Category: 60789-54-0

Related Products of 60789-54-0, These common heterocyclic compound, 60789-54-0, name is ((4-Bromobutoxy)methyl)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Reference Example 18 4-Benzyloxy-3-(4-benzyloxybutoxy)benzonitrile 4-Benzyloxy-3-hydroxybenzonitrile (3.4g) and potassium carbonate (6.3g) were dissolved in N,N-dimethylformamide (20mL). To the mixture was added benzyl 4-bromobutylether (3mL), and the mixture was stirred at 50C for 16 hours. To the reaction mixture was added dropwise 2mol/L hydrochloric acid (4mL), and the resulting mixture was extracted with ethyl acetate. The organic layer was washed with brine and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure, and the obtained residue was purified by column chromatography on silica gel (eluent:ethyl acetate/hexane=1/5) to give the title compound (5.9g). 1H-NMR (CDCl3) delta ppm: 1.70-2.10 (4H, m), 3.55 (2H, t, J=6.1Hz), 4.04 (2H, t, J=6.5Hz), 4.49 (2H, s), 5.17 (2H, s), 6.90 (1H, d, J=8,2Hz), 7.08 (1H, d, J=1.9Hz), 7.19 (1H, dd, J=1.9Hz, 8.2Hz), 7.24-7.45 (10H, m)

Statistics shows that ((4-Bromobutoxy)methyl)benzene is playing an increasingly important role. we look forward to future research findings about 60789-54-0.

Reference:
Patent; Kissei Pharmaceutical Co., Ltd.; EP1698635; (2006); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 60789-54-0,Some common heterocyclic compound, 60789-54-0, name is ((4-Bromobutoxy)methyl)benzene, molecular formula is C11H15BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Reference Example 32 3-(4-Benzyloxybutoxy)-4-(morpholin-4-yl)benzaldehyde 3-Hydroxy-4-(morpholin-4-yl)benzaldehyde (0.28g) and potassium carbonate (0.38g) were suspended in N,N-dimethylformamide (2 mL). To the reaction mixture was added benzyl 4-bromobutylether (0.36g), and the mixture was stirred at 50C for 16 hours. To the reaction mixture was added water, and the resulting mixture was extracted with ethyl acetate. The organic layer was washed with brine and dried over anhydrous magnesiumsulfate. The filtrate was concentrated under reduced pressure, and the obtained residue was purified by column chromatography on silica gel (ethyl acetate/hexane=1/5) to give the title compound (0.50g). 1H―NMR (CDCl3) delta ppm:

The synthetic route of 60789-54-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kissei Pharmaceutical Co., Ltd.; EP1698635; (2006); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 60789-54-0, The chemical industry reduces the impact on the environment during synthesis 60789-54-0, name is ((4-Bromobutoxy)methyl)benzene, I believe this compound will play a more active role in future production and life.

Reference Example 25 3-(4-Benzyloxybutoxy)-4-hydroxybenzaldehyde 3,4-Dihydroxybenzaldehyde(0.1g)and sodium hydride(60%, 0.064g) were suspended in N,N-dimethylformamide (2 mL), and to the reaction mixture was added benzyl 4-bromobutylether (0.185g) under ice-cooling. The mixture was stirred at room temperature for 17 hours. To the reaction mixture was added water, and the resulting mixture was extracted with ethyl acetate. The organic layer was washed with brine and dried over anhydrous magnesium sulfate. The filtrate was concentrated under reduced pressure, and the obtained residue was purified by column chromatography on silica gel (ethyl acetate/hexane=1/3) to give the title compound (0.1g). 1H―NMR (CDCl3) delta ppm: 1.70-1.85 (2H, m), 1.90-2.05 (2H, m), 3.56 (2H, t, J=6.1Hz), 4.15 (2H, t, J=6.3Hz), 4.53 (2H, s), 6.42 (1H, s), 7.03 (1H, d, J=8.3Hz), 7.20-7.50 (7H, m), 9.81 (1H, s)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, ((4-Bromobutoxy)methyl)benzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Kissei Pharmaceutical Co., Ltd.; EP1698635; (2006); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

These common heterocyclic compound, 60789-54-0, name is ((4-Bromobutoxy)methyl)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C11H15BrO

. A suspension of NaH (60% in mineral oil, 440 mg, 14 mmol) in DMF [(50] ml) was slowly added to a stirred solution of benzyl-4-bromobutyl ether (3.33g, 13.7 mmol) and amide 26 (5.41 g, 5.48 mmol) (WO 00/66587) in DMF (100 ml) kept at [5C.] The reaction mixture was stirred for 10 h at [50] C, quenched with 5 ml of H20 at [0] C, and evaporated to dryness in vacuo. The residue was taken up in ethyl acetate, washed with [H20,] and purified on a silica gel column using ethyl acetate/hexane: 3/7 as eluant; [5.] [1G, (81%)] of 27 were obatained [;’H-NMR] (CDCl3) : 0.97 (t, J=7. 1 Hz, 3H), 1.2-1. 5 (m, 16H), 2.27 (s, 3H), 2.29 (s, 9H), 2.55 (s, 24H), 2.9-3. 2 (m, 16H), 3.31 (t, J=6.0 Hz), 4.41 (s, 2H), 6.9-7. 0 (m, 8H), 7.2- 7.4 (m, [5H).]

The synthetic route of ((4-Bromobutoxy)methyl)benzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SLIL BIOMEDICAL CORPORATION; WO2004/2991; (2004); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 60789-54-0, name is ((4-Bromobutoxy)methyl)benzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 60789-54-0, name: ((4-Bromobutoxy)methyl)benzene

2-(4-benzyloxy)butyl-propanedioic acid, diethyl ester 19 To a warm solution of sodium (49.5 g, 2.15 mol) in 1 L abs. ethanol there is added diethyl malonate (325 mL, 2.11 mol). The solution is warmed up to 50 C. and crude bromide 18 (410 g, 1.68 mol) is added over a 30 m period. The mixture warms up to 65 C. and is then heated under reflux for 1 h. Most of the solvent is evaporated and to the residue there is added 1 L toluene and 500 mL water. The layers are separated and the organic layer is washed with 2*750 mL water, then dried and evaporated. The residue is purified by bulb-to-bulb distillation to afford 410 g of 19 (1.273 mol, 76%) with bp 170 C. (0.2 mmHg). This product is used as such in the next step. 1 H-NMR (CCl4): delta 1.0-2.0 (m) and 1.2 (t) (12H), 3.2(t, 1II), 3.4 (t, 2H), 4.0 (q, 4H), 4.3 (s, 2II), 7.2 (s, 5H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; The Horticulture and Food Research Institute of New Zealand Limited; US5677432; (1997); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 60789-54-0, A common heterocyclic compound, 60789-54-0, name is ((4-Bromobutoxy)methyl)benzene, molecular formula is C11H15BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 115 4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride (1.1 g) as starting compound, potassium carbonate (1.5 g) and 4-benzyloxybutyl bromide (1.0 g) were reacted and treated in the same manner as in Example 52 to give 0.32 g of 4-amino-5-chloro-2-methoxy-N-((1-(4-benzyloxybutyl)piperidin-4-yl)methyl)benzamide. 1H-NMR (CDCl3,ppm)delta:1.40-1.81(9H,m), 2.82(2H,t), 2.98(2H,t), 3.20(2H,t), 3.44(4H,m), 3.82(3H,s), 4.45(3H,s), 5.93(2H,s), 6.48(1H,s), 7.33-7.45(5H,m), 7.66(1H,s), 8.00(1H,t)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD.; EP873990; (1998); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 60789-54-0, A common heterocyclic compound, 60789-54-0, name is ((4-Bromobutoxy)methyl)benzene, molecular formula is C11H15BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 115 4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride (1.1 g) as starting compound, potassium carbonate (1.5 g) and 4-benzyloxybutyl bromide (1.0 g) were reacted and treated in the same manner as in Example 52 to give 0.32 g of 4-amino-5-chloro-2-methoxy-N-((1-(4-benzyloxybutyl)piperidin-4-yl)methyl)benzamide. 1H-NMR (CDCl3,ppm)delta:1.40-1.81(9H,m), 2.82(2H,t), 2.98(2H,t), 3.20(2H,t), 3.44(4H,m), 3.82(3H,s), 4.45(3H,s), 5.93(2H,s), 6.48(1H,s), 7.33-7.45(5H,m), 7.66(1H,s), 8.00(1H,t)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD.; EP873990; (1998); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

These common heterocyclic compound, 60789-54-0, name is ((4-Bromobutoxy)methyl)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C11H15BrO

Reference Example 8 [4-(4-Benzyloxybutoxy)phenyl]methanol The title compound was prepared in a similar manner to that described in Reference Example 6 using benzyl 4-bromobutyl ether instead of benzyl 3-bromopropyl ether. 1H―NMR (CDCl3) delta ppm: 1.52 (1H, t, J=5.6Hz), 1.75-1.95 (4H, m), 3.54 (2H, t, J=6.1Hz), 3.98 (2H, t, J=6.3Hz), 4.52 (2H, s), 4.61 (2H, d, J=5.6Hz), 6.8-6.9 (2H, m), 7.2-7.4 (7H, m)

The synthetic route of ((4-Bromobutoxy)methyl)benzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kissei Pharmaceutical Co., Ltd.; EP1548024; (2005); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 60789-54-0, These common heterocyclic compound, 60789-54-0, name is ((4-Bromobutoxy)methyl)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 231 4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride (1.1 g) as starting compound, potassium carbonate (1.5 g) and 4-benzyloxybutyl bromide (1.0 g) were reacted and treated in the same manner as in Example 168 to give 0.32 g of 4-amino-5-chloro-2-methoxy-N-((1-(4-benzyloxybutyl)piperidin-4-yl)methyl)benzamide. 1 H-NMR (CDCl3,ppm) delta: 1.40-1.81(9 H,m), 2.82(2 H,t), 2.98(2 H,t), 3.20(2 H,t), 3.44(4 H,m), 3.82(3 H,s), 4.45(3 H,s), 5.93(2 H,s), 6.48(1 H,s), 7.33-7.45(5 H,m), 7.66(1 H,s), 8.00(1 H,t)

The synthetic route of 60789-54-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Yoshitomi Pharmaceutical Industries, Ltd.; US5864039; (1999); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 60789-54-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 60789-54-0 as follows.

Norspermidine (20) was reacted with benzyl 4-bromobutyl ether (21,1. 2 equiv) over a day at room temperature in the presence of 1.4 equivalents of cesium hydroxide monohydrate and 4 A molecular sieves in DMF to give 22. The amino groups were protected using di (t-butyl) dicarbonate in aqueous tetrahydrofuran (THF) to give 23. Calcium in ammonia and THF efficiently generated alcohol 24.

According to the analysis of related databases, 60789-54-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.; WO2005/23310; (2005); A2;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem