Category: 60656-87-3

Yang, Kai; Zhang, Feng; Fang, Tongchang; Li, Chaokun; Li, Wangyang; Song, Qiuling published an article in 2021. The article was titled 《Passerini-type reaction of boronic acids enables α-hydroxyketones synthesis》, and you may find the article in Nature Communications.Quality Control of 2-(Benzyloxy)acetaldehyde The information in the text is summarized as follows:

Multicomponent reactions (MCRs) facilitate the rapid and diverse construction of mol. scaffolds with modularity and step economy. In this work, engagement of boronic acids as carbon nucleophiles culminates in a Passerini-type three-component coupling reaction towards the synthesis of an expanded inventory of α-hydroxyketones with skeletal diversity. In addition to the appealing features of MCRs, this protocol portrays good functional group tolerance, broad substrate scope under mild conditions and operational simplicity. The utility of this chem. is further demonstrated by amenable modifications of bioactive products and pharmaceuticals as well as in the functionalization of products to useful compounds In addition to this study using 2-(Benzyloxy)acetaldehyde, there are many other studies that have used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Quality Control of 2-(Benzyloxy)acetaldehyde) was used in this study.

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Quality Control of 2-(Benzyloxy)acetaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wang, Cheng-Gang; Zhang, Yunxing; Wang, Simin; Chen, Bin; Li, Yang; Ni, Hai-Liang; Gao, Yuanji; Hu, Ping; Wang, Bi-Qin; Cao, Peng published their research in Organic Letters in 2021. The article was titled 《Nickel-Catalyzed Carboalkenylation of 1,3-Dienes with Aldehydes and Alkenylzirconium Reagents: Access to Skipped Dienes》.Computed Properties of C9H10O2 The article contains the following contents:

A regio- and stereoselective nickel-catalyzed three-component coupling reaction of aldehydes, 1,3-dienes, and alkenylzirconium reagents was realized. The ligand- and additive-free protocol afforded a convenient approach to the synthesis of skipped diene compounds bearing various functionals (e.g., hydroxyl, carbonyl, halide) and heterocyclic groups. The products were readily transformed into structurally diverse polyenes. The utility of this reaction was also demonstrated by the one-pot operation and scale-up preparation In addition to this study using 2-(Benzyloxy)acetaldehyde, there are many other studies that have used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Computed Properties of C9H10O2) was used in this study.

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.Computed Properties of C9H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Shi, Shuai; Qiu, Wenting; Miao, Pannan; Li, Ruining; Lin, Xianfeng; Sun, Zhankui published an article in 2021. The article was titled 《Three-component radical homo Mannich reaction》, and you may find the article in Nature Communications.Related Products of 60656-87-3 The information in the text is summarized as follows:

By employing a radical process, enolizable aldehydes were utilized as substrates in the three-component radical homo-Mannich reaction for the streamlined synthesis of γ-amino-carbonyl compounds. The electrophilic radicals were generated from thiols HSCHR1C(O)R2 (R1 = H, Me; R2 = Me, EtO, PhCH2O, 1-adamantyl, Et2N, etc.) via the desulfurization process facilitated by visible-light, and then added to the electron-rich double bonds of enamines, formed in-situ from aldehydes or ketones R3CH2C(O)R4 [R3 = H, Et, MeSCH2, Ph, PhCH2, etc., R4 = H; R3 = H, R4 = Ph, 3-FC6H4, etc.; R3R4 = (CH2)5, CH2CHPhCH2CH2, CH2N(CH2Ph)CH2CH2, etc.] and amines R5NHR6 [R5 = Me, R6 = H2C:CHCH2, PhCH2, cyclohexyl, etc.; R5 = PhCH2, R6 = PhCH2, EtO2CCH2, etc.; R5R6 = (CH2)4, CHPh(CH2)3, etc.] to provide the products I in a single step. The broad scope, mild conditions, high functional group tolerance, and modularity of this metal-free approach for the synthesis of complex tertiary amine scaffolds will likely be of great utility to chemists in both academia and industry. In addition to this study using 2-(Benzyloxy)acetaldehyde, there are many other studies that have used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Related Products of 60656-87-3) was used in this study.

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Related Products of 60656-87-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Direct Access to Highly Enantioenriched α-Branched Acrylonitriles through a One-Pot Sequential Asymmetric Michael Addition/Retro-Dieckmann/Retro-Michael Fragmentation Cascade》 was written by Duchemin, Nicolas; Cattoen, Martin; Gayraud, Oscar; Anselmi, Silvia; Siddiq, Bilal; Buccafusca, Roberto; Daumas, Marc; Ferey, Vincent; Smietana, Michael; Arseniyadis, Stellios. Computed Properties of C9H10O2 And the article was included in Organic Letters in 2020. The article conveys some information:

A highly enantioselective synthesis of α-branched acrylonitriles is reported featuring a one-pot sequential asym. Michael addition/retro-Dieckmann/retro-Michael fragmentation cascade. The method, which relies on a solid, bench-stable, and com. available acrylonitrile surrogate, is practical, scalable, and highly versatile and provides a direct access to a wide range of enantioenriched nitrile-containing building blocks. Most importantly, the method offers a new tool to incorporate an acrylonitrile moiety in an asym. fashion. In addition to this study using 2-(Benzyloxy)acetaldehyde, there are many other studies that have used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Computed Properties of C9H10O2) was used in this study.

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Computed Properties of C9H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Catalytic Ynone-Amidine Formal [4 + 2]-Cycloaddition for the Regioselective Synthesis of Tricyclic Azepines》 was written by Reddy, T. Prabhakar; Gujral, Jagjeet; Roy, Pritam; Ramachary, Dhevalapally B.. COA of Formula: C9H10O2This research focused onynone amidine calcium cycloaddition catalyst; azepine tricyclic stereoselective preparation. The article conveys some information:

A Ca(OTf)2- and self-promoted ynone-amidine atom-economic formal [4 + 2]-cycloaddition of various ynones with amidines is reported for the construction of highly functionalized tricyclic azepines. High reaction rate, ease of operation, and high product selectivity with wide substrate scope are the key advantages of the present annulation protocol. The experimental part of the paper was very detailed, including the reaction process of 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3COA of Formula: C9H10O2)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).COA of Formula: C9H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Enantioselective three-component Ugi reaction catalyzed by chiral phosphoric acid》 was published in Science China: Chemistry in 2020. These research results belong to Zhang, Jian; Wang, Yi-Yan; Sun, He; Li, Shao-Yu; Xiang, Shao-Hua; Tan, Bin. Safety of 2-(Benzyloxy)acetaldehyde The article mentions the following:

A catalytic enantioselective three-component Ugi reaction was developed. SPINOL-derived phosphoric acid with bulky 2,4,6-tricyclohexylphenyl groups at the 6,6′ positions I was found to be the best catalyst to afford α-amino amide derivatives, e.g., II in good to excellent yields (62% to 99%) and enantiocontrol (81% to >99% enantiomeric excess). This asym. reaction was applicable well to an array of aliphatic aldehydes. The gram-scale synthesis, modification of dapsone, and enantioselective synthesis of (R)-Lacosamide underline the general utility of this methodol. Influence of dihedral angles and substituents of the chiral phosphoric acids on the enantioselectivity was also discussed in this article. After reading the article, we found that the author used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Safety of 2-(Benzyloxy)acetaldehyde)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.Safety of 2-(Benzyloxy)acetaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Rapid Discovery of Aspartyl Protease Inhibitors Using an Anchoring Approach》 was published in ChemMedChem in 2020. These research results belong to Konstantinidou, Markella; Magari, Francesca; Sutanto, Fandi; Haupenthal, Joerg; Jumde, Varsha R.; Uenver, M. Yagiz; Heine, Andreas; Camacho, Carlos Jamie; Hirsch, Anna K. H.; Klebe, Gerhard; Doemling, Alexander. Category: ethers-buliding-blocks The article mentions the following:

Pharmacophore searches that include anchors, fragments contributing above average to receptor binding, combined with one-step syntheses are a powerful approach for the fast discovery of novel bioactive mols. Here, the authors are presenting a pipeline for the rapid and efficient discovery of aspartyl protease inhibitors. First, the authors hypothesized that hydrazine could be a multi-valent warhead to interact with the active site Asp carboxylic acids. The authors incorporated the hydrazine anchor in a multicomponent reaction and created a large virtual library of hydrazine derivatives synthetically accessible in one-step. Next, the authors performed anchor-based pharmacophore screening of the libraries and resynthesized top-ranked compounds The inhibitory potency of the mols. was finally assessed by an enzyme activity assay and the binding mode confirmed by several soaked crystal structures supporting the validity of the hypothesis and approach. The herein reported pipeline of tools will be of general value for the rapid generation of receptor binders beyond Asp proteases.2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Category: ethers-buliding-blocks) was used in this study.

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Garnes-Portoles, Francisco; Miguelez, Ruben; Grayson, Matthew N.; Barrio, Pablo published an article in 2022. The article was titled 《Heteroatom-Tethered ω-Alkenylallylboronates: Stereoselective Synthesis of Heterocyclic Derived Alcohols》, and you may find the article in Synthesis.Reference of 2-(Benzyloxy)acetaldehyde The information in the text is summarized as follows:

The synthesis of ω-alkenylallylboronates using a heteroatom tether to join both functional groups was described for the first time. Then, these unprecedented compounds were used in a tandem Bronsted acid catalyzed allylboration/ring-closing metathesis (RCM) reaction affording heterocyclic derived alcs. as single diastereoisomers. The low enantioselectivity observed in the asym. version using a chiral phosphoric acid catalyst was studied theor. The results came from multiple reactions, including the reaction of 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Reference of 2-(Benzyloxy)acetaldehyde)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.Reference of 2-(Benzyloxy)acetaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Wang, Tian-Ci; Wang, Pu-Sheng; Chen, Dian-Feng; Gong, Liu-Zhu published an article in Science China: Chemistry. The title of the article was 《Access to chiral homoallylic vicinal diols from carbonyl allylation of aldehydes with allyl ethers via palladium-catalyzed allylic C-H borylation》.Synthetic Route of C9H10O2 The author mentioned the following in the article:

An asym. carbonyl allylation of aldehydes with allyl ethers proceeding via allylic C-H borylation enabled by palladium and chiral phosphoric acid sequential catalysis, providing facile access to homoallylic vicinal anti-diols such as I [R1 = n-heptyl, 4-O2NC6H4, BnOCH2, etc.; R2 = H, Me, cyclohexyl, etc.; R3 = Bn, PMB, TBSO(CH2)3, etc.] in high yields and with excellent stereoselectivity was described. This protocol enabled total synthesis of aigialomycin D to be finished within 7 steps. The results came from multiple reactions, including the reaction of 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Synthetic Route of C9H10O2)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Synthetic Route of C9H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《The efficient synthesis of D-xylulose and formal synthesis of Syringolide 1》 was written by Kalagara, Sudhakar; Orozco, Gabriel; Mito, Shizue. Recommanded Product: 60656-87-3This research focused onxylulose stereoselective hydroxylation hydroxyacetone ethylene glycol syringolide Wittig. The article conveys some information:

Wittig reaction and asym. dihydroxylation were used as the key steps in the synthesis of D-xylulose, a com. available but costly carbohydrate. The effects of protecting groups and reactions conditions on asym. dihydroxylation are demonstrated. Optically pure D-xylulose was obtained after 4-6 steps from readily available hydroxyacetone and ethylene glycol. The method also involves some other valuable intermediates along the synthesis. Those intermediates were applied in the formal synthesis of Syringolides. A key precursor butenolide to Syringolide 1, the first non-protein specific elicitors of plant hypersensitive response, was obtained after 3 steps from the intermediate (8-10 steps from hydroxyacetone and ethylene glycol). In the experiment, the researchers used many compounds, for example, 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Recommanded Product: 60656-87-3)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Recommanded Product: 60656-87-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem