Category: 622-86-6

Kim, Yong-Hak published the artcileDegradation of alkyl ethers, aralkyl ethers, and dibenzyl ether by Rhodococcus sp. strain DEE5151, isolated from diethyl ether-containing enrichment cultures, Application In Synthesis of 622-86-6, the main research area is Rhodococcus ether biodegradation.

Twenty strains isolated from sewage sludge were found to degrade various ethers, including alkyl ethers, aralkyl ethers, and dibenzyl ether. In Rhodococcus strain DEE5151, induction of ether degradation needed substrates exhibiting at least one unsubstituted Cα-methylene moiety as the main structural prerequisite. The cleavage reaction observed with anisole, phenetole, and dibenzyl ether indicates that the initial oxidation occurs at such resp. Cα positions. Di-Et ether-induced strain DEE5151 degraded dibenzyl ether via intermediately accumulated benzoic acid. Phenetole seems to be subject also to another ether-cleaving enzyme. Other strains of this group showed different enzymic activities towards the substrate classes investigated.

Applied and Environmental Microbiology published new progress about Aromatic ethers Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Application In Synthesis of 622-86-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Sonda, Shuji published the artcileSynthesis and pharmacological evaluation of benzamide derivatives as selective 5-HT4 receptor agonists, Formula: C8H9ClO, the main research area is piperidinylmethylamine benzoic acid amidation; benzamide derivative preparation 5HT4 ligand; piperidinylmethyl benzamide stereoselective preparation 5HT4 ligand.

It is thought that selective 5-HT4 receptor agonists-such as 4-amino-5-chloro-2-methoxy-N-[1-(6-oxo-6-phenylhexyl)piperidin-4-ylmethyl]benzamide (I)-have the ability to enhance both upper and lower gastrointestinal motility without any significant adverse effects. Modification of I was performed. Variation of the piperidin-4-ylmethyl moiety of I led to a decrease in the binding affinity for the 5-HT4 receptor. Following conversion of the carbonyl group on the benzoyl part to a hydroxyl or sulfoxide group, the binding affinity for the 5-HT4 receptor was retained although the effect on defecation was reduced. Many of the 4-amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamides that had a ether or sulfide moiety in the side-chain part at the 1-position of the piperidine exhibited high affinity for the 5-HT4 receptor. Two of the compounds were selective 5-HT4 receptor agonists, and had a similar effect on defecation to I.

Bioorganic & Medicinal Chemistry published new progress about 5-HT4 receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Formula: C8H9ClO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Pittala, Valeria published the artcileSynthesis and molecular modeling of 1H-pyrrolopyrimidine-2,4-dione derivatives as ligands for the α1-adrenoceptors, SDS of cas: 622-86-6, the main research area is synthesis pyrrolo pyrimidine dione derivative alpha 1 adrenoceptor.

Three different series of 1H-pyrrolopyrimidine-2,4-dione derivatives were designed and synthesized as ligands for the α1-adrenergic receptors (α1-ARs). A microwave-assisted protocol was developed in order to improve purity and yields of some final products. The majority of the synthesized compounds, tested in binding assays, displayed α1-AR affinities in the nanomolar range. Highest affinity values were found in derivatives 10b and 10c (K i = 1.4 nM for both) whereas compound 10e was endowed with the best profile in term of α1-AR affinity (K i = 2.71 nM) coupled with high selectivity towards 5-HT1A receptors (K i >10,000). Mol. docking studies were performed on human α1-ARs and human 5-HT1A receptors in order to rationalize the observed exptl. affinity and selectivity; these computational studies helped to clarify mol. requirements for the design of high-selective α1-adrenergic ligands.

Bioorganic & Medicinal Chemistry published new progress about 5-HT1A receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, SDS of cas: 622-86-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Pais, Adi published the artcileIn Vivo Magnetic Resonance Imaging of the Estrogen Receptor in an Orthotopic Model of Human Breast Cancer, Name: (2-Chloroethoxy)benzene, the main research area is magnetic resonance imaging contrast agent estrogen receptor breast cancer.

Histol. overexpression of the estrogen receptor α (ER) is a well-established prognostic marker in breast cancer. Noninvasive imaging techniques that could detect ER overexpression would be useful in a variety of settings where patients’ biopsies are problematic to obtain. This study focused on developing, by in vivo MRI, strategies to measure the level of ER expression in an orthotopic mouse model of human breast cancer. Specifically, novel ER-targeted contrast agents based on pyridine-tetra-acetate-Gd(III) chelate (PTA-Gd) conjugated to 17β-estradiol (EPTA-Gd) or to tamoxifen (TPTA-Gd) were examined in ER-pos. or ER-neg. tumors. Detection of specific interactions of EPTA-Gd with ER were documented that could differentiate ER-pos. and ER-neg. tumors. In vivo competition experiments confirmed that the enhanced detection capability of EPTA-Gd was based specifically on ER targeting. In contrast, PTA-Gd acted as an extracellular probe that enhanced ER detection similarly in either tumor type, confirming a similar vascular perfusion efficiency in ER-pos. and ER-neg. tumors in the model. Finally, TPTA-Gd accumulated selectively in muscle and could not preferentially identify ER-pos. tumors. Together, these results define a novel MRI probe that can permit selective noninvasive imaging of ER-pos. tumors in vivo. Cancer Res; 71(24); 7387-97.

Cancer Research published new progress about Estrogen receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Name: (2-Chloroethoxy)benzene.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Soltani Rad, Mohammad Navid published the artcileDesign and Synthesis of Some Novel Oxiconazole-Like Carboacyclic Nucleoside Analogues, as Potential Chemotherapeutic Agents, Recommanded Product: (2-Chloroethoxy)benzene, the main research area is carboacyclic nucleoside oxiconazole stereoselective preparation; nucleobase alkyl halide nucleophilic substitution oximation alkylation; formation heat calculation PM3 stereoselectivity.

The synthesis of some novel carboacyclic nucleosides containing oxiconazole-like scaffolds, e.g. I, is described. In this series of carboacyclic nucleosides, pyrimidine as well as purine and other imidazole derivatives were employed as an imidazole successor in oxiconazole. These compounds could be prepared in good yields by using two different strategies. The first strategy uses N-coupling of nucleobases with 2-bromoacetophenones, followed by subsequent oximation and finally O-alkylation with diverse alkylating sources. The second strategy uses N-coupling of 2-bromoacetophenone oximes with nucleobases, followed by O-alkylation. For the rational interpretation of the dominant formation of (E)-oxime ethers rather than (Z)-oxime isomers, PM3 semiempirical quantum-mechanic calculations were discussed and the calculations indicated a lower heat of formation for (E)-isomers.

Helvetica Chimica Acta published new progress about Alkylation. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Recommanded Product: (2-Chloroethoxy)benzene.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hameury, Sophie published the artcileBis(ether-functionalized NHC) Nickel(II) Complexes, Trans to Cis Isomerization Triggered by Water Coordination, and Catalytic Ethylene Oligomerization, SDS of cas: 622-86-6, the main research area is crystal structure imidazolylidene nickel preparation conformer oligomerization catalyst ethylene; mol structure imidazolylidene nickel preparation conformer oligomerization catalyst ethylene.

The new Ni(II) complexes containing NHC ligands N-substituted by a CH2CH2OR ether group (R = Me or Ph) [NiCl2{ImMes(C2OMe)}2] (6, Im = C3H2N2; Mes = mesityl; C2OMe = CH2CH2OMe), [NiCl2{ImBu(C2OMe)}2] (7), [NiBr2{ImDiPP(C2OMe)}2] (8, Dipp = 2,6-diisopropylphenyl), [NiBr2{ImMes(C2OMe)}2] (9), [NiBr2{ImBu(C2OMe)}2] (10), [NiBr2{ImMes(C2OPh)}2] (18; C2OPh = CH2CH2OPh), [NiI2{ImDiPP(C2OMe)}2] (21), [NiI2{ImMes(C2OMe)}2] (22), and [NiI2{ImBu(C2OMe)}2] (23) were synthesized in good yields and fully characterized by NMR spectroscopy and x-ray diffraction anal. The reaction conditions were optimized and further applied to thioether or nonfunctionalized NHC ligands, affording [NiBr2{ImDiPP(C2SPh)}2] (19, C2SPh = CH2CH2SPh) and [NiBr2{ImDiPPBu}2] (20), resp. Equilibrium involving syn/anti isomers were unveiled for complexes [NiCl2{ImDiPP(C2OMe)}2] (5), 6-10, and 18-23. Reactions of 6 and 20 with a halide abstractor afforded the dicationic aquo complexes cis-[Ni{ImMes(C2OMe)}2(H2O)2][PF6]2 (27) and cis-[Ni{ImDiPPBu}2(H2O)2][PF6]2 (28), in which a cis arrangement of the carbene ligands is evidenced, which contrasts with that in their precursors. These mols. represent rare examples of Ni aquo NHC complexes and of complexes with two cis monodentate NHC ligands. The new complexes reported in this work (15 crystal structures) displayed moderate activities as precatalysts for ethylene oligomerization and favored dimerization.

Organometallics published new progress about Aluminoxanes, Me Role: CAT (Catalyst Use), USES (Uses). 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, SDS of cas: 622-86-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Di Franco, Thomas published the artcileSynthesis of E-Alkyl Alkenes from Terminal Alkynes via Ni-Catalyzed Cross-Coupling of Alkyl Halides with B-Alkenyl-9-borabicyclo[3.3.1]nonanes, Category: ethers-buliding-blocks, the main research area is alkene preparation; alkyl halide alkenylborabicyclononane Suzuki Miyaura coupling Ni catalyst.

The first Ni-catalyzed Suzuki-Miyaura coupling of alkyl halides with alkenyl-(9-BBN) reagents is reported. Both primary and secondary alkyl halides including alkyl chlorides can be coupled. The coupling method can be combined with hydroboration of terminal alkynes, allowing the expedited synthesis of functionalized alkyl alkenes from readily available alkynes with complete (E)-selectivity in one pot. The method was applied to the total synthesis of (±)-Recifeiolide, a natural macrolide.

Organic Letters published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Category: ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Dovlatyan, V. V. published the artcileSome conversions of thiazoline carboxylic acid esters, HPLC of Formula: 622-86-6, the main research area is methylthioxothiazoline hydrazone synthesis; thiazoline carboxylate solvolysis hydrazinolysis.

The authors have carried out solvolysis of the previously described Et esters of 3-methyl(aryl)-4-methyl-2-thioxothiazoline-5-carboxylic acids, leading to the corresponding acids without breaking down the heterocycle. They synthesized a series of novel esters from the latter by treatment with di-Me sulfate or reactive halides. Of these, only in the case of the Et ester of 3,4-dimethyl-2-thioxothiazoline-5-carboxylic acid did they obtain the hydrazinolysis product (the hydrazide), from which they synthesized novel hydrazones by treatment with aldehydes and ketones.

Chemistry of Heterocyclic Compounds published new progress about Hydrazinolysis. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, HPLC of Formula: 622-86-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hufsky, Franziska published the artcileDe novo analysis of electron impact mass spectra using fragmentation trees, Related Products of ethers-buliding-blocks, the main research area is electron impact mass spectrum fragmentation tree metabolite.

The automated fragmentation anal. of high resolution EI mass spectra based on a fragmentation tree algorithm is introduced. Fragmentation trees are constructed from EI spectra by automated signal extraction and evaluation. These trees explain relevant fragmentation reactions and assign mol. formulas to fragments. The method enables the identification of the mol. ion and the mol. formula of a metabolite if the mol. ion is present in the spectrum. These identifications are independent of existing library knowledge and, thus, support assignment and structural elucidation of unknown compounds The method works even if the mol. ion is of very low abundance or hidden under contaminants with higher masses. The authors apply the algorithm to a selection of 50 derivatized and underivatized metabolites and demonstrate that in 78% of cases the mol. ion can be correctly assigned. The automatically constructed fragmentation trees correspond very well to published mechanisms and allow the assignment of specific relevant fragments and fragmentation pathways even in the most complex EI-spectra in the authors’ dataset. This method will be very helpful in the automated anal. of metabolites that are not included in common libraries and it thus has the potential to support the explorative character of metabolomics studies.

Analytica Chimica Acta published new progress about Aldehydes Role: ANT (Analyte), BSU (Biological Study, Unclassified), ANST (Analytical Study), BIOL (Biological Study). 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Related Products of ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hardcastle, Ian R. published the artcile4′-Substituted analogs of idoxifene: antiestrogens and calmodulin antagonists, Recommanded Product: (2-Chloroethoxy)benzene, the main research area is idoxifene analog preparation antiestrogen; calmodulin antagonist idoxifene analog.

4′-Substituted analogs, e.g. I, of the antiestrogen idoxifene have been prepared All the compounds were assayed for antagonism of calmodulin dependent c-AMP phosphodiesterase and for binding to rat uterine estrogen receptor. The 4′-amino compound I was the most potent antiestrogen (RBA = 47) while retaining a similar calmodulin antagonism to idoxifene.

Bioorganic & Medicinal Chemistry Letters published new progress about Calmodulins Role: BAC (Biological Activity or Effector, Except Adverse), BSU (Biological Study, Unclassified), BIOL (Biological Study). 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Recommanded Product: (2-Chloroethoxy)benzene.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem