Category: 6482-24-2

Zhou, Ning; Wang, Yufeng; Zhou, Yang; Shen, Jinyou; Zhou, Yong; Yang, Yong published the artcile< Star-shaped multi-arm polymeric ionic liquid based on tetraalkylammonium cation as high performance gel electrolyte for lithium metal batteries>, COA of Formula: C3H7BrO, the main research area is polymerized ionic liquid starshaped lithium metal battery gel electrolyte.

Star-shaped polymeric ionic liquids (PIL-3 and PIL-4) based on poly(2-(dimethyl-ethyl-amino)ethyl methacrylate) bis(trifluoromethylsulfonyl)imide (P(EtDMAEMA-TFSI)) with three-arm and four-arm architectures were prepared through atom transfer radical polymerization (ATRP) and ion exchange. Subsequently, gel polymer electrolytes (GPEs) comprising PIL host, N,N-diethyl-N-methyl-N-(2-methoxyethyl)ammonium bis(trifluoromethylsulfonyl)imide (DEME-TFSI) ionic liquid (IL) plasticizer with the same anion unit and LiTFSI salt were obtained. Compared with the linear PIL possessing the same elements, the increase of branches for PIL decreases the crystallity and glass transition temperature (Tg) of the corresponding GPEs. Accordingly, the ionic conductivity, electrochem. window and ion transport number of three-arm and four-arm PILs based GPEs (PIL-GPE-3 and PIL-GPE-4) are obviously superior to the linear contrastive sample. Among lithium metal batteries assembled by linear, three-arm and four-arm PILs based GPEs, Li/PIL-GPE-4/LiFePO4 presents the best performance. The specific discharge capacity attains 151 mAh g-1 at 0.1 C, the capacity retention ratio achieves 93.6% after 100 cycles at 60 °C, and the coulombic efficiency is around 99%. The outstanding compatibility between PIL-4 and IL and the resulted interfacial stability between PIL-GPE-4 and electrodes both contribute to the excellent performance.

Electrochimica Acta published new progress about Atom transfer radical polymerization. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, COA of Formula: C3H7BrO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Dombrowski, Amanda W.; Gesmundo, Nathan J.; Aguirre, Ana L.; Sarris, Katerina A.; Young, Jonathon M.; Bogdan, Andrew R.; Martin, M. Cynthia; Gedeon, Shasline; Wang, Ying published the artcile< Expanding the Medicinal Chemist Toolbox: Comparing Seven C(sp2)-C(sp3) Cross-Coupling Methods by Library Synthesis>, HPLC of Formula: 6482-24-2, the main research area is carbon cross coupling library synthesis medicinal chemist synthetic toolbox.

Despite recent advances in the field of C(sp2)-C(sp3) cross-couplings and the accompanying increase in publications, it can be hard to determine which method is appropriate for a given reaction when using the highly functionalized intermediates prevalent in medicinal chem. Thus a study was done comparing the ability of seven methods to directly install a diverse set of alkyl groups on “”drug-like”” aryl structures via parallel library synthesis. Each method showed substrates that it excelled at coupling compared with the other methods. When analyzing the reactions run across all of the methods, a reaction success rate of 50% was achieved. Whereas this is promising, there are still gaps in the scope of direct C(sp2)-C(sp3) coupling methods, like tertiary group installation. The results reported herein should be used to inform future syntheses, assess reaction scope, and encourage medicinal chemists to expand their synthetic toolbox.

ACS Medicinal Chemistry Letters published new progress about Combinatorial library. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, HPLC of Formula: 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wang, Xiaomei; Qian, Jianqiang; Zhu, Peng; Hua, Rong; Liu, Ji; Hang, Jiaying; Meng, Chi; Shan, Wenpei; Miao, Jiefei; Ling, Yong published the artcile< Novel Phenylmethylenecyclohexenone Derivatives as Potent TrxR Inhibitors Display High Antiproliferative Activity and Induce ROS, Apoptosis, and DNA Damage>, Related Products of 6482-24-2, the main research area is Phenylmethylenecyclohexenone derivative TrxR inhibitor ROS antiproliferative DNA damage anticancer; Antiproliferative activities; Aqueous solubility; DNA damage; Phenylmethylenecyclohexenone; Reactive oxygen species; Thioredoxin reductase.

The natural product piperlonguminine (PL) has been shown to exert potential anticancer activity against several types of cancer via elevation of reactive oxidative species (ROS). However, the application of PL has been limited due to its poor water solubility and moderate activity. To improve PL′s potency, we designed and synthesized a series of 17 novel phenylmethylenecyclohexenone derivatives and evaluated their pharmacol. properties. Most of them exerted antiproliferative activities against four cancer cell lines with IC50 values lower than PL. Among these, compound 10 e not only showed good water solubility and exerted the most potent antiproliferative activity against HGC27 cells (IC50=0.76 μM), which was 10-fold lower than PL (IC50=7.53 μM), but also exhibited lower cytotoxicity in human normal gastric epithelial cells GES-1 compared with HGC27 cells. Mechanistically, compound 10 e inhibited thioredoxin reductase (TrxR) activity, increased ROS levels, and diminished mitochondrial transmembrane potential (MTP) in HGC27 cells. Furthermore, 10 e also induced G2/M cell-cycle arrest, and triggered cancer cell apoptosis through the regulation of apoptotic proteins. Finally, 10 e promoted DNA damage in HGC27 cells via the activation of the H2AX(S139ph) and p53 signaling. In conclusion, 10 e, with prominent tumor selectivity and water solubility, could be a promising candidate for the treatment of cancer and, as such, warrants further investigation.

ChemMedChem published new progress about Antiproliferative agents. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Related Products of 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Amanchukwu, Chibueze V.; Yu, Zhiao; Kong, Xian; Qin, Jian; Cui, Yi; Bao, Zhenan published the artcile< A New Class of Ionically Conducting Fluorinated Ether Electrolytes with High Electrochemical Stability>, Quality Control of 6482-24-2, the main research area is ionically conducting fluorinated ether electrolyte high electrochem stability.

Increasing battery energy d. is greatly desired for applications such as portable electronics and transportation. However, many next-generation batteries are limited by electrolyte selection because high ionic conductivity and poor electrochem. stability are typically observed in most electrolytes. For example, ether-based electrolytes have high ionic conductivity but are oxidatively unstable above 4 V, which prevents the use of high-voltage cathodes that promise higher energy densities. In contrast, hydrofluoroethers (HFEs) have high oxidative stability but do not dissolve lithium salt. In this work, we synthesize a new class of fluorinated ether electrolytes that combine the oxidative stability of HFEs with the ionic conductivity of ethers in a single compound We show that conductivities of up to 2.7 x 10-4 S/cm (at 30°C) can be obtained with oxidative stability up to 5.6 V. The compounds also show higher lithium transference numbers compared to typical ethers. Furthermore, we use NMR (NMR) and mol. dynamics (MD) to study their ionic transport behavior and ion solvation environment, resp. Finally, we demonstrate that this new class of electrolytes can be used with a Ni-rich layered cathode (NMC 811) to obtain over 100 cycles at a C/5 rate. The design of new mols. with high ionic conductivity and high electrochem. stability is a novel approach for the rational design of next-generation batteries.

Journal of the American Chemical Society published new progress about Battery cathodes. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Quality Control of 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

McPherson, Andrew K.; Capaldi, Daniel; Chen, Lijian; Olsen, Philip published the artcile< An Improved Process for the Manufacture of 5'-O-(4,4'-Dimethoxytrityl)-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine>, Category: ethers-buliding-blocks, the main research area is alkylation aminopurine riboside bromomethoxyethane nucleoside nucleotide preparation enzymic.

A revised, optimized process for the manufacture of 5′-O-(4,4′-dimethoxytrityl)-N2-isobutyryl-2′-O-(2-methoxyethyl)guanosine (MOE G PNS) that controls critical impurities to less than 0.2% was developed. The 2′-O-alkylation of 2,6-diaminopurine riboside (DAPR) with 1-bromo-2-methoxyethane (MOE-Br) in DMSO was examined using a DOE approach, which lead to the selection of LiOH as the optimal base choice. DMSO was removed with a solid-phase extraction using SP-207 resin, affording the desired 2′-O-(2-methoxyethyl)-2,6-diaminopurine riboside (MOE DAPR) in an aqueous solution in 53% yield. The methylbromide impurity commonly found in bulk source MOE-Br was controlled using a co-distillation with MEK, thereby controlling the resulting critical 2′-O-Me nucleoside impurity. The aqueous solution was telescoped into the enzymic conversion of MOE-DAPR to 2′-O-(2-methoxyethyl)guanosine (MOE G) using adenosine deaminase. MOE G purity is enhanced at this step due to enzymic selectivity and crystallization from the reaction mixture, which together significantly reduce levels of the 3′ MOE G isomer. The improved process was carried out at production-scale to afford 59 kg of MOE G PNS with no critical impurity over 0.2% in an overall yield of 26%.

Organic Process Research & Development published new progress about Alkylation. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Category: ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zheng, Yunlong; Zhang, Sainan; Guo, Jinbiao; Shi, Ruixuan; Yu, Jiangyue; Li, Kaipeng; Li, Ning; Zhang, Zhenjie; Chen, Yao published the artcile< Green and Scalable Fabrication of High-Performance Biocatalysts Using Covalent Organic Frameworks as Enzyme Carriers>, Product Details of C3H7BrO, the main research area is biocatalyst covalent organic framework stability; Biocatalysts; Chiral Catalysis; Covalent Organic Frameworks; Enzyme Immobilization; Porous Materials.

Enzyme immobilization is essential to the com. viability of various critical large-scale biocatalytic processes. However, challenges remain for the immobilization systems, such as difficulties in loading large enzymes, enzyme leaching, and limitations for large-scale fabrication. Herein, we describe a green and scalable strategy to prepare high-performance biocatalysts through in situ assembly of enzymes with covalent organic frameworks (COFs) under ambient conditions (aqueous solution and room temperature). The obtained biocatalysts have exceptional reusability and stability and serve as efficient biocatalysts for important industrial reactions that cannot be efficiently catalyzed by free enzymes or traditional enzyme immobilization systems. Notably, this versatile enzyme immobilization platform is applicable to various COFs and enzymes. The reactions in an aqueous solution occurred within a short timeframe (ca. 10-30 min) and could be scaled up readily (ca. 2.3 g per reaction).

Angewandte Chemie, International Edition published new progress about Adsorption. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Product Details of C3H7BrO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Piatti, Erik; Guglielmero, Luca; Tofani, Giorgio; Mezzetta, Andrea; Guazzelli, Lorenzo; D′Andrea, Felicia; Roddaro, Stefano; Pomelli, Christian Silvio published the artcile< Ionic liquids for electrochemical applications: Correlation between molecular structure and electrochemical stability window>, Product Details of C3H7BrO, the main research area is ionic liquid electrochem application mol structure stability.

Ionic gating has emerged as an effective and versatile tool to tune the charge-carrier d. of a material and control its electronic ground state, as well as to develop low-temperature devices such as electrochem. transistors. Ionic liquids are a promising gating agent due to their high thermal- and electrochem. stability for both fundamental and applied research. However, the understanding of the correlation between the mol. structure of ionic liquids and their electrochem. stability is quite limited. For this reason, this study aims at determining the guidelines for synthesizing ionic liquids suitable for their use as electrolytes at low temperatures A series of twenty-three ionic liquids having various ammonium cations, composed of three ′ ′short chains ′ ′ and one ′ ′long chain ′ ′, and Tf2N as the anion, were synthesized. Afterwards, their thermal behavior was determined to identify those ionic liquids exhibiting Tg < -50 °C. The anodic and cathodic limits of the selected ionic liquids were measured via linear-sweep voltammetry using an electrochem. transistor configuration, working at -33 °C. Electrochem. windows having absolute values from 2.9 to 5.7 V were measured. Overall, five guidelines were determined from the exptl. results: first, the cations influence both cathodic and anodic limits; second, the asym. ammonium cations show larger electrochem. stability than sym. ones; third, the electrochem. stability decreases at the increase of the length of the ′ ′long chain ′ ′; fourth, alkyl long chains show a larger anodic limit, but smaller cathodic limit than ether long chains having the same length; fifth, the ether chain with largest electrochem. stability comprises three carbon atoms and one oxygen. Journal of Molecular Liquids published new progress about Anions. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Product Details of C3H7BrO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Verma, Piyush Kumar; Prasad, K. Sujit; Varghese, Dominic; Geetharani, K. published the artcile< Cobalt(I)-Catalyzed Borylation of Unactivated Alkyl Bromides and Chlorides>, Recommanded Product: 1-Bromo-2-methoxyethane, the main research area is cobalt catalyzed borylation unactivated alkyl bromide chloride diboron reagent; alkyl boronic ester preparation.

A Co-complex-catalyzed borylation of a wide range of alkyl halides with a diboron reagent (B2pin2 or B2neop2) was developed under mild reaction conditions, demonstrating the 1st Co-mediated cross-coupling with alkyl electrophiles. This protocol allows alkyl boronic esters to be accessed from alkyl halides, including alkyl chlorides, which were used rarely as coupling partners. Mechanistic studies reveal the possible involvement of an alkyl radical intermediate in this Co-mediated catalytic cycle.

Organic Letters published new progress about Boronic acids, esters Role: SPN (Synthetic Preparation), PREP (Preparation) (alkyl boronic esters). 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Recommanded Product: 1-Bromo-2-methoxyethane.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Jones, J. Howard; Xin, Zhili; Himmelbauer, Martin; Dechantsreiter, Michael; Enyedy, Istvan; Hedde, Joseph; Fang, Terry; Coomaraswamy, Janaky; King, Kristopher W.; Murugan, Paramasivam; Santoro, Joseph C.; Hesson, Thomas; Walther, Dirk M.; Wei, Ru; Zheng, Fengmei; Marcotte, Douglas J.; Spilker, Kerri; Kumar, P. Rajesh; Liu, Ying; Gilfillan, Rab; Gonzalez-Lopez de Turiso, Felix published the artcile< Discovery of Potent, Selective, and Brain-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors that Modulate Brain Inflammation In Vivo>, Electric Literature of 6482-24-2, the main research area is ASK1 inhibitor brain inflammation pharmacokinetic penetration.

Apoptosis signal-regulating kinase 1 (ASK1) is one of the key mediators of the cellular stress response that regulates inflammation and apoptosis. To probe the therapeutic value of modulating this pathway in preclin. models of neurol. disease, we further optimized the profile of our previously reported inhibitor 3. This effort led to the discovery of 32, a potent (cell IC50 = 25 nM) and selective ASK1 inhibitor with suitable pharmacokinetic and brain penetration (rat Cl/Clu = 1.6/56 L/h/kg and Kp,uu = 0.46) for proof-of-pharmacol. studies. Specifically, the ability of 32 to inhibit ASK1 in the central nervous system (CNS) was evaluated in a human tau transgenic (Tg4510) mouse model exhibiting elevated brain inflammation. In this study, transgenic animals treated with 32 (at 3, 10, and 30 mg/kg, BID/PO for 4 days) showed a robust reduction of inflammatory markers (e.g., IL-1β) in the cortex, thus confirming inhibition of ASK1 in the CNS.

Journal of Medicinal Chemistry published new progress about Anti-inflammatory agents. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Electric Literature of 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem