Category: 62415-74-1

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 62415-74-1, name is 1,2-Dibromo-4-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 62415-74-1

Add 4-methoxy-o-dibromobenzene (1.0 mmol), thentBuOOH (1.2mmol), Cu (acac) 2 (0.08mmol), then add 2mL of solvent water, and react at room temperature for 8 hours,After the reaction was completed, the reaction solution was concentrated, and the corresponding product was separated by column chromatography, with a separation yield of 91%.

According to the analysis of related databases, 62415-74-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Shanghai Institute of Technology; Yao Zijian; Qiao Xinchao; (6 pag.)CN110981702; (2020); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 62415-74-1, name is 1,2-Dibromo-4-methoxybenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 62415-74-1, Product Details of 62415-74-1

General procedure: Into a dried two-necked flask (50 mL) equipped with a condenser were placed a stirrer bar, Mg powder (99.9%, 8 mmol), LiCl (8 mmol),DMI (10 mL), and chlorotrimethylsilane (16 mmol). After stirring the mixture at rt for 15 min, 1,2-dibromoarene (1 mmol) was added and the mixture was stirred for 4 h. The mixture was quenched with sat.NaHCO3 and the resulting precipitates were filtered off. The filtrate was extracted with hexane (3 ×) and the combined organic extracts were washed with brine, dried (anhyd Na2SO4), and concentrated by a rotary evaporator. The crude product was purified by column chromatography (silica gel, hexane or hexane/CH2Cl2).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,2-Dibromo-4-methoxybenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Kitamura, Tsugio; Yamada, Rin; Gondo, Keisuke; Eguchi, Nobuo; Oyamada, Juzo; Synthesis; vol. 49; 11; (2017); p. 2495 – 2500;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 62415-74-1, name is 1,2-Dibromo-4-methoxybenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 62415-74-1, name: 1,2-Dibromo-4-methoxybenzene

The zinc reagent 2b was prepared according to TP1 from 1,2-dibromo-4-methoxybenzene (1b, 3.98 g, 15 mmol), Zn-powder(2.94 mg, 45 mmol) and InCl3 (0.25 g, 1.13 mmol). The reaction was carried out in 15 mL DMPU at 50 C for 2 h. Iodolysis indicated a yield of 59% bimetallic reagent (8.85 mmol). The solution containing the zinc reagent was separated from the remaining zinc powder and transferred to a new flask containing a solution of methyl 4-iodobenzoate (3k, 788 g,30 mmol) and PEPPSI-iPr (0.14 g, 0.21 mmol) in THF (15 mL).The reaction mixture was stirred at 50 C for 12 h before being quenched with HCl (2 M, 40 mL). Flash column chromatographical purification on silica gel (pentane/diethylether = 5:1) afforded 4m as a white solid (2.37 g, 6.29 mmol,71%).

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Reference of 62415-74-1,Some common heterocyclic compound, 62415-74-1, name is 1,2-Dibromo-4-methoxybenzene, molecular formula is C7H6Br2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Synthesis of Intermediate I-1 (0258) 5.31 g (20.0 mmol) of 1,2-dibromo-4-methoxybenzene, 3.30 g (30.0 mmol) of pyrocatechol, 0.190 g (1.0 mmol) of CuI, 0.264 g (1.0 mmol) of 18-crown-6, and 8.28 g (60.0 mmol) of K2CO3 were dissolved in 150 mL of dimethylformamide (DMF), and stirred at a temperature of about 140 C. for about 24 hours. The solution was cooled to room temperature, 60 mL of water was added thereto, and an organic layer was extracted three times therefrom using 60 mL of diethyl ether. The obtained organic layer was dried using magnesium sulfate (MgSO4), and the MgSO4 was removed by filtration. A solvent was next removed therefrom by evaporation. The obtained residue was separated and purified through silica gel chromatography to produce 3.21 g of Intermediate I-1 (yield: 75%). The obtained compound was identified by liquid chromatography-mass spectrometry (LC-MS). C13H10O3: M+1 215.1

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,2-Dibromo-4-methoxybenzene, its application will become more common.

Reference:
Patent; SAMSUNG DISPLAY CO., LTD.; Kim, Youngkook; Jung, Hyejin; Han, Sanghyun; Hwang, Seokhwan; (115 pag.)US2017/77419; (2017); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem