Category: 637-58-1

Thoma, K. published the artcileColloid association and biological availability of local anesthetics. Part 1. Surface activity studies on critical micelle concentrations, Formula: C17H28ClNO3, the publication is Pharmaceutica Acta Helvetiae (1988), 63(2), 34-9, database is CAplus and MEDLINE.

Surface activities of local anesthetics are reported. The ability to associate to micelles in aqueous solution was found with 9 benzoic acid esters, 3 anilides or acid amides, and for all compounds with ether structures. Twelve of the 29 investigated compounds do not associate to micelles. The critical micelle concentrations (CMC) in 0.9% NaCl solution range from 6.0·10^-5 mol/L for the nonionic polydocanol to 6.6·10^-2 mol/L for cornecaine-HCl. Cyclomethycaine has the lowest CMC (4.3·10^-4 mol/L) of basic local anesthetics.

Pharmaceutica Acta Helvetiae published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C9H12BClO3, Formula: C17H28ClNO3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Kim, Min published the artcileEffects of drugs on the stability of phospholipid liposomal membranes, Product Details of C17H28ClNO3, the publication is Yakhak Hoechi (1994), 38(6), 637-45, database is CAplus.

The effect of various drugs on the stability of the liposomal membrane of phosphatidylcholine and cholesterol was studied, employing the fluorescence self-quenching method. Calcein was entrapped into the phospholipid small unilamellar vesicles and the leakage of the fluorescence probe was monitored on adding the drug to the system. Phenothiazine derivatives, some potent local anesthetics and surface active agents were very effective in inducing the leakage of calcein from the liposome. The leakage-inducing activity of these drug substances has been ascribed to their surface activity and the pertubation of the liposomal membrane by these substances. On the other hand a drug with low surface activity or without amphiphilic moieties did not show any effect or only a small effect on the leakage of calcein from the liposomes. The effect of lipid concentration on the stability of the liposomes was also investigated to show that the higher concentrations of lipid more drug was required to induce the leakage. The effect of surface charges of vesicles was also studied, and the results showed that the charge on the liposomes enhanced the stability of the liposomes against the leakage-inducing activity of these drug substances.

Yakhak Hoechi published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, Product Details of C17H28ClNO3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Tavlarakis, Panagiotis published the artcileSimultaneous determination of pramoxine HCl and benzalkonium chloride in wound care solutions by HPLC, Name: 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, the publication is Analytical Methods (2010), 2(6), 722-727, database is CAplus.

A simple gradient reversed-phase high performance liquid chromatog. (HPLC) method was developed for the simultaneous determination of total benzalkonium chloride (BAC) and pramoxine HCl in wound care solutions Laboratory formulations were diluted 1:10 with water and injected into a HPLC system equipped with a Phenomenex, Luna CN column (100 Å, 5μm, 250 mm × 4.6 mm) in order for BAC and pramoxine to sep. from other excipients and be detected by a UV detector (λ = 262 nm). The mobile phase was 0.075 mM sodium acetate trihydrate buffer (pH = 5.0) using multi-ramp gradient elution with acetonitrile. Quantitation was achieved by direct comparison of the peaks of BAC and pramoxine HCl of the sample to a reference standard of known concentrations A stress study with acid, base, peroxide, heat, and light indicated no interference from drug product or excipients. The mean recovery results for both pramoxine and benzalkonium chloride at 100% level were 100.5 ± 0.3%, 100.5 ± 0.1% resp. (mean ± SD, n = 6). In this report, the full exptl. results from developing and validating this method are presented.

Analytical Methods published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C9H10O3S, Name: 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ibrahim, Fawzia published the artcileComparative study of two different chromatographic approaches for quantitation of hydrocortisone acetate and pramoxine hydrochloride in presence of their impurities, Formula: C17H28ClNO3, the publication is Journal of Food and Drug Analysis (2018), 26(3), 1160-1170, database is CAplus and MEDLINE.

In the present study, we compare the performance of two reversed-phase liquid chromatog. approaches using different eluents either conventional hydro-organic eluent or micellar one for simultaneous estimation of hydrocortisone acetate and pramoxine hydrochloride in presence of their degradants and process-related impurities; hydrocortisone and 4-butoxyphenol, resp. For conventional reversed-phase liquid chromatog. (RPLC), separation of the studied compounds was completed on an Inertsil ODS 3-C18 column (150 mm × 4.6 mm, 5μm particle size) with a mobile phase consists of 50 mM phosphate buffer (pH 5.0): acetonitrile (50: 50, volume/volume). For micellar liquid chromatog. (MLC), an Eclipse XDB-C8 column (150 mm × 4.6 mm, 5μm particle size) was chosen for the separation with a green mobile phase consists of 0.15 M sodium dodecyl sulfate, 0.3% triethylamine and 10% n-butanol in 20 mM orthophosphoric acid (pH 5.0). Both methods were extended to analyze hydrocortisone acetate and pramoxine hydrochloride in their co-formulated cream. RPLC was superior to MLC with regard to sensitivity for the estimation of impurities. While, MLC represents an eco-friendly, less hazardous and biodegradable approach. Furthermore, the direct injection of the cream to the system without the need to laborious samples pretreatment, excessive amount of anal. time and/or use of large amount of toxic organic solvents is one of the outstanding advantages of MLC.

Journal of Food and Drug Analysis published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, Formula: C17H28ClNO3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Delbeke, F. T. published the artcileDetection of some local anesthetics in horse urine and plasma by gas-liquid chromatography, COA of Formula: C17H28ClNO3, the publication is Journal of Chromatography (1981), 206(3), 594-9, database is CAplus and MEDLINE.

A gas-liquid chromatog. (GLC) method using a N specific detector is described for the screening of several local anesthetics in horse plasma and urine. The glass columns used were: 5% OV-101, 3% OV-7, and 3% OV-25 on Chromosorb W (80-100 mesh). Blank plasma or urine samples were spiked with the local anesthetics, echothiophate iodide was added followed by NH₄⁺/NH₃ buffer (pH 9.4) and the mixture extracted with cyclohexane. The residue from the organic layer was used for GLC anal. Detection limits and percentage recoveries for the 11 anesthetics studied are given for urine and plasma.

Journal of Chromatography published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, COA of Formula: C17H28ClNO3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Megemont, C. published the artcileComparative activities of some local anesthetics in modifying the effect of acetylcholine in presence of the isolated ventricle of Helix pomatia and the denervated dorsal muscle of Hirudo medicinalis, Application of 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, the publication is Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales (1960), 64-6, database is CAplus.

In low concentrations all of 11 diverse local anesthetics augmented the neg. chronotropic and inotropic effects of acetylcholine on the isolated snail ventricle, and all but 2 antagonized the effect of acetylcholine on the denervated leech muscle.

Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, Application of 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Watts-Oquendo, Erika T. published the artcileEffect of topical pramoxine hydrochloride on discomfort, wheal and flare associated with epicutaneous allergy test, Application of 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, the publication is Annals of Allergy, Asthma, & Immunology (2019), 122(6), 652-653, database is CAplus and MEDLINE.

Thus, our results about treatment effect cannot be extrapolated to children or men. Future studies in children, using more antigens and intradermal test, are warranted based on these results. We report that topical pramoxine does not affect wheal and flare response to allergens nor histamine control and can be used in subjects with hyperalgesia to reduce discomfort associated with the skin test procedure.

Annals of Allergy, Asthma, & Immunology published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C14H26O2, Application of 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Mainville, C. A. published the artcileScope of acetonitrile as a solvent in the nonaqueous titration of organic medicinals, Recommanded Product: 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, the publication is Journal of Pharmaceutical Sciences (1964), 53(2), 154-7, database is CAplus and MEDLINE.

Acetonitrile is a useful solvent for nonaqueous titration of organic medicinals as very few excipients interfere. Its scope, however, for each individual compound must be investigated as solubility cannot be predicted on the basis of chem. similarity.

Journal of Pharmaceutical Sciences published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, Recommanded Product: 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ayehunie, Seyoum published the artcileOrganotypic human vaginal-ectocervical tissue model for irritation studies of spermicides, microbicides, and feminine-care products, Name: 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, the publication is Toxicology in Vitro (2006), 20(5), 689-698, database is CAplus and MEDLINE.

A three-dimensional organotypic vaginal-ectocervical (VEC) tissue model has been developed to test the irritation of topically applied spermicides, microbicides, and vaginal-care products. The in vitro tissue model was reconstructed using normal VEC epithelial cells and is well stratified, containing differentiated basal, suprabasal, intermediate, and superficial cell layers similar to in vivo tissue. The intermediate and superficial cell layers contain glycogen, and the expression of cytokeratins 13 and 14 in the tissue also parallels that of native tissue. The MTT viability assay and histol. assessment were used to test inter-lot and intra-lot reproducibility. The MTT average intra-lot coefficient of variation (CV) was less than 10% and the time required to reduce tissue viability by 50% (ET-50) following application of 1% Triton X-100 averaged 1.25±0.24 h (n = 23) upon completion of the 11-day culture period and 1.30 h ± 0.19 for the same tissues stored overnight at 4° on agarose gels. The utility of the VEC model for irritation studies was examined by testing com. available products using the MTT assay and histol. assessment. The average ET-50 values ranged between 1.8 and 2.7 h for feminine washes, 3.9-6.7 h for spermicides, 6.8-18 h for anti-itch creams, and >18 h for douches, lubricants, and anti-fungal creams. Studies of cytokines released from VEC cultures following product application showed that elevated concentrations of IL-1α and IL-1β were associated with toxicity of test materials. In conclusion, the VEC tissue model is a highly reproducible, non-animal means to assess the irritation of contraceptives, microbicides, and vaginal-care products.

Toxicology in Vitro published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, Name: 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zirwas, Matthew J. published the artcileAnti-pruritic efficacy of itch relief lotion and cream in patients with atopic history: comparison with hydrocortisone cream, Formula: C17H28ClNO3, the publication is Journal of Drugs in Dermatology (2017), 16(3), 243-247, database is CAplus and MEDLINE.

Objective: To evaluate the speed of onset and duration of relief of two ceramide-containing formulations with 1% pramoxine hydroxide (CeraVe Itch Relief Lotion and Cream,Valeant Pharmaceuticals North America LLC, Irvine, CA) in patients with atopic history, including those with active flare and the comparative efficacy of CeraVe Itch Relief Cream to hydrocortisone 1% cream and night-time itch relief with continued use. Methods: Two double-blind, split-body, randomized studies in 66 male and female subjects, ages 11+ years, with history of atopic dermatitis (AD). Itch severity was assessed on a 10-point scale (where 0=none and 7-9=severe). Study one: single applications of ceramide-containing lotion or cream incorporating 1% pramoxine hydrochloride applied to opposite sides of the body. Study two (part 1): single application of ceramide-containing cream or hydrocortisone 1% cream. Study two (part 2): ceramide-containing pramoxine cream applied up to 4 times in a 24-h period, over the course of 6 days. Itch relief assessed at baseline, 2, and 5 min, 1 (2 in study two), 4, and 8 h post-application. Efficacy and aesthetic attributes were assessed at the same timepoints. Clin. evaluation of performance and mildness of the ceramide-containing 1% pramoxine hydrochloride cream at day 6 (study two, part 2). Results: Study one: Relief of itching was rapid and long-lasting with significant reductions in severity after 2 min, and continued improvement over the 8 h test period (P <than.001 vs. baseline at all timepoints). Mean itch severity scores reduced progressively from 6 (moderate) at baseline to 1-2 (mild) after 8 h, with all patients experiencing relief from itching. Rapid and long-lasting relief to dry, itchy, irritated skin was confirmed through patient self-assessment. Both lotion and cream formulations were non-greasy, absorbed quickly and easily, and were non-irritating. Study two: Ceramide-containing cream incorporating 1% pramoxine hydrochloride provided comparable improvement in itch relief (24.6% reduction in mean itch severity 2 min post-application, and 58.0% reduction 8 h post-application) compared to hydrocortisone cream 1% (18.5% reduction and 59.7% reduction, resp.). Daily use of the ceramide-containing 1% pramoxine cream over 6-days provided all-night relief (87.5% agreement), and perception of skin looking and feeling healthier with each use (71.9% and 81.3% agreement, resp.). Limitations: Results of study one and subsequent comparative study with hydrocortisone 1% cream are based on a single application. There were no placebo controls. Conclusions: Ceramide-containing lotion or cream containing 1% pramoxine provides both rapid and long-lasting relief of itching following a single application in atopic patients with or without active flare. Both formulations were well tolerated with aesthetic appeal. Comparable itch relief to hydrocortisone 1% cream was seen with the ceramide-containing cream over an 8-h period following a single application. Further ceramide-containing 1% pramoxine hydrochloride cream was well tolerated with continued use over 6 days, delivering comfort and all-night relief for patients with atopic history suffering from reoccurrant itching.

Journal of Drugs in Dermatology published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C6H12F3NO5S, Formula: C17H28ClNO3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem