Category: 673-22-3

《The crystal structure of (5-chloro-2-hydroxy-N-(4-methoxy-2-oxidobenzylidene)benzohydrazonato-κ3N,O,O′)-(pyridine-κ1N)copper(II), C20H16ClCuN3O4》 was published in Zeitschrift fuer Kristallographie – New Crystal Structures in 2020. These research results belong to Xin, Wang; Li, Shuli; Yang, Liguo; Song, Haixiang; Niu, Yongsheng. Safety of 2-Hydroxy-4-methoxybenzaldehyde The article mentions the following:

C20H16ClCuN3O4, triclinic, P1[n.772] (number 2), a = 7.629(4) Å, b = 8.893(5) Å, c = 14.193(8) Å, α = 88.603(6)°, β = 81.093(6)°, γ = 83.715(6)°, V = 945.6(9) Å3, Z = 2, Rgt(F) = 0.0245, wRref(F2) = 0.0709, T = 296(2) K. CCDC number: 1964895. 2-Hydroxy-4-methoxybenzaldehyde 5-chlorosalicylhydrazide (0.32 g, 1 mmol) in 10 mL methanol and 1 mL pyridine was stirred at room temperature for 1 h. The mixture was filtered, and left at room temperature After a few days, colorless block crystals formed. Yield (0.22 g, 50%). In the experiment, the researchers used many compounds, for example, 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Safety of 2-Hydroxy-4-methoxybenzaldehyde)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Safety of 2-Hydroxy-4-methoxybenzaldehyde

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The author of 《Evaluation of phytochemical compounds and antimicrobial activities of Hemidesmus indicus》 were Ashalatha, K. S.; Raja, Shantha Reddy A.; Raveesha, H. R.. And the article was published in Asian Journal of Pharmaceutical and Clinical Research in 2019. Category: ethers-buliding-blocks The author mentioned the following in the article:

The present study was aimed to investigate the phytochem. screening, antibacterial activities, and identification of bioactive compounds by gas chromatog.-mass spectrometry (GC-MS) and high-performance liquid chromatog. (HPLC) in Hemidesmus indicus root extracts The qual. and quant. phytochem. anal. was carried out using standard methods. Bioactive compounds were identified by GC-MS and HPLC anal. Antibacterial activity of different solvent extracts was carried out using the agar well diffusion method. Preliminary phytochem. anal. showed the presence of phenols, tannins, alkaloids, flavonoids, proteins, reducing sugar, glycosides, amino acids, steroids, terpenoids, resins, volatile oil, emodols, and coumarins. Total phenolic and flavonoid contents were higher in the methanolic extracts compared to other solvent extracts 2-hydroxy 4-methoxy benzaldehyde was identified as the major compound The maximum zone of inhibition was observed in the methanolic extracts of root against Klebsiella pneumoniae, Staphylococcus aureus, and Escherichia coli. Our results suggest that H. indicus plant contains many chem. compounds and its root exhibits the wide range of antimicrobial activity. Further studies have to be carried out regarding the in vitro multiplication of plant and to enhance the root flavoring compounds for medicinal, food, and beverage industries. In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Category: ethers-buliding-blocks)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Category: ethers-buliding-blocks

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Gharpure, Santosh J.; Jegadeesan, S.; Vishwakarma, Dharmendra S. published an article in 2021. The article was titled 《Acid-catalysed iterative generation of o-quinone methides for the synthesis of dioxabicyclo[3.3.1]nonanes: total synthesis of myristicyclins A-B》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Recommanded Product: 673-22-3 The information in the text is summarized as follows:

A practical and efficient method for the synthesis of bioactive flavanoids relying on the strategic use of o-quinine methide (o-QM) intermediates was reported. This involved Bronsted acid-catalyzed iterative generation of o-QMs/[4+2] cycloaddition/intermol. Michael addition/cyclative acetalization in a cascade sequence for the synthesis of dioxabicyclo[3.3.1]nonanes I [R1 = H, 7-OMe, 8-OMe; R2 = H, CO2Me, CO2Et; R3 = H, Me, Ph, etc.]. The ‘one-pot’, controlled cascade sequence successfully provided the shortest route amenable for gram scale synthesis of natural products (±)-myristicyclins A-B II and III. In the experimental materials used by the author, we found 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Recommanded Product: 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Recommanded Product: 673-22-3

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Ndima, Lubabalo; Hosten, Eric C.; Betz, Richard published an article in 2021. The article was titled 《Crystal structure of 2-hydroxy-4-methoxy benzaldehyde, C8H8O3》, and you may find the article in Zeitschrift fuer Kristallographie – New Crystal Structures.Recommanded Product: 673-22-3 The information in the text is summarized as follows:

C8H8O3, monoclinic, P21/c (number 14), a = 6.3037(3) Å, b = 33.102(2) Å, c = 7.0471(4) Å, β = 102.105(3)°, V = 1437.79(14) Å3, Z = 8, R gt(F) = 0.0433, wR ref(F 2) = 0.1087, T = 200 K. In the experiment, the researchers used many compounds, for example, 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Recommanded Product: 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Recommanded Product: 673-22-3

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《A novel near-infrared turn-on fluorescent probe for the detection of Fe3+ and Al3+ and its applications in living cells imaging》 was written by Li, Bai; Mei, Huihui; Chang, Yongxin; Xu, Kuoxi; Yang, Li. Computed Properties of C8H8O3 And the article was included in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 2020. The article conveys some information:

A new hemicyanidine-based colorimetric-fluorescent probe L (I) has been synthesized and characterized by x-ray single crystal diffraction, NMR, HRMS and other technologies. The probe L serves as a “”turn-on”” probe for the detection of Fe3+ and Al3+ ions in DMF-HEPES system with a high sensitivity and an excellent selectivity. The probe L manifesting the color of the solution containing L turns red on the addition of Fe3+, and turns pink on the addition of Al3+. The fluorescence turn-on detection of Fe3+ and Al3+ ions is attributed to the photo-induced electron transfer (PET) process and the exertion of the chelation-enhanced fluorescence effect (CHEF) mechanism. The results of thin layer silica gel plate coloration experiments also present the same characteristics. Addnl., further the probe L exhibit good cell permeability and could be employed to monitor Fe3+ and Al3+ ions in the living cells. The experimental part of the paper was very detailed, including the reaction process of 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Computed Properties of C8H8O3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Computed Properties of C8H8O3

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《A colorimetric and near-infrared ratiometric fluorescent probe for hydrazine detection and bioimaging》 was published in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 2020. These research results belong to Wu, Cuiyan; Xie, Ruihua; Pang, Xiao; Li, Yaqian; Zhou, Zile; Li, Haitao. Quality Control of 2-Hydroxy-4-methoxybenzaldehyde The article mentions the following:

Hydrazine (N2H4) is extensively used in industry but highly toxic; hence, highly sensitive detection of N2H4 is extremely meaningful. Herein, a colorimetric and near-IR (NIR) ratiometric fluorescent probe named DXM-OH was rationally designed and synthesized based on oxanthrene malononitrile derivative for the specific detection of N2H4. The dicyanovinyl group in DXM-OH was served as the recognition unit for N2H4. DXM-OH showed high sensitivity to N2H4 in the range of 1-900 μM, with the limit of detection (LOD) of 0.09 μM (2.87 ppb), which is much lower than the U. S. Environmental Protection Agency standard (10 ppb). Furthermore, the practical applications of DXM-OH in detecting N2H4 in real water samples and imaging of N2H4 in living cells were demonstrated, indicating its potential utility for N2H4 sensing in environmental and biol. samples. In the experiment, the researchers used many compounds, for example, 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Quality Control of 2-Hydroxy-4-methoxybenzaldehyde)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Quality Control of 2-Hydroxy-4-methoxybenzaldehyde

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The author of 《A novel near-infrared fluorescent probe for detecting intracellular alkaline phosphatase and imaging of living cells》 were Xu, Longbin; He, Xu; Huang, Yibing; Ma, Pinyi; Jiang, Yanxiao; Liu, Xin; Tao, Shuo; Sun, Ying; Song, Daqian; Wang, Xinghua. And the article was published in Journal of Materials Chemistry B: Materials for Biology and Medicine in 2019. Electric Literature of C8H8O3 The author mentioned the following in the article:

Development of novel near-IR (NIR) fluorescent probes for the monitoring of active substances in living organism is desirable in biol. studies. Herein, we designed a novel NIR MTR fluorophore which has a longer emission wavelength, greater Stokes shift and higher quantum yield than the classic hemicyanine NIR fluorophore. The synthesized MTR-derived NIR probe (MTR-P, I) is highly selective and sensitive to alk. phosphatase (ALP) activity. In the presence of ALP, MTR-P exhibited increased fluorescence signal by up to 56 fold at 723 nm, and it was determined to be 0.042 U L-1. In addition, the mechanism of the MTR-P probe was further examined by HPLC, mass spectrometry and DFT/TDDFT calculations The NIR probe MTR-P was successfully applied to measure the levels of alk. phosphatase in different types of cells by fluorescence imaging. The experimental process involved the reaction of 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Electric Literature of C8H8O3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Electric Literature of C8H8O3

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COA of Formula: C8H8O3In 2020 ,《Experimental and theoretical investigation of ground state intramolecular proton transfer (GSIPT) in salicylideneaniline Schiff base derivatives in polar protic medium》 was published in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy. The article was written by Das, Bijoya; Chakraborty, Amrita; Chakraborty, Shamik. The article contains the following contents:

Ground state intramol. proton transfer process has been comprehensively investigated in three salicylideneaniline Schiff base derivatives (SB1, SB2, and SB3) using exptl. and theor. methods. It has been confirmed that all the three Schiff base mols. in the ground electronic state exist in the enol form in non-polar and polar aprotic solvents. Keto form is being populated by the polar protic solvent through ground state intramol. proton transfer (GSIPT) process. Ground state equilibrium between the enol and keto tautomers for SB1 and SB3 is mainly governed by the proton donating ability of the solvent. Ground state equilibrium between the enol and keto tautomers of SB2 which is a positional isomer of SB3 is governed by the polarity and proton donating ability of the solvents. Excited state intramol. proton transfer (ESIPT) process is also evidenced in all the three Schiff base mols. Theor. calculations at the B3LYP/cc-pVDZ level in the gas phase and in different solvents using polarisable continuum model (PCM) have failed to establish the GSIPT process. Microsolvation of individual enol and keto conformers has been investigated considering upto three solvent mols. The energetics of the individual conformers together with the corresponding transition state have been calculated It has been confirmed that the keto conformer is more stable compared to the enol conformer in microsolvated cluster of three methanol mols. Lowering of activation energy for the enol to keto tautomerisation in the presence of methanol also supports the exptl. observation for GSIPT process. TDDFT/B3LYP/cc-pVDZ single point calculations for microsolvated clusters of enol and keto form of the Schiff base mols. exhibit an excellent agreement with the exptl. obtained absorption spectra. Difference in spectral nature of the Schiff base mols. has been explained using natural bond orbital (NBO) anal. Quantum theory of atoms in mols. (QTAIM) has also been utilized to understand the GSIPT process in detail. The results came from multiple reactions, including the reaction of 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3COA of Formula: C8H8O3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.COA of Formula: C8H8O3

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《Quadruple Bond Forming Multicomponent Approach to 5-(3-chromenyl)-5H-chromeno[2,3-b]pyridines and Its Interaction with the Neuropeptide Y1 Receptor》 was published in Chemistry of Heterocyclic Compounds (New York, NY, United States) in 2020. These research results belong to Ryzhkov, Fedor V.; Ryzhkova, Yuliya E.; Elinson, Michail N.; Vereshchagin, Anatoly N.; Korolev, Victor A.; Egorov, Mikhail P.. Application of 673-22-3 The article mentions the following:

A new multicomponent, one-pot reaction yielding previously unknown 5-(4-hydroxy-2-oxo-2H-chromen-3-yl)-5H-chromeno[2,3-b]pyridines I (R1 = H, OMe, OEt, Br; R2 = H, OH, OMe; R3 = H, Br, Cl, NO2) in 52-94% yield has been found. This multicomponent approach allows to construct four new bonds to synthesize some 5H-chromeno[2,3-b]-pyridines I under mild conditions. Mol. docking and dynamics studies of the synthesized structures I were carried out to identify their interaction with the binding pocket of the neuropeptide Y1 receptor. After reading the article, we found that the author used 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Application of 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Application of 673-22-3

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Ether – Wikipedia,
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《Palladium(II) complexes with thione and thioalkylated thiosemicarbazones: Electrochemical, antimicrobial and thermogravimetric investigations》 was written by Eglence-Bakir, Songul; Sahin, Musa; Salt, Betul Zehra; Tuzun, Elif; Kara, Emel Mataraci; Atun, Gulten; Cavus, Selva; Kizilcikli, Irfan. Electric Literature of C8H8O3 And the article was included in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 2020. The article conveys some information:

Four methoxy substitute salicylidene thiosemicarbazones were synthesized. The reaction of both thione and thioalkylated thiosemicarbazones with PdCl2 in ethanol yields ONS-coordinated chelate complexes with general formula [Pd(L)Cl]. The structures of eight compounds were characterized by using anal. and spectroscopic methods. Electrochem. of the Pd(II) complexes was studied using cyclic voltammetric technique. The CVs of the complexes were quite complicate because of some oxidative responses of the ligands which proceed by forming conjugated -N:CH-, -HC:CH- and -N:CH-HC:CH- groups. Two cathodic responses attributed to one electron reduction of Pd(II)/(I) and Pd(I)/(0) were observed for the central ion coordinated with S atom of H3C-S- group whereas only one reduction peak appeared when the Pd(II) coordinated with S atom of >C:S group of thiosemicarbazone ligand. The latter also showed an addnl. anodic response assigned to Pd(II)/(III) oxidation Thermogravimetric anal. (TGA) technique was used to investigate and compare the thermal properties of the ligands and their metal complexes. In vitro antimicrobial activity of thiosemicarbazones and their complexes was evaluated against four Gram-neg. bacteria, three Gram-pos. bacteria, and antifungal activity against three fungi. After reading the article, we found that the author used 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Electric Literature of C8H8O3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Electric Literature of C8H8O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem