578-58-5 Archives - Page 9 of 9 - Ethers-buliding-blocks

Sahoo, Kanchanbala et al. published their research in Advanced Synthesis & Catalysis in 2022 |CAS: 578-58-5

The Article related to amidophenol iron chloride regioselective chlorination heterocyclization, chloro benzoxazole preparation, methoxybenzene amidophenol iron chloride heterocyclization cross dehydrogenative coupling, methoxyphenyl benzoxazole preparation and other aspects.Application In Synthesis of 2-Methylanisole

On March 1, 2022, Sahoo, Kanchanbala; Panda, Niranjan published an article.Application In Synthesis of 2-Methylanisole The title of the article was Iron(III) Chloride Mediated para-Selective C-H Functionalization: Access to C5-Chloro and C5,C7-Dichloro/Dianisyl Substituted 2-Arylbenzoxazoles. And the article contained the following:

Iron(III) chloride mediated para-selective C-H chlorination and subsequent annulation of 2-amidophenol to synthesize C5- and C5, C7-chlorinated benzoxazoles was developed. Further, the oxidative cross-dehydrogenative coupling of amidophenol with anisole by ferric chloride was explored to achieve the remotely anisylated benzoxazoles. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Application In Synthesis of 2-Methylanisole

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kang, Qi-Kai et al. published their research in Angewandte Chemie, International Edition in 2021 |CAS: 578-58-5

The Article related to phenol preparation dft mechanistic study, water aryl fluoride hydroxylation rhodium catalyst, ester preparation dft mechanistic study, aryl fluoride alc alkoxylation rhodium catalyst, c−o bond formation, meisenheimer-type intermediate, rhodium, η6-coordination and other aspects.Quality Control of 2-Methylanisole

On September 6, 2021, Kang, Qi-Kai; Lin, Yunzhi; Li, Yuntong; Xu, Lun; Li, Ke; Shi, Hang published an article.Quality Control of 2-Methylanisole The title of the article was Catalytic SNAr Hydroxylation and Alkoxylation of Aryl Fluorides. And the article contained the following:

A reliable method for accessing phenols ArOH (Ar = C6H5, 4-CH3OC6H4, 9H-fluoren-2-yl, etc.) and Ph alkyl ethers Ar1OR (Ar1 = 4-CH3C6H4, 9H-fluoren-2-yl, 1-methyl-2-oxo-2,3-dihydro-1H-indol-5-yl, etc.; R = Me, cyclohexylmethyl, oxan-4-yl, etc.) via catalytic SnAr reactions has been described. The method is applicable to a broad array of electron-rich and neutral aryl fluorides ArF and Ar1F, which are inert under classical SnAr conditions. Although the mechanism of SNAr reactions involving metal arene complexes is hypothesized to involve a stepwise pathway (addition followed by elimination), exptl. data that support this hypothesis is still under exploration. Mechanistic studies and DFT calculations suggest either a stepwise or stepwise-like energy profile. Notably, a rhodium η5-cyclohexadienyl complex intermediate with an sp3-hybridized carbon bearing both a nucleophile and a leaving group was isolated. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Quality Control of 2-Methylanisole

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kim, Hyun Tae et al. published their research in Organic Letters in 2021 |CAS: 578-58-5

The Article related to bidentate pyrazolonaphthyridine ligand palladium catalyst preparation, aryl amine terminal alkene pyrazolonaphthyridine palladium catalyst regioselective alkenylation, alkoxyarene terminal alkene pyrazolonaphthyridine palladium catalyst regioselective alkenylation and other aspects.Related Products of 578-58-5

On May 7, 2021, Kim, Hyun Tae; Kang, Eunsu; Kim, Minkyu; Joo, Jung Min published an article.Related Products of 578-58-5 The title of the article was Synthesis of Bidentate Nitrogen Ligands by Rh-Catalyzed C-H Annulation and Their Application to Pd-Catalyzed Aerobic C-H Alkenylation. And the article contained the following:

A new class of bidentate ligands was prepared by a modular approach involving Rh-catalyzed C-H annulation reactions. The resulting conformationally constrained ligands enabled the Pd-catalyzed C-H alkenylation at electron-rich and sterically less hindered positions of electron-rich arenes while promoting the facile oxidation of Pd(0) intermediates by oxygen. This newly introduced ligand class was complementary to the ligands developed for Pd-catalyzed oxidative reactions and may find broad application in transition-metal-catalyzed reactions. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Related Products of 578-58-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wu, Zhuo et al. published their research in Chemical Science in 2021 |CAS: 578-58-5

The Article related to methoxy alkylarene preparation regioselective, haloalkane methoxy aryliodide palladium tandem alkylation oxidative cross coupling, benzyloxy alkylbenzene preparation regioselective, phenyl benzyloxyiodide haloalkane palladium tandem alkylation oxidative cross coupling and other aspects.Formula: C8H10O

Wu, Zhuo; Jiang, Hang; Zhang, Yanghui published an article in 2021, the title of the article was Pd-catalyzed cross-electrophile Coupling/C-H alkylation reaction enabled by a mediator generated via C(sp3)-H activation.Formula: C8H10O And the article contains the following content:

Pd-catalyzed cascade cross-electrophile coupling and C-H alkylation reaction of 2-iodo-alkoxylarenes with alkyl chlorides were reported. Methoxy and benzyloxy groups, which were ubiquitous functional groups and common protecting groups, were utilized as crucial mediators via primary or secondary C(sp3)-H activation. The reaction provided an innovative and convenient access for the synthesis of alkylated phenol derivatives, which were widely found in bioactive compounds and organic functional materials. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Formula: C8H10O

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhao, Lanxiao et al. published their research in ACS Catalysis in 2021 |CAS: 578-58-5

The Article related to calcium benzyl complex catalyzed dehydrogenative silylation aromatic ether hydrosilane, scorpionate supported calcium benzyl ether complex preparation crystal structure, mol structure scorpionate supported calcium benzyl ether complex, silyl substituted aromatic ether derivative preparation and other aspects.Application of 578-58-5

On February 19, 2021, Zhao, Lanxiao; Shi, Xianghui; Cheng, Jianhua published an article.Application of 578-58-5 The title of the article was Calcium-Catalyzed Dehydrogenative Silylation of Aromatic Ethers with Hydrosilane. And the article contained the following:

The catalytic regioselective C-H silylation of a wide range of alkoxy-substituted benzene derivatives with primary hydrosilane was achieved using scorpionate-supported Ca benzyl complex [(TpAd,iPr)Ca(p-CH2C6H4Me)(THP)] (1) (TpAd,iPr = hydrotris(3-adamantyl-5-isopropylpyrazolyl)borate, THP = tetrahydropyran) as the precatalyst. This protocol offers an atom-efficient and straightforward method for the synthesis of a variety of silyl-substituted aromatic ether derivatives without a H acceptor and free of transition metal. Ca anisyl complexes [(TpAd,iPr)Ca(o-MeO-m-Br-C6H3)] (5) and [(TpAd,iPr)Ca(o-Me-OCH2C6H4)] (6), proposed as the catalytic reaction intermediates, were isolated and structurally characterized. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Application of 578-58-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yuan, Tao et al. published their research in Chemical Science in 2021 |CAS: 578-58-5

The Article related to boron carbonitride preparation surface structure, aryl halide boron carbonitride photocatalyst hydrodehalogenation, aromatic hydrocarbon preparation, arene aryl halide boron carbonitride photocatalyst cross coupling arylation, biaryl preparation, haloarene sodium sulfinate boron carbonitride photocatalyst cross coupling sulfonylation, arylsulfone preparation and other aspects.COA of Formula: C8H10O

Yuan, Tao; Zheng, Meifang; Antonietti, Markus; Wang, Xinchen published an article in 2021, the title of the article was Ceramic boron carbonitrides for unlocking organic halides with visible light.COA of Formula: C8H10O And the article contains the following content:

Here, boron carbonitride (BCN) ceramics were such a system and can reduce organic halides, including (het)aryl and alkyl halides, with visible light irradn was reported. Cross-coupling of halides to afford new C-H, C-C, and C-S bonds was proceeded at ambient reaction conditions. Hydrogen, (het)aryl, and sulfonyl groups were introduced into the arenes and heteroarenes at the designed positions by means of mesolytic C-X (carbon-halogen) bond cleavage in the absence of any metal-based catalysts or ligands. BCN was used not only for half reactions, like reduction reactions with a sacrificial agent, but also redox reactions through oxidative and reductive interfacial electron transfer. The BCN photocatalyst showed tolerance to different substituents and conserved activity after five recycles. The apparent metal-free system opened new opportunities for a wide range of organic catalysts using light energy and sustainable materials, which were metal-free, inexpensive and stable. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).COA of Formula: C8H10O

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Some tips on 578-58-5

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 578-58-5, its application will become more common.

Some common heterocyclic compound, 578-58-5, name is 2-Methylanisole, molecular formula is C8H10O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 2-Methylanisole

a) A solution of 24 g of 2-methylanisole, 35 g of N-bromosuccinimide and 1.24 g of dibenzoyl peroxide in 150 ml of carbon tetrachloride was heated to boiling under reflux for 12 hours. After cooling the solution was filtered and the filtrate is evaporated. The residue was recrystallized from hexane. There were obtained 18.6 g (47%) of 4-bromo-2-methylanisole as a colorless solid; m.p. 66-68.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 578-58-5, its application will become more common.

Reference:
Patent; Hoffmann-La Roche Inc.; US5214046; (1993); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Some scientific research about 578-58-5

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Methylanisole, and friends who are interested can also refer to it.

Related Products of 578-58-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 578-58-5 name is 2-Methylanisole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: 1 mL [Bmim]NO3, 0.5 mmolsubstrate and 0.25 mmol Br2 were added to a dried 45 mL tube equipped witha magnetic stirring (note: the air in the tube was not removed). Then thereaction tube was sealed to perform the reaction at 80 C for 24 h. Once thereaction time was reached, the mixture was cooled to room temperature and3 mL water was added. Then the desired product was extracted with CH2Cl2(3 10 mL). GC analysis of the mixture provided the GC yield of the product.The product in another parallel experiment was purified by columnchromatography, and identified by 1H NMR and 13C NMR.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Methylanisole, and friends who are interested can also refer to it.

Reference:
Article; Ren, Yun-Lai; Wang, Binyu; Tian, Xin-Zhe; Zhao, Shuang; Wang, Jianji; Tetrahedron Letters; vol. 56; 46; (2015); p. 6452 – 6455;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem