Category: 6482-24-2

Eeda, Venkateswararao; Awasthi, Vibhudutta published the artcile< Catalyst-Free and Scalable Process for Synthesis of Novel MAP4K4 Inhibitor DMX-5804 and Its Glyco-Conjugates>, Application of C3H7BrO, the main research area is MAP4K4 inhibitor DMX 5804 glyco conjugate preparation.

Here, the process development of scalable and practical synthesis of DMX-5804 I was reported. Process optimization resulted in the following, removal of transition metals from the process and reduced duration of reactions, a streamlined process with significantly improved yields using low-cost raw materials, importantly, microwave-assisted reactions were removed, column purification avoided throughout the process, and crystallized products showed over 95% purity in each step.

Organic Process Research & Development published new progress about Pyrrolopyrimidines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Application of C3H7BrO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Guo, Yunhang; Liu, Ye; Hu, Nan; Yu, Desheng; Zhou, Changyou; Shi, Gongyin; Zhang, Bo; Wei, Min; Liu, Junhua; Luo, Lusong; Tang, Zhiyu; Song, Huipeng; Guo, Yin; Liu, Xuesong; Su, Dan; Zhang, Shuo; Song, Xiaomin; Zhou, Xing; Hong, Yuan; Chen, Shuaishuai; Cheng, Zhenzhen; Young, Steve; Wei, Qiang; Wang, Haisheng; Wang, Qiuwen; Lv, Lei; Wang, Fan; Xu, Haipeng; Sun, Hanzi; Xing, Haimei; Li, Na; Zhang, Wei; Wang, Zhongbo; Liu, Guodong; Sun, Zhijian; Zhou, Dongping; Li, Wei; Liu, Libin; Wang, Lai; Wang, Zhiwei published the artcile< Discovery of Zanubrutinib (BGB-3111), a Novel, Potent, and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase>, Electric Literature of 6482-24-2, the main research area is Zanubrutinib BGB3111 Bruton tyrosine kinase inhibitor antitumor.

Aberrant activation of Bruton’s tyrosine kinase (BTK) plays an important role in pathogenesis of B-cell lymphomas, suggesting that inhibition of BTK is useful in the treatment of hematol. malignancies. The discovery of a more selective on-target covalent BTK inhibitor is of high value. Herein, we disclose the discovery and preclin. characterization of a potent, selective, and irreversible BTK inhibitor as our clin. candidate by using in vitro potency, selectivity, pharmacokinetics (PK), and in vivo pharmacodynamic for prioritizing compounds Compound BGB-3111 (31a, Zanubrutinib) demonstrates (i) potent activity against BTK and excellent selectivity over other TEC, EGFR and Src family kinases, (ii) desirable ADME, excellent in vivo pharmacodynamic in mice and efficacy in OCI-LY10 xenograft models.

Journal of Medicinal Chemistry published new progress about B-cell lymphoma. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Electric Literature of 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yoon, Hyunjee; Shin, Seoyoon; Park, Sooyeol; Shin, Moo Whan published the artcile< Low-viscosity quaternary ammonium-based ionic liquid electrolytes for lithium air batteries>, Category: ethers-buliding-blocks, the main research area is ammonium ionic liquid electrolyte lithium air battery viscosity.

Ionic liquids (ILs) have attracted significant attention as candidates for Li-air battery electrolyte solvents owing to their novel properties, such as non-volatility and low reactivity with lithium metal anodes. However, the main drawback of IL-based electrolytes is their high viscosity, which results in poor battery capacity and conductivity In this study, we synthesized low-viscosity ILs with reduced mol. weights using the side-chain shortening method. In particular, the IL: tri-Me ethoxymethyl ammonium bis(fluoromethylsulfonyl)imide (N111(1O2) FSI), has a lower viscosity (111.4 cP) than that of the electrochem. stable reference material, diethylmethyl (2-methoxyethyl) ammonium bis(fluoromethylsulfonyl)imide (DEME FSI; viscosity of 131.1cP). The use of the optimal IL, N111(1O2) FSI, resulted in an initial capacity 3.75 times higher than that obtained using DEME FSI in the cell test. The chem. stability of N111(1O2) FSI with lithium metal was confirmed by microstructure anal. of the lithium surface. The physicochem. properties, such as viscosity, ionic conductivity, m.p., and electrochem. properties, were thoroughly characterized.

Journal of Molecular Liquids published new progress about Electric current-potential relationship. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Category: ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhang, Tao; Luan, Yu-Xin; Lam, Nelson Y. S.; Li, Jiang-Fei; Li, Yue; Ye, Mengchun; Yu, Jin-Quan published the artcile< A directive Ni catalyst overrides conventional site selectivity in pyridine C-H alkenylation>, Category: ethers-buliding-blocks, the main research area is alkenylated pyridine preparation; alkyne pyridine alkenylation heterocyclic carbene ligated nickel aluminum catalyst.

Herein, application of bifunctional N-heterocyclic carbene-ligated Ni-Al catalyst in C3-H alkenylation of pyridines was described. This method overrode the intrinsic C2 and/or C4 selectivity, and provided a series of C3-alkenylated pyridines such as I in 43-99% yields and up to 98:2 C3 selectivity. This method not only allowed a variety of pyridine and heteroarene substrates to be used as the limiting reagent, but was also effective for the late-stage C3 alkenylation of diverse complex pyridine motifs in bioactive mols.

Nature Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Category: ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Li, Rui; Gong, Zhong-Liang; Zhu, Qijian; Sun, Meng-Jia; Che, Yanke; Yao, Jiannian; Zhong, Yu-Wu published the artcile< A pre-organized monomer-reservoir strategy to prepare multidimensional phosphorescent organoplatinum nanocrystals and suprastructures>, SDS of cas: 6482-24-2, the main research area is phosphorescent organoplatinum nanocrystal suprastructure.

The preparation of multidimensional nano- and micro structures, in particular suprastructures with well-defined morphol. and bright emissions, is a challenging task in supramol. assembly. For this purpose, a new type of amphiphilic diplatinum complexes is presented as an excellent building block to assemble into highly phosphorescent nanofibers by supramol. Pt···Pt interactions. These organoplatinum supramol. fibers are further used as a pre-organized monomer reservior for the metal ion-triggered post-transformation into crystalline nanoneedles, nanorods, nanobunches, microplates, and microflowers with controllable morphol. and bright phosphorescence. A reverse transformation of the obtained nanorods into nanofibers is demonstrated with the aid of ethylenediamine tetraacetic acid. In contrast, the direct treatment of diplatinum complexes with different metal ions fails to give well-defined nano and microstructures, suggestive of the pre-organized role of nanofibers for the morphol. transformation. Preliminary applications of these nano- and suprastructures in sensing temperature and organic vapors by emission signal changes are demonstrated. In contrast to the conventional hierarchical assembly, the pre-organized monomer-reservoir strategy disclosed in this study offers a versatile method for the synthesis of organic nano and suprastructures with multidimensional morphol. and controllable emission properties.

Science China: Chemistry published new progress about Crystallinity. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, SDS of cas: 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Josse, Pierre; Allain, Magali; Calupitan, Jan Patrick; Jiang, Yue; Cabanetos, Clement; Roncali, Jean published the artcile< Structural Control of the Molecular Packing and Dynamics of Mechanofluorochromic Materials Based on Small Donor-Acceptor Systems with Turn-On Luminescence>, Quality Control of 6482-24-2, the main research area is mechanofluorochromic mol packing luminescence density functional theory.

A series of simple donor-acceptor mols. consisting of an oligo-oxyethylene (OOE) N-substituted diphenylamine connected to a dicyanovinyl (DCV) acceptor group by a thienyl π-conjugating spacer are synthesized. Amorphous deep-red freshly cast thin films rapidly evolve towards an almost colorless pale beige poly-crystalline stable material from which a deep-red photoluminescent state can be switched-on by mech. stimulation. The effects of the length of the OOE chain on the mol. packing of the material and on the dynamics of the recovery process and aggregation in solution are analyzed. Crystallog. results show that the length of the OOE chain directly controls the mol. packing from head-to-tail arrangement of the dipoles for short chain to co-facial dimers leading to a non-centrosym. material with nonlinear optics (NLO) activity for the longer ones. The anal. of the dynamics of the self-recovery process of thin films and of mol. aggregation in solution shows that the dynamics of both processes is directly controlled by the length of the OOE chain. Since, as confirmed by optical and electrochem. results, the OOE substituents have strictly no influence on the electronic properties of the π-conjugated system, the observed effects are unambiguously related to changes in intermol. interactions.

Advanced Optical Materials published new progress about Aldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Quality Control of 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Xing, Nannan; Niu, Kaixuan; Liu, Kefeng; Fang, Dawei; Ma, Xiaoxue; Guan, Wei; Yang, Jiazhen published the artcile< The molar surface quasi-Gibbs energy and its application to the binary mixtures of 1-(2-methoxyethyl)-3-methylimidazolium bis[(trifluoromethyl)sulfonyl]imide [MOEMIM][NTf2] with methanol and ethanol>, Category: ethers-buliding-blocks, the main research area is molar surface Gibbs energy sulfonylimide methanol ethanol binary mixture.

The IL (ionic liquid) 1-(2-methoxyethyl)-3-methylimidazolium bis[(trifluoromethyl)sulfonyl]imide [MOEMIM][NTf2] was prepared and confirmed by 1H NMR (1H NMR) spectroscopy and 13C NMR (13C NMR) spectroscopy. The d. and surface tension for the binary mixtures of [MOEMIM][NTf2] with methanol and ethanol were measured across the entire range of mole fraction (x1 = 0.0000-1.0000) at T = (288.15-318.15) K. The average molar volumes of the binary mixtures were calculated from the exptl. d., which increased with the increase of mole fraction and temperature The excess molar volumes, VEm, were obtained and fitted by Redlich-Kister equation. The interaction between ionic liquid and alc. is the strongest efficient packing and/or attractive interaction at the min. point. The lower the temperature was, the smaller the absolute value of excess molar volume was. The new function – the molar surface quasi-Gibbs energy of mixtures was obtained by us in this work. On a basis of molar surface quasi-Gibbs energy of mixtures, a new Eotvos equation was obtained of mixtures and applied to binary mixtures of [MOEMIM][NTf2] with alcs. The absolute value of the slope of the new Eotvos equation is the mole surface entropy, s, and the intercept is the molar surface enthalpy, h, which is temperature-independent. The deviation of molar surface quasi-Gibbs energy, Δgs, of mixtures for [MOEMIM][NTf2] with methanol and ethanol were calculated Δgs was well fitted by Redlich-Kister equation. In terms of Redlich-Kisters parameters, Ai, a new method for estimating the surface tension, γ, with any component of the mixtures is proposed and the estimated values, γ (estimate), are in good agreement with the corresponding exptl. ones, γ(exp.).

Journal of Chemical Thermodynamics published new progress about Binary mixtures, liquid. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Category: ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Xin, Zhili; Himmelbauer, Martin K.; Jones, J. Howard; Enyedy, Istvan; Gilfillan, Rab; Hesson, Thomas; King, Kristopher; Marcotte, Douglas J.; Murugan, Paramasivam; Santoro, Joseph C.; Gonzalez-Lopez de Turiso, Felix published the artcile< Discovery of CNS-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors>, Computed Properties of 6482-24-2, the main research area is preparation CNS penetrant apoptosis signal regulating kinase inhibitor.

Apoptosis signal-regulating kinase 1 (ASK1) is a key mediator in the apoptotic and inflammatory cellular stress response. To investigate the therapeutic value of modulating this pathway in neurol. disease, we have completed medicinal chem. studies to identify novel CNS-penetrant ASK1 inhibitors starting from peripherally restricted compounds reported in the literature. This effort led to the discovery of 21, a novel ASK1 inhibitor with good potency (cell IC50 = 138 nM), low clearance (rat Cl/Clu = 0.36/6.7 L h-1 kg-1) and good CNS penetration (rat Kp,uu = 0.38).

ACS Medicinal Chemistry Letters published new progress about Apoptosis. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Computed Properties of 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Feng, Shao-Ping; Huang, Kun published the artcile< Enhanced separation of Pd(II) and Pt(IV) from hydrochloric acid aqueous solution using 2-((2-methoxyethyl)thio)-1H-benzimidazole>, Synthetic Route of 6482-24-2, the main research area is palladium platinum separation extraction methoxyethyl thiobenzimidazole.

Separation of palladium (Pd) and platinum (Pt) by solvent extraction is difficult because of their extremely similar physicochem. properties. Development of new extractants with a high extraction efficiency and excellent separation selectivity is the primary focus for enhancing the separation of Pd and Pt by solvent extraction In this study, a new extractant, 2-((2-methoxyethyl)thio)-1H-benzimidazole (MOBI), which contains N, S, and O atoms, was synthesized and used to sep. Pd(II) and Pt(IV) from a hydrochloric acid aqueous solution The exptl. results revealed that Pd(II) and Pt(IV) were effectively separated under the optimal conditions: MOBI concentration of 0.005 mol·L-1, HCl concentration of 0.2 mol·L-1, organic/aqueous (O/A) phase ratio of 1.0, and contact time of 15 min. The separation coefficient between Pd(II) and Pt(IV) was 1246.40, which indicates that MOBI has a higher selectivity for Pd(II) than Pt(IV). In addition, the mechanism of coordination between Pd(II) and MOBI was demonstrated through the slope method, Fourier transform IR spectroscopy (FTIR), hydrogen-1 NMR spectroscopy (1H NMR), and carbon-13 NMR spectroscopy (13C NMR). The results revealed that MOBI could coordinate with Pd(II) via the N atom in the benzimidazole ring of MOBI mols. to form [Pd(MOBI)2Cl2](O).

Rare Metals (Beijing, China) published new progress about Extraction (stripping). 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Synthetic Route of 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Siddiqui, Sheema; Bhawar, Ramesh; Geetharani, K. published the artcile< Iron-Based Catalyst for Borylation of Unactivated Alkyl Halides without Using Highly Basic Organometallic Reagents>, Safety of 1-Bromo-2-methoxyethane, the main research area is alkyl halide unactivated borylation catalyst iron amide complex; alkylboronate preparation borylation unactivated alkyl halide iron hexamethyldisilazide catalyst.

The mild borylation of alkyl bromides and chlorides with bis(neopentylglycolato)diborane (B2neop2) mediated by iron-bis amide is described. The reaction proceeds with a broad substrate scope and good functional group compatibility. Moreover, sufficient catalytic activity was obtained for primary and secondary alkyl halides. Mechanistic studies indicate that the reaction proceeds through a radical pathway.

Journal of Organic Chemistry published new progress about Amines Role: CAT (Catalyst Use), USES (Uses) (amido complexes). 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Safety of 1-Bromo-2-methoxyethane.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem