Category: 6443-69-2

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6443-69-2, name is 1,2,3-Trimethoxy-5-methylbenzene, A new synthetic method of this compound is introduced below., COA of Formula: C10H14O3

General procedure: To a stirred mixture of 5a-c (0.01mol) and paraformaldehyde (0.45 g, 0.015 mol) was added 3ml of conc. hydrochloric acid (37%) at room temperature. Then, the mixture was stirred at 40 C for 1 h, Water (10 ml) was then added and the mixture was extracted with petroleum ether (4 ¡Á 10 ml), and the combined organic extracts were washed with brine. The solution was dried over Na2SO4 and concentrated in vacuo to afford desired compounds which were used in the next step without further purification. Compound 6a,7 yellow oil, 90% yield. 1H NMR (500 MHz,CDCl3): delta 4.69 (s,2H), 3.89 (s,3H),3.86 (s,3H), 3.84 (s,3H), 2.26(s,3H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Wang, Jin; Li, Shuo; Hu, Xiao; Yang, Jian; Organic Preparations and Procedures International; vol. 46; 5; (2014); p. 469 – 474;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 6443-69-2,Some common heterocyclic compound, 6443-69-2, name is 1,2,3-Trimethoxy-5-methylbenzene, molecular formula is C10H14O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: BF3¡¤Et2O was slowly added dropwise, to a stirred solution of polyhydroxy or polymethoxy phenols and alkyl alchol in dioxane at 0C. After the addition was completed, the stirring was continued for 3h at room temperature. The mixture was poured water and extracted with EtOAc. The organic layer was dried over Na2SO4 and filtered. The solvent was evaporated under reduced pressure. The crude was chromatographed on silica gel.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,2,3-Trimethoxy-5-methylbenzene, its application will become more common.

Reference:
Article; Kamauchi, Hitoshi; Oda, Takumi; Horiuchi, Kanayo; Takao, Koichi; Sugita, Yoshiaki; Bioorganic and Medicinal Chemistry; vol. 28; 1; (2020);,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem