Category: 60656-87-3

Liang, Zhanqun; Lv, Kang; Zhou, Shaofang; Zhu, Changlei; Bao, Xiaoguang published an article in 2021. The article was titled 《Visible-light photocatalytic preparation of alkenyl thioethers from 1,2,3-thiadiazoles and Hantzsch esters: synthetic and mechanistic investigations》, and you may find the article in Organic Chemistry Frontiers.Electric Literature of C9H10O2 The information in the text is summarized as follows:

A protocol to synthesize trisubstituted alkenyl thioethers I (R1 = Ph, 3-ClC6H4, 2-naphthyl, 2-thienyl, etc.; R2 = i-Pr, cyclohexyl, PhCH2, PhCMe2, etc.) through a direct S-alkylation of 1,2,3-thiadiazoles II with C-radical precursors, 4-alkyl-1,4-dihydropyridines III (R3 = EtO2C, t-BuO2C, CN), driven by visible-light photocatalysis is disclosed. A broad range of primary, secondary and tertiary C-radical precursors is suitable for this reaction and the desired products can be obtained in good to excellent yields under mild conditions. Remarkably, high stereoselectivity with Z-alkenyl thioethers was achieved in the presence of a Cu(OAc)2 catalyst. Synergistic exptl. and computational studies were carried out to shed light on the mechanisms of this reaction, in which the quenching pathway of an excited photocatalyst (*RuII) could be altered in the presence of the Cu(OAc)2 catalyst. A reductive quenching pathway (RuII/*RuII/RuI/RuII) was proposed in the absence of the Cu(OAc)2 catalyst while an oxidative quenching pathway (RuII/*RuII/RuIII/RuII) was suggested with the assistance of the Cu(OAc)2 catalyst. In addition, the origin of the Z-selectivity of the product was discussed. In the experimental materials used by the author, we found 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Electric Literature of C9H10O2)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Electric Literature of C9H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Yuan, Jinping; Jain, Pankaj; Antilla, Jon C. published an article in Journal of Organic Chemistry. The title of the article was 《Chiral Phosphoric Acid-Catalyzed Enantio- and Diastereoselective Allylboration of Aldehydes with β,γ-Substituted Allylboronates》.Recommanded Product: 2-(Benzyloxy)acetaldehyde The author mentioned the following in the article:

The catalytic asym. addition of β,γ-substituted allylboronates to aldehydes was described. Promoted by 5 mol % chiral H3PO4, the reactions were broadly applicable, scalable, and efficient, allowing for the formation of 3,4-anti/syn-homoallylic alcs. bearing adjacent tertiary or quaternary stereogenic centers in a highly enantio- and diastereoselective manner (≤99% ee and dr >20:1). The rigid chair-like transition state involving the chiral H3PO4 contributed to the highly controlled reaction. In the part of experimental materials, we found many familiar compounds, such as 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Recommanded Product: 2-(Benzyloxy)acetaldehyde)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.Recommanded Product: 2-(Benzyloxy)acetaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Lewis Acid-Catalyzed Vinyl Acetal Rearrangement of 4,5-Dihydro-1,3-dioxepines: Stereoselective Synthesis of cis- and trans-2,3-Disubstituted Tetrahydrofurans》 was published in Journal of Organic Chemistry in 2020. These research results belong to Ghosh, Arun K.; Belcher, Miranda R.. COA of Formula: C9H10O2 The article mentions the following:

Lewis acid-catalyzed rearrangements of 4,5-dihydro-1,3-dioxepines have been investigated. Rearrangement of vinyl acetals under a variety of conditions resulted in cis- and trans-2,3-disubstituted THF derivatives in a highly stereoselective manner. Rearrangements at lower temperatures typically provided the cis-2,3-disubstituted THF carbaldehydes. At higher temperatures, the corresponding trans-2,3-disubstituted THF carbaldehydes are formed. The requisite substrates for the vinyl acetal rearrangement were synthesized via ring-closing olefin metathesis of bis(allyoxy)methyl derivatives using Grubbs second-generation catalyst followed by olefin isomerization using a catalytic amount of RuCl2(PPh3)3. We examined the substrate scope using substituted aromatic and aliphatic derivatives Addnl., the rearrangement was utilized in the synthesis of a stereochem.-defined bis-tetrahydrofuran (bis-THF) derivative, which is one of the key structural elements of darunavir, an FDA-approved drug for the treatment of HIV/AIDS. The experimental part of the paper was very detailed, including the reaction process of 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3COA of Formula: C9H10O2)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.COA of Formula: C9H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Pal, Ashutosh published an article in 2021. The article was titled 《Synthesis of salicylate and salicylamide alcohols for the preparation of phosphorodiamidates and ifosfamide prodrugs》, and you may find the article in Oriental Journal of Chemistry.Application In Synthesis of 2-(Benzyloxy)acetaldehyde The information in the text is summarized as follows:

Different types of salicylate and salicylamide alcs. for the preparation of phosphorodiamidates and ifosfamide prodrugs were reported. In drug discovery and development, prodrugs were well-known for pharmacokinetic effects of pharmacol. nimble products. Almost 10% of drugs permitted, whole world were classified as prodrugs, where the application of a prodrug method during initial stages of development was an emergent fashion. In the experiment, the researchers used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Application In Synthesis of 2-(Benzyloxy)acetaldehyde)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Application In Synthesis of 2-(Benzyloxy)acetaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Synthesis and cytotoxicity of (-)-homo-renieramycin G and its derivatives》 was written by Ma, Yantao; Pan, Xuan; Guan, Baohe; Zhang, Guangyan; Liu, Zhanzhu. Electric Literature of C9H10O2 And the article was included in Organic & Biomolecular Chemistry in 2020. The article conveys some information:

(-)-Homo-renieramycin G (I) and its twenty derivatives were prepared from L-tyrosine Me ester via a multi-step route. Their cytotoxicities were tested against four human cancer cell lines (A549, HeLa, KB and BGC-823). (-)-Renieramycin G and (-)-homo-renieramycin G showed comparable cytotoxicity against these four cancer cell lines, which indicated that the expansion of ring C from the six-membered 1,4-piperazinone to the seven-membered 1,4-diazepanone had no obvious impact on the cytotoxicity. The compound with Me side chain and compounds with heterocyclic aromatic side chains at C-23 exhibited the most potent cytotoxicity with the IC50 values at the level of 10-6 M. In the experiment, the researchers used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Electric Literature of C9H10O2)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Electric Literature of C9H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application In Synthesis of 2-(Benzyloxy)acetaldehydeIn 2021 ,《Construction of Enantioenriched 4,5,6,7-Tetrahydrofuro[2,3-b]pyridines through a Multicatalytic Sequence Merging Gold and Amine Catalysis》 was published in Advanced Synthesis & Catalysis. The article was written by Genet, Manon; Takfaoui, Abdelilah; Marrot, Jerome; Greck, Christine; Moreau, Xavier. The article contains the following contents:

A series of enantioenriched 4,5,6,7-tetrahydrofuro[2,3-b]pyridines I (R1 = Ph, 2-MeC6H4, 2-thienyl, etc.; R2 = Me, Pr, Bn, etc.; R3 = Ph, 4-MeOC6H4, 4-FC6H4, etc.) were accessed by a cycloisomerization/cycloaddition strategy. Starting from ynamide derivatives and aldehydes, yields ranging from 27 to 90% and high levels of stereoselectivity (de>95%, 93-99% ee) were obtained through sequential relay catalysis. The concurrent use of a gold complex with a diphenylprolinol silyl ether was applied to a combination of diversely functionalized substrates. The experimental process involved the reaction of 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Application In Synthesis of 2-(Benzyloxy)acetaldehyde)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Application In Synthesis of 2-(Benzyloxy)acetaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Lebrene, Arthur; Martzel, Thomas; Gouriou, Laura; Sanselme, Morgane; Levacher, Vincent; Oudeyer, Sylvain; Afonso, Carlos; Loutelier-Bourhis, Corinne; Briere, Jean-Francois published their research in Journal of Organic Chemistry in 2021. The article was titled 《The Catalytic Regio- and Stereoselective Synthesis of 1,6-Diazabicyclo[4.3.0]nonane-2,7-diones》.Electric Literature of C9H10O2 The article contains the following contents:

A straightforward synthesis of original 1,6-diazabicyclo[4.3.0]nonane-2,7-diones I (n = 1, 2; R = Me, Ph, methoxycarbonyl, etc.; R1 = i-Pr, 4-chlorophenyl, cyclopropyl, pyridin-4-yl, etc.) was achieved through a DBU-organocatalyzed multicomponent Knoevenagel-aza-Michael-Cyclocondensation reaction which takes advantage of an unprecedented highly regio- and diastereoselective conjugate addition of pyridazinones II to alkylidene Meldrum’s acid intermediates. The key reactive intermediates of this complex process were analyzed by means of electrospray ionization mass spectrometry coupled to ion mobility spectrometry, allowing to validate the proposed mechanism. In addition to this study using 2-(Benzyloxy)acetaldehyde, there are many other studies that have used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Electric Literature of C9H10O2) was used in this study.

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.Electric Literature of C9H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Alberca, Saul; Velazquez, Marta; Trujillo-Sierra, Jose; Iglesias-Sigueenza, Javier; Fernandez, Rosario; Lassaletta, Jose M.; Monge, David published an article in Advanced Synthesis & Catalysis. The title of the article was 《Pd(II)-Catalyzed Asymmetric Addition of Arylboronic Acids to Aliphatic N-Carbamoyl Hydrazones》.Recommanded Product: 60656-87-3 The author mentioned the following in the article:

Catalysts generated by combinations of Pd(TFA)2 and 2-pyridinecarbohydrazone ligands have been applied to 1,2 addition of arylboronic acids ArB(OH)2 to aliphatic N-carbamoyl (Cbz) hydrazones RCH:NNR1R2 (R1R2 = phthaloyl; R1 = Cbz, R2 = H), affording protected α-aryl monoalkylhydrazines RCHArNHNR1R2 with high enantioselectivities (37-99% ee). Subsequent removal of the benzyloxy carbonyl protecting group provides a direct entry to free monosubstituted hydrazines, key building blocks for the synthesis of appealing 1,2-diaza-heterocycles, amino acid derived hydrazides and other pharmacophores thereof. The experimental process involved the reaction of 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Recommanded Product: 60656-87-3)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.Recommanded Product: 60656-87-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Park, Yunjeong; Lee, Ji Sun; Ryu, Jae-Sang published their research in Advanced Synthesis & Catalysis in 2021. The article was titled 《Gold(I)-Catalyzed Intramolecular Dehydrative Amination of Sulfamate Esters Tethered to Allylic Alcohols: A Strategy for the Synthesis of Cyclic Sulfamidates》.COA of Formula: C9H10O2 The article contains the following contents:

An efficient synthesis protocol for cyclic sulfamidates I [R1 = t-Bu, n-pentyl, cyclohexyl, etc.; R2 = H; R3 = H, Me; R4 = H, Me; R5 = H, Me] was developed via catalytic intramol. cyclizations of sulfamate esters tethered to allylic alcs. The reactions proceeded smoothly at room temperature in the presence of (IPr)AuCl (5 mol%) and AgBF4 (5 mol%). This protocol featured good to excellent yields, high selectivity, broad substrate scope, and mild reaction conditions. This method was also applicable to the synthesis of a seven-membered sulfamidate.2-(Benzyloxy)acetaldehyde(cas: 60656-87-3COA of Formula: C9H10O2) was used in this study.

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.COA of Formula: C9H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Organocatalytic multicomponent synthesis of α/β-dipeptide derivatives》 was published in Chemistry – A European Journal in 2020. These research results belong to Martzel, Thomas; Annibaletto, Julien; Millet, Pierre; Pair, Etienne; Sanselme, Morgane; Oudeyer, Sylvain; Levacher, Vincent; Briere, Jean-Francois. SDS of cas: 60656-87-3 The article mentions the following:

A straightforward multicomponent Knoevenagel-aza-Michael-cyclocondensation reaction involving readily available hydroxamic acid-derived from naturally occurring α-amino acids allows a diversity-oriented synthesis of novel isoxazolidin-5-ones possessing an N-protected α-amino acid pendant with good to high diastereoselectivities thanks to a match effect with a chiral organocatalyst. These diversely substituted heterocycles, easily isolated as a single diastereoisomer, proved to be versatile platforms for the formation of an array of α/β-dipeptide fragments. The experimental part of the paper was very detailed, including the reaction process of 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3SDS of cas: 60656-87-3)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.SDS of cas: 60656-87-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem