Category: 673-22-3

Lupascu, Gina; Pahontu, Elena; Shova, Sergiu; Barbuceanu, Stefania Felicia; Badea, Mihaela; Paraschivescu, Codruta; Neamtu, Johny; Dinu, Mihaela; Ancuceanu, Robert Viorel; Draganescu, Doina; Dinu-Pirvu, Cristina Elena published their research in Applied Organometallic Chemistry in 2021. The article was titled 《Co(II), Cu(II), Mn(II), Ni(II), Pd(II), and Pt(II) complexes of bidentate Schiff base ligand: Synthesis, crystal structure, and acute toxicity evaluation》.HPLC of Formula: 673-22-3 The article contains the following contents:

5-Methoxy-2-(((2-chloro-5-(trifluoromethyl)phenyl)imino)methyl)phenol (HL) and its cobalt(II), copper(II), manganese(II), nickel(II), palladium(II), and platinum(II) complexes, [Co(L)2]·4H2O (1), [Cu(L)2] (2), [Mn(L)2(H2O)2]·H2O (3), [Ni(L)2] (4), [Pd(L)2] (5), [Pt(L)2] (6), were synthesized and characterized. The compounds were investigated by different physico-chem. techniques including IR, 1H-NMR, 13C-NMR, UV-Vis, mass spectroscopies, elemental and thermal anal., magnetic susceptibility measurements, and molar elec. conductivity The mol. structures of the HL ligand and copper(II), nickel(II), and palladium(II) complexes were confirmed by x-ray crystallog. anal. on the monocrystal. Each metal ion, in these complexes, is four-coordinated in N2O2 coordination environment. The coordination geometry of Ni2+ and Pd2+ is square planar due to crystallog. imposed inversion symmetry of the metal centers, and the coordination geometry of copper atom can be described as tetrahedrally distorted square planar. The assessed toxicity of the ligand and its complex combinations on plant cell of Triticum aestivum L. were macroscopically and microscopically consistent. The same substances were investigated for the animal cell toxicity on crustacean Artemia Franciscan Kellogg, and Mn2+ complex did not record any lethal effect. The experimental part of the paper was very detailed, including the reaction process of 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3HPLC of Formula: 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.HPLC of Formula: 673-22-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Safety of 2-Hydroxy-4-methoxybenzaldehydeIn 2019 ,《Synthesis of new TCH/Ni-based nanocomposite supported on SBA-15 and its catalytic application for preparation of benzimidazole and perimidine derivatives》 was published in Applied Organometallic Chemistry. The article was written by Kalhor, Mehdi; Rezaee-Baroonaghi, Fahimeh; Dadras, Akbar; Zarnegar, Zohre. The article contains the following contents:

A stable nickel-decorated SBA-15 nanocomposite (Ni/TCH@SBA-15) was synthesized through surface modification of silica nanoparticles with 3-chloropropyltriethoxysilane (CPTES) and thiocarbohydrazide (TCH) followed by metal-ligand coordination with Ni(II). The structure of this organometallic nanocomposite was characterized by Fourier transform-IR, field emission-SEM, EDAX, transmission electron microscopy, at. absorption spectroscopy and N2 adsorption-desorption (Brunauer-Emmett-Teller) techniques. The catalytic performance of Ni/TCH@SBA-15 (NNTS-15) was determined for synthesis of 2-aryl-substituted benzimidazoles I [R1 = H, Me, NO2; R2 = H, 4-MeO, 2,3-di-Cl, etc.] and 2,3-dihydroperimidines II. The excellent yields within shorter reaction times, simplicity of catalytic methods, non-toxicity and clean reactions, mild reaction conditions and easy work-up procedure were important merits of these synthetic protocols. Moreover, the Ni(II) bonded to SBA-15 surface was stable under catalytic reaction conditions resulting in its efficient recycling and reuse. The experimental process involved the reaction of 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Safety of 2-Hydroxy-4-methoxybenzaldehyde)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Safety of 2-Hydroxy-4-methoxybenzaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Hu, Yijie; Wang, Xiaoli; Ren, Nan; Li, Na; Li, Jianyang; Chen, Jie; Zhang, Hui; Deng, Hongmei; Cao, Weiguo; Lin, Jin-Hong published an article in European Journal of Organic Chemistry. The title of the article was 《A Convenient Synthesis of Fluoroalkylated Benzimidazole- or Indole-fused Benzoxazines》.Reference of 2-Hydroxy-4-methoxybenzaldehyde The author mentioned the following in the article:

Herein, the first synthesis of fluoroalkylated benzimidazole- or indole-fused benzoxazines I (R = CF3, C2F5, C3H7; R1 = 2-OMe, 2-Br, 4-Cl, etc.) or II (R2 = H, F; R3 = H, 10-Me, 10-Br, 9,11-(Me)2) by using fluoroalkylated propiolates RCCC(O)2Me as building blocks is described. The reactions proceeded smoothly under mild conditions to give the desired products I and II in moderate to high yields. Notably, benzimidazole-fused products I were obtained by a convenient one-pot two-step process. In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Reference of 2-Hydroxy-4-methoxybenzaldehyde)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Reference of 2-Hydroxy-4-methoxybenzaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Synthesis of substituted pyrimidine using ZnFe2O4 nanocatalyst via one pot multi-component reaction ultrasonic irradiation》 was published in Journal of Heterocyclic Chemistry in 2020. These research results belong to Chavan, Pravin; Bangale, Sachin; Pansare, Dattatraya; Shelke, Rohini; Jadhav, Shivaji; Tupare, Shrikrushna; Kamble, Dhanraj; Rai, Megha. Product Details of 673-22-3 The article mentions the following:

A highly efficient, eco-friendly, recyclable heterogeneous ZnFe2O4 nanocatalyzed synthesis of 2-amino-4-substituted 1,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carbonitrile derivatives I (R = 4-chlorophenyl, 4-hydroxyphenyl, 2,4-dichlorophenyl, 3-bromophenyl, etc.) via one pot multicomponent reaction of 1H-1,3-benzodiazol-2-amine, substituted aromatic aldehyde RCHO and malononitrile under ultrasonic irradiations is described. Significance of this synthetic approach is short reaction time, easy handling, simplicity, efficiency, high yield, and recoverable catalyst. The experimental part of the paper was very detailed, including the reaction process of 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Product Details of 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Product Details of 673-22-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ding, Y.-F.; La, Y.-T.; Li, W.-D.; Yao, G.-X.; Wang, L.; Dong, W.-K. published an article in 2021. The article was titled 《Experimental and Theoretical Studies of Two New Trinuclear Ni(II) Asymmetric Salamo-Based Complexes》, and you may find the article in Russian Journal of General Chemistry.Recommanded Product: 2-Hydroxy-4-methoxybenzaldehyde The information in the text is summarized as follows:

Two new trinuclear Ni(II) complexes, [{Ni(L)(DMF)(μ-OAc)}2Ni] (1) and [{Ni(L)(EtOH)(μ-OAc)}2Ni]·2CH2Cl2 (2), have been successfully synthesized from a new asym. salamo-based hexa-dentate chelating ligand (H2L) and Ni(OAc)2·4H2O, and characterized by elemental anal., IR and UV-Vis spectra, and X-ray crystallog. The binding ratio of H2L and Ni(II) ion has been confirmed by UV-Vis titration All Ni(II) atoms are hexa-coordinated, and the complexes have octahedral configuration, though with difference in the solvent mols. (DMF/EtOH) involved in the coordination, composition of the hydrogen bond and chem. stability. This conclusion is confirmed by Hirshfeld surfaces analyses and D. Functional Theory (DFT). In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Recommanded Product: 2-Hydroxy-4-methoxybenzaldehyde)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Recommanded Product: 2-Hydroxy-4-methoxybenzaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Plant Cell, Tissue and Organ Culture included an article by Ahmad, Zishan; Shahzad, Anwar; Sharma, Shiwali. Recommanded Product: 673-22-3. The article was titled 《Chitosan versus yeast extract driven elicitation for enhanced production of fragrant compound 2-hydroxy-4-methoxybenzaldehyde (2H4MB) in root tuber derived callus of Decalepis salicifolia (Bedd. ex Hook.f.) Venter》. The information in the text is summarized as follows:

Decalepis salicifolia (Bedd. ex Hook.f.) Venter is a new source of the com. important flavor compound 2-hydroxy-4-methoxybenzaldehyde (2H4MB), a structural isomer of vanillin, with high pharmacol. value and used as a flavoring agent at industrial level for making soft drink and bakery products. The natural availability of this high-valued plant is not able to meet the ever-increasing demands due to limited studies. Considering the importance of suspension culture over excised root culture, present communication provides a protocol for the suspension culture of root tuber derived callus of D. salicifolia for the first time. Maximum frequency (84.8%) callus induction was obtained on Murashige and Skoog (MS) medium augmented with (1.0μM) thidiazuron (TDZ) + (1.0μM) α-naphthalene acetic acid (NAA). Two important biotic elicitors, chitosan (CH) and yeast extract (YE) at different concentrations (50, 100, 200 and 300μM) were used as elicitor to investigate the effects on biomass content, 2H4MB content, total phenolic content (TPC), total flavonoid content (TFC) and antioxidant activity in cell suspension culture with different contact periods i.e. 24, 48 72 and 96 h. The results showed the supremacy of CH over YE and maximum biomass was 9.7 DW g/l at optimum contact period of 72 h when suspension culture was treated with 200μM CH. Maximum content of 2H4MB was14.8μg/g at 200μM CH and it was found to be 1.4-fold increase in relation to the control (10.8μg/g). The maximum TPC and TFC were 4.8 mg/g and 4.0 mg/g resp. at 200μM CH and 72 h of the contact period. The DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity (RSA) had also been evaluated and most of the suspension culture showed the correlation with TPC and TFC. The maximum RSA (63.8%) and hydroxyl radical scavenging activity (HRSA) (55.2%) were revealed the ability of plant as a potent antioxidant agent. Thus, a new protocol has been developed for the elicitors-induced enhancement of metabolites and antioxidant activity in suspension culture of D. salicifolia. The experimental process involved the reaction of 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Recommanded Product: 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Recommanded Product: 673-22-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Song, Xue; Zhang, Jie; Wu, Yu-Xing; Ouyang, Qin; Du, Wei; Chen, Ying-Chun published an article in Journal of the American Chemical Society. The title of the article was 《Asymmetric Formal Nucleophilic o-Cresolylation with Morita-Baylis-Hillman Carbonates of 2-Cyclohexenones via Palladium Catalysis》.Computed Properties of C8H8O3 The author mentioned the following in the article:

Here Authors report an asym. formal nucleophilic o-cresolylation reaction with the Morita-Baylis-Hillman (MBH) carbonates from 2-cyclohexanones and diverse aldehydes under palladium catalysis, by in situ generation of electron-neutral and HOMO-raised η2-Pd(0)-dienone complexes via an oxidative insertion/π-σ-isomerization/β-H elimination activation sequence. The subsequent umpolung vinylogous addition to a variety of imines is realized upon Pd(0)-mediated π-Lewis base catalysis, finally furnishing o-cresolylated products followed by another cascade of a π-σ-isomerization/β-H elimination/aromatization process. Moderate to excellent diastereo- and enantioselectivity are achieved for substantial substrate assemblies by employing a newly designed bulky chiral phosphonamidite ligand, and the resultant multifunctional products can be facilely elaborated to access diverse enantioenriched architectures. In addition, the catalytic reaction pathway is finely illuminated by control experiments In the experiment, the researchers used many compounds, for example, 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Computed Properties of C8H8O3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Computed Properties of C8H8O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《A near-infrared excitation/emission fluorescent probe for imaging of endogenous cysteine in living cells and zebrafish》 was written by Xie, Ruihua; Li, Yaqian; Zhou, Zile; Pang, Xiao; Wu, Cuiyan; Yin, Peng; Li, Haitao. Quality Control of 2-Hydroxy-4-methoxybenzaldehyde And the article was included in Analytical and Bioanalytical Chemistry in 2020. The article conveys some information:

The fluorescence imaging technique provides an essential tool for studying biol. systems. However, due to the interference of autofluorescence of biol. tissues, the application of short-wavelength fluorescent probes in biol. imaging was limited. The near-IR (NIR) excitation/emission fluorescent probe possesses unique advantages in optical imaging in vivo, including less light scattering, minimal photo-damage to biol. samples, deep tissue penetration, and weak autofluorescence interference from complicated biol. systems. A convenient fluorophore (E)-2-[2-(6-hydroxy-2,3-dihydro-1H-xanthen-4-yl)vinyl]-3- methylbenzo[d]thiazol-3-ium iodide (DXM-OH) with NIR excitation and emission was rationally designed and developed. What′s more, DXM-OH was applied to construct an “”OFF-ON”” fluorescent probe (E)-2-{2-[6-(acryloyloxy)-2,3-dihydro-1H- xanthen-4-yl]vinyl}-3-methylbenzo[d]thiazol-3-ium iodide (DXM) for sensitive and selective detection of cysteine (Cys). DXM had the advantages of good cell permeability, low toxicity, and excellent optical properties (NIR excitation/emission) and it was successfully applied to image Cys of living cells and zebrafish. In the experiment, the researchers used many compounds, for example, 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Quality Control of 2-Hydroxy-4-methoxybenzaldehyde)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Quality Control of 2-Hydroxy-4-methoxybenzaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Titania-silica nanoparticles ensemblies assisted heterogeneous catalytic strategy for the synthesis of pharmacologically significant 2,3-diaryl-3,4-dihydroimidazo[4,5-b]indole scaffolds》 was published in Journal of Heterocyclic Chemistry in 2020. These research results belong to Geedkar, Deepika; Kumar, Ashok; Reen, Gagandeep Kour; Sharma, Pratibha. Recommanded Product: 673-22-3 The article mentions the following:

Present paper elicits the multicomponent reaction (MCR) strategy assisted by titania nanoparticles hosted on silica (TiO2.SiO2 NPs) as heterogeneous catalyst to synthesize a series of pharmacol. significant 2,3-diaryl-3,4-dihydroimidazo[4,5-b]indole derivatives The decrease in reaction time, low catalyst loading, high product yield (up to 92%), and excellent reusability of the catalyst (up to 7 cycles) put this protocol under the umbrella of green chem. tenets. Characterization of catalysts was achieved through a number of techniques viz., energy-dispersive X-ray (EDX) spectroscopy, field emission SEM (FESEM), powder X-ray diffraction (XRD), fourier transform IR (FTIR) spectra of adsorbed pyridine, temperature-programmed desorption of ammonia, and porosity measurements by nitrogen adsorption (Brunauer-Emmett-Teller [BET] method). Also, the structures of synthesized compounds were corroborated on the basis of FTIR, NMR (NMR), mass, and elemental analyses data. In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Recommanded Product: 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Recommanded Product: 673-22-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Multiwalled carbon nanotubes crowned with nickel-ferrite magnetic nanoparticles assisted heterogeneous catalytic strategy for the synthesis of benzo[d]imidazo[2,1-b]thiazole scaffolds》 was published in Journal of Heterocyclic Chemistry in 2020. These research results belong to Geedkar, Deepika; Kumar, Ashok; Sharma, Pratibha. Recommanded Product: 673-22-3 The article mentions the following:

Present manuscript elicits an account of the sonication promoted multicomponent reactions strategy assisted by multiwalled carbon nanotubes embraced with nickel-ferrite (NiFe2O4-CNTs) magnetic nanoparticles, as a heterogeneous catalyst to synthesize a novel series of pharmacol. active benzo[d]imidazo[2,1-b]thiazole scaffolds I [R1 = H, 4-OH, 4-Cl, etc.; R2 = H, 4-Me, 2-OH, etc.]. The synthesis of these biol. active derivatives was achieved via A3 coupling involving 2-aminobenzothiazole, pertinent aryl aldehydes and Ph acetylene derivatives, proceeded in PEG 400 as green solvent under aerobic conditions to afford the products in good to excellent yields. The higher environmental compatibility and sustainability factors such as higher ecoscale score, smaller E-factor and appreciable atom economy put this etiquette under the parasol of green chem. precepts. The characterization of synthesized catalysts was attained through varied techniques viz. powder X-ray diffraction, field emission SEM with energy-dispersive X-ray spectroscopy, Raman, FT-IR, VSM and TGA-DTA-DTG analyzes, dispersion studies, and nitrogen porosimetry analyzes. The structures of the synthesized compounds were also endorsed by extensive spectroscopic studies (FT-IR, 1H and 13C NMR, mass) and elemental analyzes. In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Recommanded Product: 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Recommanded Product: 673-22-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem