Category: 673-22-3

《Microwave-assisted Single Step Cinnamic Acid Derivatization and Evaluation for Cytotoxic Potential》 was published in Current Pharmaceutical Biotechnology in 2020. These research results belong to Mishra, Sonali; Singh, Shilpi; Ali, Arif; Gupta, Amit C.; Shanker, Karuna; Bawankule, Dnyaneshwar U.; Luqman, Suaib. Related Products of 673-22-3 The article mentions the following:

Background: Phenylpropylene biosynthesis pathway plays a crucial role in the vanillin and their derivative(s) production in the plants. The intermediate of vanillin synthesis i.e. cinnamic acid (CA) is converted into 2-Hydroxy 4-MethoxyBenzaldehyde (HMB) in Decalepis arayalpathra having a number of therapeutic value. Objective: Microwave-assisted modifications in cinnamic acid were planned for potential anticancer properties with better yield and efficiency. The present study also confirms the presence of HMB and its precursor i.e. cinnamic acid in D. arayalpathra tubers. Methods: We used a single step Microwave Assisted Synthesis (MAS) to modify cinnamic acid, and then examined the synthetic and natural cinnamic acid derivatives anticancer potential against six human cancer (K-562, WRL-68, A549, A431, MCF-7, and COLO-201) and two normal (L-132 and HEK-293) cell lines at 2, 10 and 50μg/mL concentrations Results: β-bromostyrene and β -nitrostyrene have shown inhibition with IC50 values ranging 0.10-21μM and 0.03-0.06μM, resp. to the cancer cell lines. β-bromostyrene was the most potent anticancer derivative of CA with better cellular safety and biocompatibility. Conclusion: The present study of microwave-assisted synthesis demonstrates a single-step modification in cinnamic acid. MAS is a fast, reliable, and robust method. The resultant compounds have shown in-vitro anticancer activity against human lung carcinoma and breast adenocarcinoma. In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Related Products of 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Related Products of 673-22-3

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Wang, Xiaxia; Xiang, Dinglei; Wang, Ziyi; Wang, Zhaoguo; Yang, Xue; Yu, Shuai; Pang, Qiuxia; Liu, Sheng; Yan, Li published their research in Ecotoxicology and Environmental Safety in 2021. The article was titled 《Label-free quantitative proteomics analysis of Humulus scandens (Lour.) Merr. leaves treated by an odor compound of Periploca sepium Bunge》.Computed Properties of C8H8O3 The article contains the following contents:

The odor compound from Periploca sepium Bunge, 2-hydroxy-4-methoxy-benzaldehyde (HMB), is an allelochem. agent and is one of the least investigated isomers of vanillin. In this study, we used label-free quant. proteomics anal. technol. to investigate the effect of HMB on the protein expression of Humulus scandens (Lour.) Merr. leaves in July 2019 on Guiyang. A total of 269 proteins of 624 identified proteins were differentially expressed, among which 21.18% of the proteins were up-regulated and 32.71% down-regulated. These proteins were classified into 11 cell components and more than 20% of differentially expressed proteins were located in cell membrane and chloroplast. Functional classification anal. showed that 12 mol. functions were altered upon HMB treatment, and the ratio of catalytic activity was the highest (19.53%). At least 12 biol. functions were affected, which involved small mol. metabolic processes, organic substance metabolic processes, gene expression, and photosynthesis. Our data provide resources and insights into the biochem. mechanism by which HMB kills weeds. The experimental process involved the reaction of 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Computed Properties of C8H8O3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Computed Properties of C8H8O3

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Name: 2-Hydroxy-4-methoxybenzaldehydeIn 2020 ,《Enantioselective Construction of Spirooxindole-Fused Cyclopenta[c]chromen-4-ones Bearing Five Contiguous Stereocenters via a Stepwise (3+2) Cycloaddition》 was published in Advanced Synthesis & Catalysis. The article was written by Vagh, Sandip Sambhaji; Karanam, Praneeth; Liao, Cheng-Chieh; Lin, Ting-Han; Liou, Yan-Cheng; Edukondalu, Athukuri; Chen, Yi-Ru; Lin, Wenwei. The article contains the following contents:

The bifunctional quinine-catalyzed stepwise (3+2) cycloaddition for the enantioselective construction of spirooxindole-fused cyclopenta[c]chromen-4-ones, e.g., I was developed. The reactions of 3-homoacylcoumarins and alkylidene oxindole electrophiles generate aforementioned spirooxindole-chromenone adducts bearing five contiguous stereocenters, of which one was the spiro all-carbon quaternary stereocenter in high yields (up to 99%) with excellent stereoselectivities (up to >20:1 dr and 99% ee). This methodol. was investigated for three different alkylidene oxindole electrophiles and could also be practically demonstrated on a gram scale. Mechanistic investigations revealed that the (3+2) cycloaddition for the enantioselective synthesis of spirooxindole-fused cyclopenta[c]chromen-4-ones was proceeding via a stepwise reaction pathway. In the experiment, the researchers used many compounds, for example, 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Name: 2-Hydroxy-4-methoxybenzaldehyde)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Name: 2-Hydroxy-4-methoxybenzaldehyde

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In 2019,Angewandte Chemie, International Edition included an article by Wang, Huamin; Zhang, Junyou; Tu, Youshao; Zhang, Junliang. Related Products of 673-22-3. The article was titled 《Phosphine-Catalyzed Enantioselective Dearomative [3+2]-Cycloaddition of 3-Nitroindoles and 2-Nitrobenzofurans》. The information in the text is summarized as follows:

Over the past years, the metal-catalyzed dearomative cycloaddition of 3-nitroindoles and 2-nitrobenzofurans have emerged as a powerful protocol to construct chiral fused heterocyclic rings. However, organocatalytic dearomative reaction of these two classes of heteroarenes has become a long-standing challenging task. Herein, a report on the first example of phosphine-catalyzed asym. dearomative [3+2]-cycloaddition of 3-nitroindoles and 2-nitrobenzofurans, which provides a new, facile, and efficient protocol for the synthesis of chiral 2,3-fused cyclopentannulated indolines and dihydrobenzofurans by reacting with allenoates and MBH carbonates, resp. through a dearomative [3+2]-cycloaddn has been described. In the experimental materials used by the author, we found 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Related Products of 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Related Products of 673-22-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Synthesis and evaluation of antimicrobial and antioxidant activity of novel 7-Aryl-6H,7H-benzo[f]chromeno[4,3-b]chromen-6-one by MgO nanoparticle as green catalyst》 was published in Journal of Heterocyclic Chemistry in 2020. These research results belong to Hosseinzadegan, Sara; Hazeri, Nourallah; Maghsoodlou, Malek T.. Formula: C8H8O3 The article mentions the following:

Novel 7-aryl-6H,7H-benzo[f]chromeno[4,3-b]chromen-6-one derivatives I [R = C6H5, 4-MeOC6H4, 3-O2NC6H4, etc.] were synthesized via multicomponent reaction of 2-naphthol, aldehyde derivatives, 4-hydroxycoumarin using MgO nanoparticles as a recyclable and efficient catalyst. This method offered some benefits such as shorter time, high yields and concordance with green chem. All the synthesized compounds were evaluated for their antibacterial, antifungal and antioxidant activities. The results came from multiple reactions, including the reaction of 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Formula: C8H8O3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Formula: C8H8O3

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《Ultrasound assisted eco-friendly synthesis of 3-cinnamoyl coumarins using N,N’-(1,2-phenylene)bis(2-aminobenzamide)dichloro cobalt immobilized on mesoporous Al-SBA-15 as a new and recyclable catalyst》 was published in Green Chemistry Letters and Reviews in 2020. These research results belong to Akbarzadeh, Zeinab; Safaei-Ghomi, Javad. Safety of 2-Hydroxy-4-methoxybenzaldehyde The article mentions the following:

A novel mesoporous Al-SBA-15 modified by N,N’-(1,2-phenylene)bis(2-aminobenzamide) dichloro cobalt has been prepared and applied as a reusable catalyst in the 3-cinnamoyl coumarins I (R = 4-Br, 2-OH, 4-F, etc.; R1 = H, 7-OMe, 6-OMe, 6-Br) synthesis via three-component reaction between benzaldehydes RC6H4CHO, salicylaldehydes like salicylaldehyde, 2-hydroxy-4-methoxybenzaldehyde, 2-hydroxy-5-methoxybenzaldehyde, 5-bromo-2-hydroxybenzaldehyde and Et acetoacetate by the assist of ultrasonic irradiation By using the nanocatalyst and also ultrasound irradiation, the facility and velocity of the above mentioned reaction were enhanced and an environment friendly condition was provided to synthesis of various 3-cinnamoyl coumarin compounds I. The properties and structure of nanocatalyst have been specified by methods including powder X-ray diffraction (XRD), energy dispersive spectroscopy (EDS), Fourier transform IR spectroscopy (FT-IR), transmission electron microscopy (TEM), nitrogen adsorption-desorption anal. and scanning electronic microscopy (SEM). Superiority of this novel and viable method is due to mild reaction condition, short reaction times, high yields of 3-cinnamoyl coumarins I, environmentally benign, recoverability of the CoCl2N,N’-(1,2-phenylene)bis (2-aminobenzamide)/Al-SBA-15 catalyst and reusability with important preservation in its catalytic activity. The experimental process involved the reaction of 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Safety of 2-Hydroxy-4-methoxybenzaldehyde)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Safety of 2-Hydroxy-4-methoxybenzaldehyde

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In 2019,Indian Journal of Heterocyclic Chemistry included an article by Yang, Qianqian; Tian, Shaopeng; Wu, Jing; Gao, Wu; Guo, Huining. Electric Literature of C8H8O3. The article was titled 《Facile Synthesis of New 4-Aryl-2,6-di(7-methoxycoumarin-3-yl)pyridines and their Fluorescent Properties》. The information in the text is summarized as follows:

A series of 4-aryl-2,6-di(7-methoxycoumarin-3-yl)pyridines I (R = OCH3, OH, Cl, NO2) was synthesized in the presence of Cesium Fluoride (CsF) catalyst through a facile one-pot synthesis method for the 1st time. The UV absorption and fluorescent properties of these compounds dissolved in chloroform were also investigated, which show a remarkable potential applicability in the area of fluorescent emitting materials. In the experiment, the researchers used 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Electric Literature of C8H8O3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Electric Literature of C8H8O3

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In 2022,AL-Shammri, Khairiah Nasser; Elkanzi, Nadia A. A.; Arafa, Wael A. A.; Althobaiti, Ibrahim O.; Bakr, Rania B.; Moustafa, Shaima Mohamed Nabil published an article in Arabian Journal of Chemistry. The title of the article was 《Novel indan-1,3-dione derivatives: Design, green synthesis, effect against tomato damping-off disease caused by Fusarium oxysporum and in silico molecular docking study》.Category: ethers-buliding-blocks The author mentioned the following in the article:

An effective method for synthesizing series of twenty-two new compounds was performed starting from reaction of 1,2,3-indenetrione thiourea, and Et cyanoacetate under microwave irradiation and / or 2-(1,3-dioxo-1H-inden-2(3H)-ylidene) hydrazine carbothioamide with acetic anhydride. The designed new compounds have been successfully examined in-vitro for their antifungal activities. The relation between the structure of the synthesized compounds and their activity against tomato damping-off disease caused by Fusarium oxysporum fungi was studied and favorable results were obtained. The antifungal studies indicated that few compounds exerted the highest antifungal activities, while 7′-thioxo-7′,8′-dihydrospiro[indene-2,5′-pyrimido[4,5-d][1,3]oxazine]-1,3,4′(6’H)-trione and Et 6′-(4-hydroxybenzylideneamino)-1,3-dioxo-2′-thioxo-1,2′,3,3′-tetrahydro-1’H-spiro [indene-2,4′-pyrimidine]-5′-carboxylate recorded the lowest effect. The obtained results confirmed the possibility of the application of Et 6′-amino-1,3-dioxo-2′-thioxo-1,2′,3,3′-tetrahydro-1’H-spiro[indene-2,4′-pyrimidine]-5′-carboxylate as a new effective regulator of the vegetative growth of tomatoes. The mol. docking anal. was performed within succinate dehydrogenase (SDH) as a target enzyme in order to rationalize the promising findings obtained for the active compounds In the experiment, the researchers used many compounds, for example, 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Category: ethers-buliding-blocks)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Category: ethers-buliding-blocks

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Product Details of 673-22-3In 2021 ,《Unsymmetrical Pyridoxal-Based Bisazomethines》 appeared in Russian Journal of General Chemistry. The author of the article were Bagautdinova, R. H.; Kibardina, L. K.; Burilov, A. R.; Pudovik, M. A.. The article conveys some information:

The reaction of equimolar amounts of pyridoxal and 1,2-propylenediamine led to the formation of monoimine I, which exists as cyclic imidazolidine tautomer II. The latter reacts with aromatic aldehydes ArCHO to form unsym. bisazomethines, e.g., III. The reaction of II with Ph isocyanate produces a compound containing a carbamate group, IV, and the reaction with hydrochloric acid leads to the formation of a salt-based furopyridine. After reading the article, we found that the author used 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Product Details of 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Product Details of 673-22-3

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Product Details of 673-22-3In 2020 ,《Indian sarsaparilla, Hemidesmus indicus (L.) R. Br. ex Schult: tissue culture studies》 appeared in Applied Microbiology and Biotechnology. The author of the article were Kher, Mafatlal M.; Shekhawat, Mahipal S.; Nataraj, M.; Teixeira da Silva, Jaime A.. The article conveys some information:

A review. Abstract: Hemidesmus indicus (L.) R. Br. ex Schult is commonly known as anantmul or Indian sarsaparilla. The roots of this plant, which display a wide range of medicinal, biol., and phytopharmaceutical properties, are used in the pharmaceutical and food industries. Conventionally, the plant is propagated by seed germination or vegetatively, but the efficacy of traditional methods has some limitations: plants derived from seed germination are prone to seed-borne diseases, or plantlet production using vegetative propagation is limited. In contrast, plant tissue culture allows for large-scale propagation and secondary metabolite production in vitro without sacrificing plants from their natural habitats. Many efforts have been made over 40 years of research to establish efficient micropropagation protocols to speed up cultivation of this plant, including callus-mediated in vitro propagation, somatic embryogenesis, and shoot multiplication using cotyledenory nodes, stem segments, shoot tips, and nodal explants. Among these explants, nodal explants are the most commonly used for H. indicus micropropagation. The application of adenine sulfate, citric acid, ascorbic acid, and arginine may be useful in preventing explant browning, premature leaf senescence, and shoot tip abscission during in vitro culture. This review provides insight into micropropagation, use of synthetic seeds for short-term germplasm preservation, and in vitro production of secondary metabolites such as 2-hydroxy-4-methoxybenzaldehyde, lupeol, vanillin, and rutin, from in vitro root and callus cultures. Furthermore, unexplored and possible innovative areas of research in Hemidesmus biotechnol. are also discussed. Key Points: • Hemidesmus indicus has multiple therapeutic applications. • H. indicus roots are used in confectionary and pharmacy. • This review comprehensively assesses H. indicus tissue culture. • Challenges and future research of H. indicus biotechnol. are discussed. In the experiment, the researchers used many compounds, for example, 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Product Details of 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Product Details of 673-22-3

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