Category: 645-36-3

Chemistry, like all the natural sciences, Application In Synthesis of 2,2-Diethoxyethanamine, begins with the direct observation of nature¡ª in this case, of matter.645-36-3, Name is 2,2-Diethoxyethanamine, SMILES is CCOC(OCC)CN, belongs to ethers-buliding-blocks compound. In a document, author is Zhang, Jie, introduce the new discover.

Atomistic insights into friction and wear mechanisms of graphene oxide

Graphene oxide (GO) is a promising solid lubricant used as a protective coating to reduce friction, while a detailed atomic scale understanding about its tribological behavior is required. In this study, ReaxFF reactive molecular dynamics simulations are used to explore the friction and wear mechanisms of GO. At low load, the structure of GO can be tailored via the tribochemical induced conversion from graphene oxide to graphene (GO-to-Gr), achieving low friction during the sliding process. The effects of multiple sliding and system temperature on the GO-to-Gr conversion are considered. At high load, wear of GO at the nanoscale is characterized by the emergence of the C-C bond and C-O bond breaking, both of which are related to the transformation from the epoxide groups to the ether groups. Furthermore, we show that decreasing the concentration of epoxide groups is a feasible method to enhance wear resistance of GO.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 645-36-3. Application In Synthesis of 2,2-Diethoxyethanamine.

645-36-3, Name is 2,2-Diethoxyethanamine, molecular formula is C6H15NO2, HPLC of Formula: C6H15NO2, belongs to ethers-buliding-blocks compound, is a common compound. In a patnet, author is Xiong, Siyuan, once mentioned the new application about 645-36-3.

Accumulation and influencing factors of novel brominated flame retardants in soil and vegetation from Fildes Peninsula, Antarctica

The concentrations and distributions of nine novel brominated flame retardants (NBFRs) were analyzed in soil, lichen (Usnea aurantiaco-atra), and moss (Sanionia uncinata) samples collected from the Chinese Antarctic Great Wall Station and surrounding Fildes Peninsula area in west Antarctica. Total NBFR concentrations ranged from 61.2-225 pg/g dry weight (dw) in soil, 283-1065 pg/gdw in moss, and 135-401 pg/g dw in lichen, respectively. Decabromodiphenyl ethane (DBDPE) was the dominant NBFR in all samples, accounting for 652%, 50.1%, and 72.4% of cumulative NBFR concentration in soil, moss, and lichen, respectively. The concentrations of NBFRs in plant samples were higher than those in soil, which may be related to plant bioaccumulation. Significant log/log-linear correlations (p < 0.05) were found between the concentrations of BEHTEBP and total organic carbon (TOC) in soil, and between DBDPE and lipid content in mosses, indicating that TOC and lipid content potentially affect certain NBFRs in Antarctic soil and moss. This study presents the first report on NBFR contamination in soil and various vegetation in Antarctica. (C) 2020 Elsevier B.V. All rights reserved. I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 645-36-3 help many people in the next few years. HPLC of Formula: C6H15NO2.

Electric Literature of 645-36-3, These common heterocyclic compound, 645-36-3, name is 2,2-Diethoxyethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound 3 was prepared by the condensation of commercially available aminoacetaldehyde diethyl acetal with the phthalic anhydride (1:1 mol ratio), using toluene under reflux, in the presence of a catalytic amount of DMAP (yield 52%) for 2 h. In the next step, 2-(2,2-diethoxyethyl)isoindoline-1,3-dione (3) underwent acid hydrolysis (sulphuric acid at 70%) in reflux for 2 h. After the reaction was completed, it was allowed to reach at room temperature and was then cooled to induce precipitation. The formed precipitate was filtered on a sintered funnel with distilled water, yielding 55% of the pure product. For the synthesis of 5a and 5b, 2-(1,3-dioxoisoindol-2-yl) acetaldehyde (4) reacted with thiosemicarbazide (in the ratio 1:1) (for 5a) or 4-phenyl-3-thiosemicarbazide (for 5b), in ethanol, under reflux with catalytic amount of HCl (4 drops) for 4 h. The reactions were followed by thin layer chromatographic plate analysis. The formed precipitate was filtered on a sintered funnel with ethanol to yield the pure product (yield 76% for 5a and 70% for 5b).

Statistics shows that 2,2-Diethoxyethanamine is playing an increasingly important role. we look forward to future research findings about 645-36-3.

Reference:
Article; De Moraes Gomes, Paulo Andre Teixeira; Oliveira, Arsenio Rodrigues; De Oliveira Cardoso, Marcos Verissimo; De Farias Santiago, Edna; De Oliveira Barbosa, Miria; De Siqueira, Lucianna Rabelo Pessoa; Moreira, Diogo Rodrigo Magalhaes; Bastos, Tanira Matutino; Brayner, Fabio Andre; Soares, Milena Botelho Pereira; De Oliveira Mendes, Andresa Pereira; De Castro, Maria Carolina Accioly Brelaz; Pereira, Valeria Rego Alves; Leite, Ana Cristina Lima; European Journal of Medicinal Chemistry; vol. 111; (2016); p. 46 – 57;,
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Electric Literature of 645-36-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 645-36-3, name is 2,2-Diethoxyethanamine, This compound has unique chemical properties. The synthetic route is as follows.

Synthesis of rac-(5aR,6S,7R,8R,8aS)-5a-(4-bromophenyl)-3-chloro-N-(2,2-diethoxyethyl)-8,8a-dihydroxy-6-phenyl-5a,7,8,8a-tetrahydro-6H-cyclopenta[4,5]furo[3,2-b]pyridine-7-carboxamide (3) To a solution of rac-(5aR,6S,7R,8R,8aS)-5a-(4-bromophenyl)-3-chloro-8,8a-dihydroxy-6-phenyl-5a,7,8,8a-tetrahydro-6H-cyclopenta[4,5]furo[3,2-b]pyridine-7-carboxylic acid (1, 1.4 g, 2.7 mmol) in dichloromethane (20 mL), 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (1.6 g, 8.3 mmol), 1-hydroxybenzotriazole (1.13 g, 8.3 mmol) and N,N-diisopropylethylamine (2.88 mL, 16.0 mmol) were added at 0 C. and stirred the mixture for 5 min. 2,2-diethoxyethan-1-amine (2, 2.35 g, 13.0 mmol) was then added at same temperature and the reaction was stirred at 35 C. for 16 h. After completion, reaction mass was diluted with dichloromethane and washed with cold water. The organic layer was separated and dried over anhydrous sodium sulphate, filtered and concentrated to give crude. The crude was purified by Combi-flash (12 g, RediSep column) using 2% methanol in dichloromethane as eluent. The desired fractions were concentrated under reduced pressure to afford rac-(5aR,6S,7R,8R,8aS)-5a-(4-bromophenyl)-3-chloro-N-(2,2-diethoxyethyl)-8,8a-dihydroxy-6-phenyl-5a,7,8,8a-tetrahydro-6H-cyclopenta[4,5]furo[3,2-b]pyridine-7-carboxamide (3) as light brown oil. Yield: 1.1 g, 64%; MS (ESI) m/z 617.12[M+1]+.

The chemical industry reduces the impact on the environment during synthesis 2,2-Diethoxyethanamine. I believe this compound will play a more active role in future production and life.

Reference:
Patent; eFFECTOR Therapeutics, Inc.; ERNST, Justin T.; REICH, Siegfried H.; SPRENGELER, Paul A.; TRAN, Chinh Viet; PACKARD, Garrick Kenneth; XIANG, Alan X.; NILEWSKI, Christian; MICHELS, Theo; (478 pag.)US2017/145026; (2017); A1;,
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Adding a certain compound to certain chemical reactions, such as: 645-36-3, name is 2,2-Diethoxyethanamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 645-36-3, Computed Properties of C6H15NO2

N-(3-Bromo-4-chlorobenzyl)-2,2-diethoxyethanamine To a solution of 3-bromo-4-chlorobenzaldehyde (10.0 g, 45 mmol) and 2,2-diethoxyethanamine (6.68 g,50 mmol) in 200 mL of DCM at RT, 0.5 mL of AcOH was added and the resulting mixture was stirred at RT for 30 min. To this mixture, NaCNBH3 (8.1 g, 135 mmol) was added in portions and then stirred at RT overnight. The reaction mixture was portioned between water and DCM. The organic layer was washed with water (80 mL x 2) and brine, dried over anhydrous Na2SO4, filtered and concentrated in vacuo to afford the desired product (11 g, 72% yield) as an oil. The crude product obtained was used directly in the next step without further purification

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,2-Diethoxyethanamine, and friends who are interested can also refer to it.

Reference:
Patent; ARAXES PHARMA LLC; LI, Liansheng; FENG, Jun; WU, Tao; REN, Pingda; LIU, Yi; LIU, Yuan; LONG, Yun, Oliver; WO2015/54572; (2015); A1;,
Ether – Wikipedia,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 645-36-3, name is 2,2-Diethoxyethanamine, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 2,2-Diethoxyethanamine

A mixture of 2-bromo-5,6-dihydro-4H-pyrazolo[1,5-d][1,4]diazepine-7(8H)-thione (265.0 mg, 1.07 mmol), 2,2-diethoxyethan-1-amine(1.42 g, 10.7 mmol) and silver carbonate (590 mg, 2.14 mmol) in tetrahydrofuran (10 mL) was stirred at 80 C. for 1 h. The solvent was concentrated under vacuum. The residue was purified by reverse-phase column eluting with water (0.05% TFA)/CH3CN (85/15) to afford 2-bromo-N-(2,2-diethoxyethyl)-5,8-dihydro-4H-pyrazolo[1,5-d][1,4]diazepin-7-amine (295 mg, 80%) as a brown oil. LCMS (ESI) [M+H]+=345.0

According to the analysis of related databases, 645-36-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Genentech, Inc.; Chan, Bryan; Drobnick, Joy; Gazzard, Lewis; Heffron, Timothy; Liang, Jun; Malhotra, Sushant; Mendonca, Rohan; Rajapaksa, Naomi; Stivala, Craig; Tellis, John; Wang, Weiru; Wei, BinQing; Zhou, Aihe; Cartwright, Matthew W.; Lainchbury, Michael; Gancia, Emanuela; Seward, Eileen; Madin, Andrew; Favor, David; Fong, Kin Chiu; Hu, Yonghan; Good, Andrew; US2018/282282; (2018); A1;,
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Synthetic Route of 645-36-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 645-36-3 as follows.

2,2-diethoxyethan-1-amine 8 (3.63 g; 34.15 mmol) was dissolved in dry DCM (100 ml) and cooled to 0 C, then1,4-cyclohexanedione monoethylene acetal 7 (5.0 g; 31.05 mmol) was added dropwise. After10 min NaBH(OAc)3 (7.89 g; 37.26 mmol) was added in one portion and stirred for 2h atroom temp. The reaction mixture was diluted with DCM and saturated aq. NaHCO3 wasadded slowly, and then stirred for additional 15 min at rt. The layers were separated, theDCM layer was washed couple of times with saturated aq. NaHCO3, water, brine solutionand dried over anhydrous Na2SO4. After concentration the crude residue was filtered throughsilica column to afford pure compound 9a 7.2 g (85% yield).

According to the analysis of related databases, 645-36-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Annamalai, Murali; Hristeva, Stanimira; Bielska, Martyna; Ortega, Raquel; Kumar, Kamal; Molecules; vol. 22; 5; (2017);,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 645-36-3, name is 2,2-Diethoxyethanamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 645-36-3, Computed Properties of C6H15NO2

49 g of Compound 3 was suspended in a solvent mixture of CH3OH (1 l) and THF (1 l), and 42.4 ml (1.1 eq) of diethyl aminoacetal and 22.8 ml (1.5 eq) of acetic acid were added at room temperature, and the mixture was warmed to 50 C. so that undissolved Compound 3 was completely dissolved, and then the mixture was stirred at room temperature for 1 hour. 18.4 g (1.1 eq) of NaCNBH4 was added at room temperature and the mixture was stirred for 1 hour, followed by performing layer separation using H2O and EA, dehydrating with MgSO4, filtering and drying under reduced pressure, thus obtaining a crude title compound. This crude title compound was purified using column chromatography, yielding 70 g (87.3%) of the title compound (Compound 4). 1H NMR (300 MHz, DMSO-d6, ppm, delta): 9.37 (bs, 1H), 8.28 (s, 1H), 7.69 (d, J=7.58, 1H), 7.49 (bs, 1H), 7.31 (t, J=8.05, 1H), 4.90 (bs, 1H), 4.63 (bs, 2H), 4.15 (s, 3H), 3.60 (m, 4H), 3.15 (bs, 2H), 1.15 (t, J=6.98, 6H)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,2-Diethoxyethanamine, and friends who are interested can also refer to it.

Reference:
Patent; JW PHARMACEUTICAL CORPORATION; Chung, Jae-Uk; Kim, Mi-Jung; Lee, Yong-Sil; Ma, Sang-Ho; Cho, Young-Seok; Lee, Sang-Hak; Na, Young-Jun; Kang, Myoung-Joo; Park, Woul-Seong; US2013/196972; (2013); A1;,
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Electric Literature of 645-36-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 645-36-3, name is 2,2-Diethoxyethanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Preparation 26; 5-Chloro-thiophene-2-carboxylic acid (2,2-diethoxyethyl) amide; Add 5-chlorothiophene-2-carboxylic acid (100 g, 0.60 mol) and dichloromethane (1000 mL) to a 3 L three-necked round bottom flask equipped with an overhead stirrer, nitrogen inlet/outlet, addition funnel, and thermocouple. Stir the resulting solution under nitrogen while cooling to 4 0C. Add via addition funnel 2,2-diethyoxyethylamine (88.5 ml, 0.60 mol) in dichloromethane (35 mL) over 12 minutes. Add l-(3- dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (123 g, 0.64 mol) to the chilled mixture. Add additional dichloromethane (165 mL) and stir the reaction mixture for 22 h at room temperature. Quench the reaction with water (1000 mL) and separate the resulting layers. Back extract the aqueous layer with dichloromethane (500 mL) and combine the organic layers. Dry over sodium sulfate and purify through a silica gel bed eluting with dichloromethane followed by a mixture of 1% MeOH in dichloromethane and then a mixture of 10% MeOH in dichloromethane to afford 108 g (65%) of the title compound as a white solid. 1H NMR (500 MHz, CDCl3): delta 7.26 (d, J= 3.5 Hz, IH), 6.85 (d, J= 3.5 Hz, IH), 6.37 (bs, IH), 4.57 (t, J= 5.5 Hz, IH), 3.68-3.74 (m, 2H), 3.48-3.57 (m, 4H), 1.19 (t, J= 7.5 Hz, 6H).

The synthetic route of 2,2-Diethoxyethanamine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ELI LILLY AND COMPANY; WO2007/146758; (2007); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 645-36-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 645-36-3 as follows.

In a 100 mL flask, 3-fluoro-4-((phenoxycarbonyl)amino)benzoic acid methyl ester was added(3. 3 g, 11. 4 mmol, 1 Oeq.),2, 2-diethoxyethanamine (1.28 g, 13. 68 mmol, 1.2 eq.),piperidine (1.4 ml, 17.1 mmol, 1.5 eq.)And 6 mL of N, N-dimethylformamide,95 degrees Celsius heating and stirring 15h.To the reaction solution was added lmL concentrated hydrochloric acid for quenching,Then 40 mL of water was added to extract with ethyl acetate (40 X 3)The organic phases were combined,The organic phase was washed with saturated brine (40 mL)Dried over anhydrous Na2S04, filtered, and the organic solvent was distilled off under reduced pressure to give a brown liquid (3.3 g, Y = 89%)

According to the analysis of related databases, 645-36-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Hubei Xinxiwang Bio-technology Co.,Ltd; xiao, hong; (19 pag.)CN105294567; (2016); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem