Category: 673-22-3

《Discovery of potential Q-marker of traditional Chinese medicine based on plant metabolomics and network pharmacology: Periplocae Cortex as an example》 was written by Li, Zi-ting; Zhang, Feng-xiang; Fan, Cai-lian; Ye, Meng-nan; Chen, Wei-wu; Yao, Zhi-hong; Yao, Xin-sheng; Dai, Yi. Recommanded Product: 673-22-3This research focused ontraditional Chinese medicine plant metabolomic pharmacol Periplocae; Multivariate statistical analysis; Network pharmacology; Periplocae Cortex; Q-marker; Quantification. The article conveys some information:

Quality control exerted great importance on the clin. application of drugs for ensuring effectiveness and safety. Due to chem. complexity, diversity among different producing areas and harvest seasons, as well as unintentionally mixed with non-medicinal parts, the current quality standards of traditional Chinese medicine (TCM) still faced challenges in evaluating the overall chem. consistency. We aimed to develop a new strategy to discover potential quality marker (Q-marker) of TCM by integrating plant metabolomics and network pharmacol., using Periplocae Cortex (GP, the dried root bark of Periploca sepium Bge.) as an example. First, plant metabolomics anal. was performed by UPLC/Q-TOF MS in 89 batches of samples to discover chem. markers to distinguish medicinal parts (GP) and non-medicinal parts (the dried stem bark of Periploca sepium Bge. (JP)), harvest seasons and producing region of Periplocae Cortex. Second, network pharmacol. was applied to explore the initial linkages among chem. constituents, targets and diseases. Last, potential Q-marker were selected by integrating anal. of plant metabolomics and network pharmacol., and the quantification method of Q-marker was developed by using UPLC-TQ-MS. The chem. profiling of GP and JP was investigated. Fifteen distinguishing features were designated as core chem. markers to distinguish GP and JP. Besides, the content of 4-methoxybenzaldehyde-2-O-β-D-xylopyranosyl-(1→6)-β-D-glucopyranoside could be used to identify Periplocae Cortex harvested in spring-autumn or summer. Meanwhile, a total of 15 components targeted rheumatoid arthritis were screened out based on network pharmacol. Taking absorbed constituents into consideration, 23 constituents were selected as potential Q-marker. A simultaneous quantification method (together with 11 semi-quant. anal.) was developed and applied to the anal. of 20 batches of com. Periplocae Cortex on the market. The PLS-DA model was successfully developed to distinguish GP and JP samples. In addition, the artificially mixed GP sample, which contained no less than 10% of the adulterant (JP), could also be correctly identified. Our results indicated that 9 ingredients could be considered as Q-marker of Periplocae Cortex. This study has also demonstrated that the plant metabolomics and network pharmacol. could be used as an effective approach for discovering Q-marker of TCM to fulfill the evaluation of overall chem. consistency among samples from different producing areas, harvest seasons, and even those com. crude drugs, which might be mixed with a small amount of non-medicinal parts. The experimental part of the paper was very detailed, including the reaction process of 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Recommanded Product: 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Recommanded Product: 673-22-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Yamaguchi, Hinano; Kondo, Mizuho; Sasaki, Tomoyuki; Sakamoto, Moritsugu; Ono, Hiroshi; Kawatsuki, Nobuhiro published an article in Langmuir. The title of the article was 《Polarized Fluorescence of N-Salicylideneaniline Derivatives Formed by In Situ Exchange from N-Benzylideneaniline Side Groups in Photoaligned Liquid Crystalline Copolymer Films》.Electric Literature of C8H8O3 The author mentioned the following in the article:

Polarized fluorescence of oriented N-salicylideneaniline (SA) derivatives is explored based on the thermally stimulated photoinduced mol. reorientation of liquid crystalline (LC) copolymethacrylate with N-benzylideneaniline derivative (NBA2) and benzoic acid (BA) side groups. The LC copolymer films show significant cooperative mol. reorientation of the NBA2 and BA side groups (D > 0.7). Subsequent thermal hydrolysis of the NBA2 side groups yields free phenylamine moieties. These moieties can form oriented SA derivatives via in situ condensation with 2-hydroxybenzaldehyde derivatives The excited-state intermol. proton transfer of the oriented SA mols. induces polarized fluorescence at 510-548 nm with a polarization ratio up to 6.2. Direct in situ exchange from the oriented NBA2 to SA derivatives achieves polarized fluorescence similar to that of the SA side groups. In addition to this study using 2-Hydroxy-4-methoxybenzaldehyde, there are many other studies that have used 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Electric Literature of C8H8O3) was used in this study.

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Electric Literature of C8H8O3

Referemce:
Ether – Wikipedia,
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《Investigation of DNA binding and bioactivities of thioether containing Schiff base Copper(II), Cobalt(II) and Palladium(II) complexes: Synthesis, characterization, spectrochemical study, viscosity measurement》 was written by Maiti, Subir Kr; Kalita, Mukul; Singh, Anmol; Deka, Jahnabi; Barman, Pranjit. Recommanded Product: 673-22-3This research focused ontransition metal Schiff salicylaldehyde benzylthioaniline complex preparation bactericide; DNA binding transition metal Schiff salicylaldehyde benzylthioaniline complex; crystal structure transition metal salicylaldehyde benzylthioaniline complex. The article conveys some information:

Three complexes of an ONS donor ligand of the Schiff base [C21H19NO2S] (HL), [Cu(C21H18NO2S)2] (1) [Co(C21H18NO2S)2] (2) and [Pd(C21H18NO2SCl)] (3), were synthesized and characterized by elemental anal., FT-IR, 1H NMR, UV-Visible spectroscopy and single-crystal X-ray diffraction anal. Single crystal X-ray diffraction anal. reveals that the copper complex acquires a distorted pyramidal structure and the palladium complex acquires a square planar structure. All the compounds are stable at room temperature and they show very good antibacterial activities against gram-pos. and gram-neg. bacteria. DNA binding activities of the ligand and its Cu(II), Pd(II) and Co(II) complexes with CT-DNA were carried out in DMF and tris-buffer (5 mM, pH 7.3) solution; all the three complexes along with the ligand show a very good intercalative mode of DNA interaction with Kb values of 1.56(±0.03) x 105 for 1 and 1.02(±0.09) x 105 for 3. The DNA binding activity was confirmed by a hydrodynamic study (viscosity). The order of DNA binding activity is 1 > 3 > 2.2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Recommanded Product: 673-22-3) was used in this study.

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Recommanded Product: 673-22-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Catalyst-solvent system for pase approach to hydroxyquinolinone-substituted chromeno[2,3-b]pyridines its quantum chemical study and investigation of reaction mechanism》 was published in Molecules in 2020. These research results belong to Ryzhkov, Fedor V.; Ryzhkova, Yuliya E.; Elinson, Michail N.; Vorobyev, Stepan V.; Fakhrutdinov, Artem N.; Vereshchagin, Anatoly N.; Egorov, Mikhail P.. COA of Formula: C8H8O3 The article mentions the following:

The Pot, Atom, and Step Economy (PASE) approach is based on the Pot economy principle and unites it with the Atom and Step Economy strategies; it ensures high efficiency, simplicity and low waste formation. The PASE approach is widely used in multicomponent chem. This approach was adopted for the synthesis of previously unknown hydroxyquinolinone substituted chromeno[2,3-b]pyridines via reaction of salicylaldehydes, malononitrile dimer and hydroxyquinolinone. It was shown that an ethanol-pyridine combination is more beneficial than other inorganic or organic catalysts. Quantum chem. studies showed that chromeno[2,3-b]pyridines has potential for corrosion inhibition. Real time 1H NMR monitoring was used for the investigation of reaction mechanism and 2-((2H-chromen-3-yl)methylene)malononitrile was defined as a key intermediate in the reaction. In the experimental materials used by the author, we found 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3COA of Formula: C8H8O3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.COA of Formula: C8H8O3

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Formula: C8H8O3In 2019 ,《Syntheses, structures and Hirschfeld analyses of trinuclear Ni(Π) salamo-type complexes》 was published in Wuji Huaxue Xuebao. The article was written by Yu, Meng; Mu, Hao-ran; Liu, Ling-zhi; Li, Na; Bai, Yang; Dong, Xiu-yan. The article contains the following contents:

Two newly designed complexes, {[Ni(L1)(n-propanol)]2(OAc)2Ni}·2(n-propanol) (1) and {[Ni(L2)(n-butanol)]2(OAc)2Ni}·2(n-butanol) (2) derived from tetradentate Salamo-type chelating ligands (H2L1=5-methoxy-2,2′-(ethylenedioxybis(azomethine))diphenol and H2L2=4,4′-dinitro-2,2′-(ethylenediyldioxybis(nitrilomethylidyne))diphenol) have been synthesized and characterized by elemental analyses, IR and UV-Vis spectra, Hirschfeld surfaces analyses and single crystal X-ray crystallog. X-ray crystallog. analyses showed that complexes 1 and 2 are all sym. trinuclear Ni(Π) complexes. Nickel(Π) in both 1 and 2 is hexa-coordinated, forming a twisted octahedral geometry. Both crystal structure and Hirschfeld surface anal. indicate that 1 and 2 form stable one-dimensional chain and two-dimensional supramol. structures, resp., by intermol. hydrogen bonding. The results came from multiple reactions, including the reaction of 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Formula: C8H8O3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Formula: C8H8O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《A new zinc(II) complex with N2O2-tetradentate Schiff-base derived from pyridoxal-S-methylthiosemicarbazone: Synthesis, characterization, crystal structure, DFT, molecular docking and antioxidant activity studies》 was written by Poladian, Qumars; Sahin, Onur; Karakurt, Tuncay; Ilhan-Ceylan, Berat; Kurt, Yasemin. Related Products of 673-22-3This research focused onzinc Schiff methylthiosemicarbazone hydroxymethoxybenzaldehyde complex preparation antioxidant; frontier mol orbital zinc Schiff methylthiosemicarbazone hydroxymethoxybenzaldehyde complex; crystal structure zinc Schiff methylthiosemicarbazone hydroxymethoxybenzaldehyde complex. The article conveys some information:

A new unsym. N2O2-tetradentate Schiff-base complex of zinc(II) was synthesized by the template reaction of pyridoxal-S-methylthiosemicarbazone and 2-hydroxy-4-methoxy-benzaldehyde as starting compounds S-methylthiosemicarbazone (1) and zinc(II) complex [Zn(L)CH3OH] (2) were characterized by elemental anal., FT-IR, UV-visible, 1H, and 13C NMR spectra. The mol. structure of 2 was determined by single crystal X-ray diffraction technique. The structure consists of a distorted square-pyramidal geometry around the central metal, Zn(II). Quantum chem. calculations were carried out using d. functional theory DFT/B3LYP, 6-31G (d), and LanL2DZ basis sets for theor. characterization of the compounds The exptl. and theor. data were compared comprehensively. The potential energy distribution (PED) anal. was performed for the assignment of vibration frequencies. In order to support in vitro studies, mol. docking studies were carried out so that the title compound can be an inhibitor of Epidermal Growth Factor Receptor (1 m17), and the relationship between calculated HOMO energies and docking studies was examined In addition, the total antioxidant capacity (as TEAC value) and free radical scavenging activity of the compounds were determined by Cupric Reducing Antioxidant Capacity (CUPRAC) and 1,1-diphenyl-2-picryl hydrazyl (DPPH) methods, resp. In the experimental materials used by the author, we found 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Related Products of 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Related Products of 673-22-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Organic Letters included an article by Yoo, Huen Ji; Youn, So Won. Recommanded Product: 673-22-3. The article was titled 《Zn(II)-Catalyzed One-Pot Synthesis of Coumarins from Ynamides and Salicylaldehydes》. The information in the text is summarized as follows:

Substituted coumarins and iminocoumarins were prepared regioselectively by cyclocondensation of ynamides (particularly N-alkynyl-N-methylmethanesulfonamides) with salicylaldehydes, o-hydroxyphenyl ketones, and o-aminophenyl ketones in the presence of ZnBr2. Generation of an ynamide in situ from 1-bromo-2-phenylethyne and N-methylmethanesulfonamide allowed the recycling of the methanesulfonamide through five cycles; the presence of coumarin did not inhibit the copper-catalyzed amination of the bromoalkyne. The experimental part of the paper was very detailed, including the reaction process of 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Recommanded Product: 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Recommanded Product: 673-22-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

HPLC of Formula: 673-22-3In 2022 ,《Recyclable palladium-catalyzed cyclocarbonylation between benzyl chlorides and salicylic aldehydes towards coumarins》 was published in Molecular Catalysis. The article was written by Zhou, Yan; Zhou, Zebiao; Liu, Siqi; Cai, Mingzhong. The article contains the following contents:

A novel and practical route to coumarin derivatives was developed via the heterogeneous Pd-catalyzed carbonylative reaction and subsequent intramol. condensation process starting from com. easily available benzyl chlorides and salicylic aldehydes. Reactions were performed in the existence of 2 mol% of an SBA-15-immobilized bidentate phosphine palladium complex [SBA-15-P,P-PdCl2] in dioxane at 110°C with Et3N as base under 10 bar of CO to afford a wide range of coumarin derivatives mostly with good to high yields. Importantly, this new heterogenized palladium complex was easy to recover via filtration of the reaction mixture, and was recyclable up to 8 times without apparent drop in its catalytic performance. After reading the article, we found that the author used 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3HPLC of Formula: 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.HPLC of Formula: 673-22-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Organic Letters included an article by Tan, Jian-Ping; Yu, Peiyuan; Wu, Jia-Hong; Chen, Yuan; Pan, Jianke; Jiang, Chunhui; Ren, Xiaoyu; Zhang, Hong-Su; Wang, Tianli. Recommanded Product: 2-Hydroxy-4-methoxybenzaldehyde. The article was titled 《Bifunctional Phosphonium Salt Directed Enantioselective Formal [4 + 1] Annulation of Hydroxyl-Substituted para-Quinone Methides with α-Halogenated Ketones》. The information in the text is summarized as follows:

A highly diastereo- and enantioselective [4 + 1] cycloaddition of para-quinone methides to α-halogenated ketones was realized by bifunctional phosphonium salt catalysis, furnishing functionalized 2,3-dihydrobenzofurans in high yields and excellent stereoselectivities (>20:1 dr and up to >99.9% ee). Mechanistic observations suggested that the reaction underwent a cascade intermol. substitution/intramol. 1,6-addition process. DFT calculations revealed multiple H-bonding interactions between the catalyst and the enolate intermediate in the stereodetermining transition states. In addition to this study using 2-Hydroxy-4-methoxybenzaldehyde, there are many other studies that have used 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Recommanded Product: 2-Hydroxy-4-methoxybenzaldehyde) was used in this study.

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Recommanded Product: 2-Hydroxy-4-methoxybenzaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wang, Xing; Du, Ming-Hao; Xu, Han; Long, La-Sheng; Kong, Xiang-Jian; Zheng, Lan-Sun published their research in Inorganic Chemistry in 2021. The article was titled 《Cocrystallization of Chiral 3d-4f Clusters {Mn10Ln6} and {Mn6Ln2}》.Recommanded Product: 673-22-3 The article contains the following contents:

Cocrystn. of different metal nanoclusters facilitates the preparation of cluster-based nanomaterials with enhanced properties. Herein, two pairs of enantiomeric 3d-4f cocrystn. structures of clusters R/S-[Mn10Ln6] and R/S-[Mn6Ln2] (Ln = Dy for 1R and 1S, Y for 2R and 2S) have been reported. Compounds R/S-[Mn10Ln6][Mn6Ln2] exhibit a large optical activity and magneto-optic effect as verified by natural CD (NCD) and magnetic CD (MCD). In addition, a.c. magnetic measurements show that the chiral R/S-[Mn10Dy6][Mn6Dy2] cocrystn. structure displays slow magnetic relaxation with Ueff = 25.1 K. In addition to this study using 2-Hydroxy-4-methoxybenzaldehyde, there are many other studies that have used 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Recommanded Product: 673-22-3) was used in this study.

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Recommanded Product: 673-22-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem