Synthetic Route of 633335-94-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 633335-94-1 name is 1-Fluoro-2-methoxy-4-vinylbenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution crude C-16 (110 g, 723.39 mmol) in 39 ethanol (1000 mL) was added 10% 108 Pd/C (50 g). A balloon of hydrogen gas was mounted and the reaction was evacuated and back-filled with hydrogen three times. The reaction was stirred under a hydrogen atmosphere overnight at room temperature. After stirring at RT overnight, the reaction was complete. It was filtered through a pad of Celite and concentrated in vacuo to provide crude compound, which was purified through column chromatography (100-200) silica gel, eluted using 3-5% 47 ethyl acetate/hexane to obtain the desired product C-15 as colorless liquid (24 g, 48% over the 2 steps).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Fluoro-2-methoxy-4-vinylbenzene, and friends who are interested can also refer to it.
Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; FATHEREE, PAUL R.; JIANG, LAN; MCKINNELL, ROBERT MURRAY; THALLADI, VENKAT R.; ZHANG, HAO; DABROS, MARTA; NZEREM, JERRY; BENJAMIN, NOAH; KLEINSCHEK, MELANIE A.; CRATER, GLENN D.; (40 pag.)US2018/311255; (2018); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem