Category: 6482-24-2

Gao, Xinpei; Wu, Fanglin; Mariani, Alessandro; Passerini, Stefano published the artcile< Concentrated Ionic-Liquid-Based Electrolytes for High-Voltage Lithium Batteries with Improved Performance at Room Temperature>, Reference of 6482-24-2, the main research area is concentration ionic liquid electrolyte lithium battery room temperature viscosity; Li-rich cathode; asymmetric anions; ether-functionalized cations; high concentrated electrolytes; ionic liquids.

Ionic liquids (ILs) have been widely explored as alternative electrolytes to combat the safety issues associated with conventional organic electrolytes. However, hindered by their relatively high viscosity, the electrochem. performances of IL-based cells are generally assessed at medium-to-high temperature and limited cycling rate. A suitable combination of alkoxy-functionalized cations with asym. imide anions can effectively lower the lattice energy and improve the fluidity of the IL material. The Li/Li1.2Ni0.2Mn0.6O2 cell employing N-N-diethyl-N-methyl-N-(2-methoxyethyl)ammonium (fluorosulfonyl)(trifluoromethanesulfonyl)imide (DEMEFTFSI)-based electrolyte delivered an initial capacity of 153 mAh g-1 within the voltage range of 2.5-4.6 V, with a capacity retention of 65.5 % after 500 cycles and stable coulombic efficiencies exceeding 99.5 %. Moreover, preliminary battery tests demonstrated that the drawbacks in terms of rate capability could be improved by using Li-concentrated IL-based electrolytes. The improved room-temperature rate performance of these electrolytes was likely owing to the formation of Li+-containing aggregate species, changing the concentration-dependent Li-ion transport mechanism.

ChemSusChem published new progress about Activation energy. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Reference of 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Li, Jing; Shi, Qiang; Han, Ying; Chen, Chuan-Feng published the artcile< Complexation of 2,6-helic[6]arene and its derivatives with 1,1'-dimethyl-4,4'-bipyridinium salts and protonated 4,4'-bipyridinium salts: an acid-base controllable complexation>, Name: 1-Bromo-2-methoxyethane, the main research area is helicarene preparation inclusion compound formation constant crystal mol structure; 4,4′-bipyridinium salts; complexation; helic[6]arene; hydrogen bond; macrocycles; macrocyclic arene.

2,6-Helic[6]arene and its derivatives I [R = H, Me, (CH2)3, (CH2)2OCH3, (CH2)2OH] were synthesized, and their complexation with 1,1′-dimethyl-4,4′-bipyridinium and protonated 4,4′-bipyridinium salts were investigated in detail. It was found that the helic[6]arene and its derivatives could all form 1:1 complexes with both 1,1′-dimethyl-4,4′-bipyridinium salts and protonated 4,4′-bipyridinium salts II (R1 = H, Me; X = PF6, tetrakis[3,5-bis(trifluoromethyl)phenyl]boranuide) in solution and in the solid state. Especially, the helic[6]arene and its derivatives I [R = (CH2)2OCH3, (CH2)2OH] exhibited stronger complexation with the guests than the other helic[6]arene derivatives for the addnl. multiple hydrogen bonding interactions between the hosts and the guests, which were evidenced by 1H NMR titrations, X-ray crystal structures and DFT calculations Moreover, it was also found that the association constants (Ka) of the complexes could be significantly enhanced with larger counteranions of the guests and in less polar solvents. Furthermore, the switchable complexation between the helic[6]arene and protonated 4,4′-bipyridinium salt could be efficiently controlled by acids and bases.

Beilstein Journal of Organic Chemistry published new progress about Acid-base titration. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Name: 1-Bromo-2-methoxyethane.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yang, Xiaoguang; Hou, Zhuang; Wang, Dun; Mou, Yanhua; Guo, Chun published the artcile< Design, synthesis and biological evaluation of novel heptamethine cyanine dye-erlotinib conjugates as antitumor agents>, SDS of cas: 6482-24-2, the main research area is heptamethine cyanine dye erlotinib conjugate preparation EGFRTK lung cancer; EGFR-TK inhibitor; Heptamethine cyanine dye; Non-small cell lung cancer.

Epidermal growth factor receptor tyrosine kinase (EGFR-TK) has been proved as a target for the treatment of non-small cell lung cancer (NSCLC) with specific gene mutations. However, EGFR-TK inhibitors (EGFR-TKIs) need to enter cancer cells and then competitively interact with the active site of tyrosine kinase receptors to suppress the downstream signaling pathway to inhibit tumor proliferation. In this study, in order to improve the tumor cell targeting ability of EGFR-TKI, EGFR-TKI erlotinib was conjugated with the cancer cell-targeting heptamethine cyanine dyes to form seventeen novel erlotinib-dye conjugates. The efficiency of tumor targeting properties of conjugates against cancer cell growth and EGFR-TK inhibition was evaluated in vitro. The result revealed that most erlotinib-dye conjugates exhibited stronger inhibitory effect on A549, H460, H1299 and MDA-MB-231 cell lines than the parent drug erlotinib. Meanwhile, representative compounds exhibited weak cytotoxicity on human normal mammary epithelial MCF-10A cells. Moreover, the conjugate CE17 also showed ∼14-fold higher EGFR-TK inhibition activity (IC50 = 0.124 μM) than erlotinib (IC50 = 5.182 μM) in A549 cell line. Finally, mol. docking anal. verified that the erlotinib moiety of compound CE17 could form hydrogen bond with Met-769 and occupy active cavity of EGFR-TK. Therefore, we believed the integration strategy between heptamethine cyanine dyes and EGFR-TKI will contribute to enhancing the therapeutic effect of EGFR-TKI for NSCLC treatment.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, SDS of cas: 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Lin, Xiao-Long; Yu, Yan; Zhang, Liang; Leng, Li-Jing; Xiao, Dong-Rong; Cai, Tian; Luo, Qun-Li published the artcile< Switchable synthesis of 1,4-bridged dihydroisoquinoline-3-ones and isoquinoline-1,3,4-triones through radical oxidation of isoquinolinium salts with phenyliodine(III) diacetate>, Category: ethers-buliding-blocks, the main research area is bridged dihydroisoquinolinone isoquinoline trione preparation stereoselective; isoquinolinium salt hydroxycoumarin radical oxidation annulation.

A metal-free switchable synthesis of 1,4-bridged dihydroisoquinoline-3-ones and isoquinoline-1,3,4-triones through the oxidation of isoquinolinium salts is described. 1,4-Bridged dihydroisoquinolin-3-ones were constructed for the first time via the sequential oxidation/annulation of isoquinolinium salts with 4-hydroxycoumarins. Meanwhile, the iodine(III)-oxidized intermediates of isoquinolinium salt could be converted to isoquinoline-1,3,4-triones in high yields by treatment with tert-Bu hydroperoxide. These site-selective transformations rely on an iodine(III)-mediated dual radical addition/radical coupling strategy and prove that the combination of the bromide anion and phenyliodine(III) diacetate is a useful carrier of relatively stable bromine radicals and highly labile carboxyl radicals.

Organic Chemistry Frontiers published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Category: ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wei, Jie; Lu, Donghui; Jiang, Cailian; Fang, Dawei; Hu, Xiaohong published the artcile< Experimental determination of viscosity for the binary mixtures of the ether-functionalized ionic liquids [C22O1IM][TfO] with monohydric alcohols>, Computed Properties of 6482-24-2, the main research area is ionic liquid monohydric alc viscosity binary mixture.

In order to apply ionic liquids in various fields, it is necessary to understand their phys. and chem. properties. Viscosity, in particular, is an important parameter of multicomponent solutions and plays a decisive role in mass transfer, heat transfer and fluid flow in industrial process. In this work, the ether-functionalized ionic liquid [C22O1IM][TfO] was synthesized and characterized by 1H NMR, 13C NMR, ESI mass spectrometry and elemental anal. The viscosity of the binary mixture of ionic liquid [C22O1IM][TfO] with ethanol, 1-propanol and 2-propanol in the full concentration range of T = (288.15-318.15) K were measured. The relationships between the viscosity of the binary system and concentration and temperature were investigated. By Vogel-Tamman-Fulcher (VTF) equation and Arrhenius equation, the temperature dependences of the viscosities for the binary system were described and the VTF equation showed better correlation for the binary system. The viscosity deviation that expresses the difference between the actual value and the ideal value of the mixture viscosity, Δη, was calculated At the same time, the Gibbs energy of activation for viscous flow of the relative viscosity for the mixture, ΔG≠r, was also calculated based on the relative viscosity, ηr, and ΔG≠r is neg. that is consistent with the results of, Δη, it means that the interaction between ions becomes weak due to the solvation.

Journal of Molecular Liquids published new progress about Activation energy. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Computed Properties of 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Spadaro, Angelo; Rao, Marco; Lorenti, Miriam; Romano, Mario Rosario; Augello, Antonio; Eandi, Chiara Maria; Platania, Chiara Bianca Maria; Drago, Filippo; Bucolo, Claudio published the artcile< New brilliant blue G derivative as pharmacological tool in retinal surgery>, Formula: C3H7BrO, the main research area is alkyl brilliant blue inner limiting membrane retina vitreoretinal surgery; Brilliant Blue G; drug design; inner limiting membrane; pucker; retina; vitreoretinal surgery.

Our study was aimed at assessing the retinal binding of a new synthetic Brilliant Blue G (BBG) derivative (pure benzyl-Brilliant Blue G; PBB) ophthalmic formulation, to improve vitreoretinal surgery procedure. Protein affinity of the new mol. was evaluated in vitro (cell-free assay) and in silico. Furthermore, an ex vivo model of vitreoretinal surgery was developed by using porcine eyes to assess the pharmacol. profile of PBB, compared to com. formulations based on BBG and methyl-BBG (Me-BBG). PBB showed a higher affinity for proteins (p < 0.05), compared to BBG and Me-BBG. In vitro and in silico studies demonstrated that the high selectivity of PBB could be related to high lipophilicity and binding affinity to fibronectin, the main component of the retinal internal limiting membrane (ILM). The PBB staining capabilities were evaluated in porcine eyes in comparison with BBG and Me-BBG. Forty microliters of each formulation were slowly placed over the retinal surface and removed after 30 s. After that, ILM peeling was carried out, and the retina collected. BBG, Me-BBG, and PBB quantification in ILM and retina tissues was carried out by HPLC anal. PBB levels in the ILM were significantly (p < 0.05) higher compared to BBG and Me-BBG formulations. On the contrary, PBB showed a much lower (p < 0.05) distribution in retina (52 ng/mg tissue) compared to BBG and Me-BBG, in particular PBB levels were significantly (p < 0.05) lower. Therefore, the new synthetic Brilliant Blue derivative (PBB) showed a great ILM selectivity in comparison to underneath retinal layers. In conclusion, these findings had high translational impact with a tangible improving in ex vivo model of retinal surgery, suggesting a future use during surgical practice. Frontiers in Pharmacology published new progress about Bovine serum albumin Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Formula: C3H7BrO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Marro, Nicolas; della Sala, Flavio; Kay, Euan R. published the artcile< Programmable dynamic covalent nanoparticle building blocks with complementary reactivity>, Related Products of 6482-24-2, the main research area is dynamic covalent nanoparticle monolayer complementary reactivity kinetics.

Nanoparticle-based devices, materials and technologies will demand a new era of synthetic chem. where predictive principles familiar in the mol. regime are extended to nanoscale building blocks. Typical covalent strategies for modifying nanoparticle-bound species rely on kinetically controlled reactions optimized for efficiency but with limited capacity for selective and divergent access to a range of product constitutions. In this work, monolayer-stabilized nanoparticles displaying complementary dynamic covalent hydrazone exchange reactivity undergo distinct chemospecific transformations by selecting appropriate combinations of ‘nucleophilic’ or ‘electrophilic’ nanoparticle-bound monolayers with nucleophilic or electrophilic mol. modifiers. Thermodynamically governed reactions allow modulation of product compositions, spanning mixed-ligand monolayers to exhaustive exchange. High-d. nanoparticle-stabilizing monolayers facilitate in situ reaction monitoring by quant. 19F NMR spectroscopy. Kinetic anal. reveals that hydrazone exchange rates are moderately diminished by surface confinement, and that the magnitude of this effect is dependent on mechanistic details: surface-bound electrophiles react intrinsically faster, but are more significantly affected by surface immobilization than nucleophiles. Complementary nanoparticles react with each other to form robust covalently connected binary aggregates.

Chemical Science published new progress about Aggregation. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Related Products of 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Luridiana, Alberto; Mazzarella, Daniele; Capaldo, Luca; Rincon, Juan A.; Garcia-Losada, Pablo; Mateos, Carlos; Frederick, Michael O.; Nuno, Manuel; Jan Buma, Wybren; Noel, Timothy published the artcile< The Merger of Benzophenone HAT Photocatalysis and Silyl Radical-Induced XAT Enables Both Nickel-Catalyzed Cross-Electrophile Coupling and 1,2-Dicarbofunctionalization of Olefins>, Application of C3H7BrO, the main research area is alkyl bromide bromobenzene nickel catalyst photocatalyst reductive cross coupling; alkene alkylbromide bromobenzene nickel catalyst photocatalyst reductive cross coupling; alkylbenzene preparation.

A strategy for both cross-electrophile coupling and 1,2-dicarbofunctionalization of olefins was developed. Carbon-centered radicals were generated from alkyl bromides by merging benzophenone hydrogen atom transfer (HAT) photocatalysis and silyl radical-induced halogen atom transfer (XAT) and were subsequently intercepted by a nickel catalyst to forge the targeted C(sp3)-C(sp2) and C(sp3)-C(sp3) bonds. The mild protocol was fast and scalable using flow technol., displays broad functional group tolerance and was amenable to a wide variety of medicinally relevant moieties. Mechanistic investigations revealed that the ketone catalyst, upon photoexcitation, was responsible for the direct activation of the silicon-based XAT reagent (HAT-mediated XAT) that furnishes the targeted alkyl radical and was ultimately involved in the turnover of the nickel catalytic cycle.

ACS Catalysis published new progress about Alkylbenzenes Role: SPN (Synthetic Preparation), PREP (Preparation). 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Application of C3H7BrO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yoshii, Kazuki; Uto, Takuya; Tachikawa, Naoki; Katayama, Yasushi published the artcile< The effects of the position of the ether oxygen atom in pyrrolidinium-based room temperature ionic liquids on their physicochemical properties>, Product Details of C3H7BrO, the main research area is methylpyrrolidinium ionic liquid preparation viscosity conductivity conformation cathode potential.

This study investigated, using both exptl. and computational approaches, the effect of ether oxygen atoms on the physicochem. properties of room temperature ionic liquids RTILs consisting of bis(trifluoromethylsulfonyl)amide (TFSA-) with 1-methyl-1-propylpyrrolidinium (MPP+), 1-butyl-1-methylpyrrolidinium (BMP+), 1-methoxymethyl-1-methylpyrrolidinium (MOMMP+), 1-ethoxymethyl-1-methylpyrrolidinium (EOMMP+), and 1-methoxyethyl-1-methylpyrrolidinium (MOEMP+). The viscosity of the RTILs containing the ether oxygen atom was lower than that of the alkyl analogs. Moreover, the viscosity of EOMMPTFSA was lower than that of MOEMPTFSA, albeit EOMMPTFSA and MOEMPTFSA have the same mol. weight with ether oxygen atoms at different positions. Ab initio calculations revealed that the number of methylene groups between nitrogen and oxygen atoms in the cation structure profoundly impacted the local stable structure of the cation. Furthermore, we discussed the relationship between the transport properties and the spatial distribution of ions obtained by MD simulations. This result will be valuable in the design of functionalized RTILs, via the judicious tuning of the conformational flexibility of ether oxygen atoms in related ionic liquids

Physical Chemistry Chemical Physics published new progress about Activation energy. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Product Details of C3H7BrO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Goswami, Lalit N.; Everett, Thomas A.; Khan, Aslam A.; Hawthorne, M. Frederick published the artcile< Rational Design of a Stable Two One-Electron Redox-Active closo-Dodecaalkoxyborane Ion as Biothiol Sensor>, SDS of cas: 6482-24-2, the main research area is biothiol sensor closo alkoxy dodecaborane preparation.

The interest in the incorporation of polyhedral boranes into hybrid mols. has increased tremendously. Most of those efforts have focused on the use of carboranes, as opposed to their all-B counterparts, the polyhedral borane anions. The authors’ efforts have paved the way for the synthesis and application of several inorganic-organic hybrid nanomol. scaffolds derived from closo-dodecaborate ions [B12H12]2- as high payload carriers of drugs and imaging agents. Herein the authors report a significant expansion to the scope of application for these interesting class of mols. A rationally designed water-soluble ether derivative of [B12H12]2-, the [closo-B12(OR)12]2- was synthesized as a highly efficient thiol sensing probe. The thiol sensing mechanism of the probe relies upon the unique two 1-e- redox chem. of the [closo-B12(OR)12]2- ion which is evident by a dramatic color change. This probe is effective over a wide pH range and has the ability to discriminate bio-thiols from common amino acids.

European Journal of Inorganic Chemistry published new progress about Optical biosensors (colorimetric). 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, SDS of cas: 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem