photocatalysis with 4-Amino-TEMPO for Selective Aerobic Oxidation of Amines over TiO₂ Nanotubes, Formula: C8H11NO, the publication is Chemistry – An Asian Journal (2021), 16(18), 2659-2668, database is CAplus and MEDLINE.

Attaching π-conjugated mols. onto TiO₂ can form surface complexes that could capture visible light. However, to make these TiO₂ surface complexes durable, integrating 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) or its analogs as a redox mediator with photocatalysis is the key to constructing selective chem. transformations. Herein, sodium 6,7-dihydroxynaphthalene-2-sulfonate (DHNS) was obtained by extending the π-conjugated system of catechol by adding a benzene ring and a substituent sodium sulfonate (-SO₃^–Na⁺). The DHNS-TiO₂ showed the best photocatalytic activity towards the blue light-induced selective aerobic oxidation of benzylamine. Compared to TEMPO, 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (4-amino-TEMPO) could rise above 70% in conversion of benzylamine over the DHNS-TiO₂ photocatalyst. Eventually, a wide range of amines could be selectively oxidized into imines with atm. O₂ by cooperative photocatalysis of DHNS-TiO₂ with 4-amino-TEMPO. Notably, superoxide (O₂^•-) is crucial in coupling the photocatalytic cycle of DHNS-TiO₂ and the redox cycle of 4-amino-TEMPO. This work underscores the design of surface ligands for semiconductors and the selection of a redox mediator in visible light photocatalysis for selective chem. transformations.

Chemistry – An Asian Journal published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C15H12O8, Formula: C8H11NO.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhang, Guo-Ning published the artcileDiscovery and optimization of 2-((1H-indol-3-yl)thio)-N-benzyl-acetamides as novel SARS-CoV-2 RdRp inhibitors, Application In Synthesis of 6850-57-3, the publication is European Journal of Medicinal Chemistry (2021), 113622, database is CAplus and MEDLINE.

The emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the global pandemic coronavirus disease (COVID-19), but no specific antiviral drug has been proven effective for controlling this pandemic to date. In this study, several 2-((indol-3-yl)thio)-N-benzyl-acetamides were identified as SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitors. After a two-round optimization, a new series of 2-((indol-3-yl)thio)-N-benzyl-acetamides was designed, synthesized, and evaluated for SARS-CoV-2 RdRp inhibitory effect. Compounds 6b2, 6b5, 6c9, 6d2, and 6d5 were identified as potent inhibitors with IC₅₀ values of 3.35 ± 0.21μM, 4.55 ± 0.2μM, 1.65 ± 0.05μM, 3.76 ± 0.79μM, and 1.11 ± 0.05μM, resp.; the IC₅₀ of remdesivir (control) was measured as 1.19 ± 0.36μM. All of the compounds inhibited RNA synthesis by SARS-CoV-2 RdRp. The most potent compound 6d5, which showed a stronger inhibitory activity against the human coronavirus HCoV-OC43 than remdesivir, is a promising candidate for further investigation.

European Journal of Medicinal Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C5H10N2OS, Application In Synthesis of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Guo, Jianan published the artcileN-Propargylamine-hydroxypyridinone hybrids as multitarget agents for the treatment of Alzheimer disease, Category: ethers-buliding-blocks, the publication is Bioorganic Chemistry (2021), 105013, database is CAplus and MEDLINE.

AD is a progressive brain disorder. Because of the lack of remarkable single-target drugs against neurodegenerative disorders, the multitarget-directed ligand strategy has received attention as a promising therapeutic approach. Herein, we rationally designed twenty-nine hybrids of N-propargylamine-hydroxypyridinone. The designed hybrids possessed excellent iron-chelating activity (pFe3+ = 17.09-22.02) and potent monoamine oxidase B inhibitory effects. Various biol. evaluations of the optimal compound 6b were performed step by step, including inhibition screening of monoamine oxidase (hMAO-B IC50 = 0.083 ± 0.001 μM, hMAO-A IC50 = 6.11 ± 0.08 μM; SI = 73.5), prediction of blood-brain barrier permeability and mouse behavioral research. All of these favorable results proved that the N-propargylamine-hydroxypyridinone scaffold is a promising structure for the discovery of multitargeted ligands for AD therapy.

Bioorganic Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wu, Shujuan published the artcileHydrazone-linked 2D porphyrinic covalent organic framework photocatalysis for visible light-driven aerobic oxidation of amines to imines, Category: ethers-buliding-blocks, the publication is Journal of Colloid and Interface Science (2022), 446-454, database is CAplus and MEDLINE.

A hydrazone-linked 2D (two-dimensional) porphyrinic COF, Por-DETH-COF, was assembled from 5,10,15,20-tetrakis(4-benzaldehyde)porphyrin (p-Por-CHO) and 2,5-diethoxyterephthalohydrazide (DETH) and its photocatalytic activity was duly appraised with the aerobic oxidation of amines. Thereby, the red light-driven selective oxidation of benzyl amines to imines RCH=NR¹ [R = Ph, 4-FC₆H₄, 2-thienyl, etc.; R¹ = t-Bu, Bn, 4-MeC₆H₄CH₂, etc.]was obtained in very high conversions and selectivities with ambient air as the oxidant. Importantly, the photocatalytic system exhibited remarkable compatibility of functional groups and extensive scope of benzyl amines. Notably, the Por-DETH-COF photocatalyst displayed outstanding recyclability after five successive cycles. This work suggests that 2D COFs could contribute a unique juncture for selective organic transformations by photocatalysis.

Journal of Colloid and Interface Science published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C11H16BNO3, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Cheng, Xiuyan published the artcilePeriodically nanoporous hydrogen-bonded organic frameworks for high performance photocatalysis, Recommanded Product: (2-Methoxyphenyl)methanamine, the publication is Nanoscale (2022), 14(27), 9762-9770, database is CAplus and MEDLINE.

The development of highly catalytic hydrogen-bonded organic frameworks (HOFs) is of great importance, but remains challenging. Herein, we demonstrate the fabrication of a periodically nanoporous HOF for high performance photocatalysis. Compared with the conventional microporous HOFs, the nanoporous HOF architecture has a larger number of free carboxyl groups on the surface and presents greatly improved photoelectrochem. properties. It exhibits high catalytic activity for the photo-oxidative coupling of amines under mild conditions such as air atm. and room temperature and without any co-catalysts, sacrificial reagents or photosensitizers. The relationship between the structure, properties and catalytic performance of the nanoporous HOF was studied by exptl. and theor. investigations. It shows that such a HOF structure facilitates reactant adsorption and O₂ dissociation, thus promoting the oxidative coupling reaction. This work provides a new way for improving the catalytic performance of a single HOF.

Nanoscale published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Recommanded Product: (2-Methoxyphenyl)methanamine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhang, Huan-Huan published the artcilePhotocatalytic Hydrogen Evolution Coupled with Production of Highly Value-Added Organic Chemicals by a Composite Photocatalyst CdIn₂S₄@MIL-53-SO₃Ni_1/2, Synthetic Route of 6850-57-3, the publication is Chemistry – An Asian Journal (2021), 16(11), 1499-1506, database is CAplus and MEDLINE.

Photocatalytic water splitting coupled with the production of highly value-added organic chems. is of significant importance, which represents a very promising pathway for transforming green solar energy into chem. energy. Herein, we report a composite photocatalyst CdIn₂S₄@MIL-53-SO₃Ni_1/2, which is highly efficient on prompting water splitting for the production of H₂ in the reduction half-reaction and selective oxidation of organic mols. for the production of highly value-added organic chems. in the oxidation half-reaction under visible light irradiation The superior photocatalytic properties of the composite photocatalyst CdIn₂S₄@MIL-53-SO₃Ni_1/2 should be ascribed to coating suspended ion catalyst (SIC), consisting of redox-active Ni^II ions in the anionic pores of coordination network MIL-53-SO₃^–, on the surface of photoactive CdIn₂S₄, which endows photogenerated electron-hole pairs sep. more efficiently for high rate production of H₂ and selective production of highly value-added organic products, demonstrating great potential for practical applications.

Chemistry – An Asian Journal published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C5H10Cl3O3P, Synthetic Route of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wei, Yanze published the artcileCdSe 1D/2D Mixed-Dimensional Heterostructures: Curvature-Complementary Self-Assembly for Enhanced Visible-Light Photocatalysis, SDS of cas: 6850-57-3, the publication is Small (2021), 17(33), 2102047, database is CAplus and MEDLINE.

Mixed-dimensional heterostructures (MDHs), which combine nanomaterials of different dimensionalities deliver on the promise to bypass intrinsic limitations of a given low-dimensional material. Here, a strategy to engineer MDHs between two low-dimensional materials by curvature-complementary self-assembly is described. CdSe nanotubes rolled from 2D nanosheets and 1D CdSe nanorods, with neg. and pos. curvatures, resp., are selected to illustrate complementary curvature self-assembly. The assembly process, optical, and photoelec. properties of the CdSe MDHs are thoroughly investigated. Several remarkable features of CdSe MDHs, including increased light absorption, efficient charge separation, and appropriate bandgap structure are confirmed. The MDHs significantly alleviate the sluggish kinetics of electron transfer in the quantum sized CdSe subunits (onset potential of 0.21 V vs RHE for MDHs; 0.4 V lower than their low-dimensional building blocks), while the spatial nano-confinement effect in the CdSe MDHs also assists the interfacial reaction kinetics to render them ideal photocatalysts for benzylamine oxidation (conversion > 99% in 4 h with a two times higher rate than simple mixtures). The results highlight opportunities for building MDHs from low-dimensional building blocks with curvature-complementary features and expand the application spectrum of low dimensional materials in artificial photosynthesis.

Small published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is Al2H32O28S3, SDS of cas: 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Li, Xia published the artcileExtending the 2D conjugated microporous polymers linked by thiazolo[5,4-d]thiazole for green light-driven selective aerobic oxidation of amines, Safety of (2-Methoxyphenyl)methanamine, the publication is Journal of Materials Chemistry A: Materials for Energy and Sustainability (2022), 10(28), 14965-14975, database is CAplus.

Donor-π-acceptor (D-π-A) type CMPs linked by the electron-deficient thiazolo[5,4-d]thiazole (TzTz, i.e. the acceptor) were designed by extending the donor from benzene to pyrene to broaden the visible light activity. Subsequently, two-dimensional (2D) CMPs, TzTz-CMP-Be and TzTz-CMP-Py, were constructed via a solvothermal process. The more extended π-conjugation and planar pyrene bestow upon TzTz-CMP-Py with broader absorption of visible light and higher efficiency of charge transfer than TzTz-CMP-Be. Significantly, TzTz-CMP-Py outperformed TzTz-CMP-Be in the green light-driven selective aerobic oxidation of amines RCH₂NHR¹ [R = Ph, pyridin-2-yl, thiophen-2-yl, etc.; R¹ = H, t-Bu, Bn, 4-fluorobenzyl, etc.]. Remarkable photocatalytic performance was observed in converting a wealth of primary and secondary amines to corresponding imines RCH=NR¹ with mol. oxygen (O₂) over TzTz-CMP-Py. This work suggests that CMPs can be rationally designed for extensive visible light-driven selective organic transformations.

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Safety of (2-Methoxyphenyl)methanamine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem