Category: 60656-87-3

The author of 《Catalytic Asymmetric Synthesis of syn Aldols with Methyl Ketone Functionality and anti Aldols with a Thioamide Group》 were Ota, Yuya; Li, Zhao; Kumagai, Naoya; Shibasaki, Masakatsu. And the article was published in Synlett in 2019. Application In Synthesis of 2-(Benzyloxy)acetaldehyde The author mentioned the following in the article:

Catalytic asym. synthesis of syn aldols I [R = (CH2)6CH3, CH2OBn, (CH2)7OBz, etc.] with a Me ketone functionality were studied to confirm the generality of the methodol. In addition, catalytic asym. synthesis of anti aldols II [R1 = Et, i-Pr, c-hex, etc.] with a thioamide group was carefully examined, giving the desired products, albeit with moderate diastereoselectivity. In the experiment, the researchers used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Application In Synthesis of 2-(Benzyloxy)acetaldehyde)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Application In Synthesis of 2-(Benzyloxy)acetaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Copper-Catalyzed One-Pot Synthesis of 2,3-Dihydroquinazolin-4(1 H )-ones from 2-Nitrobenzonitriles and Carbonyl Compounds Mediated by Diboronic Acid in Methanol-Water》 was published in Synlett in 2020. These research results belong to Liu, Qixing; Sui, Yuebo; Zhang, Yin; Zhang, Kaili; Chen, Yongsheng; Zhou, Haifeng. Name: 2-(Benzyloxy)acetaldehyde The article mentions the following:

A copper-catalyzed one-pot synthesis of 2,3-dihydroquinazolin-4(1 H)-ones with diboronic acid as a reductant in an aqueous medium is described. Various 2,3-dihydroquinazolin-4(1 H)-ones were prepared with good functional-group tolerance in good yields under mild conditions from readily available 2-nitrobenzonitriles and various carbonyl compounds The experimental part of the paper was very detailed, including the reaction process of 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Name: 2-(Benzyloxy)acetaldehyde)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.Name: 2-(Benzyloxy)acetaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Choi, Hosam; Jang, Hanho; Choi, Joohee; Lee, Kiyoun published their research in Molecules in 2021. The article was titled 《Stereoselective synthesis of oxazolidin-2-ones via an asymmetric aldol/Curtius reaction: concise total synthesis of (-)-cytoxazone》.COA of Formula: C9H10O2 The article contains the following contents:

An efficient approach toward the synthesis of 4,5-disubstituted oxazolidin-2-one scaffolds I [R1 = n-Bu, 2-thienyl, 4-ClC6H4, etc.] was reported. The developed approach was based on a combination of an asym. aldol and a modified Curtius protocol, which used an effective intramol. ring closure to rapidly access a range of oxazolidin-2-one building blocks. This strategy also permited a straightforward and concise asym. total synthesis of (-)-cytoxazone. Consisting of three steps, this was one of shortest synthesis reported to date. Ultimately, this convenient platform would provide a promising method for early phases of drug discovery. In the experiment, the researchers used many compounds, for example, 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3COA of Formula: C9H10O2)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).COA of Formula: C9H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Wang, Zichen; Hao, Mingtian; Li, Xiaoyu; Zhang, Beibei; Jiao, Mingyang; Chen, Bo-Zhen published an article in iScience. The title of the article was 《Promising and efficient lignin degradation versatile strategy based on DFT calculations》.COA of Formula: C9H10O2 The author mentioned the following in the article:

The extraction of higher-value products from lignin degradations under mild conditions is a challenge. Previous research reported efficient two-step oxidation and reduction strategies for lignin degradation, which has great significance to lignin degradation In this paper, the mechanism about the C-O bond cleavage of lignin with and without Cα oxidations has been studied systematically. Our calculation results show that the degradation of anionized lignin with Cα oxidations is kinetically and thermodynamically feasible. In addition, the calculations predict that the anionized lignin compounds without Cα oxidation also could be degraded under mild conditions. Moreover, we propose special lignin catalytic degradation systems containing the characteristic structure of “”double hydrogen bonds””. The double hydrogen bonds structure could further decrease the energy barriers of the C-O bond cleavage reaction. This provides a versatile strategy to design novel lignin degradation In the experiment, the researchers used many compounds, for example, 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3COA of Formula: C9H10O2)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).COA of Formula: C9H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《General Route to Purin-2-ylmagnesium Halides by Metal-Halogen Exchange in Dichloromethane》 was written by Gazzola, Silvia; Gordon, Malcolm R.; Lindell, Stephen D.. Product Details of 60656-87-3 And the article was included in Synlett in 2020. The article conveys some information:

Treatment of a solution of 2-iodopurines in dichloromethane with an ethereal solution of ethylmagnesium bromide at -5°C generated the corresponding purin-2-ylmagnesium bromide, which reacted with aldehydes to give the corresponding 2-(hydroxyalkyl)purines I [R1 = H, Cl; R2 = i-Pr, 4-MeC6H4; R3 = Ph, 2-furyl, CH2OBn, etc.] in 53-84% yield. Performing the same procedure in THF as solvent resulted either in extensive decomposition or rapid isomerization to give 8-(hydroxyalkyl)purine. In the experimental materials used by the author, we found 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Product Details of 60656-87-3)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Product Details of 60656-87-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Luo, Xiaosheng; Feng, Qiping; Wang, Ping published an article in Synthesis. The title of the article was 《Radical Addition of 4-Hydroxyquinazolines and Alkylation of Quinones by the Electro-Induced Homolysis of 4-Alkyl-1,4-dihydropyridines》.HPLC of Formula: 60656-87-3 The author mentioned the following in the article:

The formation of C(sp3)-centered radicals via the electro-induced homolysis of 4-alkyl-1,4-dihydropyridines (alkyl-DHPs) is reported. The resulting alkyl radicals reacted with 4-hydroxyquinazolines or quinones to afford 2-alkyldihydroquinazolinones or alkylated quinones. A broad range of alkyl DHPs could be used as versatile radical precursors under electrolysis conditions. This alterative strategy provided a simple and effective pathway for the construction of C(sp2)-C(sp3) and C(sp3)-C(sp3) bonds under mild conditions. In the experiment, the researchers used many compounds, for example, 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3HPLC of Formula: 60656-87-3)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.HPLC of Formula: 60656-87-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Yimyaem, Jirapat; Chantana, Chayamon; Boonmee, Suthimon; Jaratjaroonphong, Jaray published an article in Synlett. The title of the article was 《Expedient Access to Indolyl-Substituted Tri- and Diarylmethanes and (±)-Colletotryptin E by Silica Sulfuric Acid Catalyzed Transindolylation》.Name: 2-(Benzyloxy)acetaldehyde The author mentioned the following in the article:

An expedient access to a series of nonsym. bis(indolyl)methanes (BIMs) through transindolylation of readily available sym. 3,3′-BIMs with various indoles catalyzed by silica-supported sulfuric acid has been established. This approach not only provides a useful strategy for the synthesis of structurally diverse BIMs, but also provides examples of nucleophilic substitution of BIMs with aromatic and nonaromatic π-systems, leading to a library of indolyl-substituted tri- and diarylmethanes. Moreover, this method was successfully applied in the first total synthesis of the 2,3′-BIM alkaloid (±)-colletotryptin E (I) in three steps with an overall yield of 46%. The features of this procedure include a metal-free process, an inexpensive and environmentally friendly catalyst, mild reaction conditions, broad functional-group tolerance, good yields, and gram-scalable preparations In the experiment, the researchers used many compounds, for example, 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Name: 2-(Benzyloxy)acetaldehyde)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Name: 2-(Benzyloxy)acetaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Asymmetric Total Syntheses of (-)-Fennebricin A, (-)-Renieramycin J, (-)-Renieramycin G, (-)-Renieramycin M, and (-)- Jorunnamycin A via C-H Activation》 was published in Organic Letters in 2020. These research results belong to Zheng, Yu; Li, Xue-Dan; Sheng, Peng-Zhen; Yang, Hong-Dou; Wei, Kun; Yang, Yu-Rong. Recommanded Product: 2-(Benzyloxy)acetaldehyde The article mentions the following:

Collective total synthesis of five tetrahydroisoquinoline alkaloids including the first total synthesis of (-)-fennebricin A and (-)-renieramycin J has been accomplished. The synthesis features employing a single common amino acid to sym. construct the pentacycle of title alkaloids. The palladium-catalyzed arylation of alanine-derived amide developed by Yu was tactically utilized to afford unnatural amino acid building block rapidly and practically. The structure of synthetic (-)-renieramycin M has been confirmed by single crystal X-ray anal. for the first time. The experimental process involved the reaction of 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Recommanded Product: 2-(Benzyloxy)acetaldehyde)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.Recommanded Product: 2-(Benzyloxy)acetaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Potenti, Simone; Spada, Lorenzo; Fuse, Marco; Mancini, Giordano; Gualandi, Andrea; Leonardi, Costanza; Cozzi, Pier Giorgio; Puzzarini, Cristina; Barone, Vincenzo published an article in 2021. The article was titled 《4-Fluoro-Threonine: From Diastereoselective Synthesis to pH-Dependent Conformational Equilibrium in Aqueous Solution》, and you may find the article in ACS Omega.Name: 2-(Benzyloxy)acetaldehyde The information in the text is summarized as follows:

4-Fluorothreonine, the only fluoro amino acid of natural origin discovered so far, is an interesting target for both synthetic and theor. investigations. In this work, we lay the foundation for spectroscopic characterization of 4-fluorothreonine. First, we report a diastereoselective synthetic route, which is suitable to produce synthetic material for exptl. characterization. The addition of the com. available Et isocyanoacetate to benzyloxyacetaldehyde led to the corresponding benzyloxy-oxazoline, which was hydrolyzed and transformed into Et (4S*,5S*)-5-hydroxymethyl-2-oxo-4-oxazolidinecarboxylate in a few steps. Fluorination with diethylamino sulfur trifluoride (DAST) afforded Et (4S*,5S*)-5-fluoromethyl-2-oxo-4-oxazolidinecarboxylate, which was deprotected to give the desired diastereomerically pure 4-fluorothreonine, in 8-10% overall yield. With the synthetic material in our hands, acid-base titrations have been carried out to determine acid dissociation constants and the isoelec. point, which is the testing ground for the theor. anal. We have used machine learning coupled with quantum chem. at the state-of-the-art to analyze the conformational space of 4-fluoro-threonine, with the aim of gaining insights from the comparison of computational and exptl. results. Indeed, we have demonstrated that our approach, which couples a last-generation double-hybrid d. functional including empirical dispersion contributions with a model combining explicit first-shell mols. and a polarizable continuum for describing solvent effects, provides results and trends in remarkable agreement with experiments Finally, the conformational anal. applied to fluoro amino acids represents an interesting study for the effect of fluorine on the stability and population of conformers. After reading the article, we found that the author used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Name: 2-(Benzyloxy)acetaldehyde)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Name: 2-(Benzyloxy)acetaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Xue, Sijing; Cristofol, Alex; Limburg, Bart; Zeng, Qian; Kleij, Arjan W. published an article in ACS Catalysis. The title of the article was 《Dual Cobalt/Organophotoredox Catalysis for Diastereo- and Regioselective 1,2-Difunctionalization of 1,3-Diene Surrogates Creating Quaternary Carbon Centers》.HPLC of Formula: 60656-87-3 The author mentioned the following in the article:

The synthesis of quaternary carbons RCH(OH)C(R1)(Me)CH=CH2(R = Ph, naphthalen-2-yl, 4-(prop-1-en-2-yl)cyclohex-1-en-1-yl, furan-2-yl, etc.; R1 = Ph, 4-MeOPh, 4-MePh, 4F-Ph, 4-Cl-Ph, etc.) through a catalytic stereo- and regioselective difunctionalization of 2-substituted 1,3-dienes C6H5CH(OH)C(C6H5)(CH2R2)CH=CH2 remains elusive. Here, a dual Co/photoredox-catalyzed cascade approach that addresses this challenge using modular vinyl cyclic carbonates functioning as masked 2-aryl-1,3-dienes I surrogates was presented. The latter species are conveniently prepared in situ and converted into nucleophilic Co(allyl) intermediates that are intercepted by aldehydes to afford homoallylic alcs. compound (I) with ample scope in reaction partners. The developed protocol marks a significant step forward in the use of structurally versatile 1,3-dienes I and their catalytic 1,2-hydroalkylation and 1,2-dicarbofunctionalization. In the experimental materials used by the author, we found 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3HPLC of Formula: 60656-87-3)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).HPLC of Formula: 60656-87-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem