Category: 592-55-2

Related Products of 592-55-2, The chemical industry reduces the impact on the environment during synthesis 592-55-2, name is 1-Bromo-2-ethoxyethane, I believe this compound will play a more active role in future production and life.

Potassium carbonate (2.43 g, 17.56 mmol) and ethyl bromoacetate (1.76 g, 10.54 mmol) were added to a solution of bis (2- (1- methylimidazolyl) methyl) amine(Lll) (1.8 g, 8.78 mmol) in dimethylfonnamide under an argon atmosphere. The resulting suspension was sheltered from light and allowed to stir at room temperature for 5 days. Water was added to the resulting mixture, and the solution was extracted with chloroform (3 x 50 mL). After the solvent was evaporated, the resulting oil was purified by silica gel column chromatography using a MeOH/CHC13 (5: 95) solution to giveLllEt as white powder. Yield: 1.05 g (41%). 1H NMR((ppm), MeOH-d4) : 6.87 (d, J) 1.2 Hz, 2H, ImH), 6.79(d, J) 1.2 Hz, 2H, ImH), 4.06 (q, J) 14.4 Hz, 2H,OCH2), 3.75 (s, 4H, ImCH2), 3.51 (s, 6H,NCH3), 3.35 (s, 2H, NCH2CO2), 1.19 (t, J) 7.2 Hz, 3H,CHs).”C NMR(b(ppm), MeOH-d4) : 172.09 (C,C02Et), 146.24 (2C, Im), 127.17 (2CH, Im), 123.79 (2CH, Im), 61.73 (C, OCH2), 55.03 (2C, ImCH2), 52.37 (2C,NCH3), 33.24 (C,NCH2), 14.67 (C, CH3).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2-ethoxyethane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MOLECULAR INSIGHT PHARMACEUTICALS; WO2005/79865; (2005); A1;,
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Ether | (C2H5)2O – PubChem

Reference of 592-55-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 592-55-2, name is 1-Bromo-2-ethoxyethane, This compound has unique chemical properties. The synthetic route is as follows.

4-Nitro-1 H-pyrazole-3, 5-dicarboxylic acid dimethyl ester (2. 0g, 8. 83MMOL) was added to a solution of 2-ethoxyethyl bromide (1. 18ML, 10. 45mmol) and potassium carbonate (1.32g, 9. 56MMOL) in N, N-dimethylformamide (35mL) and the reaction mixture stirred-for 48 hours at room temperature. The reaction mixture was concentrated IN VACUO and partitioned between ethyl acetate (200mL) and water (100ML). The organic layer was separated, dried over magnesium sulphate and concentrated in vacuo The crude product was purified by column chromatography on silica gel eluting with pentane: ethyl acetate 100: 0 to 70: 30 to yield the title product, 1.63g. ‘H NMR (CDCI3, 400MHZ) B : 1.07 (t, 3H), 3.41 (q, 2H), 3.73 (t, 2H), 3.89 (s, 3H), 3.94 (s, 3H), 4.76 (t, 2H). LRMS: m/z APCI+ 302, [MH] +

The chemical industry reduces the impact on the environment during synthesis 1-Bromo-2-ethoxyethane. I believe this compound will play a more active role in future production and life.

Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2004/96810; (2004); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Some common heterocyclic compound, 592-55-2, name is 1-Bromo-2-ethoxyethane, molecular formula is C4H9BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 1-Bromo-2-ethoxyethane

General procedure: To a mixture of 1,2,4-triazole 1 (1 mmol), triethylamine (1.1 mmol)and ethanol (20 ml) was added with stirring bromoethanol (2), chloropropanol(3), chloroglycerol (4), 2,3-O-isopropylidene-1-O-(p-tolylsulfonyl)-glycerol (5), bromoethylmethyl ether (6) and/or bromoethylethylether (7) (1.1 mmol). The mixture was stirred at reflux for8 h with 2-4 and for 6 h with 5-7. Ethanol was removed under pressureand the resulting solid was collected and recrystallized from ethanol toafford the targeted S-acyclonucleoside analogues 8-13.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 592-55-2, its application will become more common.

Reference:
Article; Aouad, Mohamed Reda; Al-Mohammadi, Hannan Musallam; Al-blewi, Fawzia Faleh; Ihmaid, Saleh; Elbadawy, Hossein Mostafa; Althagfan, Sultan Saad; Rezki, Nadjet; Bioorganic Chemistry; vol. 94; (2020);,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 592-55-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 592-55-2, name is 1-Bromo-2-ethoxyethane, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a stirred solution of 22 (30 mg, 0.081 mmol) in DMF (3 mL) were added K2CO3 (170 mg, 1.20 mmol), NaI (180 mg, 1.20 mmol) and 2-bromoethyl methyl ether (75 muL, 0.81 mmol), and stirred at 100 C under an Ar atmosphere. After 3 h with stirring, the reaction mixture was evaporated in vacuo. The resulting mixture was basified (pH 9) with saturated NaHCO3 aqueous solution and extracted with CHCl3 three times. The combined organic extracts were washed with brine, dried over Na2SO4, and evaporated in vacuo. The residue was purified by preparative TLC (CHCl3/MeOH = 10:1) to give 26 (27 mg, 77%) as a colorless oil.

The chemical industry reduces the impact on the environment during synthesis 1-Bromo-2-ethoxyethane. I believe this compound will play a more active role in future production and life.

Reference:
Article; Nemoto, Toru; Ida, Yoshihiro; Iihara, Yusuke; Nakajima, Ryo; Hirayama, Shigeto; Iwai, Takashi; Fujii, Hideaki; Nagase, Hiroshi; Bioorganic and Medicinal Chemistry; vol. 21; 24; (2013); p. 7628 – 7647;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem