Category: 578-58-5

Ishida, Naoki; Shinoya, Hiroki; Kamino, Yuka; Kawasaki, Tairin; Murakami, Masahiro published an article in 2022, the title of the article was Dehydrogenative Three-component Coupling of CO with Methylarenes Forming Dibenzyl Ketones.Recommanded Product: 2-Methylanisole And the article contains the following content:

NUM Herein reported is a photoinduced dehydrogenative three-component coupling reaction of carbon monoxide with two mols. of methylarenes fArCH3 (Ar = Ph, 2-naphthyl, 2-thiophenyl, etc.) forming dibenzyl ketones ArCH2C(O)CH2Ar. A gaseous dihydrogen mol. evolves as the byproduct, and neither oxidants nor hydrogen acceptors are required. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Recommanded Product: 2-Methylanisole

The Article related to dibenzyl ketone preparation photochem, methylarene carbon monoxide dehydrogenative three component coupling iridium catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Recommanded Product: 2-Methylanisole

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On July 15, 2022, Zhang, Wenxuan; Sun, Jiaying; Lian, Zhendong; Song, Ran; Yang, Daoshan; Lv, Jian published an article.Synthetic Route of 578-58-5 The title of the article was Enantioselective Friedel-Crafts Reaction of 2-Alkynyphenols with Aromatic Ethers by Chiral Bronsted Acid Catalysis. And the article contained the following:

Herein, authors report chiral strong Bronsted acid-catalyzed enantioselective Friedel-Crafts reaction of 2-alkynyphenols with aromatic ethers. The reaction affords the corresponding axially chiral styrenes in up to 91% yield and 97% ee. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Synthetic Route of 578-58-5

The Article related to axially chiral styrene preparation enantioselective strong bronsted acid catalyst, alkynyphenol aromatic ether friedel crafts, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Synthetic Route of 578-58-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On October 31, 2022, Waddell, Lachlan J. N.; Henry, Martyn C.; Mostafa, Mohamed A. B.; Sutherland, Andrew published an article.Synthetic Route of 578-58-5 The title of the article was One-Pot Synthesis of Diaryl Sulfonamides using an Iron- and Copper-Catalyzed Aryl C-H Amidation Process. And the article contained the following:

A one-pot, two-stage synthesis of diaryl sulfonamides using sequential iron and copper catalysis is developed. Regioselective para-iodination of activated arenes by the super Lewis acid, iron triflimide and N-iodosuccinimide (NIS), is followed by a copper(I)-catalyzed N-arylation reaction. The process is found to be applicable for the coupling of a range of anisoles, anilines and acetanilides with primary sulfonamides and is used for the one-pot synthesis of biol. important compounds The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Synthetic Route of 578-58-5

The Article related to diaryl sulfonamide one pot preparation, arene primary sulfonamide amidation iron copper catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Sulfenic, Sulfinic, and Sulfonic Acids and Derivatives and other aspects.Synthetic Route of 578-58-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On July 1, 2022, Zhao, Lanxiao; Deng, Peng; Gong, Xun; Kang, Xiaohui; Cheng, Jianhua published an article.Synthetic Route of 578-58-5 The title of the article was Regioselective C-H Alkylation of Aromatic Ethers with Alkenes by a Half-Sandwich Calcium Catalyst. And the article contained the following:

The catalytic ortho-regioselective C-H alkylation of a of alkoxy-substituted benzene derivatives with alkenes could be achieved by the use of a half-sandwich calcium alkyl complex [(CpAr5)Ca{CH(SiMe3)2}(THF)] (CpAr5 = C5Ar5, Ar = 3,5-i-Pr-C6H3) as the precatalyst to form 1-alkoxy-2-phenethylbenzene derivatives I [R = H, 4-Me, 4-SMe, etc.; R1 = OMe, OEt, i-Pr, etc.]. The potential catalytic reaction intermediates, half-sandwich calcium anisyl complexes [(CpAr5)Ca(o-MeO-m-Ph-C6H3) (THF)2] and [(CpAr5)Ca(o-MeO-2-Np) (THF)2] (Np = naphthyl), were isolated and X-ray structurally characterized. DFT calculations were carried out to elucidate the different reaction profiles of sp2 and sp3 C-H activations. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Synthetic Route of 578-58-5

The Article related to alkoxy phenethylbenzene preparation, arylether alkene regioselective carbon hydrogen alkylation half sandwich calcium, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ethers, Sulfides, and The Corresponding Onium Compounds and other aspects.Synthetic Route of 578-58-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On December 4, 2020, Wanniang, Kmendashisha; Shangpliang, O. Risuklang; Marpna, Ibakyntiew D.; Lipon, Tyrchain Mitre; Laloo, Badaker M.; Myrboh, Bekington published an article.Recommanded Product: 2-Methylanisole The title of the article was Metal-Free Three-Component Coupling Reaction of Ketones with Electron-rich Arenes and Selenium Dioxide for the Synthesis of α-Arylselanyl Ketones. And the article contained the following:

A metal-free three-component coupling reaction of aryl alkyl/alkyl ketones, SeO2, and phenols/anisoles is described. This multicomponent reaction provides a straightforward and facile pathway for the synthesis of α-((4-hydroxy/methoxyphenyl)selanyl)-aryl alkyl/alkyl ketones in the presence of p-toluenesulfonic acid for the C-Se bond formation process. The method offers an attractive and simple procedure using commonly available shelf reagents to deliver organoselenides that, to our knowledge, are being reported here for the first time. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Recommanded Product: 2-Methylanisole

The Article related to organoselenide synthesis three component coupling ketone arene selenium dioxide, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ketones and Derivatives, Including Quinones and Sulfur Analogs and other aspects.Recommanded Product: 2-Methylanisole

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On October 1, 2021, Li, Xue; Bai, Fang; Liu, Chaogan; Ma, Xiaowei; Gu, Chengzhi; Dai, Bin published an article.Safety of 2-Methylanisole The title of the article was Selective Electrochemical Oxygenation of Alkylarenes to Carbonyls. And the article contained the following:

An efficient electrochem. method for benzylic C(sp3)-H bond oxidation has been developed. A variety of methylarenes, e.g., p-chlorotoluene, methylheteroarenes, e.g., 6-methylquinoline and benzylic (hetero)methylenes, e.g., p-ethyltoluene could be converted into the desired aryl aldehydes, e.g., 4-chlorobenzaldehyde/e.g., quinoline-6-carbaldehyde and aryl ketones, e.g., 1-(p-tolyl)ethan-1-one in moderate to excellent yields in an undivided cell, using O2 as the oxygen source and lutidinium perchlorate as an electrolyte. On the basis of cyclic voltammetry studies, 18O labeling experiments, and radical trapping experiments, a possible single-electron transfer mechanism has been proposed for the electrooxidation reaction. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Safety of 2-Methylanisole

The Article related to aldehyde preparation chemoselective, alkylarene selective electrochem oxygenation, ketone preparation chemoselective, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ketones and Derivatives, Including Quinones and Sulfur Analogs and other aspects.Safety of 2-Methylanisole

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On August 31, 2021, Bao, Can-Can; Luo, Yan-Long; Du, Hui-Zhen; Guan, Bing-Tao published an article.SDS of cas: 578-58-5 The title of the article was Benzylic aroylation of toluenes with unactivated tertiary benzamides promoted by directed ortho-lithiation. And the article contained the following:

The deprotonative functionalization of toluenes, for their weak acidity, generally needed strong bases, thus led to the requirement of harsh conditions and the generation of byproducts. Direct nucleophilic acyl substitution reaction of amides with organometallic reagents could provide an ideal solution for ketone synthesis. However, the inert amides and highly reactive organometallic reagents brought great challenges for an efficient and selective synthetic approach. Herein, an lithium diisopropylamide (LDA)-promoted benzylic aroylation of toluenes with unactivated tertiary benzamides, providing a direct and efficient synthesis of various aryl benzyl ketones ArC(O)CH2Ar1 [Ar = Ph, 3,4-di-MeOC6H3, 2-naphthyl, etc.; Ar1 = Ph, 4-MeOC6H4, 3,5-di-MeC6H3, etc.] was reported. This process featured a kinetic deprotonative functionalization of toluenes with a readily available base LDA. Mechanism studies revealed that the directed ortho-lithiation of the tertiary benzamide with LDA promoted the benzylic kinetic deprotonation of toluene and triggered the nucleophilic acyl substitution reaction with the amide. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).SDS of cas: 578-58-5

The Article related to aryl arylethanone preparation, toluene tertiary arylamide benzylic aroylation ortho lithiation catalyst lda, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ketones and Derivatives, Including Quinones and Sulfur Analogs and other aspects.SDS of cas: 578-58-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On January 7, 2022, Gu, Yuanyun; Zhang, Zhen; Wang, Yan-En; Dai, Ziteng; Yuan, Yaqi; Xiong, Dan; Li, Jie; Walsh, Patrick J.; Mao, Jianyou published an article.Formula: C8H10O The title of the article was Benzylic Aroylation of Toluenes Mediated by a LiN(SiMe3)2/Cs+ System. And the article contained the following:

Chemoselective deprotonative functionalization of benzylic C-H bonds is challenging, because the arene ring contains multiple aromatic C(sp2)-H bonds, which can be competitively deprotonated and lead to selectivity issues. Recently it was found that bimetallic [MN(SiMe3)2 M = Li, Na]/Cs+ combinations exhibit excellent benzylic selectivity. Herein, is reported the first deprotonative addition of toluenes to Weinreb amides mediated by LiN(SiMe3)2/CsF for the synthesis of a diverse array of 2-arylacetophenones. Surprisingly, simple Me benzoates also react with toluenes under similar conditions to form 2-arylacetophenones without double addition to give tertiary alc. products. This finding greatly increases the practicality and impact of this chem. Some challenging substrates with respect to benzylic deprotonations, such as fluoro and methoxy substituted toluenes, are selectively transformed to 2-aryl acetophenones. The value of benzylic deprotonation of 3-fluorotoluene is demonstrated by the synthesis of a key intermediate in the preparation of Polmacoxib. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Formula: C8H10O

The Article related to aryl acetophenone preparation, methyl benzoate weinreb amide toluene benzylic aroylation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ketones and Derivatives, Including Quinones and Sulfur Analogs and other aspects.Formula: C8H10O

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On August 31, 2021, Li, Rui; Du, Tianshu; Liu, Jingxing; Aquino, Adelia J. A.; Zhang, Jianyu published an article.Recommanded Product: 578-58-5 The title of the article was Theoretical Study of O-CH3 Bond Dissociation Enthalpy in Anisole Systems. And the article contained the following:

Understanding ubiquitous Me transfer reactions requires a systematic study of thermodynamical parameters that could reveal valuable information about the nature of the chem. bond and the feasibility of those processes. In the present study, the O-CH3 bond dissociation enthalpies (BDEs) of 67 compounds belonging to phenol/anisole systems were calculated employing the Gaussian-4 (G4) method. Those compounds contain different substituents including alkyl groups, electron-donating groups (EDGs), and electron-withdrawing groups (EWGs). The results show that the bigger branched alkyl groups and EDGs will destabilize the O-CH3 bond, while EWGs have the opposite effect. A combination of different effects including steric effects, hydrogen bonds, and substituents and their position can achieve around 20 kcal/mol difference compared to the basic Ph frame. Also, the linear correlation between σp+ and O-CH3 BDE can provide a reference for the O-CH3 BDE prediction. The present study represents a step forward to establish a comprehensive O-CH3 BDE database to understand the substituent effect and make its contribution to the rational design of inhibitors and drugs. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Recommanded Product: 578-58-5

The Article related to oxygen methyl bond dissociation enthalpy anisole substituent effect, Physical Organic Chemistry: Theoretical Organic Chemical Concepts, Including Quantum and Molecular Mechanical Studies and other aspects.Recommanded Product: 578-58-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On April 17, 2020, See, Yi Yang; Sanford, Melanie S. published an article.Quality Control of 2-Methylanisole The title of the article was C-H Amination of Arenes with Hydroxylamine. And the article contained the following:

This Letter describes the development of a TiIII-mediated reaction for the C-H amination of arenes with hydroxylamine. This reaction is applied to a variety of electron-rich (hetero)arene substrates, including a series of natural products and pharmaceuticals. It offers the advantages of mild conditions (room temperature), fast reaction rates (<30 min), compatibility with ambient moisture and air, scalability, and the use of inexpensive com. reagents. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Quality Control of 2-Methylanisole

The Article related to arene hydroxylamine titanium amination, aniline preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amines, Amine Oxides, Imines, and Quaternary Ammonium Compounds and other aspects.Quality Control of 2-Methylanisole

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem